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ONTOLOGY REPORT - ANNOTATIONS


Term:cisplatin
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Accession:CHEBI:27899 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Synonyms:exact_synonym: (SP-4-2)-diamminedichloridoplatinum;   (SP-4-2)-diamminedichloroplatinum;   cis-diamminedichloridoplatinum(II)
 related_synonym: Briplatin;   CDDP;   Cismaplat;   Formula=Cl2H6N2Pt;   Formula=H6Cl2N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   Lederplatin;   Neoplatin;   Peyrone's chloride;   Peyrone's salt;   Platamine;   Platinex;   Platinol;   Randa;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   [PtCl2(NH3)2];   cis-DDP;   cis-Diamminedichloroplatinum(II);   cis-[PtCl2(NH3)2];   cis-diamminedichloroplatinum;   cis-diammineplatinum(II) dichloride;   cis-dichlorodiammineplatinum(II);   cis-platin;   cisplatine;   cisplatino;   cisplatinum
 alt_id: CHEBI:23314;   CHEBI:3722
 xref: CAS:15663-27-1 "ChemIDplus";   CAS:15663-27-1 "KEGG COMPOUND";   DrugBank:DB00515;   Gmelin:2519 "Gmelin";   HMDB:HMDB0014656;   KEGG:C06911;   KEGG:D00275
 xref_mesh: MESH:D002945
 xref: MetaCyc:CPD0-1392;   MolBase:25;   PMID:10883661 "Europe PMC";   PMID:12537968 "Europe PMC";   PMID:12831510 "Europe PMC";   PMID:12935404 "Europe PMC";   PMID:16327988 "Europe PMC";   PMID:18472761 "Europe PMC";   PMID:1855275 "Europe PMC";   PMID:23554447 "Europe PMC";   PMID:23604226 "Europe PMC";   PMID:23651576 "Europe PMC";   Patent:DE2318020;   Patent:DE2329485;   Reaxys:11324567 "Reaxys";   Wikipedia:Cisplatin


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Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    role 20952
      application 20373
        reagent 17615
          cross-linking reagent 7451
            cisplatin 7410
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  metal atom 17998
                    transition element atom 17446
                      d-block element atom 17432
                        nickel group element atom 10250
                          platinum 8486
                            platinum molecular entity 8486
                              platinum coordination entity 8486
                                diamminedichloroplatinum 7410
                                  cisplatin 7410
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