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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aldosterone
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Accession:CHEBI:27584 term browser browse the term
Definition:A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Synonyms:exact_synonym: 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
 related_synonym: (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al;   11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1;   InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C=O)C(=O)CO
 alt_id: CHEBI:22306;   CHEBI:2563;   CHEBI:40919
 xref: Beilstein:3224996;   CAS:52-39-1;   DrugBank:DB04630;   Drug_Central:111;   HMDB:HMDB0000037;   KEGG:C01780;   LINCS:LSM-42770;   LIPID_MAPS_instance:LMST02030026
 xref_mesh: MESH:D000450
 xref: PDBeChem:AS4;   PMID:10438974;   Reaxys:3224996;   Wikipedia:Aldosterone


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aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases secretion
increases expression
multiple interactions
ISO ABCB1 protein results in increased secretion of Aldosterone
Aldosterone results in increased expression of ABCB1 mRNA
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]
CTD PMID:12387747, PMID:22464980 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace angiotensin I converting enzyme increases activity
multiple interactions
increases expression
EXP Aldosterone results in increased activity of ACE protein
AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Genistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; RTKI cpd inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]
CTD PMID:15932931 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO
EXP
Aldosterone results in increased expression of ACTA2 mRNA; Aldosterone results in increased expression of ACTA2 protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]
eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]
CTD PMID:17596522, PMID:25204689 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen increases abundance
multiple interactions
increases secretion
increases expression
ISO
EXP
AGT protein modified form results in increased abundance of Aldosterone; AGT protein results in increased abundance of Aldosterone
AGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone]
AGT protein results in increased secretion of Aldosterone
Aldosterone results in increased expression of AGT protein alternative form
AGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]
[AGT co-treated with REN] results in increased abundance of Aldosterone; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]; efonidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Mibefradil inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]
CTD PMID:6257467, PMID:7588239, PMID:8952583, PMID:11549694, PMID:16788141, PMID:17303656, PMID:18331727, PMID:18660453, PMID:18679781, PMID:19371736, PMID:20175999, PMID:22452651, PMID:22798349, PMID:25617244, PMID:26564064 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
ISO
EXP
[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone
Aldosterone results in increased expression of AGTR1A mRNA
CTD PMID:9087624, PMID:9124547, PMID:15302841 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Aldosterone results in increased expression of AGTR2 mRNA CTD PMID:15809360 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of Aldosterone CTD PMID:25500266 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [Acetaminophen results in increased abundance of Aldosterone] CTD PMID:1825077 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; alachlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Atrazine metabolite inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; bifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; cypermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Dimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fenvalerate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fipronil inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Methoxychlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Permethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; terbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Zineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP [Aldosterone co-treated with Lithium] affects the expression of AQP2 protein CTD PMID:16159898 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Aldosterone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:15755911 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
EXP
ISO
Aldosterone results in increased expression of CCN2 protein
Aldosterone results in increased expression of CTGF mRNA
Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein]
CTD PMID:17278980, PMID:30809271 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] CTD PMID:27773435 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO Aldosterone results in decreased expression of CDH1 mRNA; Aldosterone results in decreased expression of CDH1 protein
eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]
CTD PMID:17596522 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] CTD PMID:27773435 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Aldosterone results in increased expression of COL1A2 mRNA CTD PMID:30809271 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO
EXP
Aldosterone results in increased expression of COL3A1 mRNA
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA]
CTD PMID:27773435, PMID:30809271 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]] CTD PMID:18682491 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Crebbp CREB binding protein multiple interactions EXP Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]; Aldosterone results in increased expression of and results in increased localization of CREBBP protein CTD PMID:19966502 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases chemical synthesis
affects chemical synthesis
multiple interactions
ISO
EXP
CYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone; CYP11B2 protein results in increased chemical synthesis of Aldosterone
CYP11B2 protein affects the chemical synthesis of Aldosterone
[CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of Aldosterone
CTD PMID:12525251, PMID:12783697, PMID:16043663, PMID:16054388, PMID:19900470, PMID:21384875 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Dab2 DAB adaptor protein 2 multiple interactions EXP AGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone] CTD PMID:17303656 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 multiple interactions ISO Aldosterone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of DHRS3 protein] CTD PMID:23275455 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP Aldosterone results in increased expression of EDN1 protein
[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]
CTD PMID:18660453 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Aldosterone results in increased expression of EGFR mRNA CTD PMID:11507004 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of F2R mRNA CTD PMID:27773435 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Faslg Fas ligand increases expression EXP Aldosterone results in increased expression of FASLG protein CTD PMID:19001025 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gas6 growth arrest specific 6 increases expression
multiple interactions
EXP Aldosterone results in increased expression of GAS6 protein
NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]
CTD PMID:19564549 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP Aldosterone results in increased expression of GATA4 protein CTD PMID:19966502 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP Aldosterone results in increased expression of GCLC protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]; tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein]
CTD PMID:24512358, PMID:25204689 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Aldosterone results in increased expression of GSTP1 protein CTD PMID:25204689 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Aldosterone results in increased expression of HMOX1 protein CTD PMID:25204689 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression EXP Aldosterone results in increased expression of HNRNPA2B1 mRNA; Aldosterone results in increased expression of HNRNPA2B1 protein CTD PMID:23139218 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hpse heparanase increases expression
multiple interactions
EXP Aldosterone results in increased expression of HPSE mRNA; Aldosterone results in increased expression of HPSE protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]
CTD PMID:19429930 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions
EXP Aldosterone results in increased expression of IL18 mRNA; Aldosterone results in increased expression of IL18 protein
[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; SN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]
CTD PMID:18660453 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il6 interleukin 6 increases expression ISO Aldosterone results in increased expression of IL6 protein CTD PMID:17043157 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation
multiple interactions
EXP Aldosterone results in increased phosphorylation of JAK2 protein
Dactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]
CTD PMID:15932931 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions
decreases secretion
ISO KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone]
KCNJ5 protein results in decreased secretion of Aldosterone
CTD PMID:22798349 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:17596522 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects chemical synthesis ISO MAPK14 protein affects the chemical synthesis of Aldosterone CTD PMID:14592955 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:17596522 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
EXP [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] CTD PMID:17616752, PMID:19333130 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 increases expression
multiple interactions
EXP Aldosterone results in increased expression of MTF1 mRNA; Aldosterone results in increased expression of MTF1 protein
Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]
CTD PMID:19333130 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase multiple interactions ISO Aldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein] CTD PMID:23348737 NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
multiple interactions
EXP Aldosterone results in increased activity of NFE2L2 protein
Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]
CTD PMID:25204689 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nol3 nucleolar protein 3 decreases phosphorylation EXP Aldosterone results in decreased phosphorylation of NOL3 protein CTD PMID:19001025 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases secretion
increases expression
EXP
ISO
Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]
NPPA protein results in decreased secretion of Aldosterone
CTD PMID:2434734, PMID:2931268, PMID:19966502 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B decreases abundance
affects abundance
ISO NPPB protein results in decreased abundance of Aldosterone
NPPB affects the abundance of Aldosterone
CTD PMID:16333235, PMID:20339970 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
increases activity
decreases expression
ISO
EXP
Aldosterone binds to and results in increased activity of NR3C1 protein
NR3C1 protein binds to Aldosterone
Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]
Aldosterone results in increased activity of NR3C1 protein
Aldosterone results in decreased expression of NR3C1 mRNA
Aldosterone binds to NR3C1 protein mutant form
CTD PMID:1597467, PMID:8969928, PMID:11861974, PMID:15362971, PMID:15774500, PMID:22465009 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
increases activity
increases phosphorylation
decreases expression
affects localization
increases expression
affects binding
ISO
EXP
4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; alachlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; alachlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Aldosterone binds to and results in increased activity of NR3C2 protein; Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; Aldosterone results in decreased expression of and affects the ubiquitination of NR3C2 protein; Atrazine metabolite inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Atrazine metabolite inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bisphenol A inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bisphenol B inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; cypermethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; cypermethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dihydrotestosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; fenvalerate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; fipronil inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Methoxychlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Methoxychlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Permethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Permethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Pesticides inhibits the reaction [Aldosterone results in increased expression of NR3C2 mRNA]; Soil Pollutants inhibits the reaction [Aldosterone results in increased expression of NR3C2 mRNA]; Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Aldosterone results in increased phosphorylation of NR3C2 protein
Aldosterone results in decreased expression of NR3C2 protein
Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; FR 180204 inhibits the reaction [Aldosterone results in increased phosphorylation of NR3C2 protein]
Aldosterone results in increased expression of NR3C2 mRNA; Aldosterone results in increased expression of NR3C2 protein
Aldosterone binds to NR3C2 protein
Aldosterone results in decreased expression of NR3C2 mRNA
Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]; Aldosterone results in increased expression of and results in increased localization of NR3C2 protein; NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]; torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein]
CTD PMID:7954537, PMID:8798622, PMID:8969928, PMID:15362971, PMID:15780662, PMID:15974890, PMID:17105867, PMID:17596522, PMID:19564549, PMID:19966502, PMID:20207834, PMID:20508287, PMID:22798426, PMID:29149346, PMID:29248852, PMID:30951782 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions
increases expression
ISO Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein]
Aldosterone results in increased expression of OLR1 mRNA; Aldosterone results in increased expression of OLR1 protein
CTD PMID:20508287 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of PLAT mRNA CTD PMID:27773435 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plg plasminogen multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased activity of PLG protein modified form CTD PMID:27773435 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases abundance
decreases abundance
ISO
EXP
Dexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone]
POMC results in increased secretion of Aldosterone
POMC protein results in decreased abundance of Aldosterone
CTD PMID:1659878, PMID:2551692, PMID:3015796 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects abundance ISO PPARG protein affects the abundance of Aldosterone CTD PMID:16007095 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Aldosterone results in increased expression of PPARGC1A mRNA CTD PMID:19808358 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
EXP Aldosterone results in increased activity of RELA protein
Bezafibrate inhibits the reaction [Aldosterone results in increased activity of RELA protein]; pioglitazone inhibits the reaction [Aldosterone results in increased activity of RELA protein]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased activity of RELA protein]; SN50 peptide inhibits the reaction [Aldosterone results in increased activity of RELA protein]
CTD PMID:18660453 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions ISO [AGT co-treated with REN] results in increased abundance of Aldosterone; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] CTD PMID:18679781 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha increases expression
multiple interactions
affects expression
ISO Aldosterone results in increased expression of SCNN1A mRNA; Aldosterone results in increased expression of SCNN1A protein
Aldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein]
Aldosterone affects the expression of SCNN1A mRNA
CTD PMID:16555725, PMID:18665318, PMID:23348737 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta increases expression ISO Aldosterone results in increased expression of SCNN1B mRNA; Aldosterone results in increased expression of SCNN1B protein CTD PMID:18665318 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma increases expression ISO Aldosterone results in increased expression of SCNN1G mRNA; Aldosterone results in increased expression of SCNN1G protein CTD PMID:18665318 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
EXP
ISO
[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA; [Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein; [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of SERPINE1 mRNA; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Aldosterone results in increased expression of SERPINE1 mRNA
CTD PMID:18682491, PMID:27773435, PMID:30809271 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases expression
increases expression
EXP
ISO
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]
Aldosterone results in decreased expression of SGK1 protein
TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein]
CTD PMID:15130897, PMID:19429930, PMID:22798426 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] CTD PMID:12668585 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression
EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] CTD PMID:19333130 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc39a1 solute carrier family 39 member 1 multiple interactions
increases expression
EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] CTD PMID:19333130 NCBI chr 2:189,609,766...189,615,367
Ensembl chr 2:189,609,800...189,615,366
JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases expression
multiple interactions
EXP Aldosterone results in increased expression of SLC9A1 mRNA
eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA]
CTD PMID:16373419 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions
increases abundance
ISO AGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone] CTD PMID:26564064 NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] CTD PMID:17596522 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases activity
EXP [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein; [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein; Amlodipine inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] CTD PMID:17616752, PMID:19333130 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA] CTD PMID:22465009 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
multiple interactions
increases expression
EXP Aldosterone results in increased secretion of TGFB1 protein
[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein; [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]
CTD PMID:15130897, PMID:18682491, PMID:25204689, PMID:27773435 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] CTD PMID:27773435 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tsg101 tumor susceptibility 101 multiple interactions ISO Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein] CTD PMID:22798426 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; cicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Indomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; pirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        organic group 18495
          3-oxo-Delta(4)-steroid group 7935
            3-oxo-Delta(4) steroid 7935
              aldosterone 74
                5beta-dihydroaldosterone 0
                aldosterone hemiacetal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            formyl group 7847
                                              aldehyde 7847
                                                steroid aldehyde 90
                                                  aldosterone 74
                                                    5beta-dihydroaldosterone 0
                                                    aldosterone hemiacetal 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.