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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antimycin A
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Accession:CHEBI:2762 term browser browse the term
Definition:A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.
Synonyms:exact_synonym: (2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate
 related_synonym: Antimycin A1;   Antipiricullin;   Fintrol;   Formula=C28H40N2O9;   InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23+,25+/m1/s1;   InChIKey=UIFFUZWRFRDZJC-SBOOETFBSA-N;   SMILES=C1([C@H]([C@H](OC([C@@H]([C@H]([C@@H](O1)C)OC(CC(C)C)=O)CCCCCC)=O)C)NC(C2=C(C(=CC=C2)NC(=O)[H])O)=O)=O;   Virosin;   antimycin A1b
 alt_id: CHEBI:22584;   CHEBI:40908
 xref: Beilstein:72665;   CAS:1397-94-0;   CAS:642-15-9;   KEGG:C11339
 xref_mesh: MESH:D000968
 xref: MetaCyc:CPD-5744;   PDBeChem:AY1;   PMID:16819166


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antimycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox2 acyl-CoA oxidase 2 increases expression ISO Antimycin A results in increased expression of ACOX2 mRNA CTD PMID:19304788 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO Antimycin A results in increased expression of AKR1B7 mRNA CTD PMID:19304788 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases activity
ISO Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein] CTD PMID:21466842, PMID:21782929 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Antimycin A results in increased expression of ALDH1L2 mRNA CTD PMID:19304788 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression ISO Antimycin A results in increased expression of ANGPTL6 mRNA CTD PMID:19304788 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Antimycin A results in increased expression of ATF3 mRNA CTD PMID:19304788 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg13 autophagy related 13 multiple interactions ISO Antimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]; ATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein] CTD PMID:27629431 NCBI chr 3:80,580,549...80,614,554
Ensembl chr 3:80,581,247...80,601,410
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA CTD PMID:28366621 NCBI chr 5:14,262,352...14,367,898
Ensembl chr 5:14,262,349...14,367,898
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein] CTD PMID:24040102 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
multiple interactions
ISO BCL2 protein results in decreased susceptibility to Antimycin A
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Antimycin A]
CTD PMID:12730627 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO Antimycin A results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD PMID:23624148 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Antimycin A results in increased expression of BNIP3 mRNA CTD PMID:19304788 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Ca6 carbonic anhydrase 6 increases expression ISO Antimycin A results in increased expression of CAR6 mRNA CTD PMID:19304788 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786
JBrowse link
G Casp1 caspase 1 increases activity ISO Antimycin A results in increased activity of CASP1 protein CTD PMID:30582969 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO
EXP
Antimycin A results in increased cleavage of CASP3 protein
Antimycin A results in increased activity of CASP3 protein
NAD inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Niacinamide promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]
CTD PMID:11078377, PMID:24040102 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Antimycin A results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Antimycin A results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Antimycin A results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Antimycin A results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions
ISO Antimycin A results in decreased expression of CCNA2 mRNA; Antimycin A results in decreased expression of CCNA2 protein
Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]
CTD PMID:12730239 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
Antimycin A results in decreased expression of CCNB1 mRNA; Antimycin A results in decreased expression of CCNB1 protein
CTD PMID:12730239 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd14 CD14 molecule increases expression ISO Antimycin A results in increased expression of CD14 mRNA CTD PMID:10491287 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd34 CD34 molecule decreases expression ISO Antimycin A results in decreased expression of CD34 mRNA CTD PMID:19304788 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd38 CD38 molecule increases expression ISO Antimycin A results in increased expression of CD38 mRNA CTD PMID:10491287 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd68 Cd68 molecule increases expression ISO Antimycin A results in increased expression of CD68 mRNA CTD PMID:19304788 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 increases expression ISO Antimycin A results in increased expression of CHCHD10 mRNA CTD PMID:19304788 NCBI chr20:13,665,046...13,666,845
Ensembl chr20:13,665,031...13,667,333
JBrowse link
G Col16a1 collagen type XVI alpha 1 chain decreases expression ISO Antimycin A results in decreased expression of COL16A1 mRNA CTD PMID:19304788 NCBI chr 5:148,257,030...148,311,645
Ensembl chr 5:148,257,642...148,311,645
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression ISO Antimycin A results in increased expression of COX6A2 mRNA CTD PMID:19304788 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
JBrowse link
G Cp ceruloplasmin increases degradation
decreases expression
ISO Antimycin A results in increased degradation of CP mRNA
Antimycin A results in decreased expression of CP mRNA; Antimycin A results in decreased expression of CP protein
CTD PMID:19019832 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein]; acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:21538410, PMID:22180388 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Antimycin A results in increased expression of CTH mRNA CTD PMID:19304788 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Antimycin A inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA] CTD PMID:24316229 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO glabridin inhibits the reaction [Antimycin A affects the localization of CYCS protein] CTD PMID:21621525 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP
ISO
Antimycin A results in increased expression of DDIT3 protein
Antimycin A results in increased expression of DDIT3 mRNA
CTD PMID:19304788, PMID:21337367 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G E2f7 E2F transcription factor 7 decreases expression ISO Antimycin A results in decreased expression of E2F7 mRNA CTD PMID:19304788 NCBI chr 7:53,275,659...53,318,261
Ensembl chr 7:53,275,676...53,316,481
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
decreases localization
ISO Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
Antimycin A results in decreased localization of ELAVL1 protein
CTD PMID:12730239 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 increases expression ISO Antimycin A results in increased expression of ENTPD2 mRNA CTD PMID:19304788 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions EXP Antimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Antimycin A results in increased expression of ERO1A mRNA CTD PMID:19304788 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Antimycin A results in decreased expression of FAS mRNA CTD PMID:8902626 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Antimycin A results in decreased expression of FGF1 mRNA CTD PMID:19304788 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases expression
ISO [Antimycin A co-treated with Resveratrol] results in decreased acetylation of FOXO1 protein; [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A results in decreased expression of FOXO1 protein
CTD PMID:24040102 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 decreases expression
multiple interactions
ISO Antimycin A results in decreased expression of FOXO3 protein
[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
CTD PMID:24040102 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxo4 forkhead box O4 multiple interactions
decreases expression
ISO [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A results in decreased expression of FOXO4 protein
CTD PMID:24040102 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Antimycin A results in increased expression of GADD45A mRNA CTD PMID:19304788 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Antimycin A results in increased expression of GCH1 mRNA CTD PMID:19304788 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Antimycin A results in increased expression of GSTA2 mRNA CTD PMID:19304788 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO Antimycin A results in increased expression of GSTA1 mRNA CTD PMID:19304788 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Antimycin A results in increased expression of GSTA2 mRNA CTD PMID:19304788 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects expression EXP Antimycin A affects the expression of HIF1A protein CTD PMID:16034640 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Antimycin A results in increased expression of HSPA5 protein CTD PMID:21337367 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Antimycin A results in increased expression of HTRA1 mRNA CTD PMID:19304788 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Antimycin A results in decreased expression of ICAM1 mRNA
Antimycin A inhibits the reaction [N-caproylsphingosine results in increased expression of ICAM1 mRNA]
CTD PMID:12952965, PMID:19304788 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Acetylcysteine inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Antimycin A promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Antimycin A promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Antimycin A promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; IL1B protein promotes the reaction [Antimycin A results in increased expression of PTGS2 protein]; Resveratrol inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein] CTD PMID:22549761, PMID:24609059 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]; 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of IL6 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]; Antimycin A results in increased expression of and results in increased secretion of IL6 protein; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:21381053, PMID:21910134 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Antimycin A results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Itgb7 integrin subunit beta 7 increases expression ISO Antimycin A results in increased expression of ITGB7 mRNA CTD PMID:19304788 NCBI chr 7:143,820,236...143,837,802
Ensembl chr 7:143,820,900...143,837,780
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO [Antimycin A co-treated with Paraquat] results in increased expression of JUN protein
Antimycin A results in increased expression of JUN protein
CTD PMID:16237197 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA CTD PMID:28366621 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Antimycin A results in decreased expression of LSM6 mRNA CTD PMID:19304788 NCBI chr19:32,770,640...32,785,215
Ensembl chr19:32,770,655...32,785,215
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Antimycin A inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] CTD PMID:15650392 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Antimycin A results in increased expression of MMP13 mRNA CTD PMID:19304788 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases activity
ISO [Antimycin A results in increased abundance of Reactive Oxygen Species] which results in increased activity of MMP2 protein
Antimycin A results in increased activity of MMP2 protein
CTD PMID:11929863 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Antimycin A results in increased expression of NDRG1 mRNA CTD PMID:19304788 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:24316229 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO Antimycin A results in decreased expression of NRP1 mRNA CTD PMID:19304788 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Antimycin A results in increased expression of NT5E mRNA CTD PMID:19304788 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Antimycin A results in increased expression of NUPR1 mRNA CTD PMID:19304788 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Antimycin A results in increased cleavage of PARP1 protein
[Antimycin A co-treated with Paraquat] results in increased cleavage of PARP1 protein
CTD PMID:16237197 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Ppl periplakin decreases expression ISO Antimycin A results in decreased expression of PPL mRNA CTD PMID:19304788 NCBI chr10:10,644,572...10,690,223
Ensembl chr10:10,644,572...10,690,223
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Antimycin A results in increased expression of PPP1R15A mRNA CTD PMID:19304788 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein; [Oligomycins co-treated with Antimycin A] affects the localization of PRKN protein; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein] CTD PMID:28366621, PMID:28673964 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Antimycin A results in increased expression of PTGS2 protein
Antimycin A results in increased expression of PTGS2 mRNA
Antimycin A promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; IL1B protein promotes the reaction [Antimycin A results in increased expression of PTGS2 protein]
CTD PMID:19304788, PMID:24609059 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Antimycin A results in decreased expression of RBL1 mRNA CTD PMID:19304788 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO Antimycin A affects the localization of RELA protein
Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:24316229, PMID:24609059 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression ISO Antimycin A results in increased expression of RND1 mRNA CTD PMID:19304788 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO Antimycin A results in decreased expression of RRM2 mRNA CTD PMID:19304788 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Antimycin A results in increased expression of SNAI2 mRNA CTD PMID:19304788 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Antimycin A inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA; [Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA]
Antimycin A results in increased expression of SOD2 protein
CTD PMID:11264281, PMID:22718889, PMID:24040102 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO Antimycin A results in increased expression of SQSTM1 mRNA
[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]
CTD PMID:19304788, PMID:28366621 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Antimycin A results in decreased expression of STAR protein CTD PMID:16469751 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Antimycin A results in increased expression of TNF protein
Antimycin A inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Antimycin A promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Antimycin A promotes the reaction [TNF protein results in increased expression of CXCL8 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNF protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; Antimycin A inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Antimycin A results in increased expression of and results in increased secretion of TNF protein; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein]
CTD PMID:11264281, PMID:21381053, PMID:21910134, PMID:22549761, PMID:23624148, PMID:24316229 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA] CTD PMID:24316229 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression ISO Antimycin A results in decreased expression of TNFRSF11B protein CTD PMID:21381053 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression
multiple interactions
ISO Antimycin A results in increased expression of TNFSF11 protein
23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein]
CTD PMID:21381053, PMID:21910134 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnxb tenascin XB decreases expression ISO Antimycin A results in decreased expression of TNXB mRNA CTD PMID:19304788
G Tp53 tumor protein p53 multiple interactions
increases response to substance
increases acetylation
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Antimycin A results in increased acetylation of TRP53 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased acetylation of TRP53 protein]
TRP53 protein results in increased susceptibility to Antimycin A
CTD PMID:24040102 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Antimycin A results in increased expression of TRIB3 mRNA CTD PMID:19304788 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 decreases expression ISO Antimycin A results in decreased expression of TRIP12 mRNA CTD PMID:19304788 NCBI chr 9:92,305,059...92,435,388
Ensembl chr 9:92,305,051...92,435,365
JBrowse link
G Tshz2 teashirt zinc finger homeobox 2 decreases expression ISO Antimycin A results in decreased expression of TSHZ2 mRNA CTD PMID:19304788 NCBI chr 3:166,469,752...166,748,558
Ensembl chr 3:166,743,544...166,746,597
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO Antimycin A results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
multiple interactions
ISO Antimycin A results in increased expression of ULK1 mRNA; Antimycin A results in increased expression of ULK1 protein
Antimycin A inhibits the reaction [Cycloheximide results in decreased expression of ULK1 protein]; Antimycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]; Antimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]; ATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein]; Cycloheximide inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]; Nitrogen deficiency inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]
CTD PMID:27629431 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Uts2 urotensin 2 increases expression ISO Antimycin A results in increased expression of UTS2 mRNA CTD PMID:19304788 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Antimycin A results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wnt7a Wnt family member 7A increases expression ISO Antimycin A results in increased expression of WNT7A mRNA CTD PMID:19304788 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
G Xbp1 X-box binding protein 1 increases expression EXP Antimycin A results in increased expression of XBP1 protein CTD PMID:21337367 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Zhx1 zinc fingers and homeoboxes 1 decreases expression ISO Antimycin A results in decreased expression of ZHX1 mRNA CTD PMID:19304788 NCBI chr 7:97,915,280...97,944,787
Ensembl chr 7:97,915,581...97,944,491
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antifungal agent 14870
            antimycin A 98
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  arenecarboxamide 6507
                                                    benzamides 6507
                                                      antimycin A 98
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.