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ONTOLOGY REPORT - ANNOTATIONS


Term:myxothiazol
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Accession:CHEBI:25461 term browser browse the term
Definition:A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.
Synonyms:exact_synonym: (2E,4R,5S,6E)-3,5-dimethoxy-4-methyl-7-{2'-[(2S,3E,5E)-7-methylocta-3,5-dien-2-yl]-2,4'-bi-1,3-thiazol-4-yl}hepta-2,6-dienamide
 related_synonym: Formula=C25H33N3O3S2;   InChI=1S/C25H33N3O3S2/c1-16(2)9-7-8-10-17(3)24-28-20(15-33-24)25-27-19(14-32-25)11-12-21(30-5)18(4)22(31-6)13-23(26)29/h7-18,21H,1-6H3,(H2,26,29)/b9-7+,10-8+,12-11+,22-13+/t17?,18-,21+/m1/s1;   InChIKey=XKTFQMCPGMTBMD-YCSHSZEBSA-N;   Myxothiazol A;   SMILES=CO[C@@H](\\C=C\\c1csc(n1)-c1csc(n1)C(C)\\C=C\\C=C\\C(C)C)[C@@H](C)C(\\OC)=C/C(N)=O
 xref: CAS:76706-55-3 "ChemIDplus";   CAS:76706-55-3 "KEGG COMPOUND";   DrugBank:DB04741;   KEGG:C15674;   KNApSAcK:C00018319
 xref_mesh: MESH:C030517
 xref: PDBeChem:MYX


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myxothiazol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:6480464
G P2rx2 purinergic receptor P2X 2 JBrowse link 12 52,397,666 52,401,005 RGD:6480464
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:6480464
G Slc5a3 solute carrier family 5 member 3 JBrowse link 11 32,229,366 32,231,812 RGD:6480464
G Slc6a12 solute carrier family 6 member 12 JBrowse link 4 153,921,199 153,941,333 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:6480464
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        biochemical role 19192
          metabolite 19164
            myxothiazol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      carboxylic acid 17972
                                        carboacyl group 17080
                                          univalent carboacyl group 17080
                                            carbamoyl group 16809
                                              carboxamide 16809
                                                monocarboxylic acid amide 14167
                                                  myxothiazol 12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.