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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridazinone
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Accession:CHEBI:26414 term browser browse the term
Synonyms:related_synonym: pyridazinones


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Maleic hydrazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity ISO Maleic Hydrazide results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases activity ISO Maleic Hydrazide results in decreased activity of IMPDH2 protein CTD PMID:11370715 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Maleic Hydrazide co-treated with Chlorpropham] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:15853388, PMID:16608219 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
pimobendan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO pimobendan promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
pimobendan results in decreased expression of IL1B protein
CTD PMID:9004165, PMID:10193745 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO pimobendan results in decreased expression of IL6 protein
pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:9004165, PMID:10193745 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pimobendan results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO pimobendan results in decreased expression of NOS2 mRNA
[pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide
CTD PMID:10193745 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
pimobendan results in decreased expression of TNF protein
CTD PMID:9004165, PMID:10193745 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
pyridaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco2 aconitase 2 decreases activity EXP pyridaben results in decreased activity of ACO2 protein CTD PMID:26141520 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 increases expression ISO pyridaben results in increased expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 4:22,864,485...23,002,969
Ensembl chr 4:22,859,622...22,996,645
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 increases expression ISO pyridaben results in increased expression of ADCYAP1 mRNA CTD PMID:22563483 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Ago3 argonaute RISC catalytic component 3 increases expression ISO pyridaben results in increased expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Amn amnion associated transmembrane protein decreases expression ISO pyridaben results in decreased expression of AMN mRNA CTD PMID:22563483 NCBI chr 6:135,724,455...135,731,896
Ensembl chr 6:135,724,455...135,731,896
JBrowse link
G Ar androgen receptor multiple interactions ISO pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atoh7 atonal bHLH transcription factor 7 decreases expression ISO pyridaben results in decreased expression of ATOH7 mRNA CTD PMID:22563483 NCBI chr20:27,082,961...27,083,410
Ensembl chr20:27,082,961...27,083,410
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases expression ISO pyridaben results in increased expression of ATP8A2 mRNA CTD PMID:22563483 NCBI chr15:39,955,689...40,488,737
Ensembl chr15:40,000,322...40,428,800
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
multiple interactions
ISO BCL2 protein results in decreased susceptibility to pyridaben
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to pyridaben]
CTD PMID:12730627 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO pyridaben results in increased expression of BCL2A1 mRNA CTD PMID:22563483 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bicd1 BICD cargo adaptor 1 increases expression ISO pyridaben results in increased expression of BICD1 mRNA CTD PMID:22563483 NCBI chr 4:184,018,845...184,167,628
Ensembl chr 4:184,019,087...184,165,540
JBrowse link
G C2cd4d C2 calcium-dependent domain containing 4D decreases expression ISO pyridaben results in decreased expression of C2CD4D mRNA CTD PMID:22563483 NCBI chr 2:195,599,706...195,604,730
Ensembl chr 2:195,603,599...195,604,624
JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated increases expression ISO pyridaben results in increased expression of CABYR mRNA CTD PMID:22563483 NCBI chr18:4,082,175...4,096,650
Ensembl chr18:4,084,228...4,095,936
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E increases expression ISO pyridaben results in increased expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO pyridaben results in increased expression of CAMP mRNA CTD PMID:22563483 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Capn11 calpain 11 decreases expression ISO pyridaben results in decreased expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 9:17,728,845...17,750,357
Ensembl chr 9:17,728,816...17,750,363
JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO pyridaben results in increased expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr14:113,771,093...113,936,376
Ensembl chr14:113,867,209...113,932,263
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO pyridaben results in increased expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 increases expression ISO pyridaben results in increased expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Cdhr4 cadherin-related family member 4 decreases expression ISO pyridaben results in decreased expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 8:116,771,377...116,779,242 JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO pyridaben results in decreased expression of CEBPD mRNA CTD PMID:22563483 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO pyridaben results in increased expression of CEP290 mRNA CTD PMID:22563483 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Cldn3 claudin 3 decreases expression ISO pyridaben results in decreased expression of CLDN3 mRNA CTD PMID:22563483 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Crlf2 cytokine receptor-like factor 2 decreases expression ISO pyridaben results in decreased expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr14:1,456,843...1,461,543
Ensembl chr14:1,456,844...1,461,543
JBrowse link
G Dgki diacylglycerol kinase, iota increases expression ISO pyridaben results in increased expression of DGKI mRNA CTD PMID:22563483 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G Dip2b disco-interacting protein 2 homolog B increases expression ISO pyridaben results in increased expression of DIP2B mRNA CTD PMID:22563483 NCBI chr 7:141,702,034...141,878,945
Ensembl chr 7:141,702,038...141,879,951
JBrowse link
G Dmrta2 DMRT-like family A2 decreases expression ISO pyridaben results in decreased expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 5:129,754,295...129,760,045
Ensembl chr 5:129,756,149...129,758,986
JBrowse link
G Drd4 dopamine receptor D4 decreases expression ISO pyridaben results in decreased expression of DRD4 mRNA CTD PMID:22563483 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Egr4 early growth response 4 decreases expression ISO pyridaben results in decreased expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Elane elastase, neutrophil expressed increases expression ISO pyridaben results in increased expression of ELANE mRNA CTD PMID:22563483 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
ISO pyridaben results in increased activity of ESR1 protein
pyridaben inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
CTD PMID:20143881, PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO pyridaben inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; pyridaben inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Etl4 enhancer trap locus 4 increases expression ISO pyridaben results in increased expression of ETL4 mRNA CTD PMID:22563483 NCBI chr17:87,173,265...87,681,268
Ensembl chr17:87,274,944...87,681,317
JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO pyridaben results in decreased expression of H2BC9 mRNA CTD PMID:22563483 NCBI chr17:44,519,815...44,520,269
Ensembl chr17:44,519,860...44,520,240
JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO pyridaben results in decreased expression of H3C1 mRNA CTD PMID:22563483 NCBI chr17:43,616,206...43,616,735
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [pyridaben results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hmx3 H6 family homeobox 3 decreases expression ISO pyridaben results in decreased expression of HMX3 mRNA CTD PMID:22563483 NCBI chr 1:203,509,731...203,511,695
Ensembl chr 1:203,509,731...203,511,695
JBrowse link
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 decreases expression ISO pyridaben results in decreased expression of HS3ST6 mRNA CTD PMID:22563483 NCBI chr10:14,122,856...14,128,984
Ensembl chr10:14,122,878...14,128,983
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO pyridaben results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO pyridaben results in increased expression of INHBA mRNA CTD PMID:22563483 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Insl3 insulin-like 3 decreases expression ISO pyridaben results in decreased expression of INSL3 mRNA CTD PMID:22563483 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression ISO pyridaben results in increased expression of ITGB8 mRNA CTD PMID:22563483 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 increases expression ISO pyridaben results in increased expression of KCNA2 mRNA CTD PMID:22563483 NCBI chr 2:209,838,607...209,852,471
Ensembl chr 2:209,838,869...209,852,471
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 increases expression ISO pyridaben results in increased expression of KCNMA1 mRNA CTD PMID:22563483 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kif1b kinesin family member 1B increases expression ISO pyridaben results in increased expression of KIF1B mRNA CTD PMID:22563483 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression ISO pyridaben results in decreased expression of KLF2 mRNA CTD PMID:22563483 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Klhl15 kelch-like family member 15 increases expression ISO pyridaben results in increased expression of KLHL15 mRNA CTD PMID:22563483 NCBI chr  X:63,342,277...63,390,915
Ensembl chr  X:63,343,546...63,389,989
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO pyridaben results in increased expression of LAMC2 mRNA CTD PMID:22563483 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO pyridaben results in increased expression of LIFR mRNA CTD PMID:22563483 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G LOC102548682 histone H4-like decreases expression ISO pyridaben results in decreased expression of H4C14 mRNA CTD PMID:22563483 NCBI chr17:43,616,218...43,673,659
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
JBrowse link
G Lrp4 LDL receptor related protein 4 increases expression ISO pyridaben results in increased expression of LRP4 mRNA CTD PMID:22563483 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679
JBrowse link
G Lrrc63 leucine rich repeat containing 63 decreases expression ISO pyridaben results in decreased expression of LRRC63 mRNA CTD PMID:22563483 NCBI chr15:57,132,507...57,170,467
Ensembl chr15:57,133,192...57,170,443
JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 decreases expression ISO pyridaben results in decreased expression of LTB4R2 mRNA CTD PMID:22563483 NCBI chr15:34,446,478...34,448,220
Ensembl chr15:34,446,878...34,447,954
JBrowse link
G Ltf lactotransferrin increases expression ISO pyridaben results in increased expression of LTF mRNA CTD PMID:22563483 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 decreases expression ISO pyridaben results in decreased expression of MAPK15 mRNA CTD PMID:22563483 NCBI chr 7:117,041,287...117,061,799
Ensembl chr 7:117,055,395...117,061,047
JBrowse link
G Marchf9 membrane associated ring-CH-type finger 9 decreases expression ISO pyridaben results in decreased expression of MARCHF9 mRNA CTD PMID:22563483 NCBI chr 7:70,341,989...70,349,126 JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 increases expression ISO pyridaben results in increased expression of MBOAT2 mRNA CTD PMID:22563483 NCBI chr 6:44,009,872...44,135,501
Ensembl chr 6:44,009,872...44,131,387
JBrowse link
G Mdfi MyoD family inhibitor decreases expression ISO pyridaben results in decreased expression of MDFI mRNA CTD PMID:22563483 NCBI chr 9:15,166,118...15,184,469
Ensembl chr 9:15,166,118...15,184,468
JBrowse link
G Mpo myeloperoxidase increases expression ISO pyridaben results in increased expression of MPO mRNA CTD PMID:22563483 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrtfb myocardin related transcription factor B increases expression ISO pyridaben results in increased expression of MRTFB mRNA CTD PMID:22563483 NCBI chr10:1,151,163...1,273,269 JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming increases expression ISO pyridaben results in increased expression of MUC6 mRNA CTD PMID:22563483 NCBI chr 1:214,608,453...214,630,524
Ensembl chr 1:214,608,704...214,629,938
JBrowse link
G Myoc myocilin increases expression ISO pyridaben results in increased expression of MYOC mRNA CTD PMID:22563483 NCBI chr13:80,517,531...80,527,928
Ensembl chr13:80,517,536...80,527,928
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO pyridaben results in increased expression of NFAT5 mRNA CTD PMID:22563483 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO pyridaben results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfib nuclear factor I/B increases expression ISO pyridaben results in increased expression of NFIB mRNA CTD PMID:22563483 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression ISO pyridaben results in increased expression of NIPBL mRNA CTD PMID:22563483 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 decreases response to substance ISO NMNAT3 protein results in decreased susceptibility to pyridaben CTD PMID:18463239 NCBI chr 8:106,317,038...106,429,535
Ensembl chr 8:106,317,124...106,429,522
JBrowse link
G Nps neuropeptide S increases expression ISO pyridaben results in increased expression of NPS mRNA CTD PMID:22563483 NCBI chr 1:207,508,414...207,512,195
Ensembl chr 1:207,508,414...207,512,195
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO pyridaben results in decreased expression of NR4A1 mRNA CTD PMID:22563483 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
ISO pyridaben inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]
pyridaben results in increased activity of ODC1 protein
CTD PMID:9834970 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases expression ISO pyridaben results in decreased expression of OXT mRNA CTD PMID:22563483 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Park7 Parkinsonism associated deglycase decreases response to substance ISO PARK7 protein results in decreased susceptibility to pyridaben CTD PMID:21219333 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO pyridaben results in increased cleavage of PARP1 protein
[pyridaben co-treated with Paraquat] results in increased cleavage of PARP1 protein
CTD PMID:16237197 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phox2a paired-like homeobox 2a decreases expression ISO pyridaben results in decreased expression of PHOX2A mRNA CTD PMID:22563483 NCBI chr 1:166,893,734...166,898,252
Ensembl chr 1:166,893,734...166,898,252
JBrowse link
G Plce1 phospholipase C, epsilon 1 increases expression ISO pyridaben results in increased expression of PLCE1 mRNA CTD PMID:22563483 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO pyridaben inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO pyridaben results in increased expression of PPARGC1A mRNA
pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]
CTD PMID:22563483, PMID:30818834 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prr7 proline rich 7 (synaptic) decreases expression ISO pyridaben results in decreased expression of PRR7 mRNA CTD PMID:22563483 NCBI chr17:9,693,274...9,702,795
Ensembl chr17:9,694,168...9,695,292
JBrowse link
G Retnlb resistin like beta increases expression ISO pyridaben results in increased expression of RETNLB mRNA CTD PMID:22563483 NCBI chr11:54,565,471...54,567,578
Ensembl chr11:54,565,472...54,567,357
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression ISO pyridaben results in increased expression of ROCK1 mRNA CTD PMID:22563483 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO pyridaben results in increased expression of S100A8 mRNA CTD PMID:22563483 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO pyridaben results in increased expression of S100A9 mRNA CTD PMID:22563483 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Shox2 short stature homeobox 2 decreases expression ISO pyridaben results in decreased expression of SHOX2 mRNA CTD PMID:22563483 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783
JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO pyridaben results in increased expression of SLC8A1 mRNA CTD PMID:22563483 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 increases expression ISO pyridaben results in increased expression of SMOC2 mRNA CTD PMID:22563483 NCBI chr 1:56,242,289...56,374,106
Ensembl chr 1:56,242,346...56,374,120
JBrowse link
G Snca synuclein alpha increases response to substance ISO SNCA protein results in increased susceptibility to pyridaben CTD PMID:16239214 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO pyridaben results in decreased expression of SOCS1 mRNA CTD PMID:22563483 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Ston2 stonin 2 increases expression ISO pyridaben results in increased expression of STON2 mRNA CTD PMID:22563483 NCBI chr 6:115,398,586...115,547,552
Ensembl chr 6:115,399,326...115,513,354
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression ISO pyridaben results in increased expression of STRBP mRNA CTD PMID:22563483 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
JBrowse link
G Tbck TBC1 domain containing kinase increases expression ISO pyridaben results in increased expression of TBCK mRNA CTD PMID:22563483 NCBI chr 2:237,751,646...237,958,497
Ensembl chr 2:237,751,654...237,958,497
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO pyridaben results in decreased expression of TCF15 mRNA CTD PMID:22563483 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
G Tmem42 transmembrane protein 42 decreases expression ISO pyridaben results in decreased expression of TMEM42 mRNA CTD PMID:22563483 NCBI chr 8:132,105,965...132,108,462
Ensembl chr 8:132,105,443...132,108,462
JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression ISO pyridaben results in increased expression of TNNT2 mRNA CTD PMID:22563483 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 increases expression ISO pyridaben results in increased expression of TRPM3 mRNA CTD PMID:22563483 NCBI chr 1:239,741,572...240,757,583
Ensembl chr 1:240,355,149...240,757,583
JBrowse link
G Ubxn7 UBX domain protein 7 increases expression ISO pyridaben results in increased expression of UBXN7 mRNA CTD PMID:22563483 NCBI chr11:71,662,786...71,695,031 JBrowse link
G Ucn urocortin decreases expression ISO pyridaben results in decreased expression of UCN mRNA CTD PMID:22563483 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
G Unc13c unc-13 homolog C increases expression ISO pyridaben results in increased expression of UNC13C mRNA CTD PMID:22563483 NCBI chr 8:80,202,736...80,656,363
Ensembl chr 8:80,203,609...80,631,926
JBrowse link
G Vdr vitamin D receptor increases activity ISO pyridaben results in increased activity of VDR protein CTD PMID:20143881 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 increases expression ISO pyridaben results in increased expression of ZBTB44 mRNA CTD PMID:22563483 NCBI chr 8:32,165,388...32,223,341
Ensembl chr 8:32,165,810...32,217,476
JBrowse link
G Zfp580 zinc finger protein 580 decreases expression ISO pyridaben results in decreased expression of ZFP580 mRNA CTD PMID:22563483 NCBI chr 1:72,338,468...72,340,636
Ensembl chr 1:72,338,877...72,339,395
JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 increases expression ISO pyridaben results in increased expression of ZHX3 mRNA CTD PMID:22563483 NCBI chr 3:156,759,820...156,868,173
Ensembl chr 3:156,764,751...156,777,999
JBrowse link
pyridaphenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyridafenthion binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          nitrogen atom 18539
            nitrogen molecular entity 18539
              organonitrogen compound 18309
                organonitrogen heterocyclic compound 17460
                  diazines 12138
                    pyridazines 120
                      pyridazinone 117
                        (5R)-6-(4-\{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino\}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 0
                        1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine 0
                        3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester 0
                        4-chloro-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-phenyl-3-pyridazinone 0
                        5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one 0
                        5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one 0
                        5-chloro-4-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one 0
                        6-hydroxy-2-phenylpyridazin-3-one + 1
                        Maleic hydrazide 3
                        Y 23684 0
                        chloridazon 0
                        chloridazone-methyl-desphenyl 0
                        clofencet 0
                        diclomezine 0
                        flufenpyr + 0
                        flufenpyr-ethyl 0
                        levosimendan 0
                        norflurazon 3
                        pimobendan 6
                        pyridaben 102
                        pyridaphenthion 1
                        zardaverine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    diazines 12138
                                      pyridazines 120
                                        pyridazinone 117
                                          (5R)-6-(4-\{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino\}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 0
                                          1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine 0
                                          3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester 0
                                          4-chloro-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-phenyl-3-pyridazinone 0
                                          5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one 0
                                          5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one 0
                                          5-chloro-4-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one 0
                                          6-hydroxy-2-phenylpyridazin-3-one + 1
                                          Maleic hydrazide 3
                                          Y 23684 0
                                          chloridazon 0
                                          chloridazone-methyl-desphenyl 0
                                          clofencet 0
                                          diclomezine 0
                                          flufenpyr + 0
                                          flufenpyr-ethyl 0
                                          levosimendan 0
                                          norflurazon 3
                                          pimobendan 6
                                          pyridaben 102
                                          pyridaphenthion 1
                                          zardaverine 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.