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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloroethene
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Accession:CHEBI:28509 term browser browse the term
Definition:A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.
Synonyms:related_synonym: Chloroethylene;   Formula=C2H3Cl;   InChI=1S/C2H3Cl/c1-2-3/h2H,1H2;   InChIKey=BZHJMEDXRYGGRV-UHFFFAOYSA-N;   SMILES=ClC=C;   VC;   Vinyl chloride;   Vinylchlorid;   chlorure de vinyle;   cloroetileno;   cloruro de vinilo;   ethylene monochloride;   monochloroethene;   monochloroethylene;   monovinyl chloride
 alt_id: CHEBI:27293;   CHEBI:9990
 xref: Beilstein:1731576;   CAS:75-01-4;   Gmelin:100541;   KEGG:C06793
 xref_mesh: MESH:D014752
 xref: PMID:15989139;   PMID:18678006;   Reaxys:1731576;   UM-BBD_compID:c0358;   Wikipedia:Chloroethene


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chloroethene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd3 ATP binding cassette subfamily D member 3 increases expression ISO Vinyl Chloride results in increased expression of ABCD3 mRNA CTD PMID:18579281 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Vinyl Chloride results in increased expression of ACACA mRNA; Vinyl Chloride results in increased expression of ACACA protein CTD PMID:31445928 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acer2 alkaline ceramidase 2 decreases expression ISO Vinyl Chloride results in decreased expression of ACER2 mRNA CTD PMID:18579281 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Acly ATP citrate lyase increases expression ISO Vinyl Chloride metabolite results in increased expression of ACLY mRNA; Vinyl Chloride results in increased expression of ACLY mRNA CTD PMID:18579281, PMID:26962056 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression ISO Vinyl Chloride results in increased expression of ACSS2 mRNA CTD PMID:18579281 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Adgrb2 adhesion G protein-coupled receptor B2 increases expression ISO Vinyl Chloride results in increased expression of ADGRB2 mRNA CTD PMID:18579281 NCBI chr 5:148,168,530...148,231,587
Ensembl chr 5:148,193,710...148,231,587
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases expression ISO Vinyl Chloride results in increased expression of ADH4 mRNA CTD PMID:18579281 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Agk acylglycerol kinase increases expression ISO Vinyl Chloride results in increased expression of AGK mRNA CTD PMID:18579281 NCBI chr 4:68,483,345...68,561,518
Ensembl chr 4:68,483,320...68,560,801
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Vinyl Chloride metabolite results in increased phosphorylation of AKT1 protein CTD PMID:26962056 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases response to substance ISO ALDH2 gene SNP results in increased susceptibility to Vinyl Chloride CTD PMID:20100738 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases activity EXP Vinyl Chloride results in increased activity of ALDH3A1 protein CTD PMID:15211785 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Alpi alkaline phosphatase, intestinal decreases expression ISO Vinyl Chloride results in decreased expression of ALPI mRNA CTD PMID:18579281 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO Vinyl Chloride results in decreased expression of ANGPTL4 mRNA CTD PMID:18579281 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Arhgef16 Rho guanine nucleotide exchange factor 16 increases expression ISO Vinyl Chloride results in increased expression of ARHGEF16 mRNA CTD PMID:18579281 NCBI chr 5:171,626,450...171,649,124
Ensembl chr 5:171,624,796...171,648,563
JBrowse link
G Arsg arylsulfatase G increases expression ISO Vinyl Chloride results in increased expression of ARSG mRNA CTD PMID:18579281 NCBI chr10:97,722,550...97,859,975
Ensembl chr10:97,771,264...97,863,311
JBrowse link
G Atl1 atlastin GTPase 1 increases expression ISO Vinyl Chloride results in increased expression of ATL1 mRNA CTD PMID:18579281 NCBI chr 6:92,229,764...92,370,428
Ensembl chr 6:92,229,686...92,370,421
JBrowse link
G Bsg basigin (Ok blood group) decreases expression ISO Vinyl Chloride results in decreased expression of BSG mRNA CTD PMID:18579281 NCBI chr 7:12,875,536...12,882,753
Ensembl chr 7:12,875,537...12,882,753
JBrowse link
G Ca11 carbonic anhydrase 11 decreases expression ISO Vinyl Chloride results in decreased expression of CAR11 mRNA CTD PMID:18579281 NCBI chr 1:101,682,009...101,687,358
Ensembl chr 1:101,682,172...101,687,293
JBrowse link
G Casp14 caspase 14 increases expression ISO Vinyl Chloride results in increased expression of CASP14 mRNA CTD PMID:18579281 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Dietary Fats co-treated with Vinyl Chloride] results in increased secretion of CCL2 protein CTD PMID:31774537 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Dietary Fats co-treated with Vinyl Chloride] results in increased secretion of CCL3 protein CTD PMID:31774537 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Vinyl Chloride results in increased expression of CCNB1 mRNA CTD PMID:18579281 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdh17 cadherin 17 increases expression ISO Vinyl Chloride results in increased expression of CDH17 mRNA CTD PMID:18579281 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects response to substance ISO CDKN2A polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cenpe centromere protein E increases expression ISO Vinyl Chloride results in increased expression of CENPE mRNA CTD PMID:18579281 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit increases expression ISO Vinyl Chloride results in increased expression of CHRNA4 mRNA CTD PMID:18579281 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Vinyl Chloride results in increased expression of CIRBP mRNA CTD PMID:18579281 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression ISO Vinyl Chloride results in increased expression of COL15A1 mRNA CTD PMID:18579281 NCBI chr 5:62,840,360...62,950,240 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO Vinyl Chloride metabolite results in increased expression of CPT1A mRNA CTD PMID:26962056 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Dietary Fats co-treated with Vinyl Chloride] results in increased secretion of CXCL10 protein CTD PMID:31774537 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Dietary Fats co-treated with Vinyl Chloride] results in increased secretion of CXCL2 protein CTD PMID:31774537 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases oxidation
affects response to substance
increases activity
affects metabolic processing
increases metabolic processing
increases response to substance
ISO
EXP
CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of KRAS gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]
CYP2E1 protein results in increased oxidation of Vinyl Chloride
CYP2E1 gene polymorphism affects the susceptibility to Vinyl Chloride
Vinyl Chloride results in increased activity of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride]
CYP2E1 protein results in increased metabolism of Vinyl Chloride
CYP2E1 gene polymorphism results in increased susceptibility to Vinyl Chloride; CYP2E1 gene SNP results in increased susceptibility to Vinyl Chloride
CTD PMID:1664256, PMID:7871537, PMID:12010862, PMID:12705718, PMID:15211785, PMID:16270392, PMID:17384900, PMID:17710613, PMID:18350910, PMID:18420361, PMID:20100738, PMID:20134343 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression ISO Vinyl Chloride results in decreased expression of CYP3A13 mRNA CTD PMID:18579281 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO Vinyl Chloride results in decreased expression of DKK3 mRNA CTD PMID:18579281 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Vinyl Chloride results in increased expression of DUSP8 mRNA CTD PMID:18579281 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 increases expression ISO Vinyl Chloride results in increased expression of EEPD1 mRNA CTD PMID:18579281 NCBI chr 8:26,651,241...26,758,330
Ensembl chr 8:26,652,121...26,758,325
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit increases response to substance ISO ERCC2 gene SNP results in increased susceptibility to Vinyl Chloride CTD PMID:18420361 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit affects response to substance ISO ERCC4 5' UTR SNP affects the susceptibility to Vinyl Chloride CTD PMID:21216194 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Far1 fatty acyl CoA reductase 1 decreases expression ISO Vinyl Chloride results in decreased expression of FAR1 mRNA CTD PMID:18579281 NCBI chr 1:178,351,674...178,412,838
Ensembl chr 1:178,351,680...178,431,395
JBrowse link
G Fasn fatty acid synthase increases expression ISO Vinyl Chloride results in increased expression of FASN mRNA; Vinyl Chloride results in increased expression of FASN protein CTD PMID:31445928 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbxo41 F-box protein 41 increases expression ISO Vinyl Chloride results in increased expression of FBXO41 mRNA CTD PMID:18579281 NCBI chr 4:117,255,143...117,285,228
Ensembl chr 4:117,256,770...117,268,178
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Vinyl Chloride results in increased expression of FDPS mRNA CTD PMID:18579281 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO Vinyl Chloride results in decreased expression of FKBP5 mRNA CTD PMID:18579281 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Folr1 folate receptor alpha increases expression ISO Vinyl Chloride results in increased expression of FOLR1 mRNA CTD PMID:18579281 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO Vinyl Chloride results in decreased expression of G0S2 mRNA CTD PMID:18579281 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects response to substance ISO GADD45A polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression ISO Vinyl Chloride results in decreased expression of GDE1 mRNA CTD PMID:18579281 NCBI chr 1:188,367,550...188,407,125
Ensembl chr 1:188,394,814...188,407,132
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO Vinyl Chloride results in increased expression of GMPPB mRNA CTD PMID:18579281 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159
JBrowse link
G Gnb5 G protein subunit beta 5 increases expression ISO Vinyl Chloride results in increased expression of GNB5 mRNA CTD PMID:18579281 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression ISO Vinyl Chloride results in decreased expression of GOT1 mRNA CTD PMID:18579281 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpa33 glycoprotein A33 increases expression ISO Vinyl Chloride results in increased expression of GPA33 mRNA CTD PMID:18579281 NCBI chr13:84,334,598...84,368,154
Ensembl chr13:84,334,598...84,368,154
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression ISO Vinyl Chloride results in increased expression of GPAM mRNA CTD PMID:18579281 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression ISO Vinyl Chloride results in decreased expression of GPR85 mRNA CTD PMID:18579281 NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Vinyl Chloride results in increased expression of GPT protein CTD PMID:31445928 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gramd1c GRAM domain containing 1C increases expression ISO Vinyl Chloride results in increased expression of GRAMD1C mRNA CTD PMID:18579281 NCBI chr11:61,609,370...61,659,355
NCBI chr11:62,580,983...62,634,961
Ensembl chr11:61,605,937...62,634,803
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression ISO Vinyl Chloride metabolite results in increased expression of GSK3B mRNA CTD PMID:26962056 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] results in increased susceptibility to Vinyl Chloride; GSTM1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]] CTD PMID:16097394, PMID:16977343 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases response to substance
affects response to substance
ISO GSTP1 gene SNP results in increased susceptibility to Vinyl Chloride
GSTP1 gene polymorphism affects the susceptibility to Vinyl Chloride
CTD PMID:20100738, PMID:20134343 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases response to substance
ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] results in increased susceptibility to Vinyl Chloride; GSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]
GSTT1 gene polymorphism results in increased susceptibility to Vinyl Chloride
CTD PMID:16097394, PMID:16270392, PMID:16977343 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Vinyl Chloride results in decreased expression of HMOX1 mRNA CTD PMID:18579281 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxc8 homeobox C8 increases expression ISO Vinyl Chloride results in increased expression of HOXC8 mRNA CTD PMID:18579281 NCBI chr 7:144,605,072...144,607,639
Ensembl chr 7:144,605,058...144,608,538
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Vinyl Chloride results in increased expression of HSPA5 mRNA CTD PMID:31445928 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 decreases expression ISO Vinyl Chloride results in decreased expression of HSPB8 mRNA CTD PMID:18579281 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression ISO Vinyl Chloride results in decreased expression of HSPH1 mRNA CTD PMID:18579281 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dietary Fats co-treated with Vinyl Chloride] results in increased secretion of IFNG protein CTD PMID:31774537 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO Vinyl Chloride results in increased expression of IHH mRNA CTD PMID:18579281 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO Vinyl Chloride results in increased expression of IKBKE mRNA CTD PMID:18579281 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Vinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:26962056 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Vinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:26962056 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Vinyl Chloride results in decreased expression of IL1R1 mRNA CTD PMID:18579281 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il36a interleukin 36, alpha increases expression ISO Vinyl Chloride results in increased expression of IL1F6 mRNA CTD PMID:18579281 NCBI chr 3:1,330,790...1,335,811
Ensembl chr 3:1,331,226...1,335,775
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Vinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:26962056 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Impact impact RWD domain protein decreases expression ISO Vinyl Chloride results in decreased expression of IMPACT mRNA CTD PMID:18579281 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Vinyl Chloride results in increased expression of INSIG1 mRNA CTD PMID:18579281 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Kel Kell metallo-endopeptidase (Kell blood group) increases expression ISO Vinyl Chloride results in increased expression of KEL mRNA CTD PMID:18579281 NCBI chr 4:70,979,504...70,996,920
Ensembl chr 4:70,979,504...70,996,395
JBrowse link
G Klhl31 kelch-like family member 31 increases expression ISO Vinyl Chloride results in increased expression of KLHL31 mRNA CTD PMID:18579281 NCBI chr 8:84,945,444...84,968,811
Ensembl chr 8:84,945,444...84,968,811
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases mutagenesis
increases response to substance
ISO CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of KRAS gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]
KRAS gene polymorphism results in increased susceptibility to Vinyl Chloride
CTD PMID:10629081, PMID:11563603, PMID:12211074, PMID:12670519, PMID:12705718, PMID:12807761, PMID:16881598, PMID:17384900 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lce1c late cornified envelope 1C increases expression ISO Vinyl Chloride results in increased expression of LCE1C mRNA CTD PMID:18579281
G Lce3e late cornified envelope 3E increases expression ISO Vinyl Chloride results in increased expression of LCE3C mRNA CTD PMID:18579281 NCBI chr 2:193,275,472...193,276,006
Ensembl chr 2:193,275,507...193,275,803
JBrowse link
G LOC102547963 leucine-rich repeat and transmembrane domain-containing protein 1-like increases expression ISO Vinyl Chloride results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:5,078,506...5,089,888
Ensembl chr16:5,082,239...5,087,844
JBrowse link
G LOC102551406 keratin-associated protein 20-2-like increases expression ISO Vinyl Chloride results in increased expression of KRTAP6-1 mRNA CTD PMID:18579281 NCBI chr11:29,062,404...29,062,650
Ensembl chr11:29,062,404...29,062,586
JBrowse link
G LOC103690086 uncharacterized LOC103690086 increases expression ISO Vinyl Chloride results in increased expression of GBP9 mRNA CTD PMID:18579281 NCBI chr14:5,642,357...5,646,406 JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Vinyl Chloride results in decreased expression of LPAR4 mRNA CTD PMID:18579281 NCBI chr  X:78,042,859...78,056,347
Ensembl chr  X:78,042,859...78,056,347
JBrowse link
G Lrrc49 leucine rich repeat containing 49 decreases expression ISO Vinyl Chloride results in decreased expression of LRRC49 mRNA CTD PMID:18579281 NCBI chr 8:65,481,584...65,587,687
Ensembl chr 8:65,481,592...65,587,658
JBrowse link
G Lrtm1 leucine-rich repeats and transmembrane domains 1 increases expression ISO Vinyl Chloride results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:4,993,728...5,005,110
Ensembl chr16:4,997,461...5,003,066
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Vinyl Chloride results in decreased expression of MAP3K5 mRNA CTD PMID:18579281 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 increases expression ISO Vinyl Chloride results in increased expression of MAPK8IP2 mRNA CTD PMID:18579281 NCBI chr 7:130,430,588...130,440,838
Ensembl chr 7:130,431,213...130,440,703
JBrowse link
G Mcf2l MCF.2 cell line derived transforming sequence-like increases expression ISO Vinyl Chloride results in increased expression of MCF2L mRNA CTD PMID:18579281 NCBI chr16:81,839,686...81,986,007
Ensembl chr16:81,839,653...81,980,027
JBrowse link
G Mdm2 MDM2 proto-oncogene affects response to substance ISO MDM2 polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Vinyl Chloride results in increased expression of ME1 mRNA CTD PMID:18579281 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Med1 mediator complex subunit 1 decreases expression ISO Vinyl Chloride results in decreased expression of MED1 mRNA CTD PMID:18579281 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO Vinyl Chloride results in increased expression of MEIS1 mRNA CTD PMID:18579281 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression EXP Vinyl Chloride results in decreased expression of MGMT protein CTD PMID:15256147 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mid1ip1 MID1 interacting protein 1 increases expression ISO Vinyl Chloride results in increased expression of MID1IP1 mRNA CTD PMID:18579281 NCBI chr  X:13,114,557...13,119,274
Ensembl chr  X:13,114,569...13,116,743
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component increases expression ISO Vinyl Chloride results in increased expression of MPDZ mRNA CTD PMID:18579281 NCBI chr 5:99,413,184...99,566,356
Ensembl chr 5:99,413,187...99,566,318
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression EXP Vinyl Chloride analog results in increased expression of MPG mRNA CTD PMID:10882851 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Vinyl Chloride results in decreased expression of MT1 mRNA CTD PMID:18579281 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt4 metallothionein 4 decreases expression ISO Vinyl Chloride results in decreased expression of MT4 mRNA CTD PMID:18579281 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO Vinyl Chloride metabolite results in increased phosphorylation of MTOR protein CTD PMID:26962056 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression ISO Vinyl Chloride results in increased expression of MVD mRNA CTD PMID:18579281 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Nefl neurofilament light increases expression ISO Vinyl Chloride results in increased expression of NEFL mRNA CTD PMID:18579281 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Niban2 niban apoptosis regulator 2 increases expression ISO Vinyl Chloride results in increased expression of NIBAN2 mRNA CTD PMID:18579281 NCBI chr 3:11,921,715...11,971,327
Ensembl chr 3:11,921,715...11,971,327
JBrowse link
G Nip7 nucleolar pre-rRNA processing protein NIP7 decreases expression ISO Vinyl Chloride results in decreased expression of NIP7 mRNA CTD PMID:18579281 NCBI chr19:39,257,586...39,259,728
Ensembl chr19:39,257,586...39,259,728
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Vinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:26962056 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Vinyl Chloride results in increased expression of OLFML2B mRNA CTD PMID:18579281 NCBI chr13:88,995,301...89,032,487
Ensembl chr13:88,995,316...89,032,487
JBrowse link
G Olr346 olfactory receptor 346 increases expression ISO Vinyl Chloride results in increased expression of OLFR1451 mRNA CTD PMID:18579281 NCBI chr 1:229,849,892...229,850,818
Ensembl chr 1:229,849,892...229,850,818
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression
increases expression
ISO Vinyl Chloride results in decreased expression of PCK1 mRNA
Vinyl Chloride metabolite results in increased expression of PCK1 mRNA
CTD PMID:18579281, PMID:26962056 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Vinyl Chloride results in increased expression of PCSK9 mRNA CTD PMID:18579281 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO Vinyl Chloride results in decreased expression of PFKP mRNA CTD PMID:18579281 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Pkd1l2 polycystin 1 like 2 decreases expression ISO Vinyl Chloride results in decreased expression of PKD1L2 mRNA CTD PMID:18579281 NCBI chr19:49,535,122...49,624,291
Ensembl chr19:49,535,792...49,623,758
JBrowse link
G Plch2 phospholipase C, eta 2 increases expression ISO Vinyl Chloride results in increased expression of PLCH2 mRNA CTD PMID:18579281 NCBI chr 5:172,386,400...172,455,965
Ensembl chr 5:172,388,598...172,424,081
JBrowse link
G Plin4 perilipin 4 decreases expression ISO Vinyl Chloride results in decreased expression of PLIN4 mRNA CTD PMID:18579281 NCBI chr 9:10,963,494...10,972,360
Ensembl chr 9:10,963,723...10,971,277
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 increases expression ISO Vinyl Chloride results in increased expression of PNLIPRP2 mRNA CTD PMID:18579281 NCBI chr 1:279,896,973...279,927,600
Ensembl chr 1:279,896,973...279,927,600
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit increases expression ISO Vinyl Chloride results in increased expression of POLE2 mRNA CTD PMID:18579281 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996
JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G decreases expression ISO Vinyl Chloride results in decreased expression of PPP1R3G mRNA CTD PMID:18579281 NCBI chr17:29,566,032...29,570,294
Ensembl chr17:29,567,404...29,568,447
JBrowse link
G Prok1 prokineticin 1 increases expression ISO Vinyl Chloride results in increased expression of PROK1 mRNA CTD PMID:18579281 NCBI chr 2:209,986,503...209,994,438
Ensembl chr 2:209,987,992...209,993,250
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Vinyl Chloride results in increased expression of PSAT1 mRNA CTD PMID:18579281 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Pthlh parathyroid hormone-like hormone increases response to substance ISO PTHLH gene polymorphism results in increased susceptibility to Vinyl Chloride CTD PMID:12807761 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO Vinyl Chloride results in decreased expression of PTP4A1 mRNA CTD PMID:18579281 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Retreg1 reticulophagy regulator 1 decreases expression ISO Vinyl Chloride results in decreased expression of RETREG1 mRNA CTD PMID:18579281 NCBI chr 2:78,391,921...78,401,569
Ensembl chr 2:78,391,921...78,399,987
JBrowse link
G Rftn1 raftlin lipid raft linker 1 increases expression ISO Vinyl Chloride results in increased expression of RFTN1 mRNA CTD PMID:18579281 NCBI chr 9:12,740,885...12,942,358
Ensembl chr 9:12,740,885...12,942,358
JBrowse link
G Rpl39l ribosomal protein L39-like increases expression ISO Vinyl Chloride results in increased expression of RPL39L mRNA CTD PMID:18579281 NCBI chr10:5,529,580...5,533,695
Ensembl chr10:5,529,589...5,533,695
JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Vinyl Chloride results in increased expression of S100A10 mRNA CTD PMID:18579281 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO Vinyl Chloride results in decreased expression of S100A9 mRNA CTD PMID:18579281 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Serpina12 serpin family A member 12 increases expression ISO Vinyl Chloride results in increased expression of SERPINA12 mRNA CTD PMID:18579281 NCBI chr 6:127,696,501...127,711,238
Ensembl chr 6:127,696,252...127,711,212
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Vinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA] CTD PMID:26962056 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Shisa2 shisa family member 2 increases expression ISO Vinyl Chloride results in increased expression of SHISA2 mRNA CTD PMID:18579281 NCBI chr15:39,945,095...39,949,393
Ensembl chr15:39,945,095...39,949,393
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Vinyl Chloride metabolite results in increased expression of SLC2A4 mRNA CTD PMID:26962056 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc36a2 solute carrier family 36 member 2 increases expression ISO Vinyl Chloride results in increased expression of SLC36A2 mRNA CTD PMID:18579281 NCBI chr10:40,497,184...40,525,033
Ensembl chr10:40,496,622...40,525,008
JBrowse link
G Slc39a14 solute carrier family 39 member 14 decreases expression ISO Vinyl Chloride results in decreased expression of SLC39A14 mRNA CTD PMID:18579281 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Smim3 small integral membrane protein 3 increases expression ISO Vinyl Chloride results in increased expression of SMIM3 mRNA CTD PMID:18579281 NCBI chr18:55,744,809...55,797,186
Ensembl chr18:55,744,810...55,771,730
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Vinyl Chloride results in decreased expression of SOCS3 mRNA CTD PMID:18579281 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sorbs3 sorbin and SH3 domain containing 3 decreases expression ISO Vinyl Chloride results in decreased expression of SORBS3 mRNA CTD PMID:18579281 NCBI chr15:51,859,004...51,895,707
Ensembl chr15:51,859,462...51,890,832
JBrowse link
G Spon2 spondin 2 increases expression ISO Vinyl Chloride results in increased expression of SPON2 mRNA CTD PMID:18579281 NCBI chr14:82,815,158...82,824,529
Ensembl chr14:82,818,663...82,824,599
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Vinyl Chloride results in increased expression of SREBF1 mRNA CTD PMID:18579281 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 decreases expression ISO Vinyl Chloride results in decreased expression of ST3GAL5 mRNA CTD PMID:18579281 NCBI chr 4:99,937,499...99,999,905
Ensembl chr 4:99,937,558...99,999,902
JBrowse link
G Tacc2 transforming, acidic coiled-coil containing protein 2 decreases expression ISO Vinyl Chloride results in decreased expression of TACC2 mRNA CTD PMID:18579281 NCBI chr 1:201,140,264...201,329,612
Ensembl chr 1:201,055,644...201,329,622
JBrowse link
G Tango2 transport and golgi organization 2 homolog decreases expression ISO Vinyl Chloride results in decreased expression of TANGO2 mRNA CTD PMID:18579281 NCBI chr11:86,793,959...86,840,556
Ensembl chr11:86,797,557...86,840,573
JBrowse link
G Tbc1d8 TBC1 domain family, member 8 decreases expression ISO Vinyl Chloride results in decreased expression of TBC1D8 mRNA CTD PMID:18579281 NCBI chr 9:46,090,613...46,206,672
Ensembl chr 9:46,090,019...46,206,605
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dietary Fats co-treated with Vinyl Chloride] results in increased expression of TNF mRNA; [Dietary Fats co-treated with Vinyl Chloride] results in increased secretion of TNF protein CTD PMID:31774537 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tom1l2 target of myb1 like 2 membrane trafficking protein decreases expression ISO Vinyl Chloride results in decreased expression of TOM1L2 mRNA CTD PMID:18579281 NCBI chr10:46,599,392...46,720,921
Ensembl chr10:46,602,231...46,720,910
JBrowse link
G Top2a DNA topoisomerase II alpha increases activity ISO Vinyl Chloride metabolite results in increased activity of TOP2A protein CTD PMID:15751973 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
decreases expression
increases expression
increases mutagenesis
increases response to substance
ISO CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]; GSTM1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]; GSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]; XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]
TP53 polymorphism affects the susceptibility to Vinyl Chloride
Vinyl Chloride results in decreased expression of TP53 mRNA
Vinyl Chloride results in increased expression of TP53 protein; Vinyl Chloride results in increased expression of TP53 protein mutant form
TP53 gene SNP results in increased susceptibility to Vinyl Chloride
CTD PMID:12010862, PMID:12670519, PMID:12705718, PMID:14602524, PMID:14979067, PMID:16097394, PMID:16474264, PMID:16881598, PMID:17384900, PMID:18226366, PMID:22076037, PMID:24464562 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 decreases expression ISO Vinyl Chloride results in decreased expression of TRP53INP1 mRNA CTD PMID:18579281 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression ISO Vinyl Chloride results in increased expression of TRAF2 mRNA CTD PMID:18579281 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 increases expression ISO Vinyl Chloride results in increased expression of TSC22D1 mRNA CTD PMID:18579281 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Ttc23 tetratricopeptide repeat domain 23 increases expression ISO Vinyl Chloride results in increased expression of TTC23 mRNA CTD PMID:18579281 NCBI chr 1:128,604,324...128,687,900
Ensembl chr 1:128,606,770...128,687,893
JBrowse link
G Ust uronyl-2-sulfotransferase increases expression ISO Vinyl Chloride results in increased expression of UST mRNA CTD PMID:18579281 NCBI chr 1:2,330,631...2,627,654
Ensembl chr 1:2,333,778...2,627,747
JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 increases expression ISO Vinyl Chloride results in increased expression of VANGL2 mRNA CTD PMID:18579281 NCBI chr13:90,379,203...90,405,627
Ensembl chr13:90,380,632...90,405,591
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Vinyl Chloride metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] CTD PMID:26962056 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Veph1 ventricular zone expressed PH domain-containing 1 increases expression ISO Vinyl Chloride results in increased expression of VEPH1 mRNA CTD PMID:18579281 NCBI chr 2:157,869,383...158,156,266
Ensembl chr 2:157,869,392...158,156,444
JBrowse link
G Wbp1l WW domain binding protein 1-like decreases expression ISO Vinyl Chloride results in decreased expression of WBP1L mRNA CTD PMID:18579281 NCBI chr 1:266,358,728...266,415,296
Ensembl chr 1:266,358,728...266,415,296
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor affects response to substance ISO XPA gene polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:21216194 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC gene polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:21216194 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
increases response to substance
decreases expression
ISO
EXP
GSTM1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]; GSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]; XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]
XRCC1 gene SNP results in increased susceptibility to Vinyl Chloride
Vinyl Chloride results in decreased expression of XRCC1 protein
CTD PMID:12010862, PMID:14602524, PMID:15256147, PMID:16097394, PMID:16881598, PMID:17555083, PMID:18420361, PMID:20100738 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc2 X-ray repair cross complementing 2 affects response to substance ISO XRCC2 gene polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:16217922 NCBI chr 4:5,842,013...5,860,516
Ensembl chr 4:5,841,998...5,860,527
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression EXP Vinyl Chloride results in increased expression of XRCC3 protein CTD PMID:15256147 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
G Ypel1 yippee-like 1 increases expression ISO Vinyl Chloride results in increased expression of YPEL1 mRNA CTD PMID:18579281 NCBI chr11:88,171,401...88,186,000
Ensembl chr11:88,173,890...88,180,542
JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 decreases expression ISO Vinyl Chloride results in decreased expression of ZHX3 mRNA CTD PMID:18579281 NCBI chr 3:156,759,820...156,868,173
Ensembl chr 3:156,764,751...156,777,999
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        main group molecular entity 19702
          gas molecular entity 17567
            chloroethene 159
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  olefin 7187
                                    acyclic olefin 7167
                                      alkene 3988
                                        ethene 3863
                                          haloethene 3861
                                            monohaloethene 161
                                              chloroethene 159
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.