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ONTOLOGY REPORT - ANNOTATIONS


Term:cisplatin
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Accession:CHEBI:27899 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Synonyms:exact_synonym: (SP-4-2)-diamminedichloridoplatinum;   (SP-4-2)-diamminedichloroplatinum;   cis-diamminedichloridoplatinum(II)
 related_synonym: Briplatin;   CDDP;   Cismaplat;   Formula=Cl2H6N2Pt;   Formula=H6Cl2N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   Lederplatin;   Neoplatin;   Peyrone's chloride;   Peyrone's salt;   Platamine;   Platinex;   Platinol;   Randa;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   [PtCl2(NH3)2];   cis-DDP;   cis-Diamminedichloroplatinum(II);   cis-[PtCl2(NH3)2];   cis-diamminedichloroplatinum;   cis-diammineplatinum(II) dichloride;   cis-dichlorodiammineplatinum(II);   cis-platin;   cisplatine;   cisplatino;   cisplatinum
 alt_id: CHEBI:23314;   CHEBI:3722
 xref: CAS:15663-27-1 "ChemIDplus";   CAS:15663-27-1 "KEGG COMPOUND";   DrugBank:DB00515;   Gmelin:2519 "Gmelin";   HMDB:HMDB0014656;   KEGG:C06911;   KEGG:D00275
 xref_mesh: MESH:D002945
 xref: MetaCyc:CPD0-1392;   MolBase:25;   PMID:10883661 "Europe PMC";   PMID:12537968 "Europe PMC";   PMID:12831510 "Europe PMC";   PMID:12935404 "Europe PMC";   PMID:16327988 "Europe PMC";   PMID:18472761 "Europe PMC";   PMID:1855275 "Europe PMC";   PMID:23554447 "Europe PMC";   PMID:23604226 "Europe PMC";   PMID:23651576 "Europe PMC";   Patent:DE2318020;   Patent:DE2329485;   Reaxys:11324567 "Reaxys";   Wikipedia:Cisplatin


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      application 19246
        reagent 16873
          cross-linking reagent 7300
            cisplatin 7282
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  metal atom 17051
                    transition element atom 16560
                      d-block element atom 16549
                        nickel group element atom 10108
                          platinum 8385
                            platinum molecular entity 8385
                              platinum coordination entity 8385
                                diamminedichloroplatinum 7282
                                  cisplatin 7282
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