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ONTOLOGY REPORT - ANNOTATIONS


Term:tolbutamide
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Accession:CHEBI:27999 term browser browse the term
Definition:An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Synonyms:exact_synonym: N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide
 related_synonym: 1-Butyl-3-(p-methylphenylsulfonyl)urea;   1-Butyl-3-(p-tolylsulfonyl)urea;   1-Butyl-3-tosylurea;   1-p-Toluenesulfonyl-3-butylurea;   3-(p-Tolyl-4-sulfonyl)-1-butylurea;   Formula=C12H18N2O3S;   InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15);   InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N;   N-(4-Methylbenzenesulfonyl)-N'-butylurea;   N-(4-Methylphenylsulfonyl)-N'-butylurea;   N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea;   N-(p-Methylbenzenesulfonyl)-N'-butylurea;   N-Butyl-N'-(4-methylphenylsulfonyl)urea;   N-Butyl-N'-(p-tolylsulfonyl)urea;   N-Butyl-N'-p-toluenesulfonylurea;   N-n-Butyl-N'-tosylurea;   Orinase (TN);   SMILES=CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1;   Tolylsulfonylbutylurea;   tolbutamida;   tolbutamidum
 alt_id: CHEBI:27019;   CHEBI:9616
 xref: CAS:64-77-7 "ChemIDplus";   CAS:64-77-7 "KEGG COMPOUND";   CAS:64-77-7 "NIST Chemistry WebBook";   DrugBank:DB01124;   Drug_Central:2696 "DrugCentral";   KEGG:C07148;   KEGG:D00380;   LINCS:LSM-3907
 xref_mesh: MESH:D014044
 xref: PMID:11835228 "Europe PMC";   PMID:11840346 "Europe PMC";   PMID:11911494 "Europe PMC";   PMID:12042355 "Europe PMC";   PMID:12355256 "Europe PMC";   PMID:15207658 "Europe PMC";   PMID:15317941 "Europe PMC";   PMID:15620874 "Europe PMC";   PMID:15655519 "Europe PMC";   PMID:16290322 "Europe PMC";   PMID:16426753 "Europe PMC";   PMID:19059420 "Europe PMC";   PMID:20880646 "Europe PMC";   PMID:21178111 "Europe PMC";   PMID:21193530 "Europe PMC";   PMID:21471135 "Europe PMC";   PMID:21535124 "Europe PMC";   PMID:21712613 "Europe PMC";   PMID:21757329 "Europe PMC";   PMID:21827497 "Europe PMC";   PMID:21831467 "Europe PMC";   PMID:22028182 "Europe PMC";   PMID:22079696 "Europe PMC";   Patent:DE1066575;   Patent:GB808071;   Patent:US2968158;   Reaxys:1984428 "Reaxys";   Wikipedia:Tolbutamide


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tolbutamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 JBrowse link 1 258,074,797 258,139,176 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:6480464
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 JBrowse link 1 102,103,093 102,107,134 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpd52 tumor protein D52 JBrowse link 2 94,959,732 95,041,277 RGD:6480464
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            hypoglycemic agent 3743
              tolbutamide 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        carboacyl group 16948
                                          univalent carboacyl group 16948
                                            carbamoyl group 16630
                                              carboxamide 16630
                                                monocarboxylic acid amide 13200
                                                  urea 4953
                                                    ureas 4950
                                                      N-sulfonylurea 103
                                                        tolbutamide 22
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.