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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:linear tetrapyrrole
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bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein] CTD PMID:24306262 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
multiple interactions
ISO ABCC1 protein affects the transport of Bilirubin
Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]
CTD PMID:15245331 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions
affects transport
EXP Bilirubin results in decreased activity of ABCC2 protein
Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein]
ABCC2 protein affects the transport of Bilirubin
CTD PMID:15374814, PMID:15901347, PMID:24306262 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [[Bilirubin binds to and results in increased activity of AHR protein] which binds to CYP1A promoter] which results in increased expression of CYP1A mRNA CTD PMID:18187559 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase decreases expression ISO Bilirubin results in decreased expression of ALAD mRNA CTD PMID:20196124 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Bilirubin binds to ALB protein
Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein]
CTD PMID:21280114 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Bilirubin results in decreased expression of ANXA1 mRNA CTD PMID:20196124 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Areg amphiregulin increases expression ISO Bilirubin results in increased expression of AREG mRNA CTD PMID:20196124 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Bilirubin results in decreased expression of ARHGAP29 mRNA CTD PMID:20196124 NCBI chr 2:225,552,075...225,613,349
Ensembl chr 2:225,552,148...225,613,359
JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Bilirubin results in decreased expression of ASB13 mRNA CTD PMID:20196124 NCBI chr17:70,215,401...70,234,103
Ensembl chr17:70,215,401...70,234,103
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bilirubin results in increased expression of ATF3 mRNA CTD PMID:20196124 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO Bilirubin results in increased expression of ATF6 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]
CTD PMID:27578021 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression ISO Bilirubin results in decreased expression of ATP1A1 mRNA CTD PMID:20196124 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Axin2 axin 2 decreases expression ISO Bilirubin results in decreased expression of AXIN2 mRNA CTD PMID:20196124 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 decreases expression ISO Bilirubin results in decreased expression of BLOC1S1 mRNA CTD PMID:20196124 NCBI chr 7:3,342,630...3,346,238
Ensembl chr 7:3,342,630...3,346,238
JBrowse link
G C1d C1D nuclear receptor corepressor decreases expression ISO Bilirubin results in decreased expression of C1D mRNA CTD PMID:20196124 NCBI chr14:100,415,645...100,427,878
Ensembl chr14:100,415,668...100,427,260
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein] CTD PMID:20709802, PMID:23628428, PMID:27578021 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression ISO Bilirubin results in decreased expression of CAT mRNA CTD PMID:20196124 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression ISO Bilirubin results in decreased expression of CCDC80 mRNA CTD PMID:20196124 NCBI chr11:60,645,660...60,679,249
Ensembl chr11:60,645,086...60,679,555
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Bilirubin results in decreased expression of CCND1 mRNA CTD PMID:20196124 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd302 CD302 molecule decreases expression ISO Bilirubin results in decreased expression of CD302 mRNA CTD PMID:20196124 NCBI chr 3:46,327,382...46,361,092
Ensembl chr 3:46,327,383...46,361,092
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Bilirubin results in increased expression of CHAC1 mRNA CTD PMID:20196124 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Chka choline kinase alpha increases expression ISO Bilirubin results in increased expression of CHKA mRNA CTD PMID:20196124 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Clcc1 chloride channel CLIC-like 1 decreases expression ISO Bilirubin results in decreased expression of CLCC1 mRNA CTD PMID:20196124 NCBI chr 2:211,450,426...211,479,885
Ensembl chr 2:211,450,484...211,479,884
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO Bilirubin results in decreased expression of CLIP1 mRNA CTD PMID:20196124 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Bilirubin results in decreased expression of COL3A1 mRNA CTD PMID:20196124 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Bilirubin results in decreased expression of COX15 mRNA CTD PMID:20196124 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cpd carboxypeptidase D decreases expression ISO Bilirubin results in decreased expression of CPD mRNA CTD PMID:20196124 NCBI chr10:63,325,764...63,389,811
Ensembl chr10:63,325,199...63,389,817
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Bilirubin results in increased expression of CSF2 mRNA CTD PMID:20196124 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctsh cathepsin H decreases expression ISO Bilirubin results in decreased expression of CTSH mRNA CTD PMID:20196124 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Bilirubin results in increased expression of CXCL10 mRNA CTD PMID:20196124 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Bilirubin results in increased expression of CXCL11 mRNA CTD PMID:20196124 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Bilirubin results in increased expression of CXCL2 mRNA CTD PMID:20196124 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Bilirubin results in increased expression of CYP1A1 mRNA; Bilirubin results in increased expression of CYP1A1 protein CTD PMID:20196124 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Bilirubin results in decreased activity of CYP1A2 protein CTD PMID:16183037 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions
affects degradation
increases oxidation
increases degradation
increases stability
decreases activity
increases expression
ISO [CYP2A5 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine; Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]; Bilirubin results in increased expression of and results in increased activity of CYP2A5 protein; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]
CYP2A5 protein affects the degradation of Bilirubin
CYP2A5 protein results in increased degradation of Bilirubin
Bilirubin results in increased stability of CYP2A5 protein
Bilirubin results in decreased activity of CYP2A5 protein
Bilirubin results in increased expression of CYP2A5 mRNA; Bilirubin results in increased expression of CYP2A5 protein
CTD PMID:16183037, PMID:21871474, PMID:22465937, PMID:23628428, PMID:25478736 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO Bilirubin results in increased expression of CYP2B6 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]
CTD PMID:15382119 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases activity
EXP [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Bilirubin results in decreased activity of CYP7A1 protein
CTD PMID:12700418 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Bilirubin results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]
CTD PMID:20196124, PMID:27578021 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein decreases expression ISO Bilirubin results in decreased expression of DEPTOR mRNA CTD PMID:20196124 NCBI chr 7:94,795,161...95,000,750
Ensembl chr 7:94,795,214...94,995,809
JBrowse link
G Dmkn dermokine decreases expression ISO Bilirubin results in decreased expression of DMKN mRNA CTD PMID:20196124 NCBI chr 1:89,215,266...89,229,696
Ensembl chr 1:89,215,266...89,229,696
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Bilirubin affects the expression of DNAJB1 mRNA CTD PMID:20196124 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnpep aspartyl aminopeptidase decreases expression ISO Bilirubin results in decreased expression of DNPEP mRNA CTD PMID:20196124 NCBI chr 9:82,505,529...82,514,399
Ensembl chr 9:82,505,530...82,514,399
JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 decreases expression ISO Bilirubin results in decreased expression of DPY19L1 mRNA CTD PMID:20196124 NCBI chr 8:25,582,938...25,669,394
Ensembl chr 8:25,582,938...25,669,394
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Bilirubin results in increased expression of DUSP5 mRNA CTD PMID:20196124 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein] CTD PMID:27297870 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Bilirubin results in decreased expression of EGLN1 mRNA CTD PMID:20196124 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression ISO Bilirubin results in decreased expression of EI24 mRNA CTD PMID:20196124 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eid1 EP300 interacting inhibitor of differentiation 1 decreases expression ISO Bilirubin results in decreased expression of EID1 mRNA CTD PMID:20196124 NCBI chr 3:117,938,500...117,940,219
Ensembl chr 3:117,938,500...117,940,219
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions ISO [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin CTD PMID:25411909 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein; EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA] CTD PMID:20196124, PMID:27578021 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein CTD PMID:20196124 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression ISO Bilirubin results in decreased expression of ENDOD1 mRNA CTD PMID:20196124 NCBI chr 8:12,898,430...12,928,156 JBrowse link
G Fam174a family with sequence similarity 174, member A decreases expression ISO Bilirubin results in decreased expression of FAM174A mRNA CTD PMID:20196124 NCBI chr 9:102,862,761...102,881,046
Ensembl chr 9:102,862,890...102,881,038
JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF15 gene mutant form results in increased abundance of Bilirubin CTD PMID:24699334 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein] CTD PMID:25371888 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Bilirubin results in increased expression of FOSL1 mRNA CTD PMID:20196124 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Bilirubin results in increased expression of GADD45B mRNA CTD PMID:20196124 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO Bilirubin results in decreased expression of GAS5 mRNA CTD PMID:20196124 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gsn gelsolin decreases expression ISO Bilirubin results in decreased expression of GSN mRNA CTD PMID:20196124 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
multiple interactions
ISO Bilirubin results in increased expression of GSTA1 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]
CTD PMID:15382119 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
affects binding
multiple interactions
ISO
EXP
Bilirubin results in increased expression of GSTA2 mRNA
Bilirubin binds to GSTA2 protein
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]
CTD PMID:1148165, PMID:2768223, PMID:15382119 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO Bilirubin results in decreased expression of GSTA4 mRNA CTD PMID:20196124 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Bilirubin results in decreased expression of GSTK1 mRNA CTD PMID:20196124 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Bilirubin results in decreased expression of GSTM1 mRNA CTD PMID:20196124 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO Bilirubin results in decreased expression of GSTP1 mRNA CTD PMID:20196124 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Bilirubin results in increased expression of H1-4 mRNA CTD PMID:20196124 NCBI chr17:43,734,461...43,735,120
Ensembl chr17:43,734,461...43,735,120
JBrowse link
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 decreases expression ISO Bilirubin results in decreased expression of HACD4 mRNA CTD PMID:20196124 NCBI chr 5:106,728,401...106,758,068
Ensembl chr 5:106,732,513...106,758,032
JBrowse link
G Heph hephaestin decreases expression ISO Bilirubin results in decreased expression of HEPH mRNA CTD PMID:20196124 NCBI chr  X:65,377,313...65,658,479
Ensembl chr  X:65,563,122...65,658,516
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Bilirubin results in increased expression of HERPUD1 mRNA CTD PMID:20196124 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] CTD PMID:27297870 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Bilirubin results in increased expression of H4C9 mRNA CTD PMID:20196124 NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
affects activity
increases abundance
EXP
ISO
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin
HMOX1 protein results in increased chemical synthesis of Bilirubin
sodium arsenite promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
Bilirubin results in increased expression of HMOX1 mRNA
Bilirubin affects the activity of HMOX1 protein
[Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
HMOX1 protein results in increased abundance of Bilirubin
CTD PMID:12690112, PMID:15226216, PMID:15602829, PMID:20196124, PMID:21401295, PMID:22688006, PMID:26968795 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 affects abundance ISO HMOX2 affects the abundance of Bilirubin CTD PMID:16181104 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Bilirubin results in increased expression of HSPA5 mRNA; Bilirubin results in increased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]
CTD PMID:20196124, PMID:27578021 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Bilirubin results in decreased expression of IDH2 mRNA CTD PMID:20196124 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Bilirubin results in increased expression of IFRD1 mRNA CTD PMID:20196124 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Bilirubin results in decreased expression of IGFBP3 mRNA CTD PMID:20196124 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance
ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Bilirubin results in decreased susceptibility to IL18 protein
CTD PMID:18215737 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]
Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]
CTD PMID:15382119, PMID:18206168 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO Bilirubin results in increased expression of IL6 mRNA CTD PMID:20196124 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lamb1 laminin subunit beta 1 decreases expression ISO Bilirubin results in decreased expression of LAMB1 mRNA CTD PMID:20196124 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Bilirubin results in decreased expression of LAMP2 mRNA CTD PMID:20196124 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Leprot leptin receptor overlapping transcript decreases expression ISO Bilirubin results in decreased expression of LEPROT mRNA CTD PMID:20196124 NCBI chr 5:120,498,910...120,511,011
Ensembl chr 5:120,498,883...120,511,017
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Bilirubin results in increased expression of LIF mRNA CTD PMID:20196124 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G LOC690126 hypothetical protein LOC690126 increases expression ISO Bilirubin results in increased expression of H3C15 mRNA CTD PMID:20196124 NCBI chr 2:198,379,864...198,381,026
Ensembl chr 2:198,380,426...198,380,836
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Bilirubin results in decreased expression of LRP1 mRNA CTD PMID:20196124 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Ly6h lymphocyte antigen 6 family member H decreases expression ISO Bilirubin results in decreased expression of LY6A mRNA CTD PMID:20196124 NCBI chr 7:116,605,556...116,608,072
Ensembl chr 7:116,605,558...116,607,674
JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Bilirubin results in decreased expression of MAF mRNA CTD PMID:20196124 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK1 protein CTD PMID:12690112 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK3 protein CTD PMID:12690112 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Bilirubin results in decreased expression of MAPRE2 mRNA CTD PMID:20196124 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Me2 malic enzyme 2 decreases expression ISO Bilirubin results in decreased expression of ME2 mRNA CTD PMID:20196124 NCBI chr18:69,737,515...69,784,099
Ensembl chr18:69,738,686...69,784,099
JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO Bilirubin results in decreased expression of MEGF9 mRNA CTD PMID:20196124 NCBI chr 5:86,586,996...86,696,388
Ensembl chr 5:86,586,996...86,696,388
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases secretion ISO MET gene mutant form results in increased secretion of Bilirubin CTD PMID:27394961 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Bilirubin results in decreased expression of MGST2 mRNA CTD PMID:20196124 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Bilirubin results in increased expression of MMP13 mRNA CTD PMID:20196124 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mpzl2 myelin protein zero-like 2 decreases expression ISO Bilirubin results in decreased expression of MPZL2 mRNA CTD PMID:20196124 NCBI chr 8:49,342,067...49,353,080
Ensembl chr 8:49,342,067...49,353,080
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression ISO Bilirubin results in decreased expression of MRPL18 mRNA CTD PMID:20196124 NCBI chr 1:48,033,531...48,038,726
Ensembl chr 1:48,033,768...48,038,726
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO Bilirubin affects the localization of NFE2L2 protein
Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]
CTD PMID:23628428 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nid1 nidogen 1 decreases expression ISO Bilirubin results in decreased expression of NID1 mRNA CTD PMID:20196124 NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Bilirubin results in decreased expression of NNT mRNA CTD PMID:20196124 NCBI chr 2:52,189,523...52,283,095
Ensembl chr 2:52,189,529...52,282,548
JBrowse link
G Noct nocturnin increases expression ISO Bilirubin results in increased expression of NOCT mRNA CTD PMID:20196124 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18206168 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
affects abundance
affects transport
ISO Bilirubin results in increased expression of NR1I2 mRNA
NR1I2 protein affects the abundance of Bilirubin
NR1I2 protein affects the transport of Bilirubin
CTD PMID:15726644, PMID:18706437 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Bilirubin results in increased expression of NR1I3 mRNA CTD PMID:18706437 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Bilirubin results in increased expression of OSGIN1 mRNA CTD PMID:20196124 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO Bilirubin results in increased expression of PARP1 protein modified form
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]
CTD PMID:27578021 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Bilirubin results in decreased expression of PDK1 mRNA CTD PMID:20196124 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Bilirubin results in decreased expression of PGAP2 mRNA CTD PMID:20196124 NCBI chr 1:167,309,021...167,335,550
Ensembl chr 1:167,309,051...167,334,741
JBrowse link
G Phb prohibitin decreases expression ISO Bilirubin results in decreased expression of PHB mRNA CTD PMID:20196124 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 decreases expression ISO Bilirubin results in decreased expression of PIAS1 mRNA CTD PMID:20196124 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pla1a phospholipase A1 member A decreases expression ISO Bilirubin results in decreased expression of PLA1A mRNA CTD PMID:20196124 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO Bilirubin results in decreased expression of PMP22 mRNA CTD PMID:20196124 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Bilirubin results in decreased expression of PON2 mRNA CTD PMID:20196124 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression ISO Bilirubin results in decreased expression of PRDX4 mRNA CTD PMID:20196124 NCBI chr  X:43,495,453...43,512,994
Ensembl chr  X:43,497,763...43,512,991
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rassf4 Ras association domain family member 4 increases expression ISO Bilirubin results in increased expression of RASSF4 mRNA CTD PMID:20196124 NCBI chr 4:148,769,092...148,804,295
Ensembl chr 4:148,769,096...148,803,988
JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression ISO Bilirubin results in decreased expression of RBM39 mRNA CTD PMID:20196124 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO Bilirubin results in decreased expression of RBM5 mRNA CTD PMID:20196124 NCBI chr 8:116,502,941...116,532,178
Ensembl chr 8:116,502,937...116,532,169
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Bilirubin results in increased expression of RELA mRNA CTD PMID:27578021 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 decreases expression ISO Bilirubin results in decreased expression of RHOBTB3 mRNA CTD PMID:20196124 NCBI chr 2:2,627,655...2,683,305
Ensembl chr 2:2,627,393...2,683,116
JBrowse link
G Rnase4 ribonuclease A family member 4 decreases expression ISO Bilirubin results in decreased expression of RNASE4 mRNA CTD PMID:20196124 NCBI chr15:28,018,040...28,035,395
Ensembl chr15:28,018,040...28,035,389
Ensembl chr15:28,018,040...28,035,389
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Bilirubin results in decreased expression of S100A10 mRNA CTD PMID:20196124 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO Bilirubin results in decreased expression of S100A4 mRNA CTD PMID:20196124 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Scp2 sterol carrier protein 2 decreases expression ISO Bilirubin results in decreased expression of SCP2 mRNA CTD PMID:20196124 NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Bilirubin results in decreased expression of SELENBP1 mRNA CTD PMID:20196124 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Bilirubin results in decreased expression of SERPINB1A mRNA CTD PMID:20196124 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Bilirubin results in increased expression of SERPINE1 mRNA CTD PMID:20196124 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn1 sestrin 1 decreases expression ISO Bilirubin results in decreased expression of SESN1 mRNA CTD PMID:20196124 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Bilirubin results in decreased expression of SGPP1 mRNA CTD PMID:20196124 NCBI chr 6:98,675,324...98,696,492
Ensembl chr 6:98,675,326...98,695,988
JBrowse link
G Slc16a12 solute carrier family 16, member 12 decreases expression ISO Bilirubin results in decreased expression of SLC16A12 mRNA CTD PMID:20196124 NCBI chr 1:252,976,071...253,054,500
Ensembl chr 1:252,976,644...253,000,760
JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Bilirubin results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:28,413,910...28,428,133
Ensembl chr18:28,414,009...28,428,117
JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Bilirubin results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression
ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC3A2 mRNA
CTD PMID:22216172 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression
ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC7A11 mRNA
CTD PMID:22216172 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Snx14 sorting nexin 14 decreases expression ISO Bilirubin results in decreased expression of SNX14 mRNA CTD PMID:20196124 NCBI chr 8:96,018,943...96,088,405
Ensembl chr 8:96,023,445...96,088,405
JBrowse link
G Sost sclerostin decreases expression ISO Bilirubin results in decreased expression of SOST mRNA CTD PMID:20196124 NCBI chr10:89,897,087...89,900,131
Ensembl chr10:89,897,087...89,900,131
JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Bilirubin results in decreased expression of SP5 mRNA CTD PMID:20196124 NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277
JBrowse link
G Tapbp TAP binding protein decreases expression ISO Bilirubin results in decreased expression of TAPBP mRNA CTD PMID:20196124 NCBI chr20:5,468,056...5,476,007
Ensembl chr20:5,468,078...5,476,193
JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO Bilirubin results in decreased expression of TCF4 mRNA CTD PMID:20196124 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Bilirubin results in increased expression of TIPARP mRNA CTD PMID:20196124 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Bilirubin results in decreased expression of TM9SF2 mRNA CTD PMID:20196124 NCBI chr15:108,526,341...108,579,268
Ensembl chr15:108,526,014...108,579,256
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]
Bilirubin results in increased expression of TNF mRNA; Bilirubin results in increased expression of TNF protein
CTD PMID:27578021 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 decreases expression ISO Bilirubin results in decreased expression of TNFRSF19 mRNA CTD PMID:20196124 NCBI chr15:41,249,820...41,316,203
Ensembl chr15:41,246,308...41,338,284
JBrowse link
G Tpp1 tripeptidyl peptidase 1 decreases expression ISO Bilirubin results in decreased expression of TPP1 mRNA CTD PMID:20196124 NCBI chr 1:170,588,036...170,594,159
Ensembl chr 1:170,588,035...170,594,168
JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Bilirubin results in decreased expression of TRIB2 mRNA CTD PMID:20196124 NCBI chr 6:41,016,722...41,040,972
Ensembl chr 6:41,016,730...41,039,437
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Bilirubin results in decreased expression of UBE2I mRNA CTD PMID:20196124 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases glucuronidation
multiple interactions
increases metabolic processing
decreases glucuronidation
decreases activity
ISO
EXP
Bilirubin results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]
UGT1A1 protein results in increased metabolism of Bilirubin
UGT1A1 protein results in increased glucuronidation of Bilirubin; UGT1A1 results in increased glucuronidation of Bilirubin
UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin
Bilirubin results in decreased activity of UGT1A1 protein
CTD PMID:10950852, PMID:12153725, PMID:15334623, PMID:15382119, PMID:15557560, PMID:15921999, PMID:15988124, PMID:17599282, PMID:17898154, PMID:23401472, PMID:25370011, PMID:27060662 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Bilirubin results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI decreases expression ISO Bilirubin results in decreased expression of UQCR mRNA CTD PMID:20196124 NCBI chr 7:12,171,146...12,175,838
Ensembl chr 7:12,171,185...12,175,835
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein decreases expression ISO Bilirubin results in decreased expression of UQCRB mRNA CTD PMID:20196124 NCBI chr 7:71,264,501...71,269,869
Ensembl chr 7:71,264,514...71,269,869
Ensembl chr 1:71,264,514...71,269,869
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 decreases expression ISO Bilirubin results in decreased expression of UQCRC1 mRNA CTD PMID:20196124 NCBI chr 8:117,679,328...117,691,073
Ensembl chr 8:117,679,278...117,691,071
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Bilirubin results in decreased expression of UQCRH mRNA CTD PMID:20196124 NCBI chr 5:134,919,040...134,927,235
Ensembl chr 5:134,919,044...134,927,235
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO Bilirubin results in decreased expression of UXS1 mRNA CTD PMID:20196124 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790
JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Bilirubin results in decreased expression of VLDLR mRNA CTD PMID:20196124 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
ISO Bilirubin results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]
CTD PMID:27578021 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Bilirubin results in decreased expression of ZBTB20 mRNA CTD PMID:20196124 NCBI chr11:62,014,925...62,561,113
Ensembl chr11:62,014,925...62,451,184
JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand decreases expression ISO Bilirubin results in decreased expression of ZBTB8OS mRNA CTD PMID:20196124 NCBI chr 5:147,535,584...147,547,252
Ensembl chr 5:147,535,525...147,547,047
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 decreases expression ISO Bilirubin results in decreased expression of ZCCHC7 mRNA CTD PMID:20196124 NCBI chr 5:60,250,546...60,430,119
Ensembl chr 5:60,250,546...60,429,708
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Bilirubin results in increased expression of ZFAND2A mRNA CTD PMID:20196124 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO Bilirubin results in decreased expression of ZFP207 mRNA CTD PMID:20196124 NCBI chr10:67,762,970...67,784,854
Ensembl chr10:67,762,995...67,774,787
JBrowse link
biliverdin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Biliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; Biliverdine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein] CTD PMID:15486963 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases chemical synthesis
multiple interactions
ISO CYP2A5 protein results in increased chemical synthesis of Biliverdine
[CYP2A5 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine
CTD PMID:21871474 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [cobaltiprotoporphyrin results in increased activity of HMOX1 protein] which results in increased chemical synthesis of Biliverdine CTD PMID:26224716 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IFNG protein] CTD PMID:15486963 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL10 protein] CTD PMID:15486963 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance
ISO Biliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Biliverdine results in decreased susceptibility to IL18 protein
CTD PMID:18215737 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:15486963 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:15486963 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
preuroporphyrinogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase increases abundance ISO HMBS protein results in increased abundance of hydroxymethylbilane CTD PMID:23973255 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              heteroorganic entity 19184
                organic heterocyclic compound 18432
                  heteroarene 16467
                    tetrapyrrole 497
                      linear tetrapyrrole 169
                        anaerobilin 0
                        biladienes + 166
                        bilanes + 1
                        bilenes + 0
                        bilins + 10
                        biliverdin beta 0
                        biliverdin delta 0
                        mycobilin a 0
                        mycobilin b 0
                        phycourobilin-bis-L-cysteine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organonitrogen heterocyclic compound 17485
                                    polypyrrole 609
                                      tetrapyrrole 497
                                        linear tetrapyrrole 169
                                          anaerobilin 0
                                          biladienes + 166
                                          bilanes + 1
                                          bilenes + 0
                                          bilins + 10
                                          biliverdin beta 0
                                          biliverdin delta 0
                                          mycobilin a 0
                                          mycobilin b 0
                                          phycourobilin-bis-L-cysteine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.