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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:styrene
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Accession:CHEBI:27452 term browser browse the term
Definition:A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.
Synonyms:related_synonym: Formula=C8H8;   InChI=1S/C8H8/c1-2-8-6-4-3-5-7-8/h2-7H,1H2;   InChIKey=PPBRXRYQALVLMV-UHFFFAOYSA-N;   Phenylethylene;   SMILES=C=Cc1ccccc1;   Styren;   Styrol;   ethenylbenzene;   phenylethene;   vinylbenzene
 alt_id: CHEBI:26796;   CHEBI:9296
 xref: Beilstein:1071236;   CAS:100-42-5;   Gmelin:2991;   HMDB:HMDB0034240;   KEGG:C07083
 xref_mesh: MESH:D020058
 xref: MetaCyc:CPD-1092;   PMID:11934013;   PMID:24320693;   Reaxys:1071236;   UM-BBD_compID:c0115;   Wikipedia:Styrene


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styrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity ISO Styrene results in decreased activity of ALAD protein CTD PMID:16140629 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alb albumin increases secretion
multiple interactions
ISO Styrene results in increased secretion of ALB protein
Styrene promotes the reaction [styrene oxide binds to ALB protein]
CTD PMID:10511253, PMID:15895243 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aqp9 aquaporin 9 increases expression EXP Styrene results in increased expression of AQP9 mRNA CTD PMID:17654243 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression ISO Styrene results in decreased expression of ARNTL mRNA CTD PMID:28951217 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Atf3 activating transcription factor 3 affects expression ISO Styrene affects the expression of ATF3 mRNA CTD PMID:28951217 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 increases expression EXP Styrene results in increased expression of ATP6V0D2 mRNA CTD PMID:17654243 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Styrene results in decreased expression of BAX protein CTD PMID:15212811 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Styrene results in increased expression of BCL2 protein CTD PMID:15212811 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Styrene results in increased expression of BCL2L1 protein CTD PMID:16705669 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Styrene results in decreased expression of BCL6 mRNA CTD PMID:28951217 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Styrene results in increased expression of BHLHE40 mRNA CTD PMID:28951217 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO Styrene results in decreased expression of BPTF mRNA CTD PMID:28951217 NCBI chr10:95,248,573...95,350,162
Ensembl chr10:95,250,294...95,349,789
JBrowse link
G Casp8 caspase 8 increases activity EXP Styrene results in increased activity of CASP8 protein CTD PMID:17420221 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity EXP Styrene results in increased activity of CASP9 protein CTD PMID:17420221 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases activity ISO Styrene results in decreased activity of CAT protein CTD PMID:16169704 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Styrene results in increased expression of CCL2 mRNA; Styrene results in increased expression of CCL2 protein CTD PMID:15212811, PMID:17993253 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 decreases expression ISO Styrene results in decreased expression of CCR1 mRNA; Styrene results in decreased expression of CCR1 protein CTD PMID:15212811 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Clock clock circadian regulator decreases expression ISO Styrene results in decreased expression of CLOCK mRNA CTD PMID:28951217 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
JBrowse link
G Clu clusterin decreases expression EXP Styrene results in decreased expression of CLU mRNA CTD PMID:17654243 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects response to substance ISO CYP1A1 gene polymorphism affects the susceptibility to Styrene CTD PMID:12604177 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]
Styrene results in increased expression of CYP1A2 mRNA; Styrene results in increased expression of CYP1A2 protein
CTD PMID:16418063, PMID:18202523 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]
Styrene results in increased expression of CYP2B1 mRNA; Styrene results in increased expression of CYP2B1 protein
CTD PMID:16418063, PMID:18202523 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
increases expression
EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]
Styrene results in increased expression of CYP2B2 mRNA; Styrene results in increased expression of CYP2B2 protein
CTD PMID:16418063, PMID:18202523 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Styrene results in decreased expression of CYP2C11 mRNA CTD PMID:16418063 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases metabolic processing
increases oxidation
increases metabolic processing
increases expression
affects response to substance
multiple interactions
increases response to substance
affects metabolic processing
affects oxidation
ISO
EXP
CYP2E1 gene polymorphism results in decreased metabolism of Styrene
CYP2E1 protein results in increased oxidation of Styrene
CYP2E1 protein results in increased metabolism of Styrene
Styrene results in increased expression of CYP2E1 mRNA
CYP2E1 gene polymorphism affects the susceptibility to Styrene
Styrene results in increased expression of CYP2E1 mRNA; Styrene results in increased expression of CYP2E1 protein
gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; [Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene
CYP2E1 protein results in increased susceptibility to Styrene
CYP2E1 protein affects the metabolism of Styrene
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene analog; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]; S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; Smoke inhibits the reaction [CYP2E1 protein affects the metabolism of Styrene]
CYP2E1 protein affects the oxidation of Styrene
CYP2E1 gene polymorphism results in increased susceptibility to Styrene; CYP2E1 protein results in increased susceptibility to Styrene
CYP2E1 gene polymorphism affects the metabolism of Styrene; CYP2E1 protein affects the metabolism of Styrene
CTD PMID:1664256, PMID:11535253, PMID:12464798, PMID:12604177, PMID:12746132, PMID:12893075, PMID:14751678, PMID:15110085, PMID:16125881, PMID:16418063, PMID:16872732, PMID:18202523, PMID:20117323, PMID:20470765, PMID:21030303, PMID:22366341, PMID:24320693, PMID:26463279 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases response to substance
decreases response to substance
increases metabolic processing
multiple interactions
ISO CYP2F2 protein results in increased susceptibility to Styrene
CYP2F2 gene mutant form results in decreased susceptibility to Styrene
CYP2F2 protein results in increased metabolism of Styrene
[CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of 4-vinylphenol; [CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of styrene glycol
CTD PMID:22386858, PMID:24320693, PMID:28962520 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein] CTD PMID:18202523 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Styrene results in increased expression of DBP mRNA CTD PMID:28951217 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Styrene results in increased expression of E2F8 mRNA CTD PMID:28951217 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Egr1 early growth response 1 increases expression
affects expression
ISO Styrene results in increased expression of EGR1 mRNA
Styrene affects the expression of EGR1 mRNA
CTD PMID:24086524, PMID:28951217 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
decreases response to substance
affects response to substance
EXP
ISO
Styrene results in increased expression of EPHX1 mRNA
EPHX1 protein results in decreased susceptibility to Styrene
EPHX1 gene polymorphism affects the susceptibility to Styrene
CTD PMID:14751678, PMID:16418063, PMID:22386858 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erg ETS transcription factor ERG decreases expression ISO Styrene results in decreased expression of ERG mRNA CTD PMID:28951217 NCBI chr11:35,645,317...35,749,637
Ensembl chr11:35,646,116...35,749,594
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression
ISO Styrene results in increased expression of FOS protein
Styrene affects the expression of FOS mRNA
CTD PMID:15212811, PMID:28951217 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gck glucokinase increases expression EXP Styrene results in increased expression of GCK mRNA CTD PMID:28678435 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity ISO Styrene results in increased activity of GCLC protein CTD PMID:16971035 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Glud1 glutamate dehydrogenase 1 affects expression EXP Styrene affects the expression of GLUD1 mRNA CTD PMID:28678435 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance
multiple interactions
affects response to substance
ISO GSTM1 gene polymorphism results in increased susceptibility to Styrene
GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]
GSTM1 gene polymorphism affects the susceptibility to Styrene
CTD PMID:12016165, PMID:12464798, PMID:12717779, PMID:14751678, PMID:14979085 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance
increases response to substance
multiple interactions
ISO GSTP1 exon polymorphism affects the susceptibility to Styrene; GSTP1 gene polymorphism affects the susceptibility to Styrene
GSTP1 gene polymorphism results in increased susceptibility to Styrene
GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene]
CTD PMID:11535253, PMID:12397415, PMID:12604177, PMID:12893075 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases response to substance
affects response to substance
ISO GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]
GSTT1 gene polymorphism affects the susceptibility to Styrene
CTD PMID:12016165, PMID:12717779, PMID:14751678, PMID:16424821 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hes6 hes family bHLH transcription factor 6 increases expression ISO Styrene results in increased expression of HES6 mRNA CTD PMID:28951217 NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438
JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member increases expression ISO Styrene results in increased expression of HLF mRNA CTD PMID:28951217 NCBI chr10:77,836,352...77,918,656
Ensembl chr10:77,840,568...77,918,191
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions
increases mutagenesis
ISO GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene] CTD PMID:11535253, PMID:12893075 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Styrene results in increased expression of HSPA1A protein CTD PMID:16705669 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Styrene results in increased expression of HSPA1L mRNA CTD PMID:24086524 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Styrene results in increased expression of IL1B mRNA
Styrene results in increased expression of and results in increased secretion of IL1B protein
CTD PMID:24086524 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 decreases expression ISO Styrene results in decreased expression of IL4 protein CTD PMID:16879906 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Styrene results in increased expression of IL6 mRNA
Styrene results in increased expression of and results in increased secretion of IL6 protein
CTD PMID:24086524 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO Styrene affects the expression of JUN protein CTD PMID:15212811 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf7 Kruppel like factor 7 decreases expression ISO Styrene results in decreased expression of KLF7 mRNA CTD PMID:28951217 NCBI chr 9:70,740,480...70,787,913
Ensembl chr 9:70,740,480...70,787,913
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS gene polymorphism results in increased susceptibility to Styrene CTD PMID:12807761 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 decreases expression ISO Styrene results in decreased expression of LCP2 mRNA; Styrene results in decreased expression of LCP2 protein CTD PMID:15212811 NCBI chr10:18,996,523...19,043,289
Ensembl chr10:18,996,523...19,043,286
JBrowse link
G Mxd3 Max dimerization protein 3 increases expression ISO Styrene results in increased expression of MXD3 mRNA CTD PMID:28951217 NCBI chr17:9,830,326...9,834,052
Ensembl chr17:9,830,332...9,839,452
JBrowse link
G Myb MYB proto-oncogene, transcription factor affects expression ISO Styrene affects the expression of MYB mRNA CTD PMID:28951217 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated affects expression
decreases expression
ISO Styrene affects the expression of NFIL3 mRNA
Styrene results in decreased expression of NFIL3 mRNA
CTD PMID:28951217 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression ISO Styrene results in decreased expression of NPAS2 mRNA CTD PMID:28951217 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects response to substance ISO NQO1 gene polymorphism affects the susceptibility to Styrene CTD PMID:14979085 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression ISO Styrene results in increased expression of NR1D1 mRNA CTD PMID:28951217 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO Styrene results in increased expression of NR1D2 mRNA CTD PMID:28951217 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 affects expression ISO Styrene affects the expression of NR4A1 mRNA CTD PMID:28951217 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Styrene results in decreased expression of NR4A2 mRNA CTD PMID:28951217 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Styrene results in decreased expression of NR4A3 mRNA CTD PMID:28951217 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase affects response to substance
increases expression
ISO OGG1 protein polymorphism affects the susceptibility to Styrene
Styrene results in increased expression of OGG1 mRNA
CTD PMID:19563869, PMID:21030303 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 increases expression EXP Styrene results in increased expression of PACSIN3 mRNA CTD PMID:17654243 NCBI chr 3:80,072,425...80,081,058
Ensembl chr 3:80,072,489...80,081,047
JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Styrene results in increased expression of PER2 mRNA CTD PMID:28951217 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Per3 period circadian regulator 3 increases expression ISO Styrene results in increased expression of PER3 mRNA CTD PMID:28951217 NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395
JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
increases response to substance
ISO POR protein results in increased metabolism of Styrene
POR protein results in increased susceptibility to Styrene
CTD PMID:22386858 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP Styrene results in increased expression of PRDX1 mRNA CTD PMID:17654243 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Styrene results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Styrene results in increased expression of PTGS2 protein] CTD PMID:21801798 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone increases response to substance ISO PTHLH gene polymorphism results in increased susceptibility to Styrene CTD PMID:12807761 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO Styrene results in increased expression of RAF1 protein CTD PMID:15212811 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rora RAR-related orphan receptor A decreases expression ISO Styrene results in decreased expression of RORA mRNA CTD PMID:28951217 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression ISO Styrene results in decreased expression of SCGB1A1 mRNA CTD PMID:19428955 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Styrene results in decreased expression of SLC2A2 mRNA CTD PMID:28678435 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Sp5 Sp5 transcription factor increases expression ISO Styrene results in increased expression of SP5 mRNA CTD PMID:28951217 NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277
JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression ISO Styrene results in increased expression of TEF mRNA CTD PMID:28951217 NCBI chr 7:123,033,971...123,058,606
Ensembl chr 7:123,043,503...123,058,604
JBrowse link
G Tex101 testis expressed 101 increases expression EXP Styrene results in increased expression of TEX101 mRNA CTD PMID:17654243 NCBI chr 1:81,529,776...81,534,149
Ensembl chr 1:81,529,781...81,534,140
JBrowse link
G Tfec transcription factor EC affects expression ISO Styrene affects the expression of TFEC mRNA CTD PMID:28951217 NCBI chr 4:44,063,533...44,136,815
Ensembl chr 4:44,065,045...44,136,815
JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression ISO Styrene affects the expression of TGFB2 mRNA; Styrene affects the expression of TGFB2 protein CTD PMID:16705669 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 affects expression ISO Styrene affects the expression of TGFBR3 mRNA; Styrene affects the expression of TGFBR3 protein CTD PMID:16705669 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Styrene results in increased expression of and results in increased secretion of TNF protein
Styrene results in increased expression of TNF mRNA
CTD PMID:24086524 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression
multiple interactions
ISO Styrene results in increased expression of TNFSF10 mRNA
Styrene results in increased expression of and results in increased secretion of TNFSF10 protein
CTD PMID:24086524 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases response to substance ISO TRPA1 results in increased susceptibility to Styrene CTD PMID:20176620 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases response to substance
increases expression
affects response to substance
ISO XRCC1 gene polymorphism results in increased susceptibility to Styrene
Styrene results in increased expression of XRCC1 mRNA
XRCC1 protein polymorphism affects the susceptibility to Styrene
CTD PMID:15468052, PMID:15992842, PMID:21030303 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 affects response to substance ISO XRCC3 protein polymorphism affects the susceptibility to Styrene CTD PMID:15468052 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Styrene results in decreased expression of ZBTB20 mRNA CTD PMID:28951217 NCBI chr11:62,014,925...62,561,113
Ensembl chr11:62,014,925...62,451,184
JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 decreases expression ISO Styrene results in decreased expression of ZKSCAN3 mRNA CTD PMID:28951217 NCBI chr17:45,247,724...45,263,422
Ensembl chr17:45,247,776...45,263,418
JBrowse link
4-hydroxystyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions
increases abundance
ISO [CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of 4-vinylphenol
CYP2F2 protein results in increased abundance of 4-vinylphenol
CTD PMID:24320693 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
styrene oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
ISO styrene oxide promotes the reaction [styrene oxide binds to ALB protein]; Styrene promotes the reaction [styrene oxide binds to ALB protein] CTD PMID:10511253 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
increases expression
ISO
EXP
styrene oxide affects the expression of BAX mRNA
styrene oxide results in increased expression of BAX protein
CTD PMID:11230554, PMID:12663515 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
ISO
EXP
styrene oxide affects the expression of BCL2 mRNA
styrene oxide results in decreased expression of BCL2 protein
CTD PMID:11230554, PMID:12663515 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO styrene oxide results in increased expression of BCL2L1 protein CTD PMID:16705669 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP
styrene oxide results in increased activity of CASP3 protein CTD PMID:11929631, PMID:12663515, PMID:17662326, PMID:19666080 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO styrene oxide affects the expression of CDKN1A mRNA CTD PMID:11230554 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis ISO CYP2E1 results in increased chemical synthesis of styrene oxide; CYP2E1 results in increased chemical synthesis of styrene oxide analog CTD PMID:22366341 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases chemical synthesis ISO CYP2F2 protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions
affects hydrolysis
EXP
ISO
CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]
EPHX1 protein affects the metabolism of and results in decreased activity of styrene oxide
CTD PMID:11076696, PMID:12051674, PMID:12694745 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO styrene oxide results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases response to substance
multiple interactions
affects metabolic processing
ISO
EXP
GSTM1 protein results in decreased susceptibility to styrene oxide
GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
GSTM1 protein affects the metabolism of styrene oxide
CTD PMID:1638515, PMID:2604743, PMID:11424177, PMID:11599931, PMID:14698568, PMID:17689871 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing
multiple interactions
EXP GSTM2 protein affects the metabolism of styrene oxide
GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
CTD PMID:1638515, PMID:2604743 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 exon polymorphism affects the susceptibility to styrene oxide CTD PMID:12694745 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases response to substance
affects response to substance
ISO GSTT1 gene polymorphism results in increased susceptibility to styrene oxide
GSTT1 protein affects the susceptibility to styrene oxide
CTD PMID:12016165, PMID:15468052 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hbb hemoglobin subunit beta affects binding ISO styrene oxide binds to HBB protein CTD PMID:11948819 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO styrene oxide results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
ISO styrene oxide results in increased expression of HMOX1 protein
styrene oxide results in increased activity of HMOX1 protein
CTD PMID:15582351 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO styrene oxide results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO styrene oxide results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO styrene oxide results in increased expression of MYC protein CTD PMID:16705669 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO styrene oxide results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO styrene oxide results in increased cleavage of PARP1 protein CTD PMID:11929631, PMID:17662326 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO styrene oxide results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Por cytochrome p450 oxidoreductase increases chemical synthesis ISO POR protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO styrene oxide results in decreased expression of RAC1 protein CTD PMID:17662326 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression ISO styrene oxide results in decreased expression of SCGB1A1 mRNA; styrene oxide results in decreased expression of SCGB1A1 protein CTD PMID:19428955 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO styrene oxide results in increased cleavage of SPTAN1 protein CTD PMID:11929631 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Syp synaptophysin decreases expression ISO styrene oxide results in decreased expression of SYP protein CTD PMID:17662326 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression ISO styrene oxide affects the expression of TGFB2 mRNA; styrene oxide affects the expression of TGFB2 protein CTD PMID:16705669 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 affects expression ISO styrene oxide affects the expression of TGFBR3 mRNA; styrene oxide affects the expression of TGFBR3 protein CTD PMID:16705669 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO styrene oxide results in increased expression of TNFRSF9 mRNA CTD PMID:22723965 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tp53 tumor protein p53 affects expression ISO styrene oxide affects the expression of TP53 mRNA CTD PMID:11230554 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects response to substance ISO XRCC1 protein polymorphism affects the susceptibility to styrene oxide CTD PMID:15468052 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
tetrachlorvinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tetrachlorvinphos metabolite results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Tetrachlorvinphos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          genotoxin 16978
            mutagen 16794
              styrene 107
                1-phenylethenol + 2
                4-hydroxystyrene + 1
                styrene oxide + 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      styrenes 221
                                        styrene 107
                                          1-phenylethenol + 2
                                          4-hydroxystyrene + 1
                                          styrene oxide + 37
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.