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ONTOLOGY REPORT - ANNOTATIONS


Term:aristolochic acid
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Accession:CHEBI:2825 term browser browse the term
Definition:A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Synonyms:exact_synonym: 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
 related_synonym: 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid;   8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid;   Aristolochic acid I;   Formula=C17H11NO7;   InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20);   InChIKey=BBFQZRXNYIEMAW-UHFFFAOYSA-N;   SMILES=COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O;   aristolochic acid A;   aristolochin
 xref: CAS:313-67-7 "ChemIDplus";   CAS:313-67-7 "KEGG COMPOUND";   KEGG:C08469;   KNApSAcK:C00001526;   KNApSAcK:C00027516;   LINCS:LSM-2373
 xref_mesh: MESH:C000228
 xref: PMID:21558304 "Europe PMC";   PMID:21719716 "Europe PMC";   PMID:22071594 "Europe PMC";   PMID:22118289 "Europe PMC";   PMID:22126455 "Europe PMC";   PMID:22245565 "Europe PMC";   PMID:22373701 "Europe PMC";   Reaxys:345159 "Reaxys";   Wikipedia:Aristolochic_acid


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aristolochic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALOX5AP arachidonate 5-lipoxygenase activating protein JBrowse link 11 7,371,328 7,438,111 RGD:6480464
G CASP3 caspase 3 JBrowse link 15 45,744,320 45,753,252 RGD:6480464
G LTC4S leukotriene C4 synthase JBrowse link 2 78,799,446 78,802,281 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 14 50,083,079 50,165,528 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 3 18,291,444 18,299,410 RGD:6480464
G MGST3 microsomal glutathione S-transferase 3 JBrowse link 4 85,069,603 85,095,022 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 828
    role 805
      biological role 805
        biochemical role 678
          metabolite 662
            aristolochic acid 6
              aristoloterpenate-I 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 828
    subatomic particle 812
      composite particle 812
        hadron 812
          baryon 812
            nucleon 812
              atomic nucleus 812
                atom 812
                  main group element atom 800
                    p-block element atom 797
                      carbon group element atom 769
                        carbon atom 765
                          organic molecular entity 765
                            organic group 354
                              organic divalent group 352
                                organodiyl group 352
                                  carbonyl group 351
                                    carbonyl compound 351
                                      carboxylic acid 237
                                        monocarboxylic acid 131
                                          aristolochic acid 6
                                            aristoloterpenate-I 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.