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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:serotonin
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Accession:CHEBI:28790 term browser browse the term
Definition:A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Synonyms:related_synonym: 3-(2-Aminoethyl)-1H-indol-5-ol;   5-HT;   5-Hydroxytryptamine;   Enteramine;   Formula=C10H12N2O;   InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2;   InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N;   SMILES=C1=CC(=CC=2C(=CNC12)CCN)O;   serotonine;   thrombocytin;   thrombotonin
 alt_id: CHEBI:1420;   CHEBI:26652;   CHEBI:49894
 xref: Beilstein:143524;   CAS:50-67-9;   Gmelin:1861995;   HMDB:HMDB0000259;   KEGG:C00780;   KNApSAcK:C00001429;   LINCS:LSM-6589
 xref_mesh: MESH:D012701
 xref: MetaCyc:SEROTONIN;   PDBeChem:SRO;   PMID:18593914;   PMID:22770225;   PMID:24136337;   Reaxys:143524;   Wikipedia:Serotonin
 cyclic_relationship: is_conjugate_base_of CHEBI:350546


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serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; AG 1879 inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; guanosine 5'-O-(2-thiodiphosphate) inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; Serotonin results in increased expression of and results in increased activity of ACAT1 protein
Serotonin results in increased expression of ACAT1 mRNA alternative form
CTD PMID:16157345 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:26408985 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases activity
multiple interactions
ISO Serotonin results in increased activity of AKT1 protein
[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]
CTD PMID:22975078 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein increases response to substance
multiple interactions
ISO APP protein modified form results in increased susceptibility to Serotonin
Oils, Volatile inhibits the reaction [[APP protein modified form binds to APP protein modified form] which results in increased susceptibility to Serotonin]
CTD PMID:28915354 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions
increases expression
ISO
EXP
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]
CTD PMID:25766885 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP
ISO
[Butyrates co-treated with Serotonin] results in increased expression of BDNF mRNA; [trichostatin A co-treated with Serotonin] results in increased expression of BDNF mRNA; [Valproic Acid co-treated with Serotonin] results in increased expression of BDNF mRNA
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
CTD PMID:19360904, PMID:26408985 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
EXP [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] CTD PMID:11166334, PMID:12791437, PMID:14991081 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] CTD PMID:24650663 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP7 protein] CTD PMID:24650663 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Serotonin] CTD PMID:11435997 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein]
Serotonin results in increased activity of CFTR protein
CTD PMID:15151902 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:26408985 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:26408985 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]; corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin] CTD PMID:14575894 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions ISO DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]; DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin] CTD PMID:15148402 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein] CTD PMID:20887679 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein] CTD PMID:20887679 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G En2 engrailed homeobox 2 affects abundance ISO EN2 protein affects the abundance of Serotonin; EN2 protein affects the abundance of Serotonin metabolite CTD PMID:16935268 NCBI chr 4:438,668...444,508
Ensembl chr 4:438,668...444,501
JBrowse link
G Enam enamelin decreases expression ISO Serotonin results in decreased expression of ENAM mRNA CTD PMID:21083617 NCBI chr14:21,194,635...21,219,529
Ensembl chr14:21,194,664...21,219,454
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Serotonin results in increased expression of FGF1 protein CTD PMID:15264218 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf5 fibroblast growth factor 5 affects uptake EXP FGF5 protein affects the uptake of Serotonin CTD PMID:8167846 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Serotonin results in increased expression of FOS mRNA CTD PMID:10700011 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [tryptamine-4,5-dione co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein CTD PMID:23009681 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases export EXP GHRL protein results in decreased export of Serotonin CTD PMID:20553917 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gla galactosidase, alpha affects response to substance ISO GLA protein affects the susceptibility to Serotonin CTD PMID:18565198 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions ISO [Bile Acids and Salts binds to and results in increased activity of GPBAR1 protein] which results in increased secretion of Serotonin CTD PMID:23041323 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Serotonin results in increased phosphorylation of GSK3B protein CTD PMID:20190034 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein] CTD PMID:26408985 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases activity
affects binding
increases uptake
increases expression
affects response to substance
EXP
ISO
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]; Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]
Serotonin results in increased activity of HTR1A protein
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Serotonin results in increased activity of HTR1A protein]
Serotonin results in increased expression of HTR1A mRNA
HTR1A protein affects the susceptibility to Serotonin
CTD PMID:11106871, PMID:16528294, PMID:21083617, PMID:21126535, PMID:31323226 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP Serotonin binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D affects abundance ISO HTR1D gene polymorphism affects the abundance of Serotonin CTD PMID:17203304 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases response to substance
affects response to substance
affects binding
increases expression
multiple interactions
ISO
EXP
HTR2A gene SNP results in decreased susceptibility to Serotonin
HTR2A protein affects the susceptibility to Serotonin
Serotonin binds to HTR2A protein
Serotonin results in increased expression of HTR2A mRNA
[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]
HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]
[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A protein
CTD PMID:8627522, PMID:11076827, PMID:11880652, PMID:16314884, PMID:16528294, PMID:19879056, PMID:21083617 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B increases expression
affects binding
multiple interactions
affects response to substance
ISO
EXP
Serotonin results in increased expression of HTR2B mRNA
Serotonin binds to HTR2B protein
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [Serotonin binds to HTR2B protein]
HTR2B protein affects the susceptibility to Serotonin
CTD PMID:8627522, PMID:9857084, PMID:21083617 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects expression
multiple interactions
ISO
EXP
Serotonin affects the expression of HTR2C mRNA
[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]; Serotonin binds to and results in increased activity of HTR2C protein
CTD PMID:9050900, PMID:21083617, PMID:21554931 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects localization
increases activity
ISO 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]
Serotonin affects the localization of HTR3A protein alternative form
Serotonin results in increased activity of HTR3A protein
1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Toluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Trichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein]
CTD PMID:12681521, PMID:17360702, PMID:17436349 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B multiple interactions ISO 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] CTD PMID:17360702 NCBI chr 8:53,247,881...53,278,170
Ensembl chr 8:53,248,705...53,277,859
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions ISO HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions ISO HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP] CTD PMID:11406289, PMID:11880652 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP CTD PMID:14578406 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Il12b interleukin 12B affects secretion ISO Serotonin affects the secretion of IL12B protein CTD PMID:15802305 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 affects response to substance ISO IL13 protein affects the susceptibility to Serotonin CTD PMID:12370375 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta affects secretion
increases expression
ISO Serotonin affects the secretion of IL1B protein
Serotonin results in increased expression of IL1B
CTD PMID:15302781, PMID:15802305 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 affects response to substance ISO IL4 protein affects the susceptibility to Serotonin CTD PMID:12370375 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 affects expression
increases expression
multiple interactions
affects secretion
ISO Serotonin affects the expression of IL6 mRNA
Serotonin results in increased expression of IL6 mRNA
[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 protein
Serotonin affects the secretion of IL6 protein
CTD PMID:11076827, PMID:15302781, PMID:15802305 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] CTD PMID:22975078 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO
EXP
ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]
ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]
CTD PMID:18234883 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgb3 integrin subunit beta 3 affects abundance ISO ITGB3 gene polymorphism affects the abundance of Serotonin CTD PMID:16724005, PMID:17203304 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 multiple interactions EXP Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium] CTD PMID:16020457 NCBI chr 6:27,154,274...27,190,209
Ensembl chr 6:27,151,612...27,190,132
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] CTD PMID:11166334, PMID:12791437, PMID:18234883 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Maoa monoamine oxidase A increases metabolic processing
multiple interactions
increases degradation
decreases amination
increases abundance
ISO
EXP
MAOA protein results in increased metabolism of Serotonin
[MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid
MAOA protein results in increased degradation of Serotonin
[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde; Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]; Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]
MAOA protein results in decreased amination of Serotonin
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Isocarboxazid inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
MAOA mutant form results in increased abundance of Serotonin
MAOA gene polymorphism results in increased abundance of Serotonin
CTD PMID:3961266, PMID:10647887, PMID:11834493, PMID:18405062, PMID:23009399, PMID:26721607, PMID:30036687, PMID:32243540 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B increases abundance
decreases amination
multiple interactions
ISO MAOB mutant form results in increased abundance of Serotonin
MAOB protein results in decreased amination of Serotonin
3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]
CTD PMID:11834493, PMID:26721607 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Serotonin results in increased phosphorylation of MAPK1 protein CTD PMID:30592962 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Serotonin results in increased phosphorylation of MAPK3 protein CTD PMID:30592962 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp20 matrix metallopeptidase 20 decreases expression ISO Serotonin results in decreased expression of MMP20 mRNA CTD PMID:21083617 NCBI chr 8:5,823,147...5,875,555
Ensembl chr 8:5,833,359...5,875,232
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] CTD PMID:23009681 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin CTD PMID:18226494 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin CTD PMID:18226494 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP [dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Otc ornithine carbamoyltransferase affects metabolic processing
multiple interactions
ISO OTC gene mutant form affects the metabolism of Serotonin
Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]
CTD PMID:3374991 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases secretion ISO OXT protein results in increased secretion of Serotonin CTD PMID:19228979 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects abundance ISO PARP1 affects the abundance of Serotonin CTD PMID:21990073 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Penk proenkephalin multiple interactions EXP Serotonin inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] CTD PMID:1363325 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases localization
multiple interactions
ISO Serotonin results in increased localization of PPARG protein
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein]
CTD PMID:25766885 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions
increases phosphorylation
decreases phosphorylation
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
Serotonin results in increased expression of PTGS2 mRNA; Serotonin results in increased expression of PTGS2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; AG 1879 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; Calcium deficiency inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
CTD PMID:21262218, PMID:26408985 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity ISO Serotonin results in increased activity of RELA protein CTD PMID:11076827 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO [TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419, PMID:27097221 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions
increases uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding
increases uptake
increases transport
multiple interactions
affects uptake
ISO
EXP
Serotonin binds to SLC18A2 protein
SLC18A2 protein binds to Serotonin
SLC18A2 protein results in increased uptake of Serotonin
SLC18A2 protein results in increased transport of Serotonin
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]; Serotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]
SLC18A2 gene SNP affects the uptake of Serotonin
CTD PMID:1438304, PMID:7912402, PMID:9038139, PMID:15475732, PMID:18287335 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
EXP
ISO
Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A3 protein results in increased uptake of Serotonin
CTD PMID:9830022, PMID:16928864, PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Serotonin CTD PMID:20858707 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Serotonin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Serotonin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases uptake
ISO SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
SLC6A3 protein results in increased uptake of Serotonin
CTD PMID:17234900, PMID:17250655 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
decreases activity
increases uptake
affects binding
increases expression
affects abundance
ISO
EXP
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
serotonin decreases activity of Slc6a4 protein in epithelial colorectal adenocarcinoma cells
Serotonin binds to SLC6A4 protein
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Aminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Dextroamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]
Serotonin results in increased expression of SLC6A4 mRNA
SLC6A4 gene polymorphism affects the abundance of Serotonin
CTD PMID:15972295, PMID:16272152, PMID:16476009, PMID:16982082, PMID:17203304, PMID:17234900, PMID:20452607, PMID:21083617, PMID:24841869, PMID:29908239, PMID:30776375, PMID:19747920 RGD:36947380 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Sorl1 sortilin related receptor 1 multiple interactions
increases expression
ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Stxbp3 syntaxin binding protein 3 affects secretion ISO STXBP3 protein affects the secretion of Serotonin CTD PMID:18556422 NCBI chr 2:211,595,763...211,638,756
Ensembl chr 2:211,595,659...211,638,788
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Serotonin CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] CTD PMID:11166334, PMID:18234883 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin CTD PMID:16952380 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419, PMID:27097221 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor affects secretion
increases expression
ISO Serotonin affects the secretion of TNF protein
Serotonin results in increased expression of TNF
CTD PMID:15302781, PMID:15802305 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tph1 tryptophan hydroxylase 1 affects abundance
increases chemical synthesis
increases abundance
ISO TPH1 gene polymorphism affects the abundance of Serotonin
TPH1 protein results in increased chemical synthesis of Serotonin
TPH1 gene polymorphism results in increased abundance of Serotonin
CTD PMID:17203304, PMID:18405062, PMID:18506000 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
G Tph2 tryptophan hydroxylase 2 affects abundance ISO TPH2 protein affects the abundance of Serotonin CTD PMID:20722968 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased secretion of Serotonin] CTD PMID:19507004 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Serotonin promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium] CTD PMID:16901936 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions ISO TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] CTD PMID:18234883 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects glucuronidation
increases glucuronidation
multiple interactions
ISO UGT1A6 gene polymorphism affects the glucuronidation of Serotonin; UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite
UGT1A6 protein results in increased glucuronidation of Serotonin; UGT1A6 protein results in increased glucuronidation of Serotonin metabolite
bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin]
CTD PMID:15761113, PMID:15761114, PMID:18214896 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein; sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] CTD PMID:23009681 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] CTD PMID:22975078 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
2-methylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO 2-methyl-5-HT binds to and results in increased activity of HTR3A protein CTD PMID:15802305 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15802305 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:15802305 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
5-methoxy-N,N-diisopropyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO 5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion
CTD PMID:26599973 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole CTD PMID:26599973 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases metabolic processing EXP CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases metabolic processing EXP CYP2D2 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone CTD PMID:26599973 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
N-acetylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein] CTD PMID:19961921 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
O-methylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP CTD PMID:14578406 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Kmo kynurenine 3-monooxygenase increases expression EXP 5-Methoxytryptamine results in increased expression of KMO mRNA CTD PMID:32243540 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B decreases phosphorylation
increases phosphorylation
ISO 5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein
5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein
CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP 5-Methoxytryptamine results in decreased expression of SOD2 mRNA CTD PMID:32243540 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO 5-Methoxytryptamine results in increased activity of TAAR1 protein
[5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Tph1 tryptophan hydroxylase 1 decreases expression EXP 5-Methoxytryptamine results in decreased expression of TPH1 mRNA CTD PMID:32243540 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        molecular messenger 18249
          monoamine molecular messenger 575
            serotonin 108
              1-(5-methoxy-1H-indol-3-yl)-2-propanamine 0
              1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]-2-propanamine 0
              2,2,2-trideuterio-N-[1,1,2,2-tetradeuterio-2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide 0
              2-methylserotonin 3
              3-(2-aminoethyl)-6-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
              3-(2-aminoethyl)-7-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
              5-Methoxy DL-tryptophan 0
              5-nonyloxytryptamine 0
              N,O-dimethylserotonin 0
              N-acylserotonin + 1
              N-arachidonoyl-2-oxoserotonin 0
              N-methylserotonin 0
              O-methylserotonin + 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      benzopyrrole 9339
                                        indoles 9193
                                          tryptamines 398
                                            tryptamine 396
                                              serotonin 108
                                                1-(5-methoxy-1H-indol-3-yl)-2-propanamine 0
                                                1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]-2-propanamine 0
                                                2,2,2-trideuterio-N-[1,1,2,2-tetradeuterio-2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide 0
                                                2-methylserotonin 3
                                                3-(2-aminoethyl)-6-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
                                                3-(2-aminoethyl)-7-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
                                                5-Methoxy DL-tryptophan 0
                                                5-nonyloxytryptamine 0
                                                N,O-dimethylserotonin 0
                                                N-acylserotonin + 1
                                                N-arachidonoyl-2-oxoserotonin 0
                                                N-methylserotonin 0
                                                O-methylserotonin + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.