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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:28738 term browser browse the term
Definition:A primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic).
Synonyms:related_synonym: 1-amino-2,6-dimethylbenzene;   2,6-DMA;   2,6-dimethylbenzenamine;   2,6-dimethylphenylamine;   2,6-xylidine;   2,6-xylylamine;   2-amino-1,3-dimethylbenzene;   2-amino-1,3-xylene;   2-amino-m-xylene;   Formula=C8H11N;   InChI=1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3;   InChIKey=UFFBMTHBGFGIHF-UHFFFAOYSA-N;   SMILES=Cc1cccc(C)c1N;   o-xylidine;   vic-m-xylidine
 alt_id: CHEBI:19404;   CHEBI:956
 xref: Beilstein:636332;   CAS:87-62-7;   HMDB:HMDB0060677;   KEGG:C11004
 xref_mesh: MESH:C007766
 xref: PMID:11765029;   PMID:18490435;   PMID:8374321;   Reaxys:636332;   Wikipedia:2\,6-Xylidine

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2,6-dimethylaniline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing
multiple interactions
ISO CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite
fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]
CTD PMID:11409937 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine CTD PMID:20199096 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            2,6-dimethylaniline 2
              N-(2,6-dimethylphenyl)-N(2)-(3,5-dimethylphenyl)glycinamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        aromatic amine 13634
                                          anilines 12341
                                            substituted aniline 11837
                                              methylaniline 7
                                                dimethylaniline 7
                                                  2,6-dimethylaniline 2
                                                    N-(2,6-dimethylphenyl)-N(2)-(3,5-dimethylphenyl)glycinamide 0
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