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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isatin
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Accession:CHEBI:27539 term browser browse the term
Definition:An indoledione that is the 2,3-diketo derivative of indole.
Synonyms:exact_synonym: 1H-indole-2,3-dione
 related_synonym: Formula=C8H5NO2;   InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11);   InChIKey=JXDYKVIHCLTXOP-UHFFFAOYSA-N;   SMILES=O=C1Nc2ccccc2C1=O;   indole-2,3-dione
 alt_id: CHEBI:24879;   CHEBI:43625;   CHEBI:5978
 xref: Beilstein:383659;   CAS:91-56-5;   DrugBank:DB02095;   Gmelin:165206;   KEGG:C11129;   KNApSAcK:C00026981
 xref_mesh: MESH:D007510
 xref: MetaCyc:ISATIN;   PDBeChem:ISN;   PMID:15876476;   PMID:16236622;   PMID:1650428;   PMID:17330218;   PMID:17447419;   PMID:19834914;   PMID:23744416;   PMID:26846278;   PMID:9510091;   Reaxys:383659;   Wikipedia:Isatin


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isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Isatin CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 affects reduction
increases reduction
ISO Isatin affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of Isatin
CTD PMID:10510318, PMID:12604212 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin] CTD PMID:23295225 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 increases metabolic processing ISO CBR3 protein results in increased metabolism of Isatin CTD PMID:19061875 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression ISO Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Isatin results in increased expression of CYP2E1 mRNA CTD PMID:15056799 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Isatin CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Isatin CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10] CTD PMID:24316276 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO] CTD PMID:24316276 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2] CTD PMID:24316276 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]; SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF] CTD PMID:24316276 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              plant metabolite 17424
                isatin 19
                  1-methyl-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 0
                  5-(6-aminohexanamido)isatin 0
                  5-aminoisatin 0
                  6-(3'-methylbuten-2-yl)isatin 0
                  N-acetylisatin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      benzopyrrole 9530
                                        indoles 9198
                                          indolones 5850
                                            indoledione 19
                                              isatin 19
                                                1-methyl-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 0
                                                5-(6-aminohexanamido)isatin 0
                                                5-aminoisatin 0
                                                6-(3'-methylbuten-2-yl)isatin 0
                                                N-acetylisatin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.