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ONTOLOGY REPORT - ANNOTATIONS


Term:heparin
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Accession:CHEBI:28304 term browser browse the term
Definition:A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Synonyms:related_synonym: Bemiparin;   Certoparin;   Cy 222;   Enoxaparin;   Fluxum;   Formula=(C26H40N2O36S5)n;   Heparinic acid;   Parnaparin;   Reviparin;   Sandoparin;   heparina;   heparine;   heparinum
 alt_id: CHEBI:24501;   CHEBI:5664
 xref: CAS:9005-49-6 "ChemIDplus";   CAS:9005-49-6 "KEGG COMPOUND";   DrugBank:DB01109;   KEGG:C00374;   KEGG:D07510
 xref_mesh: MESH:D006493
 xref: PMID:16860191 "Europe PMC";   PMID:18809206 "Europe PMC";   PMID:8713797 "Europe PMC";   Wikipedia:Heparin


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heparin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Ackr3 atypical chemokine receptor 3 JBrowse link 9 97,355,881 97,367,455 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:6480464
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 JBrowse link 11 25,342,119 25,350,938 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Anxa6 annexin A6 JBrowse link 10 40,320,581 40,375,605 RGD:6480464
G Apcs amyloid P component, serum JBrowse link 13 91,426,621 91,427,417 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:6480464
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 13 82,737,161 82,757,681 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:6480464
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:6480464
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6480464
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6480464
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6480464
G Capg capping actin protein, gelsolin like JBrowse link 4 100,395,693 100,419,447 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Col18a1 collagen type XVIII alpha 1 chain JBrowse link 20 12,225,202 12,332,858 RGD:6480464
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6480464
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Ddah2 dimethylarginine dimethylaminohydrolase 2 JBrowse link 20 5,049,260 5,052,573 RGD:6480464
G Des desmin JBrowse link 9 82,556,574 82,564,288 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:6480464
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:6480464
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:6480464
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6480464
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:6480464
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:6480464
G Fgf3 fibroblast growth factor 3 JBrowse link 1 218,003,018 218,006,942 RGD:6480464
G Fgf4 fibroblast growth factor 4 JBrowse link 1 218,024,537 218,029,539 RGD:6480464
G Fgf5 fibroblast growth factor 5 JBrowse link 14 12,974,921 12,996,046 RGD:6480464
G Fgf7 fibroblast growth factor 7 JBrowse link 3 118,315,859 118,368,464 RGD:6480464
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6480464
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6480464
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:6480464
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 17 9,990,072 10,004,339 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:6480464
G Gns glucosamine (N-acetyl)-6-sulfatase JBrowse link 7 63,467,027 63,501,054 RGD:6480464
G Gzmb granzyme B JBrowse link 15 35,413,862 35,417,293 RGD:6480464
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Hpse heparanase JBrowse link 14 10,534,358 10,576,686 RGD:6480464
G Hrg histidine-rich glycoprotein JBrowse link 11 81,621,274 81,639,938 RGD:6480464
G Igsf10 immunoglobulin superfamily, member 10 JBrowse link 2 149,535,199 149,564,180 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Ldhb lactate dehydrogenase B JBrowse link 4 176,701,980 176,719,999 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6480464
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:6480464
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Msn moesin JBrowse link X 65,226,834 65,294,192 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6480464
G Pdhb pyruvate dehydrogenase E1 subunit beta JBrowse link 15 18,540,826 18,546,855 RGD:6480464
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:6480464
G Pitpna phosphatidylinositol transfer protein, alpha JBrowse link 10 63,731,767 63,772,049 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:6480464
G Ppbp pro-platelet basic protein JBrowse link 14 18,852,433 18,853,237 RGD:6480464
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:6480464
G Psmb5 proteasome 20S subunit beta 5 JBrowse link 15 33,259,039 33,263,634 RGD:6480464
G Psmb6 proteasome 20S subunit beta 6 JBrowse link 10 57,131,339 57,133,685 RGD:6480464
G Psmb7 proteasome 20S subunit beta 7 JBrowse link 3 22,890,072 22,951,718 RGD:6480464
G Psme1 proteasome activator subunit 1 JBrowse link 15 34,256,071 34,258,947 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6480464
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6480464
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G S100a1 S100 calcium binding protein A1 JBrowse link 2 189,900,505 189,905,348 RGD:6480464
G S100a6 S100 calcium binding protein A6 JBrowse link 2 190,007,013 190,008,512 RGD:6480464
G S100b S100 calcium binding protein B JBrowse link 20 13,130,633 13,142,856 RGD:6480464
G Sdc1 syndecan 1 JBrowse link 6 33,885,576 33,908,038 RGD:6480464
G Sdc2 syndecan 2 JBrowse link 7 71,572,731 71,686,139 RGD:6480464
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:6480464
G Sell selectin L JBrowse link 13 82,369,820 82,387,774 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Septin2 septin 2 JBrowse link 9 100,624,876 100,658,053 RGD:6480464
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:6480464
G Slc5a3 solute carrier family 5 member 3 JBrowse link 11 32,229,366 32,231,812 RGD:6480464
G Slk STE20-like kinase JBrowse link 1 267,359,761 267,415,735 RGD:6480464
G Stip1 stress-induced phosphoprotein 1 JBrowse link 1 222,274,133 222,293,139 RGD:6480464
G Tagln2 transgelin 2 JBrowse link 13 90,807,196 90,814,119 RGD:6480464
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19361
        pharmaceutical 19230
          drug 19230
            hematologic agent 4261
              anticoagulant 4051
                heparin 136
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            heteroorganic entity 19105
                              organochalcogen compound 18802
                                organooxygen compound 18713
                                  carbohydrates and carbohydrate derivatives 12111
                                    carbohydrate 12111
                                      polysaccharide 2921
                                        polysaccharide derivative 2901
                                          aminoglycan 389
                                            glycosaminoglycan 363
                                              sulfated glycosaminoglycan 181
                                                heparins 136
                                                  heparin 136
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.