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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monomethoxybenzene
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Accession:CHEBI:25235 term browser browse the term
Definition:Compounds containing a benzene skeleton substituted with one methoxy group.
Synonyms:related_synonym: monomethoxybenzenes


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2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]
CTD PMID:31029725 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein
CTD PMID:31029725 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31029725 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA] CTD PMID:31029725 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:31029725 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:31029725 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]
CTD PMID:31029725 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects localization
EXP NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein] CTD PMID:31029725 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein] CTD PMID:31029725 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA] CTD PMID:31029725 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA] CTD PMID:31029725 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA] CTD PMID:31029725 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
2-nitroanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases oxidation
increases expression
ISO CYP1A1 protein results in increased metabolism of 2-nitroanisole
CYP1A1 protein results in increased oxidation of 2-nitroanisole
2-nitroanisole results in increased expression of CYP1A1
CTD PMID:11409192, PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 2-nitroanisole results in increased expression of CYP1A2; 2-nitroanisole results in increased expression of CYP1A2 protein CTD PMID:11409192, PMID:16601807 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases oxidation
increases metabolic processing
ISO CYP2B6 protein results in increased oxidation of 2-nitroanisole
CYP2B6 protein results in increased metabolism of 2-nitroanisole
CTD PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases oxidation ISO CYP2B2 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases oxidation ISO CYP2C19 protein results in increased oxidation of 2-nitroanisole
CYP2C6V1 protein results in increased oxidation of 2-nitroanisole
CTD PMID:21218109 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases oxidation ISO CYP2C9 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases oxidation ISO CYP2C9 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
ISO CYP2E1 protein results in increased metabolism of 2-nitroanisole
CYP2E1 protein results in increased oxidation of 2-nitroanisole
CTD PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-nitroanisole results in increased expression of H2AX protein CTD PMID:26338220 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO 2-nitroanisole results in increased expression of NQO1 CTD PMID:11409192 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Xdh xanthine dehydrogenase increases reduction ISO XDH protein results in increased reduction of 2-nitroanisole CTD PMID:14729594 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196
JBrowse link
4-methoxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO 4-acetylanisole results in increased expression of CXCL8 mRNA CTD PMID:21920952 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 4-acetylanisole results in increased expression of HMOX1 mRNA CTD PMID:26244607 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
4-nitroanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases metabolic processing ISO CYP2A6 protein results in increased metabolism of 4-nitroanisole CTD PMID:12464242 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
[6]-Shogaol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of ADIPOQ mRNA]; shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO shogaol metabolite results in increased expression of AKR1B10 protein; shogaol results in increased expression of AKR1B10 mRNA; shogaol results in increased expression of AKR1B10 protein CTD PMID:25148906 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] CTD PMID:18683823 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
affects folding
ISO shogaol results in increased expression of BAX protein
shogaol promotes the reaction [BAX protein binds to BAX protein binds to BAX protein]; shogaol promotes the reaction [BAX protein binds to BAX protein]
shogaol affects the folding of BAX protein
CTD PMID:18384088, PMID:25619640 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO shogaol results in decreased expression of BCL2 protein CTD PMID:18384088 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO shogaol results in decreased expression of BCL2L1 protein CTD PMID:18384088 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions
increases expression
EXP [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF mRNA; [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF mRNA]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; [shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein
CTD PMID:22381256 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; shogaol results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18384088, PMID:25619640 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO shogaol results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18384088 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; shogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form] CTD PMID:25619640 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Chat choline acetyltransferase multiple interactions
increases expression
EXP [shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; shogaol results in increased expression of CHAT protein
CTD PMID:22381256 NCBI chr14:32,408,203...32,465,909
Ensembl chr14:32,408,203...32,465,989
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein] CTD PMID:23899529 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO shogaol results in decreased expression of CTNNB1 mRNA; shogaol results in decreased expression of CTNNB1 protein CTD PMID:27645308 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein]
shogaol results in increased expression of DDIT3 mRNA; shogaol results in increased expression of DDIT3 protein
CTD PMID:18384088 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dffa DNA fragmentation factor, alpha subunit increases degradation ISO shogaol results in increased degradation of DFFA protein CTD PMID:18384088 NCBI chr 4:149,104,142...149,120,653
Ensembl chr 4:149,104,146...149,120,647
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions
increases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of FABP4 mRNA] CTD PMID:18577375 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO shogaol results in increased expression of FAS protein CTD PMID:18384088 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO shogaol results in increased expression of FASLG protein CTD PMID:18384088 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO shogaol metabolite results in increased expression of FTL protein; shogaol results in increased expression of FTL mRNA; shogaol results in increased expression of FTL protein CTD PMID:25148906 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
shogaol metabolite results in increased expression of GCLC protein; shogaol results in increased expression of GCLC protein
shogaol results in increased expression of GCLC mRNA
NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]
CTD PMID:25148906 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO shogaol metabolite results in increased expression of GCLM protein; shogaol results in increased expression of GCLM protein CTD PMID:25148906 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO shogaol results in increased expression of GDF15 mRNA CTD PMID:25148906 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO shogaol results in increased expression of and results in increased phosphorylation of GSK3B protein CTD PMID:27645308 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] CTD PMID:23899529 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol metabolite results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 mRNA; shogaol results in increased expression of HMOX1 protein
CTD PMID:23899529, PMID:25148906 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein] CTD PMID:23899529 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein] CTD PMID:27645308 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions
increases alkylation
decreases expression
EXP
ISO
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein]
shogaol results in increased alkylation of KEAP1 protein
shogaol metabolite results in decreased expression of KEAP1 protein; shogaol results in decreased expression of KEAP1 protein
CTD PMID:23899529, PMID:25148906 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:18683823 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:18683823 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] CTD PMID:23899529 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
EXP NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol results in increased expression of MT1 mRNA; shogaol results in increased expression of MT1 protein
CTD PMID:25148906 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
affects localization
multiple interactions
ISO
EXP
shogaol analog results in increased expression of NFE2L2 protein
shogaol affects the localization of NFE2L2 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; shogaol metabolite results in increased expression of and results in increased phosphorylation of NFE2L2 protein; shogaol results in increased expression of and results in increased phosphorylation of NFE2L2 protein
CTD PMID:23899529, PMID:25148906 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP shogaol inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein]
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:18683823, PMID:23899529 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
CTD PMID:18683823, PMID:23899529 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
EXP KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein] CTD PMID:23899529 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:18384088, PMID:25619640 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases activity EXP shogaol results in increased activity of PPARG protein CTD PMID:18577375 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression
ISO shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein]
shogaol results in decreased expression of PTGES mRNA
CTD PMID:27645308 NCBI chr 2:30,889,471...30,931,020
Ensembl chr 2:30,889,471...30,929,863
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:18683823, PMID:23899529 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
shogaol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD PMID:18683823, PMID:23899529 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Slc5a7 solute carrier family 5 (choline transporter), member 7 multiple interactions
increases expression
EXP [shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein; shogaol results in increased expression of SLC5A7 protein
CTD PMID:22381256 NCBI chr17:54,273,590...54,299,038
Ensembl chr17:54,273,590...54,299,034
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions
increases response to substance
ISO [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
shogaol results in increased susceptibility to TNFSF10 protein
CTD PMID:25619640 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
aliskiren term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects response to substance ISO ABCB1 protein affects the susceptibility to aliskiren CTD PMID:24388840 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
decreases expression
ISO
EXP
aliskiren inhibits the reaction [Indomethacin results in increased expression of AGT protein]
aliskiren inhibits the reaction [microcystin RR results in increased expression of AGT protein]
aliskiren results in decreased expression of AGT protein modified form
CTD PMID:18829990, PMID:27645307, PMID:28330766 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA] CTD PMID:27645307 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA] CTD PMID:27645307 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:27645307 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ren1 renin 1 structural multiple interactions
decreases activity
ISO [aliskiren co-treated with Atenolol] results in decreased activity of REN protein
aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]
aliskiren results in decreased activity of REN protein
CTD PMID:18957387, PMID:27645307 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aliskiren inhibits the reaction [Indomethacin results in increased expression of TNF mRNA] CTD PMID:27645307 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
anethole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO anethole results in decreased phosphorylation of AKT1 protein CTD PMID:21212515 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions
ISO anethole metabolite binds to ESR1 protein
anethole analog binds to ESR1 protein
anethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12818366, PMID:27420082 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases activity ISO anethole analog results in decreased activity of GGT1 protein CTD PMID:20171274 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression ISO anethole results in increased expression of GSTA2 protein CTD PMID:8406240 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta decreases activity ISO anethole results in decreased activity of IKBKB protein CTD PMID:10871845 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il2 interleukin 2 multiple interactions EXP anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16531003 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO anethole results in decreased phosphorylation of MAPK1 protein CTD PMID:21212515 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO anethole results in decreased phosphorylation of MAPK3 protein CTD PMID:21212515 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein] CTD PMID:10871845 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity
ISO anethole results in decreased expression of MMP2 mRNA
anethole results in decreased activity of MMP2 protein
CTD PMID:21212515 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression
ISO anethole results in decreased activity of MMP9 protein
anethole results in decreased expression of MMP9 mRNA
CTD PMID:21212515 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
decreases degradation
ISO anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
anethole results in decreased degradation of NFKBIA protein
CTD PMID:10871845, PMID:21212515 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:10871845 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO anethole results in decreased expression of PLAU mRNA CTD PMID:21212515 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO anethole results in increased expression of TIMP1 mRNA CTD PMID:21212515 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein]; anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:10871845 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
capsiate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 antigen decreases localization ISO capsiate analog results in decreased localization of CD69 protein CTD PMID:12115659 NCBI chr 6:129,267,324...129,275,375
Ensembl chr 6:129,267,325...129,275,436
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases localization ISO capsiate analog results in decreased localization of ICAM1 protein CTD PMID:12115659 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP capsiate results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased activity of IKBKG protein] CTD PMID:12115659 NCBI chr  X:74,393,233...74,456,792
Ensembl chr  X:74,393,290...74,453,854
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain decreases localization ISO capsiate analog results in decreased localization of IL2RA protein CTD PMID:12115659 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein] CTD PMID:12115659 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) decreases expression ISO capsiate results in decreased expression of UCP3 mRNA CTD PMID:17264228 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression ISO coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gsr glutathione reductase increases expression ISO
EXP
coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein
CTD PMID:26275128 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein
CTD PMID:26275128 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO
EXP
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]
CTD PMID:27378624 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 multiple interactions ISO MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 1:131,053,700...131,097,871
Ensembl chr 1:131,053,700...131,097,826
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric increases expression
multiple interactions
ISO coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]
CTD PMID:31944254 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
ISO
EXP
coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein
CTD PMID:26275128 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
CTD PMID:27378624 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pkn3 protein kinase N3 multiple interactions ISO PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 2:30,077,548...30,091,023
Ensembl chr 2:30,077,684...30,091,022
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]
CTD PMID:27378624 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
enrasentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednra endothelin receptor type A multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRA protein CTD PMID:16219361 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 multiple interactions
decreases activity
ISO [[ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Olfr73 olfactory receptor 73 multiple interactions EXP [ethyl vanillin binds to and results in increased activity of OLFR73 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OLFR73 protein CTD PMID:15716417 NCBI chr 2:88,034,196...88,035,137
Ensembl chr 2:88,032,288...88,037,699
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity EXP ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr11:73,267,489...73,300,368
Ensembl chr11:73,267,388...73,300,363
JBrowse link
eugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca6 ATP-binding cassette, sub-family A (ABC1), member 6 decreases expression ISO Eugenol results in decreased expression of ABCA6 mRNA CTD PMID:17374397 NCBI chr11:110,174,638...110,251,776
Ensembl chr11:110,176,820...110,251,776
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of ACHE protein] CTD PMID:32096903 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases activity
affects localization
ISO [Eugenol co-treated with acetyleugenol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [Eugenol co-treated with acetyleugenol] results in increased activity of AHR protein; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of AHR protein]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Eugenol results in increased activity of AHR protein
Eugenol affects the localization of AHR protein
CTD PMID:17275817, PMID:22686307, PMID:29191726 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO Eugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr13:74,211,118...74,292,331
Ensembl chr13:74,211,118...74,292,331
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO Eugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472, PMID:26198647, PMID:30806763 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases expression ISO Eugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO Eugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO Eugenol results in increased expression of AKR1C2 mRNA CTD PMID:26198647 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney increases expression ISO Eugenol results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 4:137,741,731...137,796,384
Ensembl chr 4:137,741,733...137,796,384
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein] CTD PMID:20434464 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Ar androgen receptor multiple interactions ISO Eugenol binds to and results in decreased activity of AR protein CTD PMID:20226658 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Arhgap17 Rho GTPase activating protein 17 decreases expression ISO Eugenol results in decreased expression of ARHGAP17 mRNA CTD PMID:17374397 NCBI chr 7:123,279,149...123,369,948
Ensembl chr 7:123,279,218...123,369,915
JBrowse link
G Arl4c ADP-ribosylation factor-like 4C increases expression ISO Eugenol results in increased expression of ARL4C mRNA CTD PMID:17374397 NCBI chr 1:88,698,225...88,702,191
Ensembl chr 1:88,673,125...88,702,221
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Eugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G B2m beta-2 microglobulin increases expression ISO Eugenol results in increased expression of B2M mRNA CTD PMID:17936526 NCBI chr 2:122,147,687...122,153,082
Ensembl chr 2:122,147,686...122,153,083
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA] CTD PMID:20434464 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Eugenol results in increased expression of BAX mRNA
CTD PMID:20434464, PMID:20537511 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
[Eugenol results in increased activity of sulforafan] which results in decreased expression of BCL2; [sulforafan results in increased activity of Eugenol] which results in decreased expression of BCL2
Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Eugenol results in decreased expression of BCL2 mRNA
CTD PMID:20434464, PMID:20537511, PMID:21382956, PMID:21939359 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA] CTD PMID:20434464 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO Eugenol results in decreased expression of BCLAF1 mRNA CTD PMID:17374397 NCBI chr10:20,310,512...20,342,644
Ensembl chr10:20,312,469...20,344,613
JBrowse link
G Bdnf brain derived neurotrophic factor increases expression EXP Eugenol results in increased expression of BDNF mRNA CTD PMID:15157811 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA] CTD PMID:20434464 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Eugenol results in increased expression of BMP6 mRNA CTD PMID:17374397 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO Eugenol results in decreased expression of BUB1 mRNA CTD PMID:17374397 NCBI chr 2:127,800,197...127,831,859
Ensembl chr 2:127,801,122...127,831,865
JBrowse link
G Calcrl calcitonin receptor-like increases expression ISO Eugenol results in increased expression of CALCRL mRNA CTD PMID:17374397 NCBI chr 2:84,330,626...84,425,405
Ensembl chr 2:84,330,626...84,425,411
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage
EXP
ISO
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 mRNA
Eugenol results in increased activity of CASP3 protein
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; Eugenol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 protein modified form
Eugenol results in increased cleavage of CASP3 protein
CTD PMID:20434464, PMID:20537511, PMID:21656368, PMID:25455450, PMID:30518369, PMID:32096903 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 increases expression ISO Eugenol results in increased expression of CASP7 mRNA CTD PMID:30518369 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
EXP
ISO
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
Eugenol results in increased expression of CASP9 mRNA
Eugenol results in increased activity of CASP9 protein
CTD PMID:20434464, PMID:25455450, PMID:30518369 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase increases expression
multiple interactions
ISO Eugenol results in increased expression of CAT mRNA
Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of CAT protein]
CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]
CTD PMID:15576237, PMID:20566472, PMID:32096903 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases expression ISO Eugenol results in increased expression of CCL13 mRNA CTD PMID:17936526 NCBI chr11:82,101,845...82,103,399
Ensembl chr11:82,101,845...82,103,400
JBrowse link
G Ccl19 chemokine (C-C motif) ligand 19 increases expression ISO Eugenol results in increased expression of CCL19 mRNA CTD PMID:17936526 NCBI chr 4:42,754,525...42,756,365
Ensembl chr 4:42,754,525...42,756,577
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression
increases secretion
decreases expression
ISO
EXP
Eugenol results in increased expression of CCL2 mRNA
Eugenol results in increased secretion of CCL2 protein
Eugenol results in decreased expression of CCL2 mRNA
CTD PMID:15585374, PMID:17374397, PMID:17936526, PMID:22245253 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl20 chemokine (C-C motif) ligand 20 increases expression ISO Eugenol results in increased expression of CCL20 mRNA CTD PMID:30806763 NCBI chr 1:83,116,766...83,119,167
Ensembl chr 1:83,116,766...83,119,167
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases expression
increases secretion
ISO Eugenol results in increased expression of CCL3 mRNA
Eugenol results in increased secretion of CCL3 protein
CTD PMID:15585374, PMID:23624239 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 increases expression
increases secretion
ISO Eugenol results in increased expression of CCL4 mRNA; Eugenol results in increased expression of CCL4 protein
Eugenol results in increased secretion of CCL4 protein
CTD PMID:15585374, PMID:18353026, PMID:30806763 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA] CTD PMID:19851710 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA] CTD PMID:19851710 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 decreases expression ISO Eugenol results in decreased expression of CCR2 mRNA CTD PMID:17374397 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 increases expression ISO Eugenol results in increased expression of CCR5 mRNA CTD PMID:17936526, PMID:20713136 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 increases expression ISO Eugenol results in increased expression of CCR7 mRNA CTD PMID:17374397 NCBI chr11:99,144,199...99,155,077
Ensembl chr11:99,144,196...99,155,077
JBrowse link
G Cd24a CD24a antigen decreases expression ISO Eugenol results in decreased expression of CD24 protein CTD PMID:31926151 NCBI chr10:43,579,169...43,584,265
Ensembl chr10:43,578,284...43,584,265
JBrowse link
G Cd274 CD274 antigen increases expression ISO Eugenol results in increased expression of CD274 protein CTD PMID:23624239 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cd36 CD36 molecule decreases expression ISO Eugenol results in decreased expression of CD36 mRNA CTD PMID:17374397 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd44 CD44 antigen decreases expression ISO Eugenol results in decreased expression of CD44 protein CTD PMID:31926151 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression
ISO [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] CTD PMID:12423654, PMID:20488241, PMID:21742781, PMID:23624239, PMID:30806763 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Eugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions EXP
ISO
Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein]
CTD PMID:19851710, PMID:20043298 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Eugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression EXP Eugenol results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 9:107,296,659...107,302,784
Ensembl chr 9:107,296,026...107,302,784
JBrowse link
G Clec4a1 C-type lectin domain family 4, member a1 decreases expression ISO Eugenol results in decreased expression of CLEC4A protein CTD PMID:23624239 NCBI chr 6:122,921,848...122,934,619
Ensembl chr 6:122,921,848...122,934,619
JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression ISO Eugenol affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Eugenol results in increased expression of CREM mRNA CTD PMID:17374397 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression
multiple interactions
EXP
ISO
Eugenol results in decreased expression of CTNNB1 mRNA
Eugenol results in decreased expression of and affects the phosphorylation of and affects the localization of CTNNB1 protein
CTD PMID:31926151 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ctsl cathepsin L increases expression ISO Eugenol results in increased expression of CTSL mRNA CTD PMID:17374397 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 increases expression ISO Eugenol results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases secretion
increases expression
ISO Acetylcysteine inhibits the reaction [Eugenol results in increased expression of CXCL8 mRNA]; Eugenol results in increased expression of and results in increased secretion of CXCL8 protein
Eugenol results in increased secretion of CXCL8 protein
Eugenol results in increased expression of CXCL8 mRNA; Eugenol results in increased expression of CXCL8 protein
CTD PMID:20713136, PMID:21920952, PMID:23624239, PMID:25617811, PMID:30806763 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 increases expression
multiple interactions
ISO
EXP
Eugenol results in increased expression of CXCL1 mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]
CTD PMID:12963494, PMID:20713136 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 increases expression ISO Eugenol results in increased expression of CXCR4 mRNA CTD PMID:20713136 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein] CTD PMID:20434464 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases expression
decreases activity
ISO [CYP1A1 protein co-treated with Copper] results in increased activity of Eugenol; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Eugenol inhibits the reaction [CYP1A1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Eugenol results in increased expression of CYP1A1 mRNA
Eugenol results in decreased expression of CYP1A1 mRNA
Eugenol results in decreased activity of CYP1A1 protein
CTD PMID:15576237, PMID:17275817, PMID:20713136, PMID:22686307, PMID:29191726 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with Copper] results in increased activity of Eugenol CTD PMID:15576237 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; Eugenol inhibits the reaction [CYP1B1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]
Eugenol results in decreased activity of CYP1B1 protein
CTD PMID:17275817 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Eugenol results in decreased expression of CYP27A1 mRNA CTD PMID:20713136 NCBI chr 1:74,713,148...74,737,897
Ensembl chr 1:74,713,574...74,737,892
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO [CYP2C9 protein co-treated with Copper] results in increased activity of Eugenol CTD PMID:15576237 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO [CYP2C9 protein co-treated with Copper] results in increased activity of Eugenol CTD PMID:15576237 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
increases metabolic processing
ISO [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol; [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] CTD PMID:15576237 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]
[CYP2E1 protein co-treated with Copper] results in increased activity of Eugenol
CTD PMID:15576237, PMID:20036707 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G D6Wsu163e DNA segment, Chr 6, Wayne State University 163, expressed decreases expression ISO Eugenol results in decreased expression of C12ORF4 mRNA CTD PMID:17374397 NCBI chr 6:126,939,966...126,975,704
Ensembl chr 6:126,939,962...126,975,967
JBrowse link
G Dkc1 dyskeratosis congenita 1, dyskerin decreases expression ISO Eugenol results in decreased expression of DKC1 mRNA CTD PMID:17374397 NCBI chr  X:75,095,854...75,109,776
Ensembl chr  X:75,095,854...75,109,777
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO Eugenol results in decreased expression of DLGAP5 mRNA CTD PMID:17374397 NCBI chr14:47,387,779...47,418,407
Ensembl chr14:47,387,779...47,418,407
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Eugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Dnase2a deoxyribonuclease II alpha increases expression EXP Eugenol results in increased expression of DNASE2A mRNA CTD PMID:15618236 NCBI chr 8:84,908,755...84,911,703
Ensembl chr 8:84,908,560...84,922,915
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol CTD PMID:9537685 NCBI chr13:54,051,183...54,055,658
Ensembl chr13:54,051,183...54,055,705
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Eugenol results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Eugenol results in decreased expression of E2F1 mRNA; Eugenol results in decreased expression of E2F1 protein CTD PMID:15574415 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Eugenol results in decreased expression of E2F2 mRNA; Eugenol results in decreased expression of E2F2 protein CTD PMID:15574415 NCBI chr 4:136,172,274...136,196,057
Ensembl chr 4:136,172,394...136,196,057
JBrowse link
G E2f3 E2F transcription factor 3 decreases expression ISO Eugenol results in decreased expression of E2F3 mRNA; Eugenol results in decreased expression of E2F3 protein CTD PMID:15574415 NCBI chr13:29,906,575...29,986,064
Ensembl chr13:29,906,575...29,986,063
JBrowse link
G E2f4 E2F transcription factor 4 decreases expression ISO Eugenol results in decreased expression of E2F4 mRNA CTD PMID:15574415 NCBI chr 8:105,297,663...105,305,370
Ensembl chr 8:105,297,663...105,305,370
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Eugenol results in decreased expression of E2F5 mRNA CTD PMID:15574415 NCBI chr 3:14,578,602...14,606,309
Ensembl chr 3:14,578,641...14,606,309
JBrowse link
G E2f6 E2F transcription factor 6 increases expression ISO Eugenol results in increased expression of E2F6 mRNA CTD PMID:15574415 NCBI chr12:16,810,909...16,826,752
Ensembl chr12:16,810,963...16,839,742
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases expression
EXP Eugenol results in decreased expression of EGFR protein
Eugenol results in increased expression of EGFR mRNA
CTD PMID:15618236 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [[Eugenol results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA CTD PMID:12767924 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr2 early growth response 2 decreases expression ISO Eugenol results in decreased expression of EGR2 mRNA CTD PMID:17374397 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Emb embigin decreases expression ISO Eugenol results in decreased expression of EMB mRNA CTD PMID:17374397 NCBI chr13:117,220,573...117,274,415
Ensembl chr13:117,208,536...117,274,415
JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression EXP
ISO
Eugenol results in decreased expression of EPCAM protein
Eugenol results in decreased expression of EPCAM mRNA; Eugenol results in decreased expression of EPCAM protein
CTD PMID:31926151 NCBI chr17:87,635,979...87,651,127
Ensembl chr17:87,635,979...87,651,129
JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions
ISO Eugenol binds to ESR1 protein
Eugenol inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12495555 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding
multiple interactions
ISO Eugenol binds to ESR2 protein
Eugenol inhibits the reaction [Estradiol binds to ESR2 protein]
CTD PMID:12495555 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G F13a1 coagulation factor XIII, A1 subunit decreases expression ISO Eugenol results in decreased expression of F13A1 mRNA CTD PMID:17374397 NCBI chr13:36,867,178...37,050,244
Ensembl chr13:36,867,178...37,050,244
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Eugenol results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbxo9 f-box protein 9 decreases expression ISO Eugenol results in decreased expression of FBXO9 mRNA CTD PMID:17374397 NCBI chr 9:78,081,499...78,109,065
Ensembl chr 9:78,081,499...78,109,065
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb increases expression ISO Eugenol results in increased expression of FCGR2B mRNA CTD PMID:17374397 NCBI chr 1:170,960,558...170,976,071
Ensembl chr 1:170,958,617...170,976,547
JBrowse link
G Fech ferrochelatase increases expression ISO Eugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fosl2 fos-like antigen 2 increases expression ISO Eugenol results in increased expression of FOSL2 mRNA CTD PMID:17374397 NCBI chr 5:32,136,472...32,157,840
Ensembl chr 5:32,135,801...32,157,842
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO Eugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO Eugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA] CTD PMID:19851710 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression EXP Eugenol results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Eugenol results in increased expression of GCLC mRNA CTD PMID:20566472, PMID:26198647, PMID:30806763 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Eugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:26198647, PMID:27965148, PMID:30806763 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Glycam1 glycosylation dependent cell adhesion molecule 1 increases expression ISO Eugenol results in increased expression of GLYCAM1 mRNA CTD PMID:17936526 NCBI chr15:103,562,759...103,565,081
Ensembl chr15:103,562,759...103,565,081
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Eugenol results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 5:100,845,665...100,899,102
Ensembl chr 5:100,845,713...100,899,102
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Eugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression ISO Eugenol results in increased expression of GSK3B mRNA CTD PMID:17374397 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsr glutathione reductase increases expression ISO Eugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) decreases activity
increases expression
ISO Eugenol analog results in decreased activity of GSTA2 protein; Eugenol analog results in decreased activity of GSTA3 protein
Eugenol results in increased expression of GSTA2 protein
CTD PMID:8406240, PMID:8620581 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases activity ISO Eugenol analog results in decreased activity of GSTM1 protein CTD PMID:8620581 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 decreases activity ISO Eugenol analog results in decreased activity of GSTM2 protein CTD PMID:8620581 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO Eugenol analog results in decreased activity of GSTP1 protein CTD PMID:8620581 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 increases expression ISO Eugenol results in increased expression of HLA-B mRNA CTD PMID:17374397 NCBI chr17:37,480,851...37,483,554
Ensembl chr17:37,480,851...37,483,552
JBrowse link
G Heatr5b HEAT repeat containing 5B decreases expression ISO Eugenol results in decreased expression of HEATR5B mRNA CTD PMID:17374397 NCBI chr17:78,752,906...78,835,381
Ensembl chr17:78,752,898...78,835,364
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO Eugenol results in increased expression of HIF1A mRNA CTD PMID:20713136 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases expression EXP Eugenol results in decreased expression of HMGCR mRNA CTD PMID:21870829 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
Eugenol results in increased expression of HMOX1 mRNA CTD PMID:20566472, PMID:20713136, PMID:23445166, PMID:26244607, PMID:30806763 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO Eugenol results in decreased expression of HNRNPA3 mRNA CTD PMID:17374397 NCBI chr 2:75,659,105...75,669,407
Ensembl chr 2:75,659,261...75,669,407
JBrowse link
G Hras Harvey rat sarcoma virus oncogene decreases expression EXP Eugenol results in decreased expression of HRAS protein CTD PMID:20537511 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO Eugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Ibsp integrin binding sialoprotein decreases expression ISO Eugenol results in decreased expression of IBSP mRNA; Eugenol results in decreased expression of IBSP protein CTD PMID:21706355 NCBI chr 5:104,299,287...104,311,472
Ensembl chr 5:104,299,171...104,311,469
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Eugenol results in increased expression of ICAM1 mRNA; Eugenol results in increased expression of ICAM1 protein CTD PMID:30806763 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase decreases expression ISO Eugenol results in decreased expression of IDI1 mRNA CTD PMID:17374397 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Ifng interferon gamma increases secretion
multiple interactions
EXP Eugenol results in increased secretion of IFNG protein
[Methoxychlor co-treated with Eugenol] results in increased expression of IFNG protein; [Parathion co-treated with Eugenol] results in increased expression of IFNG protein
CTD PMID:20920556, PMID:22245253 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein] CTD PMID:19851710 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA] CTD PMID:21237301 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12a interleukin 12a multiple interactions EXP Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]] CTD PMID:21237301 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il12b interleukin 12b multiple interactions EXP Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]] CTD PMID:21237301 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il16 interleukin 16 multiple interactions
increases secretion
ISO Eugenol results in increased expression of and results in increased secretion of IL16 protein
Eugenol results in increased secretion of IL16 protein
CTD PMID:23624239, PMID:30806763 NCBI chr 7:83,642,819...83,746,028
Ensembl chr 7:83,642,825...83,745,726
JBrowse link
G Il18 interleukin 18 increases expression ISO Eugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Eugenol results in increased expression of IL1A mRNA CTD PMID:30806763 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO
EXP
[Eugenol results in increased activity of sulforafan] which results in decreased expression of IL1B; [sulforafan results in increased activity of Eugenol] which results in decreased expression of IL1B; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Eugenol results in increased expression of IL1B mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Eugenol results in decreased expression of IL1B mRNA
CTD PMID:12963494, PMID:17509409, PMID:20713136, PMID:21382956, PMID:21807015, PMID:21939359 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1r2 interleukin 1 receptor, type II increases expression ISO Eugenol results in increased expression of IL1R2 mRNA CTD PMID:20713136, PMID:30806763 NCBI chr 1:40,084,692...40,125,230
Ensembl chr 1:40,074,079...40,125,231
JBrowse link
G Il2 interleukin 2 increases expression
increases secretion
EXP Eugenol results in increased expression of IL2 protein
Eugenol results in increased secretion of IL2 protein
CTD PMID:22245253, PMID:22381623 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il4ra interleukin 4 receptor, alpha increases expression EXP Eugenol results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
EXP
ISO
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of IL6 protein]
Eugenol results in increased secretion of IL6 protein
Eugenol inhibits the reaction [Thioacetamide results in increased activity of IL6 protein]
Eugenol results in increased expression of IL6 mRNA
CTD PMID:20036707, PMID:20043298, PMID:21870829, PMID:22245253 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Eugenol results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr15:9,506,159...9,529,941
Ensembl chr15:9,505,788...9,530,176
JBrowse link
G Inhba inhibin beta-A decreases expression EXP Eugenol results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr13:16,004,256...16,031,609
Ensembl chr13:16,011,851...16,031,621
JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Eugenol results in decreased expression of IPCEF1 mRNA CTD PMID:17374397 NCBI chr10:6,885,779...7,054,782
Ensembl chr10:6,885,796...7,052,478
JBrowse link
G Itga6 integrin alpha 6 increases expression ISO Eugenol results in increased expression of ITGA6 mRNA CTD PMID:17936526 NCBI chr 2:71,786,886...71,858,427
Ensembl chr 2:71,745,616...71,858,416
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) increases expression ISO Eugenol results in increased expression of ITGB1 mRNA CTD PMID:17936526 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 decreases activity ISO Eugenol results in decreased activity of KCNA5 protein CTD PMID:17720863 NCBI chr 6:126,532,551...126,535,555
Ensembl chr 6:126,532,551...126,535,412
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 decreases expression ISO Eugenol results in decreased expression of KCNJ2 mRNA CTD PMID:17374397 NCBI chr11:111,066,164...111,076,825
Ensembl chr11:111,066,164...111,076,821
JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO Eugenol results in decreased expression of KIF23 mRNA CTD PMID:17374397 NCBI chr 9:61,917,277...61,946,810
Ensembl chr 9:61,915,905...61,946,774
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Eugenol results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO Eugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO Eugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,791,536...139,802,653
Ensembl chr 5:139,791,513...139,802,653
JBrowse link
G Mcts1 malignant T cell amplified sequence 1 decreases expression ISO Eugenol results in decreased expression of MCTS1 mRNA CTD PMID:17374397 NCBI chr  X:38,600,471...38,613,524
Ensembl chr  X:38,600,578...38,613,426
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO Eugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Eugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]
Eugenol results in decreased expression of MMP2 mRNA
CTD PMID:20434464, PMID:30518369 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]
Eugenol results in decreased expression of MMP9 mRNA
CTD PMID:20434464, PMID:30518369 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Eugenol inhibits the reaction [Thioacetamide results in increased activity of MPO protein] CTD PMID:20036707 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mrpl35 mitochondrial ribosomal protein L35 decreases expression ISO Eugenol results in decreased expression of MRPL35 mRNA CTD PMID:17374397 NCBI chr 6:71,812,997...71,823,784
Ensembl chr 6:71,812,997...71,826,969
JBrowse link
G Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 increases expression ISO Eugenol results in increased expression of MS4A7 mRNA CTD PMID:17374397 NCBI chr19:11,321,039...11,336,146
Ensembl chr19:11,321,039...11,336,146
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Eugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Mt3 metallothionein 3 increases expression EXP Eugenol results in increased expression of MT3 mRNA CTD PMID:15157811 NCBI chr 8:94,152,607...94,154,148
Ensembl chr 8:94,152,607...94,154,146
JBrowse link
G Mxd1 MAX dimerization protein 1 increases expression ISO Eugenol results in increased expression of MXD1 mRNA CTD PMID:20713136 NCBI chr 6:86,647,044...86,669,234
Ensembl chr 6:86,647,042...86,669,161
JBrowse link
G Myb myeloblastosis oncogene decreases expression ISO Eugenol results in decreased expression of MYB mRNA CTD PMID:17374397 NCBI chr10:21,124,930...21,160,984
Ensembl chr10:21,124,935...21,160,984
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions EXP Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC protein] CTD PMID:20537511 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Eugenol results in increased expression of NAMPT mRNA CTD PMID:17374397 NCBI chr12:32,820,335...32,853,369
Ensembl chr12:32,819,545...32,853,349
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects expression
multiple interactions
ISO Eugenol affects the expression of NFE2L2 protein
Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]
CTD PMID:17275817 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
affects expression
ISO Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol affects the expression of NFKB1 mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
CTD PMID:10871845, PMID:19851710, PMID:20385217 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKBIA protein modified form]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:12963494, PMID:19851710, PMID:20043298 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NOS2 protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:20043298, PMID:21237301 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Notch1 notch 1 decreases expression ISO
EXP
Eugenol results in decreased expression of NOTCH1 mRNA; Eugenol results in decreased expression of NOTCH1 protein CTD PMID:31926151 NCBI chr 2:26,457,902...26,503,822
Ensembl chr 2:26,457,903...26,516,663
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
increases activity
multiple interactions
ISO Eugenol results in increased expression of NQO1 mRNA; Eugenol results in increased expression of NQO1 protein
Eugenol results in increased activity of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]
CTD PMID:17275817, PMID:20566472, PMID:21742781 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Eugenol results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nup88 nucleoporin 88 increases expression ISO Eugenol results in increased expression of NUP88 mRNA CTD PMID:17374397 NCBI chr11:70,943,058...70,969,973
Ensembl chr11:70,943,058...70,969,973
JBrowse link
G Olfr73 olfactory receptor 73 multiple interactions
increases activity
affects binding
EXP [[Eugenol results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA; [Eugenol binds to and results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP; [Eugenol binds to and results in increased activity of OLFR73 protein] which results in increased transport of Calcium; [Eugenol binds to OLFR73 protein] which results in increased transport of Calcium; [Eugenol results in increased activity of OLFR73 protein] which results in increased abundance of Cyclic AMP; Eugenol binds to and results in increased activity of OLFR73 protein; isomethyleugenol inhibits the reaction [[Eugenol binds to OLFR73 protein] which results in increased transport of Calcium] CTD PMID:12767924, PMID:14685265, PMID:15716417, PMID:19723634 NCBI chr 2:88,034,196...88,035,137
Ensembl chr 2:88,032,288...88,037,699
JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 multiple interactions ISO Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate] CTD PMID:19967073 NCBI chr 2:84,996,549...85,037,108
Ensembl chr 2:84,998,583...85,037,462
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase decreases expression ISO Eugenol results in decreased expression of PAICS mRNA CTD PMID:17374397 NCBI chr 5:76,951,302...76,967,509
Ensembl chr 5:76,951,307...76,967,509
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein] CTD PMID:20434464 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP
ISO
Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
CTD PMID:19851710, PMID:20043298 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific increases expression ISO Eugenol results in increased expression of PDE4B mRNA CTD PMID:17374397 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Eugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO Eugenol results in increased expression of PICALM mRNA CTD PMID:17374397 NCBI chr 7:90,130,192...90,209,447
Ensembl chr 7:90,130,213...90,213,465
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO
EXP
Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:20724125, PMID:21870829 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Plat plasminogen activator, tissue increases expression ISO Eugenol results in increased expression of PLAT mRNA CTD PMID:17374397 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Eugenol results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression EXP
ISO
Eugenol results in decreased expression of POU5F1 protein
Eugenol results in decreased expression of POU5F1 mRNA; Eugenol results in decreased expression of POU5F1 protein
CTD PMID:31926151 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression
ISO
EXP
Eugenol analog binds to and results in increased activity of PPARG protein
Eugenol results in increased expression of PPARG mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Eugenol analog binds to and results in increased activity of PPARG protein]; Eugenol analog binds to and results in increased activity of PPARG protein
CTD PMID:20064974, PMID:21870829 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppbp pro-platelet basic protein multiple interactions
increases expression
ISO Eugenol results in increased expression of and results in increased secretion of PPBP protein
Eugenol results in increased expression of PPBP mRNA
CTD PMID:23624239 NCBI chr 5:90,768,518...90,770,063
Ensembl chr 5:90,768,518...90,770,063
JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression ISO Eugenol results in decreased expression of PRDX3 mRNA CTD PMID:17374397 NCBI chr19:60,864,066...60,874,538
Ensembl chr19:60,864,051...60,874,556
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) decreases expression ISO Eugenol results in decreased expression of PTGER3 mRNA CTD PMID:17374397 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO Eugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression
ISO
EXP
Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Eugenol results in increased expression of PTGS2 mRNA
Eugenol results in decreased expression of PTGS2 mRNA
Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2]
Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid]; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:12757841, PMID:16101137, PMID:17509409, PMID:20036707, PMID:20043298, PMID:21807015, PMID:21939359, PMID:30806763 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Eugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein] CTD PMID:20434464 NCBI chr 4:43,875,521...43,944,806
Ensembl chr 4:43,875,530...43,944,806
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of RELA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]
CTD PMID:10871845, PMID:19851710, PMID:20043298 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Eugenol results in increased expression of RGS1 mRNA CTD PMID:17374397, PMID:20713136 NCBI chr 1:144,244,669...144,249,104
Ensembl chr 1:144,242,296...144,249,242
JBrowse link
G Rpl27a ribosomal protein L27A increases expression ISO Eugenol results in increased expression of RPL27A mRNA CTD PMID:17374397 NCBI chr 7:109,519,195...109,522,369
Ensembl chr 7:109,519,147...109,522,367
JBrowse link
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) increases expression ISO Eugenol results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr15:37,923,952...37,961,119
Ensembl chr15:37,923,952...37,961,318
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Eugenol results in increased expression of SAT1 mRNA CTD PMID:17374397 NCBI chr  X:155,213,126...155,216,449
Ensembl chr  X:155,213,132...155,216,449
JBrowse link
G Sdc2 syndecan 2 increases expression ISO Eugenol results in increased expression of SDC2 mRNA CTD PMID:17374397 NCBI chr15:32,920,723...33,034,721
Ensembl chr15:32,920,723...33,034,935
JBrowse link
G Septin11 septin 11 decreases expression ISO Eugenol results in decreased expression of SEPTIN11 mRNA CTD PMID:17374397 NCBI chr 5:93,090,995...93,182,368
Ensembl chr 5:93,093,437...93,176,447
JBrowse link
G Serpinb3d serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D increases expression ISO Eugenol results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr 1:107,078,163...107,083,480
Ensembl chr 1:107,078,167...107,083,506
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 decreases expression ISO Eugenol results in decreased expression of SLAMF1 mRNA CTD PMID:20713136 NCBI chr 1:171,767,131...171,801,184
Ensembl chr 1:171,767,127...171,801,184
JBrowse link
G Slc16a10 solute carrier family 16 (monocarboxylic acid transporters), member 10 increases expression ISO Eugenol results in increased expression of SLC16A10 mRNA CTD PMID:17374397 NCBI chr10:40,033,532...40,142,270
Ensembl chr10:40,033,532...40,142,258
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 increases expression ISO Eugenol results in increased expression of SLC2A3 mRNA CTD PMID:17374397 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 increases expression EXP
ISO
Eugenol results in increased expression of SLC2A4 mRNA CTD PMID:20724125, PMID:21870829 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Eugenol results in increased expression of SLC7A11 mRNA CTD PMID:26198647, PMID:30806763 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
decreases expression
multiple interactions
ISO Eugenol results in increased expression of SOD1 mRNA
Eugenol results in decreased expression of SOD1 mRNA; Eugenol results in decreased expression of SOD1 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]
CTD PMID:16101137, PMID:20566472 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression
decreases expression
multiple interactions
ISO Eugenol results in increased expression of SOD2 mRNA
Eugenol results in decreased expression of SOD2 mRNA; Eugenol results in decreased expression of SOD2 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]
CTD PMID:16101137, PMID:20566472 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO Eugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Eugenol results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO Eugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472, PMID:26198647 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Eugenol results in decreased expression of STAT1 mRNA CTD PMID:17374397 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat4 signal transducer and activator of transcription 4 increases expression ISO Eugenol results in increased expression of STAT4 mRNA CTD PMID:17374397 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression ISO Eugenol results in increased expression of STAT5B mRNA CTD PMID:17374397 NCBI chr11:100,780,731...100,859,004
Ensembl chr11:100,780,731...100,850,724
JBrowse link
G Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 increases sulfation EXP SULT1C1 protein results in increased sulfation of Eugenol CTD PMID:9560327 NCBI chr17:53,961,615...53,990,631
Ensembl chr17:53,961,615...53,990,674
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein] CTD PMID:20434464 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO Eugenol results in increased expression of TLR4 mRNA CTD PMID:17936526 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
affects expression
ISO
EXP
Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol results in increased expression of TNF mRNA
Eugenol affects the expression of TNF mRNA
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Eugenol inhibits the reaction [Thioacetamide results in increased activity of TNF protein]
[Methoxychlor co-treated with Eugenol] results in increased expression of TNF protein; [Parathion co-treated with Eugenol] results in increased expression of TNF protein; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Bacterial Toxins results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]
CTD PMID:10871845, PMID:12963494, PMID:17509409, PMID:20036707, PMID:20043298, PMID:20385217, PMID:20639367, PMID:20920556, PMID:21237301, PMID:21807015, PMID:21870829, PMID:30806763, PMID:32096903 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 increases expression ISO Eugenol results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 increases expression ISO Eugenol results in increased expression of TNFAIP6 mRNA CTD PMID:17374397, PMID:20713136 NCBI chr 2:52,038,113...52,056,681
Ensembl chr 2:52,038,009...52,056,686
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases mutagenesis
increases expression
ISO
EXP
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TP53 protein]
Eugenol results in increased mutagenesis of TP53 gene
Eugenol results in increased expression of TRP53 mRNA; Eugenol results in increased expression of TRP53 protein
Eugenol promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 protein]
CTD PMID:15576237, PMID:19851710, PMID:20043298, PMID:20537511 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trp63 transformation related protein 63 decreases expression ISO Eugenol results in decreased expression of TP63 mRNA CTD PMID:17936526 NCBI chr16:25,683,763...25,892,088
Ensembl chr16:25,683,763...25,892,102
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
ISO [2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Eugenol
Eugenol results in increased activity of TRPA1 protein
CTD PMID:22426238 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions
increases activity
ISO
EXP
Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol results in increased activity of TRPV3 protein] which results in increased transport of Calcium
CTD PMID:16617338, PMID:20086034, PMID:21593771 NCBI chr11:73,267,489...73,300,368
Ensembl chr11:73,267,388...73,300,363
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Eugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO
EXP
Eugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO Eugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073
JBrowse link
G Ugdh UDP-glucose dehydrogenase increases expression ISO Eugenol results in increased expression of UGDH mRNA CTD PMID:16292757 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO Eugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases metabolic processing ISO UGT2B17 protein results in increased metabolism of Eugenol CTD PMID:8798464 NCBI chr 5:86,916,639...86,926,503
Ensembl chr 5:86,916,638...86,926,530
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases expression ISO Eugenol results in increased expression of VDR mRNA CTD PMID:17374397 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Zbtb17 zinc finger and BTB domain containing 17 decreases expression ISO Eugenol results in decreased expression of ZBTB17 mRNA CTD PMID:17374397 NCBI chr 4:141,444,673...141,467,937
Ensembl chr 4:141,444,654...141,467,930
JBrowse link
gingerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:18385293 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375, PMID:21851089 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:27451028 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein CTD PMID:19481070 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions EXP gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] CTD PMID:18577375 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]
gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein
CTD PMID:18030663, PMID:19481070, PMID:25034532, PMID:28249781 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO
EXP
gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein
gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
CTD PMID:18030663, PMID:19481070, PMID:25034532, PMID:27451028, PMID:28249781 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein CTD PMID:27451028 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] CTD PMID:25034532 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] CTD PMID:18030663, PMID:25034532 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
affects activity
ISO
EXP
gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein
gingerol results in increased cleavage of CASP3 protein
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
gingerol affects the activity of CASP3 protein
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
CTD PMID:17454143, PMID:18030663, PMID:19481070, PMID:25034532, PMID:28249781, PMID:28373059 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
affects activity
ISO
EXP
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]
gingerol results in increased cleavage of CASP8 protein
gingerol affects the activity of CASP8 protein
CTD PMID:17454143, PMID:25034532, PMID:28249781 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
multiple interactions
affects activity
ISO
EXP
gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein
gingerol results in increased cleavage of CASP9 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein]
gingerol affects the activity of CASP9 protein
CTD PMID:17454143, PMID:18030663, PMID:19481070, PMID:28249781 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions EXP
ISO
gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]
CTD PMID:22285432, PMID:28373059, PMID:31004597 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein CTD PMID:28249781 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
ISO
EXP
[gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein
gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein
gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein
CTD PMID:18058799, PMID:26498061, PMID:28249781 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein CTD PMID:28249781 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gingerol results in decreased expression of CDK1 mRNA CTD PMID:28249781 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO gingerol results in decreased expression of CDK4 protein CTD PMID:18058799 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression ISO gingerol results in decreased expression of CDKN1A mRNA CTD PMID:28249781 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO gingerol results in decreased expression of CDKN1B mRNA CTD PMID:28249781 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression
multiple interactions
EXP gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]
CTD PMID:26498061 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] CTD PMID:25034532 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 affects localization
increases expression
multiple interactions
ISO
EXP
gingerol affects the localization of CTNNB1 protein
gingerol results in increased expression of CTNNB1 mRNA
gingerol results in increased expression of and affects the localization of CTNNB1 protein
gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
CTD PMID:18058799, PMID:26498061, PMID:27645308 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases response to substance ISO CYP2C19 mRNA results in increased susceptibility to gingerol CTD PMID:29555536 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions ISO gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO gingerol results in increased expression of DUSP10 mRNA CTD PMID:17151092 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 increases expression EXP gingerol results in increased expression of DVL2 mRNA CTD PMID:26498061 NCBI chr11:70,000,592...70,010,109
Ensembl chr11:70,000,595...70,012,301
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) affects activity EXP gingerol affects the activity of FAS protein CTD PMID:17454143 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasn fatty acid synthase decreases expression EXP gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein CTD PMID:26498061 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:21829520 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein
GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]
CTD PMID:18058799 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases response to substance
increases phosphorylation
increases expression
ISO
EXP
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]
GSK3B protein results in increased susceptibility to gingerol
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in increased phosphorylation of GSK3B protein
gingerol results in increased expression of GSK3B protein
CTD PMID:18058799, PMID:26498061, PMID:27645308 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions EXP gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A decreases activity ISO gingerol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr 9:48,899,213...48,911,152
Ensembl chr 9:48,899,213...48,911,099
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]
CTD PMID:27645308, PMID:31004597 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] CTD PMID:22285432 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I multiple interactions EXP gingerol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased secretion of INS1 protein] CTD PMID:21851089, PMID:22285432 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458
JBrowse link
G Jun jun proto-oncogene multiple interactions EXP gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:18577375 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Klkb1 kallikrein B, plasma 1 multiple interactions
decreases expression
ISO gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]
gingerol results in decreased expression of KLKB1 protein
CTD PMID:18030663 NCBI chr 8:45,266,688...45,294,835
Ensembl chr 8:45,266,689...45,294,859
JBrowse link
G Lep leptin multiple interactions EXP gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lrp6 low density lipoprotein receptor-related protein 6 increases expression EXP gingerol results in increased expression of LRP6 mRNA CTD PMID:26498061 NCBI chr 6:134,446,476...134,566,913
Ensembl chr 6:134,446,476...134,566,965
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form CTD PMID:27451028 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 multiple interactions EXP gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 NCBI chr11:65,688,244...65,788,359
Ensembl chr11:65,688,243...65,788,297
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity
ISO gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein
gingerol results in decreased activity of MMP2 protein
CTD PMID:17683926 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity
ISO gingerol results in decreased expression of MMP9 mRNA
gingerol results in decreased activity of MMP9 protein
CTD PMID:17683926 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]
CTD PMID:28373059, PMID:31004597 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]
gingerol results in decreased expression of MTOR protein modified form
CTD PMID:27451028, PMID:28249781 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO gingerol affects the phosphorylation of and affects the activity of NFKBIA protein CTD PMID:17454143 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:18683823, PMID:31004597 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] CTD PMID:25034532 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
EXP gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein
CTD PMID:22285432, PMID:26498061 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919
JBrowse link
G Ptges prostaglandin E synthase decreases expression
increases expression
ISO gingerol results in decreased expression of PTGES protein
gingerol results in increased expression of PTGES mRNA
CTD PMID:27645308 NCBI chr 2:30,889,471...30,931,020
Ensembl chr 2:30,889,471...30,929,863
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions
ISO
EXP
gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:17454143, PMID:18683823, PMID:31004597 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO gingerol results in decreased phosphorylation of RB1 protein CTD PMID:18058799 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects expression
multiple interactions
affects localization
EXP
ISO
gingerol affects the expression of RELA protein
gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
gingerol affects the localization of RELA protein
CTD PMID:17454143, PMID:18683823 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases expression ISO gingerol results in decreased expression of RPS6KB1 protein modified form CTD PMID:28249781 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] CTD PMID:22285432 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] CTD PMID:21829520 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] CTD PMID:21382473 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]
CTD PMID:18577375, PMID:21851089, PMID:22285432, PMID:28373059, PMID:31004597 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions
increases response to substance
ISO [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] CTD PMID:25034532 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
ISO
EXP
gingerol results in increased expression of TP53 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein]
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]
CTD PMID:18030663, PMID:25034532 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO gingerol results in decreased expression of XIAP protein CTD PMID:25034532 NCBI chr  X:42,059,613...42,109,664
Ensembl chr  X:42,059,679...42,109,656
JBrowse link
guaiacol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Guaiacol binds to ALB protein CTD PMID:11334365 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Guaiacol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 3:14,766,214...14,808,365
Ensembl chr 3:14,766,216...14,808,368
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Guaiacol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol] CTD PMID:24141029 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Guaiacol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:17465205 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 increases sulfation EXP SULT1C1 protein results in increased sulfation of Guaiacol CTD PMID:9560327 NCBI chr17:53,961,615...53,990,631
Ensembl chr17:53,961,615...53,990,674
JBrowse link
homovanillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:11793163, PMID:15190105, PMID:16012872 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid CTD PMID:16012872 NCBI chr  X:16,709,281...16,817,366
Ensembl chr  X:16,709,282...16,817,366
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions EXP NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Homovanillic Acid] CTD PMID:11085313 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases abundance EXP NR3C1 protein results in increased abundance of Homovanillic Acid CTD PMID:11226678 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] CTD PMID:8884884 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of Homovanillic Acid CTD PMID:10318960 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Sct secretin increases abundance ISO SCT protein results in increased abundance of Homovanillic Acid CTD PMID:16168596 NCBI chr 7:141,278,329...141,279,174
Ensembl chr 7:141,278,330...141,279,133
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Tfam transcription factor A, mitochondrial decreases abundance EXP TFAM gene mutant form results in decreased abundance of Homovanillic Acid CTD PMID:28595911 NCBI chr10:71,225,468...71,238,328
Ensembl chr10:71,225,464...71,238,280
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor multiple interactions
increases abundance
ISO Calcitriol promotes the reaction [VDR protein results in increased abundance of Homovanillic Acid] CTD PMID:27450565 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor increases activity
affects localization
multiple interactions
ISO isoeugenol results in increased activity of AHR protein
isoeugenol affects the localization of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr13:74,211,118...74,292,331
Ensembl chr13:74,211,118...74,292,331
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases expression ISO isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases activity
increases expression
ISO isoeugenol results in increased activity of AKR1C2 promoter
isoeugenol results in increased expression of AKR1C2 mRNA
CTD PMID:20491607, PMID:21195160 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Ar androgen receptor affects binding ISO isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Cat catalase increases expression ISO isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases secretion ISO isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl27a chemokine (C-C motif) ligand 27A increases expression ISO isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 4:41,769,467...41,774,225
Ensembl chr 4:41,769,467...41,774,247
JBrowse link
G Cd274 CD274 antigen increases expression ISO isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of CXCL8 mRNA; KT 5720 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]
isoeugenol results in increased expression of CXCL8 mRNA; isoeugenol results in increased expression of CXCL8 protein
CTD PMID:21284934, PMID:21920952, PMID:21969073, PMID:25617811, PMID:31734321 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression EXP isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Fech ferrochelatase increases expression ISO isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gsr glutathione reductase increases expression ISO isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Ifng interferon gamma increases secretion EXP isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il18 interleukin 18 increases expression ISO isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il2 interleukin 2 multiple interactions
increases secretion
EXP isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 increases secretion EXP isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,791,536...139,802,653
Ensembl chr 5:139,791,513...139,802,653
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mt1 metallothionein 1 increases expression ISO isoeugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Olfr73 olfactory receptor 73 multiple interactions EXP isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr 2:88,034,196...88,035,137
Ensembl chr 2:88,032,288...88,037,699
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:10871845, PMID:17698059 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trim16 tripartite motif-containing 16 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr11:62,820,198...62,842,948
Ensembl chr11:62,820,231...62,850,808
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO
EXP
isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Zfp36 zinc finger protein 36 increases expression
multiple interactions
ISO isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr 7:28,376,784...28,379,228
Ensembl chr 7:28,376,784...28,380,253
JBrowse link
KN-93 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] CTD PMID:19647009 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Aco1 aconitase 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride affects the localization of ACO1 protein] CTD PMID:25106854 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein] CTD PMID:32522522 NCBI chr 9:22,126,727...22,135,746
Ensembl chr 9:22,126,727...22,135,711
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein] CTD PMID:18089838 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:18089838 NCBI chr13:74,211,118...74,292,331
Ensembl chr13:74,211,118...74,292,331
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein] CTD PMID:18506790 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of AKT1 protein]
CTD PMID:19233221, PMID:21933187, PMID:28025122 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29883672 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Calcr calcitonin receptor multiple interactions EXP KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714
JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I decreases activity ISO KN 93 results in decreased activity of CAMK1 protein CTD PMID:12193581 NCBI chr 6:113,334,124...113,343,922
Ensembl chr 6:113,334,124...113,343,984
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP
ISO
[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]
CTD PMID:19217379, PMID:21933187, PMID:25103225, PMID:28025122 NCBI chr18:60,925,307...60,988,152
Ensembl chr18:60,925,618...60,988,152
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta multiple interactions ISO KN 93 inhibits the reaction [Cadmium affects the localization of CAMK2D protein] CTD PMID:22553113 NCBI chr 3:126,595,487...126,846,326
Ensembl chr 3:126,596,302...126,846,326
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr18:32,934,941...33,195,767
Ensembl chr18:32,934,931...33,191,228
JBrowse link
G Casp12 caspase 12 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP12 protein] CTD PMID:29883672 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; KN 93 promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]
KN 93 inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [GW 7845 results in increased activity of CASP3 protein]
CTD PMID:19233221, PMID:20810541, PMID:26096086, PMID:26923100, PMID:28025122, PMID:29883672 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl1 chemokine (C-C motif) ligand 1 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA] CTD PMID:18089838 NCBI chr11:82,176,666...82,179,812
Ensembl chr11:82,176,657...82,305,690
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO KN 93 results in decreased expression of CCND1 protein CTD PMID:15958590 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:15385614, PMID:15631885, PMID:21113126 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr18:61,105,572...61,131,139
Ensembl chr18:61,100,598...61,132,149
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA] CTD PMID:18089838 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP KN 93 inhibits the reaction [GW 7845 affects the localization of CYCS protein] CTD PMID:20810541 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO KN 93 inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA] CTD PMID:12193581 NCBI chr15:74,850,618...74,856,231
Ensembl chr15:74,851,010...74,856,318
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO KN 93 inhibits the reaction [STO 609 results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:18089838, PMID:18755850, PMID:23298284 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:18089838 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein] CTD PMID:29883672 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin results in increased phosphorylation of DRD3 protein] CTD PMID:19217379 NCBI chr16:43,754,015...43,825,982
Ensembl chr16:43,754,026...43,822,932
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein] CTD PMID:19233221 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21933187 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) multiple interactions ISO KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of GRIA1 protein] CTD PMID:12019337 NCBI chr11:57,011,571...57,330,244
Ensembl chr11:57,011,387...57,330,244
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP KN 93 inhibits the reaction [Potassium Chloride results in increased phosphorylation of HDAC5 protein] CTD PMID:17988634 NCBI chr11:102,195,747...102,230,172
Ensembl chr11:102,194,432...102,230,166
JBrowse link
G Hexb hexosaminidase B multiple interactions ISO KN 93 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr13:97,176,331...97,198,357
Ensembl chr13:97,176,331...97,198,357
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein] CTD PMID:19647009 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 mRNA]; KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29883672 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA] CTD PMID:18089838 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Itgb7 integrin beta 7 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA] CTD PMID:18089838 NCBI chr15:102,215,994...102,233,405
Ensembl chr15:102,215,995...102,231,944
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK1 protein]
CTD PMID:15086530, PMID:15355987, PMID:19233221, PMID:21879721, PMID:21933187, PMID:28181390, PMID:29883672 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:21933187 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK3 protein]
CTD PMID:15086530, PMID:15355987, PMID:19233221, PMID:21879721, PMID:21933187, PMID:28181390, PMID:29883672 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:21933187 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions ISO Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] CTD PMID:25093688 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr14:68,083,863...68,089,095
Ensembl chr14:68,083,863...68,089,095
JBrowse link
G Nefm neurofilament, medium polypeptide multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr14:68,119,545...68,125,004
Ensembl chr14:68,082,590...68,124,846
JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions EXP KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr18:80,606,205...80,713,071
Ensembl chr18:80,606,205...80,713,071
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein] CTD PMID:15629441 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO KN 93 results in decreased phosphorylation of RB1 protein CTD PMID:15958590 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21933187 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of SRC protein] CTD PMID:19233221 NCBI chr 2:157,423,906...157,471,838
Ensembl chr 2:157,418,444...157,471,862
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein]; KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564, PMID:32522522 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
G Vim vimentin multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
Ku-0063794 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO Ku 0063794 results in decreased phosphorylation of AKT1 protein CTD PMID:22885370 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with AZD 6244] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with PD 0325901] results in decreased phosphorylation of EIF4EBP1 protein; Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:22415236 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of RPS6 protein
Ku 0063794 results in decreased phosphorylation of RPS6 protein
CTD PMID:22415236, PMID:22885370 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412
JBrowse link
methoxyfenozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases transport
ISO methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
ABCB1 protein results in increased transport of methoxyfenozide
CTD PMID:26995013 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
o-anisidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases expression ISO 2-anisidine results in decreased expression of AKT1 mRNA CTD PMID:28089782 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bcl10 B cell leukemia/lymphoma 10 affects expression ISO 2-anisidine affects the expression of BCL10 mRNA CTD PMID:28089782 NCBI chr 3:145,924,262...145,934,366
Ensembl chr 3:145,922,804...145,934,356
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO 2-anisidine results in decreased expression of BCL2 mRNA CTD PMID:28089782 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 affects expression ISO 2-anisidine affects the expression of BCL3 mRNA CTD PMID:28089782 NCBI chr 7:19,808,462...19,822,824
Ensembl chr 7:19,808,462...19,822,770
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 2-anisidine results in decreased expression of BIRC5 mRNA CTD PMID:28089782 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Btrc beta-transducin repeat containing protein increases expression ISO 2-anisidine results in increased expression of BTRC mRNA CTD PMID:28089782 NCBI chr19:45,363,688...45,533,343
Ensembl chr19:45,363,734...45,530,013
JBrowse link
G Card10 caspase recruitment domain family, member 10 decreases expression ISO 2-anisidine results in decreased expression of CARD10 mRNA CTD PMID:28089782 NCBI chr15:78,775,123...78,803,072
Ensembl chr15:78,775,138...78,803,042
JBrowse link
G Card14 caspase recruitment domain family, member 14 decreases expression ISO 2-anisidine results in decreased expression of CARD14 mRNA CTD PMID:28089782 NCBI chr11:119,307,093...119,345,379
Ensembl chr11:119,307,768...119,345,375
JBrowse link
G Ccl20 chemokine (C-C motif) ligand 20 affects expression ISO 2-anisidine affects the expression of CCL20 mRNA CTD PMID:28089782 NCBI chr 1:83,116,766...83,119,167
Ensembl chr 1:83,116,766...83,119,167
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases expression ISO 2-anisidine results in increased expression of CCL3 mRNA CTD PMID:28089782 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 increases expression ISO 2-anisidine results in increased expression of CCL5 mRNA CTD PMID:28089782 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Cd40 CD40 antigen affects expression ISO 2-anisidine affects the expression of CD40 mRNA CTD PMID:28089782 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd83 CD83 antigen decreases expression ISO 2-anisidine results in decreased expression of CD83 mRNA CTD PMID:28089782 NCBI chr13:43,785,112...43,803,133
Ensembl chr13:43,784,775...43,803,132
JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression ISO 2-anisidine affects the expression of CREB1 mRNA CTD PMID:28089782 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crebbp CREB binding protein increases expression ISO 2-anisidine results in increased expression of CREBBP mRNA CTD PMID:28089782 NCBI chr16:4,081,334...4,213,957
Ensembl chr16:4,081,328...4,213,997
JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) increases expression ISO 2-anisidine results in increased expression of CSF1 mRNA CTD PMID:28089782 NCBI chr 3:107,741,048...107,760,469
Ensembl chr 3:107,741,048...107,760,469
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) affects expression ISO 2-anisidine affects the expression of CSF3 mRNA CTD PMID:28089782 NCBI chr11:98,700,183...98,703,631
Ensembl chr11:98,701,263...98,703,629
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 affects expression ISO 2-anisidine affects the expression of CXCL1 mRNA CTD PMID:28089782 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 affects expression
increases expression
ISO 2-anisidine affects the expression of CXCL8 mRNA
2-anisidine results in increased expression of CXCL8 protein
CTD PMID:28089782 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 decreases expression ISO 2-anisidine results in decreased expression of CXCL2 mRNA CTD PMID:28089782 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 affects expression ISO 2-anisidine affects the expression of CXCL1 mRNA CTD PMID:28089782 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases oxidation
increases expression
ISO CYP1A1 protein results in increased oxidation of 2-anisidine
2-anisidine results in increased expression of CYP1A1 mRNA
2-anisidine results in increased expression of CYP1A1; 2-anisidine results in increased expression of CYP1A1 protein
CTD PMID:11409192, PMID:15828049, PMID:16601807, PMID:28089782 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
increases oxidation
ISO 2-anisidine results in increased expression of CYP1A2
CYP1A2 protein results in increased oxidation of 2-anisidine
CTD PMID:11409192, PMID:15828049 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases oxidation ISO CYP2A6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases oxidation ISO CYP2B6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases oxidation ISO CYP2B2 protein results in increased oxidation of 2-anisidine CTD PMID:16601807 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases oxidation ISO CYP2D6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases oxidation ISO CYP3A4 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Edaradd EDAR (ectodysplasin-A receptor)-associated death domain affects expression ISO 2-anisidine affects the expression of EDARADD mRNA CTD PMID:28089782 NCBI chr13:12,471,209...12,520,535
Ensembl chr13:12,472,632...12,520,438
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression ISO 2-anisidine results in decreased expression of ENPP2 mRNA CTD PMID:28089782 NCBI chr15:54,838,901...54,952,789
Ensembl chr15:54,838,901...54,952,892
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain affects expression ISO 2-anisidine affects the expression of FADD mRNA CTD PMID:28089782 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO 2-anisidine results in increased expression of HMGB1 protein CTD PMID:28089782 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Icam1 intercellular adhesion molecule 1 affects expression ISO 2-anisidine affects the expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ier3 immediate early response 3 affects expression ISO 2-anisidine affects the expression of IER3 mRNA CTD PMID:28089782 NCBI chr17:35,821,713...35,822,911
Ensembl chr17:35,821,684...35,822,923
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta affects expression ISO 2-anisidine affects the expression of IKBKB mRNA CTD PMID:28089782 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma affects expression ISO 2-anisidine affects the expression of IKBKG mRNA CTD PMID:28089782 NCBI chr  X:74,393,233...74,456,792
Ensembl chr  X:74,393,290...74,453,854
JBrowse link
G Il12a interleukin 12a increases expression ISO 2-anisidine results in increased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 2-anisidine results in increased expression of IL1B mRNA CTD PMID:28089782 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1r1 interleukin 1 receptor, type I increases expression ISO 2-anisidine results in increased expression of IL1R1 mRNA CTD PMID:28089782 NCBI chr 1:40,222,480...40,316,201
Ensembl chr 1:40,225,080...40,317,257
JBrowse link
G Il2 interleukin 2 increases expression ISO 2-anisidine results in increased expression of IL2 mRNA CTD PMID:28089782 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain decreases expression ISO 2-anisidine results in decreased expression of IL2RA mRNA CTD PMID:28089782 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Il5 interleukin 5 increases expression ISO 2-anisidine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 increases expression ISO 2-anisidine results in increased expression of IL6 mRNA CTD PMID:28089782 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 decreases expression ISO 2-anisidine results in decreased expression of IRAK1 mRNA CTD PMID:28089782 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 decreases expression ISO 2-anisidine results in decreased expression of IRAK1BP1 mRNA CTD PMID:28089782 NCBI chr 9:82,829,806...82,847,688
Ensembl chr 9:82,829,540...82,847,687
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 affects expression ISO 2-anisidine affects the expression of IRAK2 mRNA CTD PMID:28089782 NCBI chr 6:113,638,467...113,695,026
Ensembl chr 6:113,638,467...113,695,026
JBrowse link
G Ltbr lymphotoxin B receptor decreases expression ISO 2-anisidine results in decreased expression of LTBR mRNA CTD PMID:28089782 NCBI chr 6:125,306,571...125,313,885
Ensembl chr 6:125,306,571...125,313,885
JBrowse link
G Malt1 MALT1 paracaspase increases expression ISO 2-anisidine results in increased expression of MALT1 mRNA CTD PMID:28089782 NCBI chr18:65,430,939...65,478,888
Ensembl chr18:65,430,938...65,479,067
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO 2-anisidine results in decreased expression of MAP3K1 mRNA CTD PMID:28089782 NCBI chr13:111,746,428...111,818,269
Ensembl chr13:111,746,428...111,808,993
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases expression ISO 2-anisidine results in decreased expression of MAP3K14 mRNA CTD PMID:28089782 NCBI chr11:103,219,764...103,267,401
Ensembl chr11:103,219,762...103,267,472
JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 decreases expression ISO 2-anisidine results in decreased expression of MAP3K7 mRNA CTD PMID:28089782 NCBI chr 4:31,963,492...32,023,470
Ensembl chr 4:31,964,097...32,023,467
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine CTD PMID:20199096 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO 2-anisidine results in decreased expression of MYC mRNA CTD PMID:28089782 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 decreases expression ISO 2-anisidine results in decreased expression of MYD88 mRNA CTD PMID:28089782 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Nat1 N-acetyl transferase 1 increases activity ISO NAT1 protein results in increased activity of 2-anisidine CTD PMID:15450435 NCBI chr 8:67,490,968...67,492,531
Ensembl chr 8:67,480,921...67,492,104
JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases activity ISO NAT2 protein results in increased activity of 2-anisidine CTD PMID:15450435 NCBI chr 8:67,494,875...67,502,644
Ensembl chr 8:67,494,858...67,502,584
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO 2-anisidine results in decreased expression of NFKB1 mRNA CTD PMID:28089782 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 affects expression ISO 2-anisidine affects the expression of NFKB2 mRNA CTD PMID:28089782 NCBI chr19:46,300,994...46,312,400
Ensembl chr19:46,304,320...46,312,385
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha affects expression ISO 2-anisidine affects the expression of NFKBIA mRNA CTD PMID:28089782 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta affects expression ISO 2-anisidine affects the expression of NFKBIB mRNA CTD PMID:28089782 NCBI chr 7:28,758,251...28,766,644
Ensembl chr 7:28,758,251...28,767,512
JBrowse link
G Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon affects expression ISO 2-anisidine affects the expression of NFKBIE mRNA CTD PMID:28089782 NCBI chr17:45,555,700...45,563,169
Ensembl chr17:45,555,703...45,563,169
JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like protein 1 affects expression ISO 2-anisidine affects the expression of NKIRAS1 mRNA CTD PMID:28089782 NCBI chr14:18,271,136...18,284,003
Ensembl chr14:18,271,136...18,284,003
JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras-like protein 2 decreases expression ISO 2-anisidine results in decreased expression of NKIRAS2 mRNA CTD PMID:28089782 NCBI chr11:100,619,181...100,627,610
Ensembl chr11:100,619,244...100,627,607
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO 2-anisidine results in increased expression of NOS2 mRNA CTD PMID:28089782 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254