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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:novobiocin
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Accession:CHEBI:28368 term browser browse the term
Definition:A coumarin-derived antibiotic obtained from Streptomyces niveus.
Synonyms:related_synonym: Formula=C31H36N2O11;   InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1;   InChIKey=YJQPYGGHQPGBLI-KGSXXDOSSA-N;   N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide;   SMILES=CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C;   novobiocina;   novobiocine;   novobiocinum
 alt_id: CHEBI:25597;   CHEBI:44505;   CHEBI:7644
 xref: CAS:303-81-1;   DrugBank:DB01051;   Drug_Central:1974;   HMDB:HMDB0015185;   KEGG:C05080;   KNApSAcK:C00002487;   LINCS:LSM-5910
 xref_mesh: MESH:D009675
 xref: PDBeChem:NOV;   PMID:17132020;   PMID:18418407;   PMID:19282394;   PMID:19762445;   PMID:20325309;   PMID:21388139;   PMID:22897434;   PMID:26844397;   PMID:26926630;   PMID:27829510;   PMID:27914946;   PMID:28246042;   PMID:28316592;   PMID:9687383;   Patent:WO2012049521;   Patent:WO2012103487;   Reaxys:1445842
 cyclic_relationship: is_conjugate_acid_of CHEBI:71339


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novobiocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity
EXP
ISO
[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Novobiocin inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]
CTD PMID:19853032, PMID:29079042, PMID:32305507 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases degradation ISO Novobiocin analog results in increased degradation of AKT1 protein CTD PMID:20711301 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cd38 CD38 molecule increases expression ISO Novobiocin results in increased expression of CD38 mRNA; Novobiocin results in increased expression of CD38 protein CTD PMID:11853877 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Novobiocin results in decreased expression of CDH2 protein CTD PMID:11853877 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity ISO Novobiocin results in increased activity of GGT1 protein CTD PMID:1739614 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          novobiocin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  novobiocin 5
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