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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylguanine
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Accession:CHEBI:25305 term browser browse the term
Definition:A 2-aminopurine that is guanine bearing a single methyl substituent.


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2-amino-7-methyl-1,7-dihydro-6H-purin-6-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 gene polymorphism affects the susceptibility to and affects the metabolism of 7-methylguanine CTD PMID:15066569 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO GSTP1 gene polymorphism affects the susceptibility to and affects the metabolism of 7-methylguanine CTD PMID:15066569 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism affects the susceptibility to and affects the metabolism of 7-methylguanine CTD PMID:15066569 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
6-O-methylguanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of APAF1 mRNA CTD PMID:29666243 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BBC3 mRNA CTD PMID:29666243 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BID mRNA CTD PMID:29666243 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BTG2 mRNA CTD PMID:29666243 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNA2 protein CTD PMID:29666243 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNB1 protein CTD PMID:29666243 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A mRNA; [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A protein CTD PMID:29666243 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Plk2 polo-like kinase 2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PLK2 mRNA CTD PMID:29666243 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PMAIP1 mRNA CTD PMID:29666243 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of RB1 protein modified form CTD PMID:29666243 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Sfn stratifin multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of SFN mRNA CTD PMID:29666243 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [O(6)-benzylguanine results in increased susceptibility to O-(6)-methylguanine] which results in increased expression of TP53 mRNA mutant form CTD PMID:29666243 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wrn WRN RecQ like helicase decreases response to substance ISO WRN protein results in decreased susceptibility to O-(6)-methylguanine CTD PMID:29616805 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              algal metabolite 13593
                guanine 3972
                  methylguanine 16
                    1-methylguanine 0
                    3-methylguanine + 0
                    6-O-methylguanine 13
                    7-methylguanine + 3
                    N(2)-methylguanine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      imidazopyrimidine 5443
                                        purines 5441
                                          aminopurine 4398
                                            2-aminopurines 4008
                                              guanine 3972
                                                methylguanine 16
                                                  1-methylguanine 0
                                                  3-methylguanine + 0
                                                  6-O-methylguanine 13
                                                  7-methylguanine + 3
                                                  N(2)-methylguanine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.