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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:apocynin
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Accession:CHEBI:2781 term browser browse the term
Definition:An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Synonyms:exact_synonym: 1-(4-hydroxy-3-methoxyphenyl)ethan-1-one
 related_synonym: 1-(4-Hydroxy-3-methoxyphenyl)ethanone;   4'-hydroxy-3'-methoxyacetophenone;   4-Acetyl-2-methoxyphenol;   4-Hydroxy-3-methoxyphenyl methyl ketone;   Acetoguaiacon;   Acetoguaiacone;   Acetovanillone;   Formula=C9H10O3;   InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3;   InChIKey=DFYRUELUNQRZTB-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1O)C(C)=O
 xref: Beilstein:637373;   CAS:498-02-2;   KEGG:C11380;   KNApSAcK:C00002689
 xref_mesh: MESH:C056165
 xref: PMID:21848266;   PMID:21954959;   Reaxys:637373;   Wikipedia:Apocynin


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apocynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP acetovanillone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; acetovanillone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] CTD PMID:18474546 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased expression of ACTA2 protein] CTD PMID:29760339 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions
decreases activity
ISO
EXP
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein; acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
acetovanillone results in decreased activity of AGT protein
acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
acetovanillone inhibits the reaction [AGT protein results in decreased export of Sodium]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Oxygen]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:14597645, PMID:15502880, PMID:15677497, PMID:16531806, PMID:17224469, PMID:17244722, PMID:17391658, PMID:19145780, PMID:27983965 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein] CTD PMID:28202386, PMID:30366073 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B3 mRNA] CTD PMID:30651350 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein] CTD PMID:26514923 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in decreased expression of ALB protein] CTD PMID:29760339 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA] CTD PMID:24080574 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] CTD PMID:22288910 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]
CTD PMID:22431579, PMID:30366073 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]
CTD PMID:22431579, PMID:30366073 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein] CTD PMID:30366073 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA] CTD PMID:24080574 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp1 caspase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form] CTD PMID:26079697, PMID:26901245 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
CTD PMID:20153346, PMID:22147442, PMID:22497828, PMID:24291008, PMID:26522475, PMID:30366073 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of CAT mRNA]; acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]] CTD PMID:21983654, PMID:24291008, PMID:29760339, PMID:32298299 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:22414048 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:16845898, PMID:19158351, PMID:22414048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
CTD PMID:10495789, PMID:22414048 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] CTD PMID:22414048 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO acetovanillone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdh3 cadherin 3 multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein] CTD PMID:21647593 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein] CTD PMID:16531806 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:16531806 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:21538410 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] CTD PMID:22414048 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232, PMID:22414048 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]
CTD PMID:23270704, PMID:29037473 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]
CTD PMID:19878672, PMID:23270704, PMID:24080574, PMID:30797899 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Des desmin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dmd dystrophin multiple interactions ISO acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP
ISO
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]; acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]
acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
CTD PMID:17391658, PMID:20977430, PMID:22431579, PMID:24932781 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:23270704 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein] CTD PMID:26514923 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:23270704 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]
acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]
CTD PMID:15086456, PMID:16632126, PMID:22245600 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of FSHB protein] CTD PMID:23270704 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein] CTD PMID:18063801 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein] CTD PMID:23270704 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:25042521 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gna11 G protein subunit alpha 11 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of GNA11 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNA11 protein] CTD PMID:20691780 NCBI chr 7:11,033,400...11,047,284
Ensembl chr 7:11,033,317...11,047,437
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of GNAQ protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein] CTD PMID:20691780 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:22431579, PMID:29037473 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP acetovanillone inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA] CTD PMID:21983654 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein] CTD PMID:30797899 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein] CTD PMID:30378427 NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 increases expression EXP acetovanillone results in increased expression of GUCY1A1 protein CTD PMID:25217652 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 increases expression EXP acetovanillone results in increased expression of GUCY1B1 protein CTD PMID:25217652 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP
ISO
acetovanillone results in increased expression of HIF1A protein
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:12595275, PMID:23144690 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] CTD PMID:26079697 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
acetovanillone results in decreased expression of HMOX1 mRNA
CTD PMID:19414066, PMID:20934533, PMID:21690482, PMID:24291008, PMID:26945724 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
acetovanillone results in decreased expression of ICAM1 protein
CTD PMID:10495789, PMID:19417757, PMID:19632255, PMID:20920494, PMID:22414048, PMID:26901245 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
acetovanillone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]
CTD PMID:16307444, PMID:30366073 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 multiple interactions ISO acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] CTD PMID:28539244 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO
EXP
acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
acetovanillone inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]
acetovanillone results in decreased susceptibility to IL1B protein
acetovanillone inhibits the reaction [Ethanol results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]
CTD PMID:18403674, PMID:19005069, PMID:19281832, PMID:21211511, PMID:21983654, PMID:26522475, PMID:26901245, PMID:27393034, PMID:28539244 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:21983654, PMID:22414048, PMID:22472292, PMID:24631921, PMID:25042521, PMID:29760339, PMID:30366073 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]
CTD PMID:16357311, PMID:28202386, PMID:30797899 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein] CTD PMID:22288910 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lep leptin multiple interactions ISO acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]; acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein] CTD PMID:16380530 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of LHB protein] CTD PMID:23270704 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:16632126, PMID:20354174, PMID:21391979, PMID:22288910, PMID:23774252, PMID:24080574, PMID:24967690, PMID:26514923, PMID:30797899 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:16632126, PMID:20354174, PMID:21391979, PMID:22288910, PMID:23774252, PMID:24080574, PMID:24967690, PMID:26514923, PMID:30797899 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
CTD PMID:20354174, PMID:21391979, PMID:24967690, PMID:26514923 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:21391979, PMID:24967690, PMID:26514923 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] CTD PMID:22414048 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MLKL protein] CTD PMID:30378427 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]; acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]
CTD PMID:23270704, PMID:23774252, PMID:26514923 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase decreases expression
multiple interactions
ISO
EXP
acetovanillone results in decreased expression of MPO protein
acetovanillone inhibits the reaction [Cisplatin results in increased activity of MPO protein]
CTD PMID:19417757, PMID:24291008 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]
acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [arsenic trioxide affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides affects the localization of NCF1 protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF1 mRNA]
CTD PMID:16380530, PMID:18424721, PMID:19281832, PMID:19878672, PMID:20299304, PMID:23270704, PMID:24080574, PMID:24967690, PMID:29037473, PMID:30366073 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]
CTD PMID:16380530, PMID:24080574 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:24291008, PMID:27983965 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; acetovanillone inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]
CTD PMID:16845898, PMID:17065336, PMID:28202386 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein] CTD PMID:26901245 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
CTD PMID:21983654, PMID:26522475, PMID:28202386, PMID:30797899 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
ISO
EXP
acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein]
[Cadmium co-treated with acetovanillone] results in increased expression of NOS3 protein; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS3 mRNA]
acetovanillone results in increased expression of NOS3 protein
CTD PMID:19878672, PMID:21983654, PMID:23703608 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]
CTD PMID:26522475, PMID:29760339, PMID:30797899 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX4 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] CTD PMID:26522475, PMID:29760339, PMID:32298299 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Noxa1 NADPH oxidase activator 1 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXA1 mRNA] CTD PMID:24080574 NCBI chr 3:2,299,676...2,309,491
Ensembl chr 3:2,299,691...2,309,179
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXO1 mRNA] CTD PMID:24080574 NCBI chr10:14,062,331...14,066,918
Ensembl chr10:14,062,331...14,066,918
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA] CTD PMID:19878672 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]
acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
CTD PMID:15502880, PMID:18509044, PMID:24932781, PMID:29111459 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP acetovanillone inhibits the reaction [Ozone results in increased expression of PCNA protein] CTD PMID:9517619 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB1 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein] CTD PMID:20691780 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB2 protein] CTD PMID:20691780 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP acetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes] CTD PMID:16053986 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]] CTD PMID:30366073 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP acetovanillone inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein] CTD PMID:18414395, PMID:21983654 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP
ISO
acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]
acetovanillone results in decreased expression of PTGS2 mRNA
CTD PMID:17244722, PMID:18414395, PMID:21983654, PMID:22288910, PMID:23415682, PMID:24337631, PMID:24967690, PMID:26522475, PMID:28495310, PMID:30366073 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Pvalb parvalbumin multiple interactions ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] CTD PMID:18063801 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of PYCARD protein] CTD PMID:26079697 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]
acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]
CTD PMID:19281832, PMID:19608869, PMID:20354174, PMID:23774252, PMID:26930420, PMID:27393034, PMID:28202386 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of RUNX2 mRNA] CTD PMID:24080574 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein] CTD PMID:21647593 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Sele selectin E multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SELE protein] CTD PMID:26901245 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:22414048 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 protein] CTD PMID:23270704 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:21983654, PMID:22431579, PMID:29037473 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]
CTD PMID:21983654, PMID:22431579, PMID:29037473 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP acetovanillone inhibits the reaction [Hydrogen Peroxide deficiency results in decreased expression of STAR protein]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein] CTD PMID:23270704 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO acetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] CTD PMID:18322232 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased expression of TGFB1 protein] CTD PMID:29760339 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP acetovanillone results in decreased expression of TH mRNA CTD PMID:25217652 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]
acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
CTD PMID:20299304, PMID:21647593 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO
EXP
acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]; acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
acetovanillone results in decreased susceptibility to TNF protein
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:10495789, PMID:15795323, PMID:16632126, PMID:19608869, PMID:21211511, PMID:22414048, PMID:22472292, PMID:23774252, PMID:24291008, PMID:25042521, PMID:26522475, PMID:28202386, PMID:29111459, PMID:29760339, PMID:30797899 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein] CTD PMID:22431579 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of VCAM1 protein] CTD PMID:19281832, PMID:19632255, PMID:26901245 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP acetovanillone inhibits the reaction [Cocaine results in increased activity of XDH protein] CTD PMID:17217956 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12703
              apocynin 126
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      ketone 16171
                                        methyl ketone 732
                                          acetophenones 141
                                            apocynin 126
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.