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Accession:CHEBI:258351 term browser browse the term
Definition:N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.
Synonyms:exact_synonym: N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
 related_synonym: 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol;   4'-(2-hydroxy-3-(isopropylamino)propoxy)acetanilide;   Formula=C14H22N2O3;   InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17);   InChIKey=DURULFYMVIFBIR-UHFFFAOYSA-N;   N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide;   SMILES=CC(C)NCC(O)COc1ccc(NC(C)=O)cc1;   practololum
 alt_id: CHEBI:101380;   CHEBI:8348
 xref: CAS:6673-35-4 "ChemIDplus";   CAS:6673-35-4 "KEGG COMPOUND";   DrugBank:DB01297;   Drug_Central:3486 "DrugCentral";   HMDB:HMDB0015411;   KEGG:C11696;   KEGG:D05587;   LINCS:LSM-1531
 xref_mesh: MESH:D011217
 xref: PMID:6827543 "ChEMBL";   Patent:US3408387;   Wikipedia:Practolol

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practolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            cardiovascular drug 7567
              anti-arrhythmia drug 879
                practolol 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                acetamides 11598
                                                  practolol 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.