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ONTOLOGY REPORT - ANNOTATIONS


Term:amikacin
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Accession:CHEBI:2637 term browser browse the term
Definition:An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.
Synonyms:exact_synonym: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide
 related_synonym: 1-N-(L(-)-gamma-amino-alpha-hydroxybutyryl)kanamycin A;   Formula=C22H43N5O13;   InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1;   InChIKey=LKCWBDHBTVXHDL-RMDFUYIESA-N;   O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine;   SMILES=NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O;   amikacina;   amikacine;   amikacinum
 xref: Beilstein:5915117 "Beilstein";   CAS:37517-28-5 "ChemIDplus";   CAS:37517-28-5 "KEGG COMPOUND";   DrugBank:DB00479;   Drug_Central:157 "DrugCentral";   HMDB:HMDB0014622;   KEGG:C06820;   KEGG:D02543;   LINCS:LSM-5935
 xref_mesh: MESH:D000583
 xref: MetaCyc:CPD-14197;   PMID:11744283 "Europe PMC";   PMID:15305513 "Europe PMC";   PMID:17365906 "Europe PMC";   PMID:19495517 "Europe PMC";   PMID:19752274 "Europe PMC";   PMID:20195673 "Europe PMC";   PMID:25296102 "Europe PMC";   PMID:25327505 "Europe PMC";   PMID:25339395 "Europe PMC";   PMID:25630642 "Europe PMC";   PMID:8622103 "Europe PMC";   PMID:8622117 "Europe PMC";   PMID:9327246 "Europe PMC";   Patent:DE2234315;   Patent:US3781268;   Reaxys:5915117 "Reaxys";   Wikipedia:Amikacin
 cyclic_relationship: is_conjugate_base_of CHEBI:84739


show annotations for term's descendants       view all columns           Sort by:
 
amikacin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Pgd phosphogluconate dehydrogenase JBrowse link 5 165,966,128 165,982,327 RGD:6480464
G Tyr tyrosinase JBrowse link 1 151,012,598 151,106,802 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        antimicrobial agent 17143
          amikacin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            heteroorganic entity 18990
                              organochalcogen compound 18705
                                organooxygen compound 18615
                                  carbohydrates and carbohydrate derivatives 11721
                                    carbohydrate 11721
                                      carbohydrate derivative 11336
                                        glycosyl compound 10287
                                          glycoside 9103
                                            aminoglycoside 8315
                                              aminoglycoside antibiotic 2474
                                                kanamycins 24
                                                  kanamycin A 15
                                                    amikacin 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.