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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,2-dibromoethane
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Accession:CHEBI:28534 term browser browse the term
Definition:A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae.
Synonyms:related_synonym: DBE;   EDB;   Ethylene dibromide;   Formula=C2H4Br2;   InChI=1S/C2H4Br2/c3-1-2-4/h1-2H2;   InChIKey=PAAZPARNPHGIKF-UHFFFAOYSA-N;   SMILES=BrCCBr;   alpha,beta-dibromoethane;   alpha,omega-dibromoethane;   ethylene bromide;   sym-Dibromoethane
 alt_id: CHEBI:18880;   CHEBI:496
 xref: Beilstein:605266;   CAS:106-93-4;   Gmelin:1913;   HMDB:HMDB0060334;   KEGG:C11088
 xref_mesh: MESH:D015946
 xref: MetaCyc:12-DIBROMOETHANE;   PMID:10088182;   PMID:11312844;   PPDB:1484;   Reaxys:605266;   Wikipedia:1\,2-Dibromoethane


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1,2-dibromoethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO Ethylene Dibromide results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Ethylene Dibromide results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:12,573,604...12,602,407
Ensembl chr 7:12,574,198...12,601,674
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Ethylene Dibromide results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
ISO CYP2E1 protein results in increased metabolism of Ethylene Dibromide
CYP2E1 protein results in increased oxidation of Ethylene Dibromide
CTD PMID:1664256, PMID:10841534, PMID:18350910 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Ethylene Dibromide results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Ethylene Dibromide results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO Ethylene Dibromide results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr14:2,020,110...2,032,169
Ensembl chr14:2,018,500...2,032,593
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
ISO Ethylene Dibromide results in increased activity of GGT1 protein
Phentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]; Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]
CTD PMID:12628311 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases activity
affects response to substance
increases glutathionylation
ISO
EXP
GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide]; GSTT1 protein affects the metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein affects the susceptibility to Ethylene Dibromide
CTD PMID:8565128, PMID:10413528, PMID:12505322, PMID:12902151, PMID:19664997, PMID:21781954 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases expression ISO Ethylene Dibromide results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001
JBrowse link
G Krt10 keratin 10 decreases expression ISO Ethylene Dibromide results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ethylene Dibromide results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Ethylene Dibromide results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
increases response to substance
affects binding
ISO Ethylene Dibromide binds to and results in decreased activity of MGMT protein; MGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide; MGMT protein results in increased activity of and results in increased susceptibility to Ethylene Dibromide
MGMT protein results in increased susceptibility to Ethylene Dibromide
Ethylene Dibromide binds to MGMT protein
CTD PMID:10894884, PMID:12151404, PMID:14645247, PMID:17226938 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Ethylene Dibromide results in increased activity of NFE2L2 protein CTD PMID:30114225, PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Ethylene Dibromide results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity EXP Ethylene Dibromide results in increased activity of ODC1 protein CTD PMID:3801022 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression ISO Ethylene Dibromide results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression ISO Ethylene Dibromide results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 1:84,339,269...84,361,686
Ensembl chr 1:84,339,261...84,353,725
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Ethylene Dibromide results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:66,673,060...66,783,501
Ensembl chr 3:66,673,071...66,780,075
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO Ethylene Dibromide results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 4:144,537,329...144,620,606
Ensembl chr 4:144,536,729...144,620,731
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO Ethylene Dibromide results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression ISO Ethylene Dibromide results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 2:207,350,651...207,421,082
Ensembl chr 2:207,350,651...207,473,857
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Ethylene Dibromide results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:176,124,846...176,144,531
Ensembl chr 3:176,125,482...176,144,531
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethylene dibromide increases expression of Tnf mRNA in liver RGD PMID:7943184 RGD:14995476 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Ethylene Dibromide results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO Ethylene Dibromide results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Ethylene Dibromide results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
JBrowse link

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  CHEBI ontology 19816
    role 19764
      application 19426
        pesticide 16430
          fumigant 1002
            1,2-dibromoethane 28
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  halohydrocarbon 13956
                                    haloalkane 11674
                                      bromoalkane 86
                                        1,2-dibromoethane 28
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.