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ONTOLOGY REPORT - ANNOTATIONS


Term:aristolochic acid
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Accession:CHEBI:2825 term browser browse the term
Definition:A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Synonyms:exact_synonym: 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
 related_synonym: 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid;   8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid;   Aristolochic acid I;   Formula=C17H11NO7;   InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20);   InChIKey=BBFQZRXNYIEMAW-UHFFFAOYSA-N;   SMILES=COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O;   aristolochic acid A;   aristolochin
 xref: CAS:313-67-7 "ChemIDplus";   CAS:313-67-7 "KEGG COMPOUND";   KEGG:C08469;   KNApSAcK:C00001526;   KNApSAcK:C00027516;   LINCS:LSM-2373
 xref_mesh: MESH:C000228
 xref: PMID:21558304 "Europe PMC";   PMID:21719716 "Europe PMC";   PMID:22071594 "Europe PMC";   PMID:22118289 "Europe PMC";   PMID:22126455 "Europe PMC";   PMID:22245565 "Europe PMC";   PMID:22373701 "Europe PMC";   Reaxys:345159 "Reaxys";   Wikipedia:Aristolochic_acid


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  CHEBI ontology 0
    role 0
      biological role 0
        biochemical role 0
          metabolite 0
            aristolochic acid 0
              aristoloterpenate-I 0
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  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            organic group 0
                              organic divalent group 0
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                                  carbonyl group 0
                                    carbonyl compound 0
                                      carboxylic acid 0
                                        monocarboxylic acid 0
                                          aristolochic acid 0
                                            aristoloterpenate-I 0
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