Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:28445 term browser browse the term
Definition:A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Synonyms:related_synonym: 22-Oxovincaleukoblastine;   22-oxo-vincaleukoblastine;   Formula=C46H56N4O10;   InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1;   InChIKey=OGWKCGZFUXNPDA-XQKSVPLYSA-N;   SMILES=[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC;   leucristine;   leurocristine;   oncovin;   vincristin;   vinkristin
 alt_id: CHEBI:27289;   CHEBI:9987
 xref: Beilstein:4779289 "Beilstein";   CAS:57-22-7 "ChemIDplus";   CAS:57-22-7 "KEGG COMPOUND";   DrugBank:DB00541;   Drug_Central:2825 "DrugCentral";   HMDB:HMDB0014681;   KEGG:C07204;   KEGG:D08679;   KNApSAcK:C00001783
 xref_mesh: MESH:D014750
 xref: MetaCyc:CPD-19894;   PMID:18520608 "Europe PMC";   PMID:30277559 "Europe PMC";   PMID:30429697 "Europe PMC";   PMID:30599272 "Europe PMC";   PMID:30604513 "Europe PMC";   PMID:30657998 "Europe PMC";   PMID:31048222 "Europe PMC";   PMID:31161774 "Europe PMC";   PMID:31214762 "Europe PMC";   PMID:31296986 "Europe PMC";   Wikipedia:Vincristine
 cyclic_relationship: is_conjugate_base_of CHEBI:143658

show annotations for term's descendants       view all columns           Sort by:
vincristine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 14 13,644,891 13,852,829 RGD:6480464
G ABCC1 ATP binding cassette subfamily C member 1 JBrowse link 6 27,855,702 27,950,140 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 223
    role 223
      application 188
        pharmaceutical 185
          drug 185
            vincristine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 223
    subatomic particle 223
      composite particle 223
        hadron 223
          baryon 223
            nucleon 223
              atomic nucleus 223
                atom 223
                  main group element atom 216
                    p-block element atom 216
                      carbon group element atom 205
                        carbon atom 204
                          organic molecular entity 204
                            organic group 153
                              organic divalent group 152
                                organodiyl group 152
                                  carbonyl group 152
                                    carbonyl compound 152
                                      carboxylic acid 112
                                        carboacyl group 47
                                          univalent carboacyl group 47
                                            carbamoyl group 44
                                              carboxamide 44
                                                formamides 2
                                                  vincristine 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.