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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:27584 term browser browse the term
Definition:A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Synonyms:exact_synonym: 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
 related_synonym: (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al;   11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1;   InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C=O)C(=O)CO
 alt_id: CHEBI:22306;   CHEBI:2563;   CHEBI:40919
 xref: Beilstein:3224996;   CAS:52-39-1;   DrugBank:DB04630;   Drug_Central:111;   HMDB:HMDB0000037;   KEGG:C01780;   LINCS:LSM-42770;   LIPID_MAPS_instance:LMST02030026
 xref_mesh: MESH:D000450
 xref: PDBeChem:AS4;   PMID:10438974;   Reaxys:3224996;   Wikipedia:Aldosterone

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aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    chemical entity 227
      group 220
        organic group 154
          3-oxo-Delta(4)-steroid group 20
            3-oxo-Delta(4) steroid 20
              aldosterone 2
                5beta-dihydroaldosterone 0
                aldosterone hemiacetal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 227
    subatomic particle 227
      composite particle 227
        hadron 227
          baryon 227
            nucleon 227
              atomic nucleus 227
                atom 227
                  main group element atom 220
                    p-block element atom 220
                      carbon group element atom 208
                        carbon atom 207
                          organic molecular entity 207
                            organic group 154
                              organic divalent group 153
                                organodiyl group 153
                                  carbonyl group 153
                                    carbonyl compound 153
                                      carboxylic acid 114
                                        carboacyl group 48
                                          univalent carboacyl group 48
                                            formyl group 4
                                              aldehyde 4
                                                steroid aldehyde 2
                                                  aldosterone 2
                                                    5beta-dihydroaldosterone 0
                                                    aldosterone hemiacetal 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.