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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,4-dihydroxyphenylacetaldehyde
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Accession:CHEBI:27978 term browser browse the term
Definition:A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.
Synonyms:exact_synonym: (3,4-dihydroxyphenyl)acetaldehyde
 related_synonym: 2-(3,4-dihydroxyphenyl)ethanal;   DOPAL;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2;   InChIKey=IADQVXRMSNIUEL-UHFFFAOYSA-N;   Protocatechuatealdehyde;   SMILES=[H]C(=O)Cc1ccc(O)c(O)c1
 alt_id: CHEBI:1385;   CHEBI:19888
 xref: CAS:5707-55-1;   KEGG:C04043
 xref_mesh: MESH:C007430
 xref: PMID:12729575;   PMID:14556942;   PMID:17379813;   PMID:19537779;   Reaxys:1941234


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3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions
EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa
CTD PMID:21238438, PMID:21514317 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        solvent 16459
          formic acid 7881
            formyl group 7847
              aldehyde 7847
                phenylacetaldehydes 12
                  3,4-dihydroxyphenylacetaldehyde 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            formyl group 7847
                                              aldehyde 7847
                                                phenylacetaldehydes 12
                                                  3,4-dihydroxyphenylacetaldehyde 3
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