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ONTOLOGY REPORT - ANNOTATIONS


Term:cisplatin
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Accession:CHEBI:27899 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Synonyms:exact_synonym: (SP-4-2)-diamminedichloridoplatinum;   (SP-4-2)-diamminedichloroplatinum;   cis-diamminedichloridoplatinum(II)
 related_synonym: Briplatin;   CDDP;   Cismaplat;   Formula=Cl2H6N2Pt;   Formula=H6Cl2N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   Lederplatin;   Neoplatin;   Peyrone's chloride;   Peyrone's salt;   Platamine;   Platinex;   Platinol;   Randa;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   [PtCl2(NH3)2];   cis-DDP;   cis-Diamminedichloroplatinum(II);   cis-[PtCl2(NH3)2];   cis-diamminedichloroplatinum;   cis-diammineplatinum(II) dichloride;   cis-dichlorodiammineplatinum(II);   cis-platin;   cisplatine;   cisplatino;   cisplatinum
 alt_id: CHEBI:23314;   CHEBI:3722
 xref: CAS:15663-27-1 "ChemIDplus";   CAS:15663-27-1 "KEGG COMPOUND";   DrugBank:DB00515;   Gmelin:2519 "Gmelin";   HMDB:HMDB0014656;   KEGG:C06911;   KEGG:D00275
 xref_mesh: MESH:D002945
 xref: MetaCyc:CPD0-1392;   MolBase:25;   PMID:10883661 "Europe PMC";   PMID:12537968 "Europe PMC";   PMID:12831510 "Europe PMC";   PMID:12935404 "Europe PMC";   PMID:16327988 "Europe PMC";   PMID:18472761 "Europe PMC";   PMID:1855275 "Europe PMC";   PMID:23554447 "Europe PMC";   PMID:23604226 "Europe PMC";   PMID:23651576 "Europe PMC";   Patent:DE2318020;   Patent:DE2329485;   Reaxys:11324567 "Reaxys";   Wikipedia:Cisplatin


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        reagent 16857
          cross-linking reagent 7296
            cisplatin 7278
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  metal atom 17031
                    transition element atom 16541
                      d-block element atom 16530
                        nickel group element atom 10101
                          platinum 8377
                            platinum molecular entity 8377
                              platinum coordination entity 8377
                                diamminedichloroplatinum 7278
                                  cisplatin 7278
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