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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monomethoxybenzene
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Accession:CHEBI:25235 term browser browse the term
Definition:Compounds containing a benzene skeleton substituted with one methoxy group.
Synonyms:related_synonym: monomethoxybenzenes


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2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]
CTD PMID:31029725 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]
CTD PMID:31029725 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31029725 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]
CTD PMID:31029725 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:31029725 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:31029725 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein
CTD PMID:31029725 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]
CTD PMID:31029725 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein] CTD PMID:31029725 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA] CTD PMID:31029725 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]
CTD PMID:31029725 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA] CTD PMID:31029725 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
2-nitroanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases metabolic processing
increases oxidation
increases expression
EXP
ISO
CYP1A1 protein results in increased metabolism of 2-nitroanisole
CYP1A1 protein results in increased oxidation of 2-nitroanisole
2-nitroanisole results in increased expression of CYP1A1
CTD PMID:11409192, PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO 2-nitroanisole results in increased expression of CYP1A2; 2-nitroanisole results in increased expression of CYP1A2 protein CTD PMID:11409192, PMID:16601807 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases metabolic processing
increases oxidation
EXP CYP2B6 protein results in increased metabolism of 2-nitroanisole
CYP2B6 protein results in increased oxidation of 2-nitroanisole
CTD PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases oxidation EXP
ISO
CYP2C19 protein results in increased oxidation of 2-nitroanisole
CYP2C6V1 protein results in increased oxidation of 2-nitroanisole
CTD PMID:21218109 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases oxidation EXP CYP2C9 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases metabolic processing
increases oxidation
EXP
ISO
CYP2E1 protein results in increased metabolism of 2-nitroanisole
CYP2E1 protein results in increased oxidation of 2-nitroanisole
CTD PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G H2AX H2A.X variant histone increases expression ISO 2-nitroanisole results in increased expression of H2AX protein CTD PMID:26338220 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 2-nitroanisole results in increased expression of NQO1 CTD PMID:11409192 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G XDH xanthine dehydrogenase increases reduction EXP XDH protein results in increased reduction of 2-nitroanisole CTD PMID:14729594 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
4-methoxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP 4-acetylanisole results in increased expression of CXCL8 mRNA CTD PMID:21920952 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP 4-acetylanisole results in increased expression of HMOX1 mRNA CTD PMID:26244607 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
4-nitroanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases metabolic processing EXP CYP2A6 protein results in increased metabolism of 4-nitroanisole CTD PMID:12464242 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
[6]-Shogaol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of ADIPOQ mRNA]; shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP shogaol metabolite results in increased expression of AKR1B10 protein; shogaol results in increased expression of AKR1B10 mRNA; shogaol results in increased expression of AKR1B10 protein CTD PMID:25148906 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] CTD PMID:18683823 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects folding
EXP shogaol results in increased expression of BAX protein
shogaol promotes the reaction [BAX protein binds to BAX protein binds to BAX protein]; shogaol promotes the reaction [BAX protein binds to BAX protein]
shogaol affects the folding of BAX protein
CTD PMID:18384088, PMID:25619640 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP shogaol results in decreased expression of BCL2 protein CTD PMID:18384088 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP shogaol results in decreased expression of BCL2L1 protein CTD PMID:18384088 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
increases expression
ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF mRNA; [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF mRNA]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; [shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein
CTD PMID:22381256 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; shogaol results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18384088, PMID:25619640 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions EXP shogaol results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18384088 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; shogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form] CTD PMID:25619640 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CHAT choline O-acetyltransferase multiple interactions
increases expression
ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; shogaol results in increased expression of CHAT protein
CTD PMID:22381256 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,665,104
Ensembl chr10:49,609,095...49,665,104
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein] CTD PMID:23899529 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP shogaol results in decreased expression of CTNNB1 mRNA; shogaol results in decreased expression of CTNNB1 protein CTD PMID:27645308 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein]
shogaol results in increased expression of DDIT3 mRNA; shogaol results in increased expression of DDIT3 protein
CTD PMID:18384088 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DFFA DNA fragmentation factor subunit alpha increases degradation EXP shogaol results in increased degradation of DFFA protein CTD PMID:18384088 NCBI chr 1:10,456,522...10,472,529
Ensembl chr 1:10,456,522...10,472,529
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of FABP4 mRNA] CTD PMID:18577375 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP shogaol results in increased expression of FAS protein CTD PMID:18384088 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand increases expression EXP shogaol results in increased expression of FASLG protein CTD PMID:18384088 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FTL ferritin light chain increases expression EXP shogaol metabolite results in increased expression of FTL protein; shogaol results in increased expression of FTL mRNA; shogaol results in increased expression of FTL protein CTD PMID:25148906 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions
EXP
ISO
shogaol metabolite results in increased expression of GCLC protein; shogaol results in increased expression of GCLC protein
shogaol results in increased expression of GCLC mRNA
NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]
CTD PMID:25148906 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP shogaol metabolite results in increased expression of GCLM protein; shogaol results in increased expression of GCLM protein CTD PMID:25148906 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GDF15 growth differentiation factor 15 increases expression EXP shogaol results in increased expression of GDF15 mRNA CTD PMID:25148906 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GGTLC1 gamma-glutamyltransferase light chain 1 increases expression EXP shogaol metabolite results in increased expression of GGTLC1 protein; shogaol results in increased expression of GGTLC1 mRNA; shogaol results in increased expression of GGTLC1 protein CTD PMID:25148906 NCBI chr20:23,985,053...23,989,134
Ensembl chr20:23,985,050...23,988,779
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP shogaol results in increased expression of and results in increased phosphorylation of GSK3B protein CTD PMID:27645308 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] CTD PMID:23899529 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol metabolite results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 mRNA; shogaol results in increased expression of HMOX1 protein
CTD PMID:23899529, PMID:25148906 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein] CTD PMID:23899529 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein] CTD PMID:27645308 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions
increases alkylation
decreases expression
ISO
EXP
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein]
shogaol results in increased alkylation of KEAP1 protein
shogaol metabolite results in decreased expression of KEAP1 protein; shogaol results in decreased expression of KEAP1 protein
CTD PMID:23899529, PMID:25148906 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:18683823 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:18683823 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] CTD PMID:23899529 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MT1X metallothionein 1X increases expression
multiple interactions
ISO shogaol results in increased expression of MT1 mRNA; shogaol results in increased expression of MT1 protein
NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
CTD PMID:25148906 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
affects localization
multiple interactions
EXP
ISO
shogaol analog results in increased expression of NFE2L2 protein
shogaol affects the localization of NFE2L2 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; shogaol metabolite results in increased expression of and results in increased phosphorylation of NFE2L2 protein; shogaol results in increased expression of and results in increased phosphorylation of NFE2L2 protein
CTD PMID:23899529, PMID:25148906 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP
ISO
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein]
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:18683823, PMID:23899529 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO
EXP
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
CTD PMID:18683823, PMID:23899529 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein] CTD PMID:23899529 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:18384088, PMID:25619640 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases activity ISO shogaol results in increased activity of PPARG protein CTD PMID:18577375 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGES prostaglandin E synthase multiple interactions
decreases expression
EXP shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein]
shogaol results in decreased expression of PTGES mRNA
CTD PMID:27645308 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:18683823, PMID:23899529 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
shogaol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD PMID:18683823, PMID:23899529 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SLC5A7 solute carrier family 5 member 7 multiple interactions
increases expression
ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein; shogaol results in increased expression of SLC5A7 protein
CTD PMID:22381256 NCBI chr 2:107,986,524...108,014,497
Ensembl chr 2:107,986,523...108,013,994
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions
increases response to substance
EXP [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
shogaol results in increased susceptibility to TNFSF10 protein
CTD PMID:25619640 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
aliskiren term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance ISO ABCB1 protein affects the susceptibility to aliskiren CTD PMID:24388840 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G AGT angiotensinogen multiple interactions
decreases expression
ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of AGT protein]
aliskiren inhibits the reaction [microcystin RR results in increased expression of AGT protein]
aliskiren results in decreased expression of AGT protein modified form
CTD PMID:18829990, PMID:27645307, PMID:28330766 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA] CTD PMID:27645307 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA] CTD PMID:27645307 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:27645307 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G REN renin multiple interactions
decreases activity
EXP
ISO
[aliskiren co-treated with Atenolol] results in decreased activity of REN protein
aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]
aliskiren results in decreased activity of REN protein
CTD PMID:18957387, PMID:27645307 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of TNF mRNA] CTD PMID:27645307 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
anethole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP anethole results in decreased phosphorylation of AKT1 protein CTD PMID:21212515 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G ESR1 estrogen receptor 1 affects binding
multiple interactions
EXP
ISO
anethole metabolite binds to ESR1 protein
anethole analog binds to ESR1 protein
anethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12818366, PMID:27420082 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G GGT1 gamma-glutamyltransferase 1 decreases activity ISO anethole analog results in decreased activity of GGT1 protein CTD PMID:20171274 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression ISO anethole results in increased expression of GSTA2 protein CTD PMID:8406240 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta decreases activity EXP anethole results in decreased activity of IKBKB protein CTD PMID:10871845 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL2 interleukin 2 multiple interactions ISO anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16531003 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions EXP anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP anethole results in decreased phosphorylation of MAPK1 protein CTD PMID:21212515 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP anethole results in decreased phosphorylation of MAPK3 protein CTD PMID:21212515 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein] CTD PMID:10871845 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression
decreases activity
EXP anethole results in decreased expression of MMP2 mRNA
anethole results in decreased activity of MMP2 protein
CTD PMID:21212515 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases activity
decreases expression
EXP anethole results in decreased activity of MMP9 protein
anethole results in decreased expression of MMP9 mRNA
CTD PMID:21212515 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
decreases degradation
EXP anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
anethole results in decreased degradation of NFKBIA protein
CTD PMID:10871845, PMID:21212515 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:10871845 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PLAU plasminogen activator, urokinase decreases expression EXP anethole results in decreased expression of PLAU mRNA CTD PMID:21212515 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP anethole results in increased expression of TIMP1 mRNA CTD PMID:21212515 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein]; anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:10871845 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
capsiate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD69 CD69 molecule decreases localization EXP capsiate analog results in decreased localization of CD69 protein CTD PMID:12115659 NCBI chr12:9,752,486...9,760,901
Ensembl chr12:9,752,486...9,760,901
JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases localization EXP capsiate analog results in decreased localization of ICAM1 protein CTD PMID:12115659 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IGF1 insulin like growth factor 1 increases expression ISO capsiate results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions EXP capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased activity of IKBKG protein] CTD PMID:12115659 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases localization EXP capsiate analog results in decreased localization of IL2RA protein CTD PMID:12115659 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein] CTD PMID:12115659 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G UCP3 uncoupling protein 3 decreases expression ISO capsiate results in decreased expression of UCP3 mRNA CTD PMID:17264228 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases expression EXP coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression EXP coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression
multiple interactions
EXP coniferaldehyde results in increased expression of AKR1C1 mRNA; coniferaldehyde results in increased expression of AKR1C1 protein
NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]
CTD PMID:26275128 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP
ISO
coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein
CTD PMID:26275128 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein
CTD PMID:26275128 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma multiple interactions EXP coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G JAK2 Janus kinase 2 multiple interactions EXP
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]
CTD PMID:27378624 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,128,183
Ensembl chr 9:4,984,390...5,128,183
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 multiple interactions EXP MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 1:206,684,905...206,734,283
Ensembl chr 1:206,684,944...206,734,283
Ensembl chr 1:206,684,944...206,734,283
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions
EXP coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]
CTD PMID:31944254 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases expression
EXP
ISO
coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein
CTD PMID:26275128 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
CTD PMID:27378624 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PKN3 protein kinase N3 multiple interactions EXP PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 9:128,702,497...128,720,918
Ensembl chr 9:128,702,503...128,720,916
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]
CTD PMID:27378624 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 increases activity EXP coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
enrasentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDNRA endothelin receptor type A multiple interactions EXP enrasentan binds to and results in decreased activity of EDNRA protein CTD PMID:16219361 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EDNRB endothelin receptor type B multiple interactions EXP enrasentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
decreases activity
EXP [[ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G OR5D18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO [ethyl vanillin binds to and results in increased activity of OLFR73 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OLFR73 protein CTD PMID:15716417 NCBI chr11:55,819,630...55,820,571
Ensembl chr11:55,819,607...55,820,597
JBrowse link
G TRPV3 transient receptor potential cation channel subfamily V member 3 increases activity ISO ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr17:3,510,502...3,557,812
Ensembl chr17:3,510,502...3,557,995
Ensembl chr17:3,510,502...3,557,995
JBrowse link
eugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA6 ATP binding cassette subfamily A member 6 decreases expression EXP Eugenol results in decreased expression of ABCA6 mRNA CTD PMID:17374397 NCBI chr17:69,062,044...69,141,927
Ensembl chr17:69,078,702...69,141,895
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of ACHE protein] CTD PMID:32096903 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
increases activity
affects localization
EXP [Eugenol co-treated with acetyleugenol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [Eugenol co-treated with acetyleugenol] results in increased activity of AHR protein; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of AHR protein]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Eugenol results in increased activity of AHR protein
Eugenol affects the localization of AHR protein
CTD PMID:17275817, PMID:22686307, PMID:29191726 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AHRR aryl-hydrocarbon receptor repressor increases expression EXP Eugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 5:321,714...438,285
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases expression EXP Eugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP Eugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472, PMID:26198647, PMID:30806763 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP Eugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP Eugenol results in increased expression of AKR1C2 mRNA CTD PMID:26198647 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP Eugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G ALPL alkaline phosphatase, biomineralization associated increases expression EXP Eugenol results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 1:21,508,984...21,578,412
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein] CTD PMID:20434464 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G AR androgen receptor multiple interactions EXP Eugenol binds to and results in decreased activity of AR protein CTD PMID:20226658 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARHGAP17 Rho GTPase activating protein 17 decreases expression EXP Eugenol results in decreased expression of ARHGAP17 mRNA CTD PMID:17374397 NCBI chr16:24,919,389...25,015,601
Ensembl chr16:24,919,389...25,015,666
JBrowse link
G ARL4C ADP ribosylation factor like GTPase 4C increases expression EXP Eugenol results in increased expression of ARL4C mRNA CTD PMID:17374397 NCBI chr 2:234,493,041...234,497,081
Ensembl chr 2:234,493,041...234,497,081
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Eugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G B2M beta-2-microglobulin increases expression EXP Eugenol results in increased expression of B2M mRNA CTD PMID:17936526 NCBI chr15:44,711,492...44,718,145
Ensembl chr15:44,711,487...44,718,877
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA] CTD PMID:20434464 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Eugenol results in increased expression of BAX mRNA
CTD PMID:20434464, PMID:20537511 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP
ISO
[Eugenol results in increased activity of sulforafan] which results in decreased expression of BCL2; [sulforafan results in increased activity of Eugenol] which results in decreased expression of BCL2
Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Eugenol results in decreased expression of BCL2 mRNA
CTD PMID:20434464, PMID:20537511, PMID:21382956, PMID:21939359 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA] CTD PMID:20434464 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCLAF1 BCL2 associated transcription factor 1 decreases expression EXP Eugenol results in decreased expression of BCLAF1 mRNA CTD PMID:17374397 NCBI chr 6:136,256,627...136,289,846
Ensembl chr 6:136,256,627...136,289,851
JBrowse link
G BDNF brain derived neurotrophic factor increases expression ISO Eugenol results in increased expression of BDNF mRNA CTD PMID:15157811 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA] CTD PMID:20434464 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BMP6 bone morphogenetic protein 6 increases expression EXP Eugenol results in increased expression of BMP6 mRNA CTD PMID:17374397 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP Eugenol results in decreased expression of BUB1 mRNA CTD PMID:17374397 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G C12orf4 chromosome 12 open reading frame 4 decreases expression EXP Eugenol results in decreased expression of C12ORF4 mRNA CTD PMID:17374397 NCBI chr12:4,487,735...4,538,508
Ensembl chr12:4,487,735...4,538,508
JBrowse link
G CALCRL calcitonin receptor like receptor increases expression EXP Eugenol results in increased expression of CALCRL mRNA CTD PMID:17374397 NCBI chr 2:187,341,964...187,448,304
Ensembl chr 2:187,341,964...187,448,460
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage
ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 mRNA
Eugenol results in increased activity of CASP3 protein
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; Eugenol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 protein modified form
Eugenol results in increased cleavage of CASP3 protein
CTD PMID:20434464, PMID:20537511, PMID:21656368, PMID:25455450, PMID:30518369, PMID:32096903 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases expression EXP Eugenol results in increased expression of CASP7 mRNA CTD PMID:30518369 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression
increases activity
ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
Eugenol results in increased expression of CASP9 mRNA
Eugenol results in increased activity of CASP9 protein
CTD PMID:20434464, PMID:25455450, PMID:30518369 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase increases expression
multiple interactions
EXP
ISO
Eugenol results in increased expression of CAT mRNA
Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of CAT protein]
CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]
CTD PMID:15576237, PMID:20566472, PMID:32096903 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL13 C-C motif chemokine ligand 13 increases expression EXP Eugenol results in increased expression of CCL13 mRNA CTD PMID:17936526 NCBI chr17:34,356,480...34,358,610
Ensembl chr17:34,356,480...34,358,610
JBrowse link
G CCL19 C-C motif chemokine ligand 19 increases expression EXP Eugenol results in increased expression of CCL19 mRNA CTD PMID:17936526 NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression
increases secretion
increases expression
EXP
ISO
Eugenol results in decreased expression of CCL2 mRNA
Eugenol results in increased secretion of CCL2 protein
Eugenol results in increased expression of CCL2 mRNA
CTD PMID:15585374, PMID:17374397, PMID:17936526, PMID:22245253 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression EXP Eugenol results in increased expression of CCL20 mRNA CTD PMID:30806763 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression
increases secretion
EXP Eugenol results in increased expression of CCL3 mRNA
Eugenol results in increased secretion of CCL3 protein
CTD PMID:15585374, PMID:23624239 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL3L1 C-C motif chemokine ligand 3 like 1 increases expression EXP Eugenol results in increased expression of CCL3L1 mRNA CTD PMID:20713136 Ensembl chr17:36,194,869...36,196,758 JBrowse link
G CCL4 C-C motif chemokine ligand 4 increases expression
increases secretion
EXP Eugenol results in increased expression of CCL4 mRNA; Eugenol results in increased expression of CCL4 protein
Eugenol results in increased secretion of CCL4 protein
CTD PMID:15585374, PMID:18353026, PMID:30806763 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CCNB1 cyclin B1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA] CTD PMID:19851710 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA] CTD PMID:19851710 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCR2 C-C motif chemokine receptor 2 decreases expression EXP Eugenol results in decreased expression of CCR2 mRNA CTD PMID:17374397 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CCR5 C-C motif chemokine receptor 5 increases expression EXP Eugenol results in increased expression of CCR5 mRNA CTD PMID:17936526, PMID:20713136 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G CCR7 C-C motif chemokine receptor 7 increases expression EXP Eugenol results in increased expression of CCR7 mRNA CTD PMID:17374397 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472
JBrowse link
G CD24 CD24 molecule decreases expression EXP Eugenol results in decreased expression of CD24 protein CTD PMID:31926151 NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627
JBrowse link
G CD274 CD274 molecule increases expression EXP Eugenol results in increased expression of CD274 protein CTD PMID:23624239 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CD36 CD36 molecule decreases expression EXP Eugenol results in decreased expression of CD36 mRNA CTD PMID:17374397 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD44 CD44 molecule (Indian blood group) decreases expression EXP Eugenol results in decreased expression of CD44 protein CTD PMID:31926151 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD86 CD86 molecule multiple interactions
increases expression
EXP [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] CTD PMID:12423654, PMID:20488241, PMID:21742781, PMID:23624239, PMID:30806763 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Eugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions ISO Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein]
CTD PMID:19851710, PMID:20043298 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Eugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CISH cytokine inducible SH2 containing protein decreases expression ISO Eugenol results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 3:50,606,454...50,611,774
Ensembl chr 3:50,606,489...50,611,774
Ensembl chr 3:50,606,489...50,611,774
JBrowse link
G CLEC4A C-type lectin domain family 4 member A decreases expression EXP Eugenol results in decreased expression of CLEC4A protein CTD PMID:23624239 NCBI chr12:8,102,902...8,138,607
Ensembl chr12:8,123,632...8,138,607
JBrowse link
G CREB1 cAMP responsive element binding protein 1 affects expression EXP Eugenol affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREM cAMP responsive element modulator increases expression EXP Eugenol results in increased expression of CREM mRNA CTD PMID:17374397 NCBI chr10:35,126,830...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CTNNB1 catenin beta 1 decreases expression
multiple interactions
ISO
EXP
Eugenol results in decreased expression of CTNNB1 mRNA
Eugenol results in decreased expression of and affects the phosphorylation of and affects the localization of CTNNB1 protein
CTD PMID:31926151 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSL cathepsin L increases expression EXP Eugenol results in increased expression of CTSL mRNA CTD PMID:17374397 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,726,109...87,731,469
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression
multiple interactions
EXP
ISO
Eugenol results in increased expression of CXCL1 mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]
CTD PMID:12963494, PMID:20713136 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
increases expression
EXP Acetylcysteine inhibits the reaction [Eugenol results in increased expression of CXCL8 mRNA]; Eugenol results in increased expression of and results in increased secretion of CXCL8 protein
Eugenol results in increased secretion of CXCL8 protein
Eugenol results in increased expression of CXCL8 mRNA; Eugenol results in increased expression of CXCL8 protein
CTD PMID:20713136, PMID:21920952, PMID:23624239, PMID:25617811, PMID:30806763 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP Eugenol results in increased expression of CXCR4 mRNA CTD PMID:20713136 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein] CTD PMID:20434464 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
decreases expression
decreases activity
EXP [CYP1A1 protein co-treated with Copper] results in increased activity of Eugenol; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Eugenol inhibits the reaction [CYP1A1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Eugenol results in increased expression of CYP1A1 mRNA
Eugenol results in decreased expression of CYP1A1 mRNA
Eugenol results in decreased activity of CYP1A1 protein
CTD PMID:15576237, PMID:17275817, PMID:20713136, PMID:22686307, PMID:29191726 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP [CYP1A2 protein co-treated with Copper] results in increased activity of Eugenol CTD PMID:15576237 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
decreases activity
EXP Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; Eugenol inhibits the reaction [CYP1B1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]
Eugenol results in decreased activity of CYP1B1 protein
CTD PMID:17275817 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 decreases expression EXP Eugenol results in decreased expression of CYP27A1 mRNA CTD PMID:20713136 NCBI chr 2:218,781,733...218,815,293
Ensembl chr 2:218,781,749...218,815,293
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP [CYP2C9 protein co-treated with Copper] results in increased activity of Eugenol CTD PMID:15576237 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions
increases metabolic processing
EXP [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol; [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] CTD PMID:15576237 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO
EXP
Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]
[CYP2E1 protein co-treated with Copper] results in increased activity of Eugenol
CTD PMID:15576237, PMID:20036707 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G DKC1 dyskerin pseudouridine synthase 1 decreases expression EXP Eugenol results in decreased expression of DKC1 mRNA CTD PMID:17374397 NCBI chr  X:154,762,864...154,777,689
Ensembl chr  X:154,762,742...154,777,689
JBrowse link
G DLGAP5 DLG associated protein 5 decreases expression EXP Eugenol results in decreased expression of DLGAP5 mRNA CTD PMID:17374397 NCBI chr14:55,148,130...55,191,585
Ensembl chr14:55,148,112...55,191,608
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP Eugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G DNASE2 deoxyribonuclease 2, lysosomal increases expression ISO Eugenol results in increased expression of DNASE2A mRNA CTD PMID:15618236 NCBI chr19:12,875,209...12,881,449
Ensembl chr19:12,875,209...12,881,466
JBrowse link
G DRD1 dopamine receptor D1 multiple interactions ISO [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol CTD PMID:9537685 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression EXP Eugenol results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G E2F1 E2F transcription factor 1 decreases expression EXP Eugenol results in decreased expression of E2F1 mRNA; Eugenol results in decreased expression of E2F1 protein CTD PMID:15574415 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G E2F2 E2F transcription factor 2 decreases expression EXP Eugenol results in decreased expression of E2F2 mRNA; Eugenol results in decreased expression of E2F2 protein CTD PMID:15574415 NCBI chr 1:23,505,696...23,531,250
Ensembl chr 1:23,506,438...23,531,233
JBrowse link
G E2F3 E2F transcription factor 3 decreases expression EXP Eugenol results in decreased expression of E2F3 mRNA; Eugenol results in decreased expression of E2F3 protein CTD PMID:15574415 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714
JBrowse link
G E2F4 E2F transcription factor 4 decreases expression EXP Eugenol results in decreased expression of E2F4 mRNA CTD PMID:15574415 NCBI chr16:67,192,155...67,198,918
Ensembl chr16:67,192,155...67,198,918
JBrowse link
G E2F5 E2F transcription factor 5 decreases expression EXP Eugenol results in decreased expression of E2F5 mRNA CTD PMID:15574415 NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158
JBrowse link
G E2F6 E2F transcription factor 6 increases expression EXP Eugenol results in increased expression of E2F6 mRNA CTD PMID:15574415 NCBI chr 2:11,444,375...11,466,177
Ensembl chr 2:11,444,375...11,466,177
JBrowse link
G EGFR epidermal growth factor receptor decreases expression
increases expression
ISO Eugenol results in decreased expression of EGFR protein
Eugenol results in increased expression of EGFR mRNA
CTD PMID:15618236 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO [[Eugenol results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA CTD PMID:12767924 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EGR2 early growth response 2 decreases expression EXP Eugenol results in decreased expression of EGR2 mRNA CTD PMID:17374397 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,919,900
JBrowse link
G EMB embigin decreases expression EXP Eugenol results in decreased expression of EMB mRNA CTD PMID:17374397 NCBI chr 5:50,396,192...50,443,299
Ensembl chr 5:50,396,192...50,443,248
JBrowse link
G EPCAM epithelial cell adhesion molecule decreases expression EXP
ISO
Eugenol results in decreased expression of EPCAM mRNA; Eugenol results in decreased expression of EPCAM protein CTD PMID:31926151 NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601
JBrowse link
G ESR1 estrogen receptor 1 affects binding
multiple interactions
EXP Eugenol binds to ESR1 protein
Eugenol inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12495555 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 affects binding
multiple interactions
EXP Eugenol binds to ESR2 protein
Eugenol inhibits the reaction [Estradiol binds to ESR2 protein]
CTD PMID:12495555 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G F13A1 coagulation factor XIII A chain decreases expression EXP Eugenol results in decreased expression of F13A1 mRNA CTD PMID:17374397 NCBI chr 6:6,144,084...6,320,662
Ensembl chr 6:6,144,084...6,321,013
Ensembl chr 6:6,144,084...6,321,013
JBrowse link
G FASN fatty acid synthase decreases expression ISO Eugenol results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FBXO9 F-box protein 9 decreases expression EXP Eugenol results in decreased expression of FBXO9 mRNA CTD PMID:17374397 NCBI chr 6:53,057,807...53,100,873
Ensembl chr 6:53,051,991...53,100,873
JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb increases expression EXP Eugenol results in increased expression of FCGR2B mRNA CTD PMID:17374397 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,147...161,678,654
JBrowse link
G FECH ferrochelatase increases expression EXP Eugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Eugenol results in increased expression of FOSL2 mRNA CTD PMID:17374397 NCBI chr 2:28,392,855...28,417,317
Ensembl chr 2:28,392,448...28,417,317
JBrowse link
G FTL ferritin light chain increases expression EXP Eugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression EXP Eugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA] CTD PMID:19851710 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GADD45B growth arrest and DNA damage inducible beta increases expression ISO Eugenol results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Eugenol results in increased expression of GCLC mRNA CTD PMID:20566472, PMID:26198647, PMID:30806763 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Eugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:26198647, PMID:27965148, PMID:30806763 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GLYCAM1 glycosylation dependent cell adhesion molecule 1 (pseudogene) increases expression EXP Eugenol results in increased expression of GLYCAM1 mRNA CTD PMID:17936526 NCBI chr12:54,608,187...54,610,462
Ensembl chr12:54,608,187...54,610,462
JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 increases expression EXP Eugenol results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 4:83,535,634...83,605,875
Ensembl chr 4:83,535,914...83,605,875
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP Eugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases expression EXP Eugenol results in increased expression of GSK3B mRNA CTD PMID:17374397 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP Eugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases activity EXP Eugenol analog results in decreased activity of GSTA1 protein CTD PMID:8620581 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 decreases activity
increases expression
ISO Eugenol analog results in decreased activity of GSTA2 protein
Eugenol results in increased expression of GSTA2 protein
CTD PMID:8406240, PMID:8620581 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases activity EXP
ISO
Eugenol analog results in decreased activity of GSTM1 protein CTD PMID:8620581 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM2 glutathione S-transferase mu 2 decreases activity ISO Eugenol analog results in decreased activity of GSTM2 protein CTD PMID:8620581 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP
ISO
Eugenol analog results in decreased activity of GSTP1 protein CTD PMID:8620581 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GYPB glycophorin B (MNS blood group) decreases expression EXP Eugenol results in decreased expression of GYPB mRNA CTD PMID:17374397 NCBI chr 4:143,995,172...144,021,861
Ensembl chr 4:143,996,104...144,019,345
Ensembl chr 4:143,996,104...144,019,345
JBrowse link
G HEATR5B HEAT repeat containing 5B decreases expression EXP Eugenol results in decreased expression of HEATR5B mRNA CTD PMID:17374397 NCBI chr 2:36,980,895...37,084,384
Ensembl chr 2:36,968,383...37,084,372
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP Eugenol results in increased expression of HIF1A mRNA CTD PMID:20713136 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HLA-B major histocompatibility complex, class I, B increases expression EXP Eugenol results in increased expression of HLA-B mRNA CTD PMID:17374397 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,269,491...31,357,188
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Eugenol results in decreased expression of HMGCR mRNA CTD PMID:21870829 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO
EXP
Eugenol results in increased expression of HMOX1 mRNA CTD PMID:20566472, PMID:20713136, PMID:23445166, PMID:26244607, PMID:30806763 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 decreases expression EXP Eugenol results in decreased expression of HNRNPA3 mRNA CTD PMID:17374397 NCBI chr 2:177,212,694...177,223,959
Ensembl chr 2:177,212,563...177,223,958
JBrowse link
G HRAS HRas proto-oncogene, GTPase decreases expression ISO Eugenol results in decreased expression of HRAS protein CTD PMID:20537511 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,287
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Eugenol results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP Eugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G IBSP integrin binding sialoprotein decreases expression EXP Eugenol results in decreased expression of IBSP mRNA; Eugenol results in decreased expression of IBSP protein CTD PMID:21706355 NCBI chr 4:87,799,554...87,812,435
Ensembl chr 4:87,799,554...87,812,435
JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression EXP Eugenol results in increased expression of ICAM1 mRNA; Eugenol results in increased expression of ICAM1 protein CTD PMID:30806763 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Eugenol results in decreased expression of IDI1 mRNA CTD PMID:17374397 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,170
JBrowse link
G IFNG interferon gamma increases secretion
multiple interactions
ISO Eugenol results in increased secretion of IFNG protein
[Methoxychlor co-treated with Eugenol] results in increased expression of IFNG protein; [Parathion co-treated with Eugenol] results in increased expression of IFNG protein
CTD PMID:20920556, PMID:22245253 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein] CTD PMID:19851710 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL10 interleukin 10 multiple interactions ISO [Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA] CTD PMID:21237301 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12A interleukin 12A multiple interactions ISO Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]] CTD PMID:21237301 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
JBrowse link
G IL12B interleukin 12B multiple interactions ISO Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]] CTD PMID:21237301 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL16 interleukin 16 multiple interactions
increases secretion
EXP Eugenol results in increased expression of and results in increased secretion of IL16 protein
Eugenol results in increased secretion of IL16 protein
CTD PMID:23624239, PMID:30806763 NCBI chr15:81,196,879...81,314,058
Ensembl chr15:81,159,575...81,314,058
JBrowse link
G IL18 interleukin 18 increases expression EXP Eugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha increases expression EXP Eugenol results in increased expression of IL1A mRNA CTD PMID:30806763 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression
decreases expression
EXP
ISO
[Eugenol results in increased activity of sulforafan] which results in decreased expression of IL1B; [sulforafan results in increased activity of Eugenol] which results in decreased expression of IL1B; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Eugenol results in increased expression of IL1B mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Eugenol results in decreased expression of IL1B mRNA
CTD PMID:12963494, PMID:17509409, PMID:20713136, PMID:21382956, PMID:21807015, PMID:21939359 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1R2 interleukin 1 receptor type 2 increases expression EXP Eugenol results in increased expression of IL1R2 mRNA CTD PMID:20713136, PMID:30806763 NCBI chr 2:101,991,805...102,028,544
Ensembl chr 2:101,991,960...102,028,544
JBrowse link
G IL2 interleukin 2 increases expression
increases secretion
ISO Eugenol results in increased expression of IL2 protein
Eugenol results in increased secretion of IL2 protein
CTD PMID:22245253, PMID:22381623 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4R interleukin 4 receptor increases expression ISO Eugenol results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr16:27,313,668...27,364,778
Ensembl chr16:27,313,668...27,364,778
JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion
increases expression
ISO Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of IL6 protein]
Eugenol results in increased secretion of IL6 protein
Eugenol inhibits the reaction [Thioacetamide results in increased activity of IL6 protein]
Eugenol results in increased expression of IL6 mRNA
CTD PMID:20036707, PMID:20043298, PMID:21870829, PMID:22245253 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL7R interleukin 7 receptor increases expression EXP Eugenol results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr 5:35,856,891...35,879,603
Ensembl chr 5:35,852,695...35,879,603
JBrowse link
G INHBA inhibin subunit beta A decreases expression ISO Eugenol results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr 7:41,685,101...41,710,532
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G IPCEF1 interaction protein for cytohesin exchange factors 1 decreases expression EXP Eugenol results in decreased expression of IPCEF1 mRNA CTD PMID:17374397 NCBI chr 6:154,154,496...154,356,803
Ensembl chr 6:154,154,496...154,356,792
JBrowse link
G ITGA6 integrin subunit alpha 6 increases expression EXP Eugenol results in increased expression of ITGA6 mRNA CTD PMID:17936526 NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,427,354...172,506,459
JBrowse link
G ITGB1 integrin subunit beta 1 increases expression EXP Eugenol results in increased expression of ITGB1 mRNA CTD PMID:17936526 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 decreases activity EXP Eugenol results in decreased activity of KCNA5 protein CTD PMID:17720863 NCBI chr12:5,043,879...5,046,788
Ensembl chr12:5,043,879...5,046,788
JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 decreases expression EXP Eugenol results in decreased expression of KCNJ2 mRNA CTD PMID:17374397 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044
Ensembl chr17:70,168,673...70,180,044
JBrowse link
G KIF23 kinesin family member 23 decreases expression EXP Eugenol results in decreased expression of KIF23 mRNA CTD PMID:17374397 NCBI chr15:69,414,325...69,448,427
Ensembl chr15:69,414,246...69,448,427
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP Eugenol results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAFG MAF bZIP transcription factor G increases expression EXP Eugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP Eugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
JBrowse link
G MCTS1 MCTS1 re-initiation and release factor decreases expression EXP Eugenol results in decreased expression of MCTS1 mRNA CTD PMID:17374397 NCBI chr  X:120,604,101...120,621,159
Ensembl chr  X:120,594,010...120,621,159
JBrowse link
G ME1 malic enzyme 1 increases expression EXP Eugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Eugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]
Eugenol results in decreased expression of MMP2 mRNA
CTD PMID:20434464, PMID:30518369 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]
Eugenol results in decreased expression of MMP9 mRNA
CTD PMID:20434464, PMID:30518369 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Eugenol inhibits the reaction [Thioacetamide results in increased activity of MPO protein] CTD PMID:20036707 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MRPL35 mitochondrial ribosomal protein L35 decreases expression EXP Eugenol results in decreased expression of MRPL35 mRNA CTD PMID:17374397 NCBI chr 2:86,199,433...86,213,794
Ensembl chr 2:86,199,355...86,213,790
JBrowse link
G MS4A7 membrane spanning 4-domains A7 increases expression EXP Eugenol results in increased expression of MS4A7 mRNA CTD PMID:17374397 NCBI chr11:60,378,532...60,395,948
Ensembl chr11:60,378,485...60,395,951
JBrowse link
G MT1X metallothionein 1X increases expression EXP Eugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MT3 metallothionein 3 increases expression ISO Eugenol results in increased expression of MT3 mRNA CTD PMID:15157811 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G MXD1 MAX dimerization protein 1 increases expression EXP Eugenol results in increased expression of MXD1 mRNA CTD PMID:20713136 NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945
JBrowse link
G MYB MYB proto-oncogene, transcription factor decreases expression EXP Eugenol results in decreased expression of MYB mRNA CTD PMID:17374397 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC protein] CTD PMID:20537511 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase increases expression EXP Eugenol results in increased expression of NAMPT mRNA CTD PMID:17374397 NCBI chr 7:106,248,298...106,284,983
Ensembl chr 7:106,248,298...106,286,326
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects expression
multiple interactions
EXP Eugenol affects the expression of NFE2L2 protein
Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]
CTD PMID:17275817 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
affects expression
EXP
ISO
Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol affects the expression of NFKB1 mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
CTD PMID:10871845, PMID:19851710, PMID:20385217 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKBIA protein modified form]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:12963494, PMID:19851710, PMID:20043298 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NOS2 protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:20043298, PMID:21237301 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH1 notch receptor 1 decreases expression ISO
EXP
Eugenol results in decreased expression of NOTCH1 protein
Eugenol results in decreased expression of NOTCH1 mRNA; Eugenol results in decreased expression of NOTCH1 protein
CTD PMID:31926151 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
multiple interactions
EXP Eugenol results in increased expression of NQO1 mRNA; Eugenol results in increased expression of NQO1 protein
Eugenol results in increased activity of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]
CTD PMID:17275817, PMID:20566472, PMID:21742781 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases expression EXP Eugenol results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NUP88 nucleoporin 88 increases expression EXP Eugenol results in increased expression of NUP88 mRNA CTD PMID:17374397 NCBI chr17:5,384,833...5,419,662
Ensembl chr17:5,360,963...5,419,676
JBrowse link
G OR5D18 olfactory receptor family 5 subfamily D member 18 multiple interactions
increases activity
affects binding
ISO [[Eugenol results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA; [Eugenol binds to and results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP; [Eugenol binds to and results in increased activity of OLFR73 protein] which results in increased transport of Calcium; [Eugenol binds to OLFR73 protein] which results in increased transport of Calcium; [Eugenol results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP; Eugenol binds to and results in increased activity of OLFR73 protein; isomethyleugenol inhibits the reaction [[Eugenol binds to OLFR73 protein] which results in increased transport of Calcium] CTD PMID:12767924, PMID:14685265, PMID:15716417, PMID:19723634 NCBI chr11:55,819,630...55,820,571
Ensembl chr11:55,819,607...55,820,597
JBrowse link
G P2RX3 purinergic receptor P2X 3 multiple interactions ISO Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate] CTD PMID:19967073 NCBI chr11:57,335,943...57,372,399
Ensembl chr11:57,338,352...57,372,396
JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase decreases expression EXP Eugenol results in decreased expression of PAICS mRNA CTD PMID:17374397 NCBI chr 4:56,435,752...56,464,578
Ensembl chr 4:56,435,741...56,464,578
Ensembl chr 4:56,435,741...56,464,578
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein] CTD PMID:20434464 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
CTD PMID:19851710, PMID:20043298 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDE4B phosphodiesterase 4B increases expression EXP Eugenol results in increased expression of PDE4B mRNA CTD PMID:17374397 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP Eugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein increases expression EXP Eugenol results in increased expression of PICALM mRNA CTD PMID:17374397 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:20724125, PMID:21870829 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PLAT plasminogen activator, tissue type increases expression EXP Eugenol results in increased expression of PLAT mRNA CTD PMID:17374397 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP Eugenol results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,948...59,904,306
Ensembl chr18:59,899,948...59,904,306
JBrowse link
G POU5F1 POU class 5 homeobox 1 decreases expression ISO
EXP
Eugenol results in decreased expression of POU5F1 protein
Eugenol results in decreased expression of POU5F1 mRNA; Eugenol results in decreased expression of POU5F1 protein
CTD PMID:31926151 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression
EXP
ISO
Eugenol analog binds to and results in increased activity of PPARG protein
Eugenol results in increased expression of PPARG mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Eugenol analog binds to and results in increased activity of PPARG protein]; Eugenol analog binds to and results in increased activity of PPARG protein
CTD PMID:20064974, PMID:21870829 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPBP pro-platelet basic protein multiple interactions
increases expression
EXP Eugenol results in increased expression of and results in increased secretion of PPBP protein
Eugenol results in increased expression of PPBP mRNA
CTD PMID:23624239 NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190
JBrowse link
G PRDX3 peroxiredoxin 3 decreases expression EXP Eugenol results in decreased expression of PRDX3 mRNA CTD PMID:17374397 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PTGER3 prostaglandin E receptor 3 decreases expression EXP Eugenol results in decreased expression of PTGER3 mRNA CTD PMID:17374397 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP Eugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression
EXP
ISO
Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Eugenol results in increased expression of PTGS2 mRNA
Eugenol results in decreased expression of PTGS2 mRNA
Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2]
Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid]; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:12757841, PMID:16101137, PMID:17509409, PMID:20036707, PMID:20043298, PMID:21807015, PMID:21939359, PMID:30806763 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP Eugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RECK reversion inducing cysteine rich protein with kazal motifs multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein] CTD PMID:20434464 NCBI chr 9:36,036,905...36,124,455
Ensembl chr 9:36,036,913...36,124,455
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of RELA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]
CTD PMID:10871845, PMID:19851710, PMID:20043298 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RGS1 regulator of G protein signaling 1 increases expression EXP Eugenol results in increased expression of RGS1 mRNA CTD PMID:17374397, PMID:20713136 NCBI chr 1:192,575,773...192,580,024
Ensembl chr 1:192,575,763...192,580,024
JBrowse link
G RPL27A ribosomal protein L27a increases expression EXP Eugenol results in increased expression of RPL27A mRNA CTD PMID:17374397 NCBI chr11:8,682,792...8,689,872
Ensembl chr11:8,682,788...8,714,759
JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression EXP Eugenol results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 8:102,204,501...102,238,961
Ensembl chr 8:102,204,502...102,238,961
Ensembl chr 8:102,204,502...102,238,961
JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 increases expression EXP Eugenol results in increased expression of SAT1 mRNA CTD PMID:17374397 NCBI chr  X:23,783,158...23,786,223
Ensembl chr  X:23,783,173...23,786,226
JBrowse link
G SDC2 syndecan 2 increases expression EXP Eugenol results in increased expression of SDC2 mRNA CTD PMID:17374397 NCBI chr 8:96,493,601...96,611,790
Ensembl chr 8:96,493,813...96,611,790
JBrowse link
G SEPTIN11 septin 11 decreases expression EXP Eugenol results in decreased expression of SEPTIN11 mRNA CTD PMID:17374397 NCBI chr 4:76,949,752...77,040,154
Ensembl chr 4:76,949,703...77,040,384
JBrowse link
G SERPINB3 serpin family B member 3 increases expression EXP Eugenol results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr18:63,655,197...63,661,893
Ensembl chr18:63,655,197...63,661,893
JBrowse link
G SLAMF1 signaling lymphocytic activation molecule family member 1 decreases expression EXP Eugenol results in decreased expression of SLAMF1 mRNA CTD PMID:20713136 NCBI chr 1:160,608,100...160,647,311
Ensembl chr 1:160,608,106...160,647,295
JBrowse link
G SLC16A10 solute carrier family 16 member 10 increases expression EXP Eugenol results in increased expression of SLC16A10 mRNA CTD PMID:17374397 NCBI chr 6:111,087,503...111,231,194
Ensembl chr 6:111,087,503...111,231,194
JBrowse link
G SLC2A3 solute carrier family 2 member 3 increases expression EXP Eugenol results in increased expression of SLC2A3 mRNA CTD PMID:17374397 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G SLC2A4 solute carrier family 2 member 4 increases expression ISO Eugenol results in increased expression of SLC2A4 mRNA CTD PMID:20724125, PMID:21870829 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Eugenol results in increased expression of SLC7A11 mRNA CTD PMID:26198647, PMID:30806763 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SOD1 superoxide dismutase 1 increases expression
decreases expression
multiple interactions
EXP Eugenol results in increased expression of SOD1 mRNA
Eugenol results in decreased expression of SOD1 mRNA; Eugenol results in decreased expression of SOD1 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]
CTD PMID:16101137, PMID:20566472 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression
decreases expression
multiple interactions
EXP Eugenol results in increased expression of SOD2 mRNA
Eugenol results in decreased expression of SOD2 mRNA; Eugenol results in decreased expression of SOD2 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]
CTD PMID:16101137, PMID:20566472 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP Eugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SQSTM1 sequestosome 1 increases expression EXP Eugenol results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP Eugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472, PMID:26198647 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G STAT1 signal transducer and activator of transcription 1 decreases expression EXP Eugenol results in decreased expression of STAT1 mRNA CTD PMID:17374397 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT4 signal transducer and activator of transcription 4 increases expression EXP Eugenol results in increased expression of STAT4 mRNA CTD PMID:17374397 NCBI chr 2:191,029,576...191,172,684
Ensembl chr 2:191,029,576...191,151,596
JBrowse link
G STAT5B signal transducer and activator of transcription 5B increases expression EXP Eugenol results in increased expression of STAT5B mRNA CTD PMID:17374397 NCBI chr17:42,199,177...42,288,437
Ensembl chr17:42,199,177...42,276,707
Ensembl chr17:42,199,177...42,276,707
JBrowse link
G SULT1C3 sulfotransferase family 1C member 3 increases sulfation ISO SULT1C1 protein results in increased sulfation of Eugenol CTD PMID:9560327 NCBI chr 2:108,239,968...108,265,608
Ensembl chr 2:108,247,195...108,265,351
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein] CTD PMID:20434464 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TLR4 toll like receptor 4 increases expression EXP Eugenol results in increased expression of TLR4 mRNA CTD PMID:17936526 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
affects expression
EXP
ISO
Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol results in increased expression of TNF mRNA
Eugenol affects the expression of TNF mRNA
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Eugenol inhibits the reaction [Thioacetamide results in increased activity of TNF protein]
[Methoxychlor co-treated with Eugenol] results in increased expression of TNF protein; [Parathion co-treated with Eugenol] results in increased expression of TNF protein; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Bacterial Toxins results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]
CTD PMID:10871845, PMID:12963494, PMID:17509409, PMID:20036707, PMID:20043298, PMID:20385217, PMID:20639367, PMID:20920556, PMID:21237301, PMID:21807015, PMID:21870829, PMID:30806763, PMID:32096903 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP Eugenol results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 increases expression EXP Eugenol results in increased expression of TNFAIP6 mRNA CTD PMID:17374397, PMID:20713136 NCBI chr 2:151,357,592...151,380,046
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases mutagenesis
increases expression
ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TP53 protein]
Eugenol results in increased mutagenesis of TP53 gene
Eugenol results in increased expression of TRP53 mRNA; Eugenol results in increased expression of TRP53 protein
Eugenol promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 protein]
CTD PMID:15576237, PMID:19851710, PMID:20043298, PMID:20537511 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP63 tumor protein p63 decreases expression EXP Eugenol results in decreased expression of TP63 mRNA CTD PMID:17936526 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 multiple interactions
increases activity
ISO [2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Eugenol
Eugenol results in increased activity of TRPA1 protein
CTD PMID:22426238 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TRPV3 transient receptor potential cation channel subfamily V member 3 multiple interactions
increases activity
EXP
ISO
Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol results in increased activity of TRPV3 protein] which results in increased transport of Calcium
CTD PMID:16617338, PMID:20086034, PMID:21593771 NCBI chr17:3,510,502...3,557,812
Ensembl chr17:3,510,502...3,557,995
Ensembl chr17:3,510,502...3,557,995
JBrowse link
G TXN2 thioredoxin 2 increases expression EXP Eugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP
ISO
Eugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases expression EXP Eugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression EXP Eugenol results in increased expression of UGDH mRNA CTD PMID:16292757 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Eugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 2:233,681,938...233,773,299
Ensembl chr 2:233,681,938...233,773,299
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 2:233,617,645...233,773,299
Ensembl chr 2:233,617,645...233,773,310
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Eugenol; UGT2B15 protein SNP results in increased metabolism of Eugenol CTD PMID:7835232, PMID:12386133 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing EXP UGT2B17 protein results in increased metabolism of Eugenol CTD PMID:8798464 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527
JBrowse link
G VDR vitamin D receptor increases expression EXP Eugenol results in increased expression of VDR mRNA CTD PMID:17374397 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
G ZBTB17 zinc finger and BTB domain containing 17 decreases expression EXP Eugenol results in decreased expression of ZBTB17 mRNA CTD PMID:17374397 NCBI chr 1:15,939,933...15,976,132
Ensembl chr 1:15,941,869...15,976,132
JBrowse link
gingerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:18385293 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375, PMID:21851089 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:27451028 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein CTD PMID:19481070 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] CTD PMID:18577375 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]
gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein
CTD PMID:18030663, PMID:19481070, PMID:25034532, PMID:28249781 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP
ISO
gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein
gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
CTD PMID:18030663, PMID:19481070, PMID:25034532, PMID:27451028, PMID:28249781 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions EXP [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein CTD PMID:27451028 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] CTD PMID:25034532 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions
decreases expression
EXP
ISO
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] CTD PMID:18030663, PMID:25034532 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 increases expression
increases cleavage
multiple interactions
affects activity
EXP
ISO
gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein
gingerol results in increased cleavage of CASP3 protein
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
gingerol affects the activity of CASP3 protein
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
CTD PMID:17454143, PMID:18030663, PMID:19481070, PMID:25034532, PMID:28249781, PMID:28373059 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions
increases cleavage
affects activity
EXP
ISO
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]
gingerol results in increased cleavage of CASP8 protein
gingerol affects the activity of CASP8 protein
CTD PMID:17454143, PMID:25034532, PMID:28249781 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases expression
increases cleavage
multiple interactions
affects activity
EXP
ISO
gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein
gingerol results in increased cleavage of CASP9 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein]
gingerol affects the activity of CASP9 protein
CTD PMID:17454143, PMID:18030663, PMID:19481070, PMID:28249781 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]
CTD PMID:22285432, PMID:28373059, PMID:31004597 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein CTD PMID:28249781 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression
decreases expression
EXP
ISO
[gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein
gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein
gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein
CTD PMID:18058799, PMID:26498061, PMID:28249781 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein CTD PMID:28249781 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP gingerol results in decreased expression of CDK1 mRNA CTD PMID:28249781 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP gingerol results in decreased expression of CDK4 protein CTD PMID:18058799 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression EXP gingerol results in decreased expression of CDKN1A mRNA CTD PMID:28249781 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B decreases expression EXP gingerol results in decreased expression of CDKN1B mRNA CTD PMID:28249781 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression
multiple interactions
ISO gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]
CTD PMID:26498061 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] CTD PMID:25034532 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CTNNB1 catenin beta 1 affects localization
increases expression
multiple interactions
EXP
ISO
gingerol affects the localization of CTNNB1 protein
gingerol results in increased expression of CTNNB1 mRNA
gingerol results in increased expression of and affects the localization of CTNNB1 protein
gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
CTD PMID:18058799, PMID:26498061, PMID:27645308 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases response to substance EXP CYP2C19 mRNA results in increased susceptibility to gingerol CTD PMID:29555536 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DUSP10 dual specificity phosphatase 10 increases expression EXP gingerol results in increased expression of DUSP10 mRNA CTD PMID:17151092 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G DVL2 dishevelled segment polarity protein 2 increases expression ISO gingerol results in increased expression of DVL2 mRNA CTD PMID:26498061 NCBI chr17:7,225,341...7,234,544
Ensembl chr17:7,225,342...7,234,517
JBrowse link
G FAS Fas cell surface death receptor affects activity ISO gingerol affects the activity of FAS protein CTD PMID:17454143 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASN fatty acid synthase decreases expression ISO gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein CTD PMID:26498061 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FN1 fibronectin 1 multiple interactions EXP gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:21829520 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G GDF15 growth differentiation factor 15 increases expression
multiple interactions
EXP gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein
GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]
CTD PMID:18058799 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
increases response to substance
increases phosphorylation
increases expression
EXP
ISO
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]
GSK3B protein results in increased susceptibility to gingerol
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in increased phosphorylation of GSK3B protein
gingerol results in increased expression of GSK3B protein
CTD PMID:18058799, PMID:26498061, PMID:27645308 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A decreases activity EXP gingerol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,974,881...113,990,313
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]
CTD PMID:27645308, PMID:31004597 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] CTD PMID:22285432 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,317...226,799,759
JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:18577375 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KLKB1 kallikrein B1 multiple interactions
decreases expression
EXP gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]
gingerol results in decreased expression of KLKB1 protein
CTD PMID:18030663 NCBI chr 4:186,215,714...186,258,477
Ensembl chr 4:186,208,979...186,258,471
JBrowse link
G LEP leptin multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LRP6 LDL receptor related protein 6 increases expression ISO gingerol results in increased expression of LRP6 mRNA CTD PMID:26498061 NCBI chr12:12,116,025...12,267,044
Ensembl chr12:12,116,025...12,267,044
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP [gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form CTD PMID:27451028 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 NCBI chr17:12,020,822...12,143,828
Ensembl chr17:12,020,829...12,143,830
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression
decreases activity
EXP gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein
gingerol results in decreased activity of MMP2 protein
CTD PMID:17683926 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
decreases activity
EXP gingerol results in decreased expression of MMP9 mRNA
gingerol results in decreased activity of MMP9 protein
CTD PMID:17683926 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]
CTD PMID:28373059, PMID:31004597 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
decreases expression
EXP gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]
gingerol results in decreased expression of MTOR protein modified form
CTD PMID:27451028, PMID:28249781 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP gingerol affects the phosphorylation of and affects the activity of NFKBIA protein CTD PMID:17454143 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:18683823, PMID:31004597 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] CTD PMID:25034532 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein
CTD PMID:22285432, PMID:26498061 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions EXP PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PTGES prostaglandin E synthase decreases expression
increases expression
EXP gingerol results in decreased expression of PTGES protein
gingerol results in increased expression of PTGES mRNA
CTD PMID:27645308 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions
EXP
ISO
gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:17454143, PMID:18683823, PMID:31004597 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation EXP gingerol results in decreased phosphorylation of RB1 protein CTD PMID:18058799 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects expression
multiple interactions
affects localization
ISO
EXP
gingerol affects the expression of RELA protein
gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
gingerol affects the localization of RELA protein
CTD PMID:17454143, PMID:18683823 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases expression EXP gingerol results in decreased expression of RPS6KB1 protein modified form CTD PMID:28249781 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] CTD PMID:22285432 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions EXP gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] CTD PMID:21829520 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] CTD PMID:21382473 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]
CTD PMID:18577375, PMID:21851089, PMID:22285432, PMID:28373059, PMID:31004597 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b increases expression
multiple interactions
EXP gingerol results in increased expression of TNFRSF10B protein
TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]
CTD PMID:25034532 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions
increases response to substance
EXP [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] CTD PMID:25034532 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP
ISO
gingerol results in increased expression of TP53 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein]
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]
CTD PMID:18030663, PMID:25034532 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 increases glucuronidation EXP UGT2B4 protein results in increased glucuronidation of gingerol CTD PMID:25393417 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014
JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP gingerol results in decreased expression of XIAP protein CTD PMID:25034532 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
Ensembl chr  X:123,859,724...123,913,976
JBrowse link
guaiacol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP Guaiacol binds to ALB protein CTD PMID:11334365 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G CA1 carbonic anhydrase 1 decreases activity EXP Guaiacol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA2 carbonic anhydrase 2 decreases activity EXP Guaiacol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol] CTD PMID:24141029 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Guaiacol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:17465205 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G SULT1C3 sulfotransferase family 1C member 3 increases sulfation ISO SULT1C1 protein results in increased sulfation of Guaiacol CTD PMID:9560327 NCBI chr 2:108,239,968...108,265,608
Ensembl chr 2:108,247,195...108,265,351
JBrowse link
homovanillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase multiple interactions EXP
ISO
[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:11793163, PMID:15190105, PMID:16012872 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G MAOB monoamine oxidase B multiple interactions ISO [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid CTD PMID:16012872 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Homovanillic Acid] CTD PMID:11085313 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 increases abundance ISO NR3C1 protein results in increased abundance of Homovanillic Acid CTD PMID:11226678 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions ISO [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] CTD PMID:8884884 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of Homovanillic Acid CTD PMID:10318960 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G SCT secretin increases abundance EXP SCT protein results in increased abundance of Homovanillic Acid CTD PMID:16168596 NCBI chr11:626,095...627,692
Ensembl chr11:626,309...627,181
JBrowse link
G SLC22A8 solute carrier family 22 member 8 multiple interactions ISO Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G TFAM transcription factor A, mitochondrial decreases abundance ISO TFAM gene mutant form results in decreased abundance of Homovanillic Acid CTD PMID:28595911 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G VDR vitamin D receptor multiple interactions
increases abundance
EXP Calcitriol promotes the reaction [VDR protein results in increased abundance of Homovanillic Acid] CTD PMID:27450565 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor increases activity
affects localization
multiple interactions
EXP isoeugenol results in increased activity of AHR protein
isoeugenol affects the localization of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AHRR aryl-hydrocarbon receptor repressor increases expression EXP isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 5:321,714...438,285
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases expression EXP isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression
increases activity
EXP isoeugenol results in increased expression of AKR1C2 mRNA
isoeugenol results in increased activity of AKR1C2 promoter
CTD PMID:20491607, PMID:21195160 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AR androgen receptor affects binding ISO isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G CAT catalase increases expression EXP isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases secretion EXP isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL27 C-C motif chemokine ligand 27 increases expression EXP isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 9:34,661,890...34,662,657
Ensembl chr 9:34,661,880...34,664,048
JBrowse link
G CD274 CD274 molecule increases expression EXP isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP [Indomethacin co-treated with isoeugenol] results in increased expression of CXCL8 mRNA; KT 5720 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]
isoeugenol results in increased expression of CXCL8 mRNA; isoeugenol results in increased expression of CXCL8 protein
CTD PMID:21284934, PMID:21920952, PMID:21969073, PMID:25617811, PMID:31734321 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G FECH ferrochelatase increases expression EXP isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
G FTL ferritin light chain increases expression EXP isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression EXP isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP
ISO
isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP isoeugenol results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G IFNG interferon gamma increases secretion ISO isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL18 interleukin 18 increases expression EXP isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha increases expression ISO isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL2 interleukin 2 multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 increases secretion ISO isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAFG MAF bZIP transcription factor G increases expression EXP isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G ME1 malic enzyme 1 increases expression EXP isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MT1X metallothionein 1X increases expression EXP isoeugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OR5D18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr11:55,819,630...55,820,571
Ensembl chr11:55,819,607...55,820,597
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:10871845, PMID:17698059 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G TLR2 toll like receptor 2 increases expression EXP isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP
ISO
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRIM16 tripartite motif containing 16 multiple interactions
increases expression
EXP [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr17:15,627,966...15,684,311
Ensembl chr17:15,627,960...15,684,311
JBrowse link
G TXN2 thioredoxin 2 increases expression EXP isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP
ISO
isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases expression EXP isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G ZFP36 ZFP36 ring finger protein increases expression
multiple interactions
EXP isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
JBrowse link
KN-93 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] CTD PMID:19647009 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACO1 aconitase 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride affects the localization of ACO1 protein] CTD PMID:25106854 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein] CTD PMID:32522522 NCBI chr19:11,574,660...11,578,983
Ensembl chr19:11,574,660...11,579,008
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein] CTD PMID:18089838 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AHRR aryl-hydrocarbon receptor repressor multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:18089838 NCBI chr 5:321,714...438,285
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein] CTD PMID:18506790 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of AKT1 protein]
CTD PMID:19233221, PMID:21933187, PMID:28025122 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29883672 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G CALCR calcitonin receptor multiple interactions ISO KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 7:93,424,486...93,574,730
Ensembl chr 7:93,424,486...93,574,730
Ensembl chr 7:93,424,486...93,574,730
JBrowse link
G CAMK1 calcium/calmodulin dependent protein kinase I decreases activity EXP KN 93 results in decreased activity of CAMK1 protein CTD PMID:12193581 NCBI chr 3:9,757,345...9,769,987
Ensembl chr 3:9,757,347...9,769,992
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO
EXP
[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]
CTD PMID:19217379, PMID:21933187, PMID:25103225, PMID:28025122 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,291
JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta multiple interactions ISO KN 93 inhibits the reaction [Cadmium affects the localization of CAMK2D protein] CTD PMID:22553113 NCBI chr 4:113,451,032...113,762,177
Ensembl chr 4:113,451,032...113,761,927
JBrowse link
G CAMK4 calcium/calmodulin dependent protein kinase IV multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr 5:111,223,583...111,498,503
Ensembl chr 5:111,223,653...111,494,886
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP12 protein] CTD PMID:29883672 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP
KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; KN 93 promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]
KN 93 inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [GW 7845 results in increased activity of CASP3 protein]
CTD PMID:19233221, PMID:20810541, PMID:26096086, PMID:26923100, PMID:28025122, PMID:29883672 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL1 C-C motif chemokine ligand 1 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA] CTD PMID:18089838 NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233
JBrowse link
G CCND1 cyclin D1 decreases expression EXP KN 93 results in decreased expression of CCND1 protein CTD PMID:15958590 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:15385614, PMID:15631885, PMID:21113126 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA] CTD PMID:18089838 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO KN 93 inhibits the reaction [GW 7845 affects the localization of CYCS protein] CTD PMID:20810541 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 multiple interactions EXP KN 93 inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA] CTD PMID:12193581 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP
ISO
KN 93 inhibits the reaction [STO 609 results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:18089838, PMID:18755850, PMID:23298284 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:18089838 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein] CTD PMID:29883672 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DRD3 dopamine receptor D3 multiple interactions ISO KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin results in increased phosphorylation of DRD3 protein] CTD PMID:19217379 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein] CTD PMID:19233221 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21933187 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of GRIA1 protein] CTD PMID:12019337 NCBI chr 5:153,490,670...153,813,873
Ensembl chr 5:153,489,615...153,813,869
JBrowse link
G HDAC5 histone deacetylase 5 multiple interactions ISO KN 93 inhibits the reaction [Potassium Chloride results in increased phosphorylation of HDAC5 protein] CTD PMID:17988634 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions ISO KN 93 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein] CTD PMID:19647009 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 mRNA]; KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29883672 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA] CTD PMID:18089838 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G ITGB7 integrin subunit beta 7 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA] CTD PMID:18089838 NCBI chr12:53,191,318...53,207,375
Ensembl chr12:53,191,323...53,207,282
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK1 protein]
CTD PMID:15086530, PMID:15355987, PMID:19233221, PMID:21879721, PMID:21933187, PMID:28181390, PMID:29883672 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:21933187 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK3 protein]
CTD PMID:15086530, PMID:15355987, PMID:19233221, PMID:21879721, PMID:21933187, PMID:28181390, PMID:29883672 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:21933187 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] CTD PMID:25093688 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NEFL neurofilament light multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,957,110
Ensembl chr 8:24,950,955...24,957,110
JBrowse link
G NEFM neurofilament medium multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein] CTD PMID:15629441 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation EXP KN 93 results in decreased phosphorylation of RB1 protein CTD PMID:15958590 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21933187 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of SRC protein] CTD PMID:19233221 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein]; KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564, PMID:32522522 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G VIM vimentin multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
Ku-0063794 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Ku 0063794 results in decreased phosphorylation of AKT1 protein CTD PMID:22885370 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with AZD 6244] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with PD 0325901] results in decreased phosphorylation of EIF4EBP1 protein; Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:22415236 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation EXP Ku 0063794 results in decreased phosphorylation of RPS6 protein CTD PMID:22885370 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
methoxyfenozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases transport
EXP methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
ABCB1 protein results in increased transport of methoxyfenozide
CTD PMID:26995013 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
o-anisidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases expression EXP 2-anisidine results in decreased expression of AKT1 mRNA CTD PMID:28089782 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BCL10 BCL10 immune signaling adaptor affects expression EXP 2-anisidine affects the expression of BCL10 mRNA CTD PMID:28089782 NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP 2-anisidine results in decreased expression of BCL2 mRNA CTD PMID:28089782 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL3 BCL3 transcription coactivator affects expression EXP 2-anisidine affects the expression of BCL3 mRNA CTD PMID:28089782 NCBI chr19:44,742,620...44,760,044
Ensembl chr19:44,747,705...44,760,044
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP 2-anisidine results in decreased expression of BIRC5 mRNA CTD PMID:28089782 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase increases expression EXP 2-anisidine results in increased expression of BTRC mRNA CTD PMID:28089782 NCBI chr10:101,353,808...101,557,313
Ensembl chr10:101,354,033...101,557,321
JBrowse link
G CARD10 caspase recruitment domain family member 10 decreases expression EXP 2-anisidine results in decreased expression of CARD10 mRNA CTD PMID:28089782 NCBI chr22:37,490,362...37,519,415
Ensembl chr22:37,490,362...37,519,542
JBrowse link
G CARD14 caspase recruitment domain family member 14 decreases expression EXP 2-anisidine results in decreased expression of CARD14 mRNA CTD PMID:28089782 NCBI chr17:80,169,992...80,209,331
Ensembl chr17:80,169,992...80,209,331
JBrowse link
G CCL20 C-C motif chemokine ligand 20 affects expression EXP 2-anisidine affects the expression of CCL20 mRNA CTD PMID:28089782 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression EXP 2-anisidine results in increased expression of CCL3 mRNA CTD PMID:28089782 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases expression EXP 2-anisidine results in increased expression of CCL5 mRNA CTD PMID:28089782 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CD40 CD40 molecule affects expression EXP 2-anisidine affects the expression of CD40 mRNA CTD PMID:28089782 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CD83 CD83 molecule decreases expression EXP 2-anisidine results in decreased expression of CD83 mRNA CTD PMID:28089782 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918
JBrowse link
G CREB1 cAMP responsive element binding protein 1 affects expression EXP 2-anisidine affects the expression of CREB1 mRNA CTD PMID:28089782 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREBBP CREB binding protein increases expression EXP 2-anisidine results in increased expression of CREBBP mRNA CTD PMID:28089782 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CSF1 colony stimulating factor 1 increases expression EXP 2-anisidine results in increased expression of CSF1 mRNA CTD PMID:28089782 NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992
JBrowse link
G CSF3 colony stimulating factor 3 affects expression EXP 2-anisidine affects the expression of CSF3 mRNA CTD PMID:28089782 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 affects expression EXP 2-anisidine affects the expression of CXCL1 mRNA CTD PMID:28089782 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 decreases expression EXP 2-anisidine results in decreased expression of CXCL2 mRNA CTD PMID:28089782 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
affects expression
EXP 2-anisidine results in increased expression of CXCL8 protein
2-anisidine affects the expression of CXCL8 mRNA
CTD PMID:28089782 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases oxidation
increases expression
ISO
EXP
CYP1A1 protein results in increased oxidation of 2-anisidine
2-anisidine results in increased expression of CYP1A1 mRNA
2-anisidine results in increased expression of CYP1A1; 2-anisidine results in increased expression of CYP1A1 protein
CTD PMID:11409192, PMID:15828049, PMID:16601807, PMID:28089782 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
increases oxidation
ISO
EXP
2-anisidine results in increased expression of CYP1A2
CYP1A2 protein results in increased oxidation of 2-anisidine
CTD PMID:11409192, PMID:15828049 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases oxidation EXP CYP2A6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases oxidation EXP CYP2B6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases oxidation EXP CYP2D6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases oxidation EXP CYP2E1 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases oxidation EXP CYP3A4 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EDARADD EDAR associated death domain affects expression EXP 2-anisidine affects the expression of EDARADD mRNA CTD PMID:28089782 NCBI chr 1:236,394,286...236,484,930
Ensembl chr 1:236,348,257...236,502,915
JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression EXP 2-anisidine results in decreased expression of ENPP2 mRNA CTD PMID:28089782 NCBI chr 8:119,557,085...119,673,404
Ensembl chr 8:119,557,086...119,673,453
JBrowse link
G FADD Fas associated via death domain affects expression EXP 2-anisidine affects the expression of FADD mRNA CTD PMID:28089782 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,163...70,207,390
Ensembl chr11:70,203,163...70,207,390
JBrowse link
G HMGB1 high mobility group box 1 increases expression EXP 2-anisidine results in increased expression of HMGB1 protein CTD PMID:28089782 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP 2-anisidine results in increased expression of HSPA6 mRNA CTD PMID:28089782 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G ICAM1 intercellular adhesion molecule 1 affects expression EXP 2-anisidine affects the expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IER3 immediate early response 3 affects expression EXP 2-anisidine affects the expression of IER3 mRNA CTD PMID:28089782 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta affects expression EXP 2-anisidine affects the expression of IKBKB mRNA CTD PMID:28089782 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects expression EXP 2-anisidine affects the expression of IKBKG mRNA CTD PMID:28089782 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046
JBrowse link
G IL12A interleukin 12A increases expression EXP 2-anisidine results in increased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
JBrowse link
G IL1B interleukin 1 beta increases expression EXP 2-anisidine results in increased expression of IL1B mRNA CTD PMID:28089782 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1R1 interleukin 1 receptor type 1 increases expression EXP 2-anisidine results in increased expression of IL1R1 mRNA CTD PMID:28089782 NCBI chr 2:102,069,638...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G IL2 interleukin 2 increases expression EXP 2-anisidine results in increased expression of IL2 mRNA CTD PMID:28089782 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases expression EXP 2-anisidine results in decreased expression of IL2RA mRNA CTD PMID:28089782 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL5 interleukin 5 increases expression EXP 2-anisidine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 increases expression EXP 2-anisidine results in increased expression of IL6 mRNA CTD PMID:28089782 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 decreases expression EXP 2-anisidine results in decreased expression of IRAK1 mRNA CTD PMID:28089782 NCBI chr  X:154,010,507...154,019,984
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 decreases expression EXP 2-anisidine results in decreased expression of IRAK1BP1 mRNA CTD PMID:28089782 NCBI chr 6:78,867,486...78,979,411
Ensembl chr 6:78,867,551...78,946,440
JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 affects expression EXP 2-anisidine affects the expression of IRAK2 mRNA CTD PMID:28089782 NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745
JBrowse link
G LTBR lymphotoxin beta receptor decreases expression EXP 2-anisidine results in decreased expression of LTBR mRNA CTD PMID:28089782 NCBI chr12:6,375,160...6,391,571
Ensembl chr12:6,375,045...6,391,571
JBrowse link
G MALT1 MALT1 paracaspase increases expression EXP 2-anisidine results in increased expression of MALT1 mRNA CTD PMID:28089782 NCBI chr18:58,671,420...58,754,477
Ensembl chr18:58,671,465...58,754,477
JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 decreases expression EXP 2-anisidine results in decreased expression of MAP3K1 mRNA CTD PMID:28089782 NCBI chr 5:56,815,543...56,896,152
Ensembl chr 5:56,815,549...56,896,152
JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 decreases expression EXP 2-anisidine results in decreased expression of MAP3K14 mRNA CTD PMID:28089782 NCBI chr17:45,263,119...45,317,048
Ensembl chr17:45,263,119...45,317,029
JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 decreases expression EXP 2-anisidine results in decreased expression of MAP3K7 mRNA CTD PMID:28089782 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,072
JBrowse link
G MPO myeloperoxidase multiple interactions EXP [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine CTD PMID:20199096 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP 2-anisidine results in decreased expression of MYC mRNA CTD PMID:28089782 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor decreases expression EXP 2-anisidine results in decreased expression of MYD88 mRNA CTD PMID:28089782 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022
JBrowse link
G NAT1 N-acetyltransferase 1 increases activity EXP NAT1 protein results in increased activity of 2-anisidine CTD PMID:15450435 NCBI chr 8:18,170,419...18,223,689
Ensembl chr 8:18,170,477...18,223,689
JBrowse link
G NAT2 N-acetyltransferase 2 increases activity EXP NAT2 protein results in increased activity of 2-anisidine CTD PMID:15450435