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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tannin
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Accession:CHEBI:26848 term browser browse the term
Definition:Any of a group of astringent polyphenolic vegetable principles or compounds, chiefly complex glucosides of catechol and pyrogallol.
Synonyms:related_synonym: tannins
 xref: Wikipedia:Tannin


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Besigomsin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO schizandrol B results in decreased activity of ACHE protein CTD PMID:16824513 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO schizandrol B promotes the reaction [Acetaminophen results in increased expression of BCL2 protein]
schizandrol B results in increased expression of BCL2 protein
CTD PMID:25319358 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO schizandrol B results in increased expression of CCND1 protein
schizandrol B promotes the reaction [Acetaminophen results in increased expression of CCND1 protein]
CTD PMID:25319358 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO schizandrol B inhibits the reaction [Acetaminophen results in increased activity of CDKN1A protein]; schizandrol B inhibits the reaction [Acetaminophen results in increased expression of CDKN1A protein] CTD PMID:25319358 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CYBB protein] CTD PMID:24211520 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO schizandrol B results in decreased activity of CYP1A2 protein CTD PMID:25753323 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
affects binding
ISO schizandrol B inhibits the reaction [CYP2E1 protein results in increased metabolism of and results in increased activity of Acetaminophen]
schizandrol B results in decreased activity of CYP2E1 protein
schizandrol B binds to CYP2E1 protein
CTD PMID:25319358 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B protein] CTD PMID:24211520 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] CTD PMID:24211520 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:24211520 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO schizandrol B binds to and results in increased activity of NR1I2 protein CTD PMID:16267138 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
ISO schizandrol B results in increased expression of PCNA protein
schizandrol B promotes the reaction [Acetaminophen results in increased expression of PCNA protein]
CTD PMID:25319358 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:24211520 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR4 protein] CTD PMID:24211520 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein] CTD PMID:24211520 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO schizandrol B inhibits the reaction [Acetaminophen results in increased activity of TRP53 protein]; schizandrol B inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of TRP53 protein] CTD PMID:25319358 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
Chebulagic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions EXP chebulagic acid inhibits the reaction [Ethanol results in increased expression of IL1B protein] CTD PMID:28963034 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP chebulagic acid inhibits the reaction [Ethanol results in decreased expression of MMP2 protein] CTD PMID:28963034 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [chebulagic acid co-treated with Ethanol] results in increased expression of TGFB1 protein CTD PMID:28963034 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP chebulagic acid inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:28963034 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP chebulagic acid inhibits the reaction [Ethanol results in decreased expression of VEGFA protein] CTD PMID:28963034 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Chebulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression ISO chebulinic acid results in decreased expression of ACHE protein CTD PMID:14769215 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Gata1 GATA binding protein 1 decreases expression
multiple interactions
ISO chebulinic acid results in decreased expression of GATA1 mRNA
chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]
CTD PMID:14769215 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO chebulinic acid promotes the reaction [Butyric Acid results in increased expression of GATA2 mRNA]
chebulinic acid results in increased expression of GATA2 mRNA
CTD PMID:14769215 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases expression
multiple interactions
ISO chebulinic acid results in decreased expression of HMBS mRNA
chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]
CTD PMID:14769215 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions
decreases expression
ISO chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of NFE2 mRNA]
chebulinic acid results in decreased expression of NFE2 mRNA
CTD PMID:14769215 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein] CTD PMID:25043994 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:25043994 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Chlorogenic Acid results in decreased activity of ACHE protein CTD PMID:20854806 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase increases expression ISO Chlorogenic Acid results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:23146752 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Chlorogenic Acid affects the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of ALB protein]
CTD PMID:11322927, PMID:23146752 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Chlorogenic Acid results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO Chlorogenic Acid results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO Chlorogenic Acid results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI protein] CTD PMID:23146752 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]
CTD PMID:25043994, PMID:28479099, PMID:28623112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in decreased expression of BCL2 protein]
CTD PMID:28479099, PMID:28623112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
CTD PMID:25043994, PMID:28479099 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein] CTD PMID:28623112 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP9 protein] CTD PMID:28479099 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in decreased activity of CAT protein]
CTD PMID:28479099, PMID:28623112, PMID:31390532 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:26079055, PMID:31306686 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein] CTD PMID:25043994 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Chlorogenic Acid results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Chlorogenic Acid results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of COL1A1 mRNA
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
CTD PMID:20706672, PMID:23146752 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cs citrate synthase increases activity ISO Chlorogenic Acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CXCL1 protein] CTD PMID:26079055 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cygb cytoglobin decreases expression ISO Chlorogenic Acid results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Chlorogenic Acid results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein] CTD PMID:25043994 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO Chlorogenic Acid results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:15,652,948...15,688,605
Ensembl chr18:15,650,526...15,688,284
JBrowse link
G Egf epidermal growth factor decreases expression ISO Chlorogenic Acid results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP Chlorogenic Acid results in decreased expression of ESR1 protein CTD PMID:29899696 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Chlorogenic Acid results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F10 coagulation factor X decreases activity ISO Chlorogenic Acid results in decreased activity of F10 protein CTD PMID:27704645 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II decreases activity ISO Chlorogenic Acid results in decreased activity of F2 protein CTD PMID:27704645 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Chlorogenic Acid results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbn2 fibrillin 2 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Chlorogenic Acid results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Chlorogenic Acid results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Chlorogenic Acid results in increased expression of GCLC mRNA
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]
CTD PMID:29136249 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chlorogenic Acid results in increased expression of GCLM mRNA CTD PMID:29136249 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of GPT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased activity of GPT protein]
CTD PMID:28479099, PMID:28623112, PMID:31390532 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grn granulin precursor increases expression ISO Chlorogenic Acid results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein] CTD PMID:28479099 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases activity ISO Chlorogenic Acid results in increased activity of GSTA1 protein CTD PMID:15944151 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases activity ISO Chlorogenic Acid results in increased activity of GSTA1 protein CTD PMID:15944151 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Chlorogenic Acid results in increased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO Chlorogenic Acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:34,357,372...34,537,798
Ensembl chr11:34,352,287...34,526,931
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
EXP
ISO
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]
Chlorogenic Acid results in decreased expression of HMGCR mRNA
CTD PMID:20696151, PMID:21870829 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Chlorogenic Acid results in increased expression of HMOX1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]
CTD PMID:25043994, PMID:29136249 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Chlorogenic Acid results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Chlorogenic Acid results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]
CTD PMID:23146752, PMID:24709313, PMID:26079055 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of IL6 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]
CTD PMID:21870829, PMID:23146752, PMID:26079055, PMID:31390532 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression
multiple interactions
EXP Chlorogenic Acid results in decreased expression of ITGB2 protein
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]
CTD PMID:21414398 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:15944151 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Krt5 keratin 5 increases expression ISO Chlorogenic Acid results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Chlorogenic Acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO Chlorogenic Acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK14 protein] CTD PMID:15944151 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Chlorogenic Acid results in increased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Chlorogenic Acid results in decreased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MPO protein] CTD PMID:26079055 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Chlorogenic Acid results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [Chlorogenic Acid co-treated with Zymosan] results in decreased expression of COX2 protein; Chlorogenic Acid inhibits the reaction [Zymosan results in increased expression of COX2 protein] CTD PMID:30481570 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 protein] CTD PMID:31390532 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]
CTD PMID:23146752, PMID:26079055 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
multiple interactions
increases response to substance
affects localization
decreases response to substance
ISO Chlorogenic Acid results in increased localization of NFE2L2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]; [Chlorogenic Acid co-treated with Acetaminophen] results in increased activity of and affects the localization of NFE2L2 protein; [Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein; U 0126 inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]
[Chlorogenic Acid co-treated with Acetaminophen] affects the localization of and results in increased activity of NFE2L2 protein
NFE2L2 results in increased susceptibility to Chlorogenic Acid
Chlorogenic Acid affects the localization of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Chlorogenic Acid
CTD PMID:15944151, PMID:29136249 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:20026373, PMID:23146752 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]
CTD PMID:20026373, PMID:23146752, PMID:28479099, PMID:31306686 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Chlorogenic Acid results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO Chlorogenic Acid results in increased activity of NQO1 protein
Chlorogenic Acid results in increased expression of NQO1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ocln occludin multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN protein] CTD PMID:31390532 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Chlorogenic Acid promotes the reaction [Cisplatin results in increased expression of PCNA protein] CTD PMID:25043994 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PECAM1 protein] CTD PMID:21414398 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgr progesterone receptor increases expression
decreases expression
ISO Chlorogenic Acid results in increased expression of PGR mRNA
Chlorogenic Acid results in decreased expression of PGR mRNA
CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Chlorogenic Acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Chlorogenic Acid results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Chlorogenic Acid results in increased expression of PPARG mRNA
Chlorogenic Acid results in decreased expression of PPARG mRNA
CTD PMID:20706672, PMID:21870829 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP2R1A protein CTD PMID:29136249 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP5C protein CTD PMID:29136249 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein]
CTD PMID:20026373, PMID:23146752, PMID:25043994, PMID:28479099, PMID:31306686 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Chlorogenic Acid results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO Chlorogenic Acid results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein] CTD PMID:20026373, PMID:26079055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Chlorogenic Acid results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sell selectin L multiple interactions EXP [Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein; Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein] CTD PMID:21414398 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein] CTD PMID:31390532 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in decreased expression of SLC22A2 protein] CTD PMID:25043994 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Chlorogenic Acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Chlorogenic Acid results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:29136249 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Chlorogenic Acid results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Chlorogenic Acid results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 protein] CTD PMID:31390532 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein] CTD PMID:26079055 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]
CTD PMID:23146752, PMID:26079055 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of TNF mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
CTD PMID:21870829, PMID:23146752, PMID:25043994, PMID:26079055, PMID:31306686, PMID:31390532 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein] CTD PMID:25043994 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO Chlorogenic Acid results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Chlorogenic Acid results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of Chlorogenic Acid
[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Chlorogenic Acid results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
corilagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30582900 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP corilagin inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; corilagin increases expression of nr1h4 mRNA and protein in rat embryonic liver cells RGD PMID:29235094 RGD:15042872 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO corilagin results in decreased secretion of TNF protein CTD PMID:12628509 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
Deoxyschizandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of AKT1 protein] CTD PMID:32057180 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO MEG3 protein affects the reaction [schizandrin A results in increased expression of BAX protein] CTD PMID:32057180 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO schizandrin A results in decreased expression of BCL2 protein
MEG3 protein affects the reaction [schizandrin A results in decreased expression of BCL2 protein]
CTD PMID:32057180 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO MEG3 protein affects the reaction [schizandrin A results in increased cleavage of CASP3 protein] CTD PMID:32057180 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO MEG3 protein affects the reaction [schizandrin A results in decreased expression of CCND1 protein] CTD PMID:32057180 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO schizandrin A results in decreased activity of CYP1A2 protein CTD PMID:25753323 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO schizandrin A results in decreased expression of MMP9 protein CTD PMID:32057180 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO schizandrin A results in decreased phosphorylation of NFKBIA protein
MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of NFKBIA protein]
CTD PMID:32057180 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO schizandrin A results in increased activity of NR1I2 protein
schizandrin A binds to and results in increased activity of NR1I2 protein
CTD PMID:16267138 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases phosphorylation
multiple interactions
ISO schizandrin A results in decreased phosphorylation of PIK3C3 protein
MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of PIK3C3 protein]
CTD PMID:32057180 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of RELA protein] CTD PMID:32057180 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO MEG3 protein affects the reaction [schizandrin A results in increased expression of TP53 protein] CTD PMID:32057180 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vim vimentin decreases expression ISO schizandrin A results in decreased expression of VIM protein CTD PMID:32057180 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
dieckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO dieckol results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:31291034 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases activity ISO dieckol results in increased activity of CASP3 protein CTD PMID:31291034 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO dieckol results in increased activity of CASP8 protein CTD PMID:31291034 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO dieckol results in increased activity of CASP9 protein CTD PMID:31291034 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdh1 cadherin 1 increases expression ISO dieckol results in increased expression of CDH1 protein CTD PMID:31291034 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO dieckol results in decreased expression of CDH2 protein CTD PMID:31291034 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO dieckol results in decreased expression of MMP1 mRNA; dieckol results in decreased expression of MMP1 protein CTD PMID:19330880 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO dieckol results in decreased expression of MMP13 mRNA; dieckol results in decreased expression of MMP13 protein CTD PMID:19330880 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO dieckol results in decreased expression of MMP3 mRNA; dieckol results in decreased expression of MMP3 protein CTD PMID:19330880 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO dieckol results in decreased expression of MMP9 protein CTD PMID:31291034 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO dieckol results in decreased phosphorylation of MTOR protein CTD PMID:31291034 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO dieckol results in decreased expression of NOS2 mRNA; dieckol results in decreased expression of NOS2 protein CTD PMID:19330880 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO dieckol results in decreased expression of PLAU protein CTD PMID:31291034 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dieckol results in decreased expression of PTGS2 mRNA; dieckol results in decreased expression of PTGS2 protein CTD PMID:19330880 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO dieckol results in decreased expression of RPS6KB1 protein CTD PMID:31291034 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO dieckol results in decreased expression of TWIST1 protein CTD PMID:31291034 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Vim vimentin decreases expression ISO dieckol results in decreased expression of VIM protein CTD PMID:31291034 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
eckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein CTD PMID:21514314 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein CTD PMID:21514314 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO eckol results in decreased expression of CTNNB1 protein CTD PMID:21514314 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO eckol results in decreased expression of CYBB protein CTD PMID:21514314 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
multiple interactions
ISO eckol results in increased phosphorylation of FOXO3 protein
FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
CTD PMID:24700636 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:21514314 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:21514314 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Msi1 musashi RNA-binding protein 1 decreases expression ISO eckol results in decreased expression of MSI1 protein CTD PMID:21514314 NCBI chr12:46,899,835...46,935,335
Ensembl chr12:46,895,447...46,920,952
JBrowse link
G Nes nestin decreases expression ISO eckol results in decreased expression of NES protein CTD PMID:21514314 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Prom1 prominin 1 decreases expression ISO eckol results in decreased expression of PROM1 protein CTD PMID:21514314 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases activity ISO eckol results in decreased activity of RAF1 protein CTD PMID:21514314 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO eckol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of SOD2 protein]; FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
eckol results in increased expression of SOD2 mRNA; eckol results in increased expression of SOD2 protein
CTD PMID:24700636 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO eckol results in decreased expression of SOX2 protein CTD PMID:21514314 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
Geraniin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of AKT1 protein] CTD PMID:27181634 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Geraniin results in increased cleavage of CASP3 protein CTD PMID:28590547 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Geraniin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein] CTD PMID:27181634 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:27181634 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein] CTD PMID:27181634 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Geraniin results in decreased phosphorylation of MAPK1 protein CTD PMID:31184425 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Geraniin results in decreased phosphorylation of MAPK3 protein CTD PMID:31184425 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO Geraniin results in decreased expression of MCL1 mRNA; Geraniin results in decreased expression of MCL1 protein
Geraniin inhibits the reaction [RELA protein binds to MCL1 promoter]
CTD PMID:28590547 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Geraniin results in decreased expression of and results in decreased activity of MMP2 protein; U 0126 inhibits the reaction [Geraniin results in decreased expression of and results in decreased activity of MMP2 protein] CTD PMID:31184425 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Geraniin promotes the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of NFE2L2 protein] CTD PMID:27181634 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIA protein]
Geraniin results in decreased phosphorylation of NFKBIA protein
CTD PMID:27181634, PMID:28590547 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of and results in increased activity of NOS2 protein] CTD PMID:27181634 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Geraniin results in decreased phosphorylation of PTK2 protein CTD PMID:31184425 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]
Geraniin inhibits the reaction [RELA protein binds to MCL1 promoter]
Geraniin results in decreased phosphorylation of RELA protein
CTD PMID:27181634, PMID:28590547 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Geraniin results in decreased phosphorylation of SRC protein CTD PMID:31184425 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO Geraniin results in decreased secretion of TNF protein
Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
CTD PMID:12628509, PMID:27181634 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
proanthocyanidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP Proanthocyanidins results in decreased activity of ACE protein CTD PMID:16390204 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Proanthocyanidins inhibits the reaction [Cadmium results in decreased activity of ACHE protein] CTD PMID:25463594 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:25088297 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of ATF1 mRNA] CTD PMID:26802905 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Proanthocyanidins results in increased expression of BAX mRNA; Proanthocyanidins results in increased expression of BAX protein
CTD PMID:18611398, PMID:29654773 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Proanthocyanidins results in decreased expression of BCL2 mRNA; Proanthocyanidins results in decreased expression of BCL2 protein
CTD PMID:18611398, PMID:29654773 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO Proanthocyanidins results in decreased expression of BCL2L11 mRNA CTD PMID:29205955 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Casp3 caspase 3 decreases expression
increases cleavage
increases expression
ISO Proanthocyanidins results in decreased expression of CASP3 mRNA
Proanthocyanidins results in increased cleavage of CASP3 protein
Proanthocyanidins results in increased expression of CASP3 mRNA
CTD PMID:29205955, PMID:29654773 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases activity ISO Proanthocyanidins results in increased activity of CAT protein CTD PMID:29205955 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO proanthocyanidin results in decreased expression of CCR2 mRNA CTD PMID:12462994
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO proanthocyanidin results in decreased expression of CCR3 mRNA; proanthocyanidin results in decreased expression of CCR3 protein CTD PMID:12462994 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO proanthocyanidin results in decreased expression of CCR5 mRNA CTD PMID:12462994 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of CREB1 mRNA] CTD PMID:26802905 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B1 protein]; Proanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B1 protein]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 mRNA]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 protein]; Proanthocyanidins inhibits the reaction [cyadox metabolite results in decreased expression of CYP11B1 mRNA]; Proanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B1 mRNA] CTD PMID:26802905 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 mRNA]; Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 protein]; Proanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B2 protein]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B2 protein]; Proanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B2 mRNA]; Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of CYP11B2 mRNA] CTD PMID:26802905 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25088297 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2S1 protein] CTD PMID:25088297 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of ERN1 protein] CTD PMID:25088297 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects binding
multiple interactions
EXP Proanthocyanidins binds to HMGCR protein
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]
CTD PMID:30273964 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA] CTD PMID:30273964 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein] CTD PMID:25088297 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of IL1B protein] CTD PMID:25088297 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein] CTD PMID:30273964 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA] CTD PMID:30273964 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein] CTD PMID:30273964 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK8 protein] CTD PMID:25088297 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK9 protein] CTD PMID:25088297 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPT protein] CTD PMID:25088297 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR4A1 mRNA] CTD PMID:26802905 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of NR4A2 mRNA] CTD PMID:26802905 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR5A1 mRNA] CTD PMID:26802905 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [3-chloroperbenzoic acid results in increased activity of ODC1 protein] CTD PMID:7653998 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein] CTD PMID:30273964 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of PTGS2 protein] CTD PMID:25088297 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate affects the localization of RELA protein] CTD PMID:25088297 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Snca synuclein alpha decreases expression ISO Proanthocyanidins results in decreased expression of SNCA protein CTD PMID:29976995 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of TNF protein] CTD PMID:25088297 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Proanthocyanidins results in increased expression of TP53 mRNA; Proanthocyanidins results in increased expression of TP53 protein CTD PMID:29654773 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
procyanidin B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein] CTD PMID:25199697 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of AKT1 protein CTD PMID:21945981 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of ALB protein] CTD PMID:25199697 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]
procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]
procyanidin B2 results in decreased expression of BAX protein
CTD PMID:21505870, PMID:27057282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA] CTD PMID:27057282 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2L11 mRNA] CTD PMID:27057282 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO procyanidin B2 results in increased expression of BRCA1 mRNA CTD PMID:25839702 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp1 caspase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of CASP1 protein] CTD PMID:30025709 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form]
3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]
procyanidin B2 results in decreased expression of CASP3 protein modified form
CTD PMID:21505870, PMID:27057282 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 decreases activity
multiple interactions
ISO procyanidin B2 results in decreased activity of CASP9 protein
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]
CTD PMID:21505870 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO
EXP
procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
procyanidin B2 inhibits the reaction [Carrageenan results in decreased activity of CAT protein]
CTD PMID:27057282, PMID:28844677 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:25199697 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh1 cadherin 1 increases expression ISO procyanidin B2 results in increased expression of CDH1 mRNA CTD PMID:25839702 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO procyanidin B2 affects the localization of CYCS protein
procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]
CTD PMID:21505870 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO procyanidin B2 results in increased expression of DNMT1 mRNA CTD PMID:25839702 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression ISO procyanidin B2 results in increased expression of DNMT3A mRNA CTD PMID:25839702 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta increases expression ISO procyanidin B2 results in increased expression of DNMT3B mRNA CTD PMID:25839702 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA] CTD PMID:27057282 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO procyanidin B2 results in increased expression of GSK3B protein modified form
procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]
CTD PMID:21505870 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of HMOX1 protein] CTD PMID:28844677 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il10 interleukin 10 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL10 protein] CTD PMID:28844677 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 protein] CTD PMID:30025709 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:30025709 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL6 protein] CTD PMID:28844677 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klk7 kallikrein-related peptidase 7 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of KLK3 protein] CTD PMID:28844677 NCBI chr 1:99,749,991...99,754,723
Ensembl chr 1:99,749,936...99,754,435
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of MAPK1 protein CTD PMID:21945981 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of MAPK3 protein CTD PMID:21945981 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing multiple interactions
affects response to substance
ISO procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form]
procyanidin B2 affects the susceptibility to MFGE8 protein
CTD PMID:21505870 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894
JBrowse link
G Mir122 microRNA 122 decreases expression EXP
ISO
procyanidin B2 results in decreased expression of MIR122 mRNA CTD PMID:24165878 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased activity of MPO protein] CTD PMID:30025709 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan affects the localization of NFE2L2 protein] CTD PMID:28844677 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of NLRP3 protein] CTD PMID:30025709 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 protein] CTD PMID:25199697 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 protein] CTD PMID:25199697 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of NQO1 protein] CTD PMID:28844677 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of PRKCA protein] CTD PMID:25199697 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:30025709 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO procyanidin B2 results in increased expression of SERPINB5 mRNA CTD PMID:25839702 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of TNF protein] CTD PMID:28844677 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO procyanidin B2 results in decreased activity of TOP2A protein CTD PMID:16536579 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA] CTD PMID:25199697 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:25199697 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
procyanidin B3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA CTD PMID:22169119 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Cat catalase multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of CAT mRNA CTD PMID:22169119 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22169119 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] CTD PMID:22169119 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA] CTD PMID:22169119 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA] CTD PMID:22169119 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA] CTD PMID:22169119 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA] CTD PMID:22169119 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA CTD PMID:22169119 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA] CTD PMID:22169119 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:22169119 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:22169119 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22169119 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA] CTD PMID:22169119 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22169119 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA] CTD PMID:22169119 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein; Eicosapentaenoic Acid promotes the reaction [[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein]; procyanidin B3 promotes the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in decreased phosphorylation of MAPK8 protein] CTD PMID:22169119 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA] CTD PMID:22169119 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 mRNA] CTD PMID:22169119 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO procyanidin B3 inhibits the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in increased phosphorylation of RELA protein] CTD PMID:22169119 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA] CTD PMID:22169119 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA] CTD PMID:22169119 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
Tellimagrandin I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO tellimagrandin I results in decreased activity of ACHE protein CTD PMID:14757314 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Gata1 GATA binding protein 1 decreases expression
multiple interactions
ISO tellimagrandin I results in decreased expression of GATA1 mRNA
tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]
CTD PMID:14757314 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO tellimagrandin I promotes the reaction [Butyric Acid results in increased expression of GATA2 mRNA]; tellimagrandin I promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GATA2 mRNA]
tellimagrandin I results in increased expression of GATA2 mRNA
CTD PMID:14757314 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions
decreases expression
ISO tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]
tellimagrandin I results in decreased expression of HMBS mRNA
CTD PMID:14757314 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO tellimagrandin I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:14757314 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions
decreases expression
ISO tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of NFE2 mRNA]
tellimagrandin I results in decreased expression of NFE2 mRNA
CTD PMID:14757314 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
Thonningianin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO thonningianin A results in decreased activity of GSTP1 protein CTD PMID:15234070 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
Wuweizisu C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO schizandrin C results in decreased activity of CYP1A2 protein CTD PMID:25753323 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO schizandrin C results in decreased activity of CYP2E1 protein CTD PMID:25753323 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            astringent 9327
              tannin 209
                3,4,3'-Tri-O-methylellagic acid 0
                4-(beta-D-glucopyranosyloxy)-3-methoxybenzoic acid 0
                5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol 0
                Alnusiin 0
                Ananosin A 0
                Besigomsin 16
                Casuarictin 0
                Casuarinin 0
                Chebulagic acid 5
                Chebulinic acid 5
                Chinese gallotannin 0
                Coriariin A 0
                Deoxygomisin A 0
                Deoxyschizandrin 13
                Fucofuroeckol B 0
                Gemin A 0
                Geraniin 16
                Gomisin B 0
                Gomisin L1 methyl ether 0
                Isogomisin O 0
                Isoterchebin 0
                Kadsurin, (-)- 0
                Mallotinic acid 0
                Mallotusinic acid 0
                Pedunculagin 0
                Rubrisandrin A(2:1 Inseparable mixture of regeoisomers) 0
                Rugosin D 0
                Saccharumoside A 0
                Saccharumoside B 0
                Schisantherin A 0
                Schizandrin 0
                Tellimagrandin I 6
                Terminalin 0
                Theasinensin A 0
                Theasinensin B 0
                Theasinensin C 0
                Thonningianin A 1
                Thonningianin B 0
                Vanillic acid-4-O-glucuronide 0
                Wuweizisu C 2
                Yunnankadsurin B 0
                agrimoniin 0
                benzoic acid [(2R,3S)-5,7-dibenzoyloxy-2-(3,4-dibenzoyloxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl] ester 0
                chlorogenic acid 110
                hydrolysable tannin + 3
                hyperidixanthone 0
                phlorotannin + 28
                proanthocyanidin + 90
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic aromatic compound 19154
                                  phenols 18145
                                    polyphenol 6668
                                      tannin 209
                                        3,4,3'-Tri-O-methylellagic acid 0
                                        4-(beta-D-glucopyranosyloxy)-3-methoxybenzoic acid 0
                                        5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol 0
                                        Alnusiin 0
                                        Ananosin A 0
                                        Besigomsin 16
                                        Casuarictin 0
                                        Casuarinin 0
                                        Chebulagic acid 5
                                        Chebulinic acid 5
                                        Chinese gallotannin 0
                                        Coriariin A 0
                                        Deoxygomisin A 0
                                        Deoxyschizandrin 13
                                        Fucofuroeckol B 0
                                        Gemin A 0
                                        Geraniin 16
                                        Gomisin B 0
                                        Gomisin L1 methyl ether 0
                                        Isogomisin O 0
                                        Isoterchebin 0
                                        Kadsurin, (-)- 0
                                        Mallotinic acid 0
                                        Mallotusinic acid 0
                                        Pedunculagin 0
                                        Rubrisandrin A(2:1 Inseparable mixture of regeoisomers) 0
                                        Rugosin D 0
                                        Saccharumoside A 0
                                        Saccharumoside B 0
                                        Schisantherin A 0
                                        Schizandrin 0
                                        Tellimagrandin I 6
                                        Terminalin 0
                                        Theasinensin A 0
                                        Theasinensin B 0
                                        Theasinensin C 0
                                        Thonningianin A 1
                                        Thonningianin B 0
                                        Vanillic acid-4-O-glucuronide 0
                                        Wuweizisu C 2
                                        Yunnankadsurin B 0
                                        agrimoniin 0
                                        benzoic acid [(2R,3S)-5,7-dibenzoyloxy-2-(3,4-dibenzoyloxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl] ester 0
                                        chlorogenic acid 110
                                        hydrolysable tannin + 3
                                        hyperidixanthone 0
                                        phlorotannin + 28
                                        proanthocyanidin + 90
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.