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ONTOLOGY REPORT - ANNOTATIONS


Term:amantadine
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Accession:CHEBI:2618 term browser browse the term
Definition:A member of the class of adamantanes that is used as an antiviral and antiparkinson drug.
Synonyms:exact_synonym: adamantan-1-ylamine
 related_synonym: 1-adamantanamine;   1-adamantylamine;   1-aminoadamantane;   Amantidine;   Aminoadamantane;   Formula=C10H17N;   InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2;   InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N;   SMILES=NC12CC3CC(CC(C3)C1)C2;   Viregyt;   Virosol;   amantadina;   amantadinum;   tricyclo[3.3.1.1(3,7)]decan-1-amine;   tricyclo[3.3.1.1(3,7)]decan-1-ylamine;   tricyclo[3.3.1.1(3,7)]decane-1-amine
 xref: Beilstein:2204333 "Beilstein";   CAS:768-94-5 "ChemIDplus";   CAS:768-94-5 "KEGG COMPOUND";   CAS:768-94-5 "NIST Chemistry WebBook";   DrugBank:DB00915;   Drug_Central:144 "DrugCentral";   Gmelin:27066 "Gmelin";   KEGG:C06818;   KEGG:D07441
 xref_mesh: MESH:D000547
 xref: PMID:23011311 "Europe PMC";   PMID:24371305 "Europe PMC";   PMID:24427376 "Europe PMC";   Reaxys:2204333 "Reaxys";   VSDB:2961;   Wikipedia:Amantadine
 cyclic_relationship: is_conjugate_base_of CHEBI:48320


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amantadine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Ifi27 interferon, alpha-inducible protein 27 JBrowse link 6 127,327,959 127,334,430 RGD:6480464
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:6480464
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Oas2 2'-5' oligoadenylate synthetase 2 JBrowse link 12 41,341,417 41,363,124 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Tdp1 tyrosyl-DNA phosphodiesterase 1 JBrowse link 6 123,895,860 123,963,688 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          analgesic 13046
            amantadine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        primary amino compound 7788
                                          primary amine 5617
                                            primary aliphatic amine 133
                                              amantadine 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.