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Accession:CHEBI:251408 term browser browse the term
Definition:A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Synonyms:related_synonym: (3-hydroxyphenyl)dimethylethylammonium;   3-hydroxy-N,N-dimethyl-N-ethylanilinium;   EDROPHONIUM ION;   Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium;   Formula=C10H16NO;   InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1;   InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O;   N-ethyl-3-hydroxy-N,N-dimethylanilinium;   N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium;   SMILES=CC[N+](C)(C)c1cccc(O)c1
 alt_id: CHEBI:42376;   CHEBI:4758
 xref: Beilstein:3905622 "Beilstein";   CAS:312-48-1 "ChemIDplus";   CAS:312-48-1 "KEGG COMPOUND";   DrugBank:DB01010;   Drug_Central:988 "DrugCentral";   KEGG:C06976;   LINCS:LSM-5867
 xref_mesh: MESH:D004491
 xref: PDBeChem:EDR;   PMID:7488499 "Europe PMC"

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edrophonium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464

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  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          diagnostic agent 649
            edrophonium 2
              edrophonium chloride 0
Path 2
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  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    main group molecular entity 19598
                      s-block molecular entity 19361
                        hydrogen molecular entity 19350
                          hydrides 18280
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17003
                                  ammonium 8225
                                    ammonium ion derivative 8220
                                      quaternary ammonium ion 5061
                                        edrophonium 2
                                          edrophonium chloride 0
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