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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heparan sulfate
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Accession:CHEBI:28815 term browser browse the term
Definition:A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.
Synonyms:related_synonym: Formula=(C12H19NO20S3)n;   Heparan N-sulfate;   Heparan sulphate;   Heparatan sulfate;   Heparin monosulfate;   Heparin sulfate;   Heparitin monosulfate;   Heparitin sulfate;   N-Acetylheparan sulfate
 alt_id: CHEBI:24502;   CHEBI:24507;   CHEBI:5661
 xref: Beilstein:8186767;   CAS:9050-30-0;   KEGG:C00925;   KEGG:D08536
 xref_mesh: MESH:D006497
 xref: PMID:8713797


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heparan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of [CCL5 protein binds to CCL5 protein]]; Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of CCL5 protein] CTD PMID:21963154 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Fgf1 fibroblast growth factor 1 affects binding ISO FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein CTD PMID:12604602 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf10 fibroblast growth factor 10 affects activity ISO Heparitin Sulfate affects the activity of FGF10 protein CTD PMID:12781692, PMID:12818887 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
affects binding
increases activity
ISO Heparitin Sulfate binds to and affects the activity of FGF2 protein
Heparitin Sulfate binds to FGF2 protein
Heparitin Sulfate analog results in increased activity of FGF2 protein
CTD PMID:12460940, PMID:15464572, PMID:15958608 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf4 fibroblast growth factor 4 affects binding ISO Heparitin Sulfate binds to FGF4 protein CTD PMID:15769253 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Fgf7 fibroblast growth factor 7 affects binding ISO Heparitin Sulfate binds to FGF7 protein CTD PMID:15769253 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgf8 fibroblast growth factor 8 affects binding
increases activity
ISO Heparitin Sulfate binds to FGF8 protein alternative form
Heparitin Sulfate analog results in increased activity of FGF8 protein
CTD PMID:12460940, PMID:15769253 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects binding
increases activity
ISO FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein
Heparitin Sulfate analog results in increased activity of FGFR1 protein alternative form
CTD PMID:12460940, PMID:12604602 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO Heparitin Sulfate analog results in decreased activity of FGFR2 protein mutant form CTD PMID:16373332 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases activity ISO Heparitin Sulfate analog results in increased activity of FGFR3 protein alternative form CTD PMID:12460940 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects binding ISO Heparitin Sulfate analog binds to FGFR4 protein CTD PMID:11278860 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase affects degradation ISO GNS affects the degradation of Heparitin Sulfate CTD PMID:3391615 NCBI chr 7:63,467,027...63,501,054
Ensembl chr 7:63,467,216...63,499,353
JBrowse link
G Gpc1 glypican 1 affects binding
multiple interactions
ISO GPC1 protein binds to Heparitin Sulfate
GPC1 protein modified form results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]; nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]; Zinc affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]
CTD PMID:12732622 NCBI chr 9:99,998,275...100,026,818
Ensembl chr 9:99,998,275...100,026,818
JBrowse link
G Hpse heparanase multiple interactions
decreases abundance
affects abundance
ISO
EXP
[Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate; [phosphomannopentaose sulfate results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate
HPSE protein results in decreased abundance of Heparitin Sulfate
HPSE protein affects the abundance of Heparitin Sulfate
CTD PMID:16899518, PMID:17121850 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein] CTD PMID:19937756 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions ISO Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 multiple interactions ISO Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491
JBrowse link
G Prnp prion protein affects binding ISO PRNP protein modified form binds to Heparitin Sulfate metabolite CTD PMID:18717736 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein CTD PMID:23109338 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] CTD PMID:20067761 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              animal metabolite 18712
                mammalian metabolite 18711
                  mouse metabolite 18388
                    heparan sulfate 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      polysaccharide 3031
                                        polysaccharide derivative 3013
                                          aminoglycan 390
                                            glycosaminoglycan 365
                                              heparan 24
                                                heparan sulfates 24
                                                  heparan sulfate 24
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