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ONTOLOGY REPORT - ANNOTATIONS


Term:busulfan
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Accession:CHEBI:28901 term browser browse the term
Definition:A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Synonyms:exact_synonym: butane-1,4-diyl dimethanesulfonate
 related_synonym: 1,4-Bis(methanesulfonoxy)butane;   1,4-Butanediol dimethanesulfonate;   1,4-Dimesyloxybutane;   1,4-Dimethanesulfonoxybutane;   Bisulfex;   Formula=C6H14O6S2;   InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3;   InChIKey=COVZYZSDYWQREU-UHFFFAOYSA-N;   Leucosulfan;   Mablin;   Mielucin;   Misulban;   Mitostan;   Myeloleukon;   Myleran;   SMILES=CS(=O)(=O)OCCCCOS(C)(=O)=O;   Tetramethylene bis(methanesulfonate);   busulfano;   busulfanum
 alt_id: CHEBI:18936;   CHEBI:3225
 xref: Beilstein:1791786 "Beilstein";   CAS:55-98-1 "ChemIDplus";   CAS:55-98-1 "KEGG DRUG";   DrugBank:DB01008;   Drug_Central:438 "DrugCentral";   KEGG:C06862;   KEGG:D00248;   LINCS:LSM-5388
 xref_mesh: MESH:D002066
 xref: PMID:10523796 "Europe PMC";   PMID:19361744 "Europe PMC";   PMID:19611402 "Europe PMC";   Patent:US2917432;   Reaxys:1791786 "Reaxys";   Wikipedia:Busulfan


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busulfan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Anp32b acidic nuclear phosphoprotein 32 family member B JBrowse link 5 62,070,709 62,094,633 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:6480464
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:6480464
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:6480464
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:6480464
G Lama1 laminin subunit alpha 1 JBrowse link 9 115,916,907 116,042,123 RGD:6480464
G Lama4 laminin subunit alpha 4 JBrowse link 20 44,060,715 44,201,966 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mgst2 microsomal glutathione S-transferase 2 JBrowse link 2 140,708,396 140,727,381 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nanos2 nanos C2HC-type zinc finger 2 JBrowse link 1 79,894,450 79,895,910 RGD:6480464
G Nanos3 nanos C2HC-type zinc finger 3 JBrowse link 19 25,284,907 25,288,680 RGD:6480464
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 JBrowse link 10 56,227,703 56,229,796 RGD:6480464
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Smc1a structural maintenance of chromosomes 1A JBrowse link X 21,710,976 21,755,708 RGD:6480464
G Smc3 structural maintenance of chromosomes 3 JBrowse link 1 274,310,120 274,352,856 RGD:6480464
G Stra8 stimulated by retinoic acid 8 JBrowse link 4 62,447,724 62,474,802 RGD:6480464
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6480464
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          carcinogenic agent 17766
            busulfan 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      chalcogen 19233
                        oxygen atom 19188
                          oxygen molecular entity 19188
                            hydroxides 18965
                              oxoacid 18076
                                chalcogen oxoacid 11397
                                  sulfur oxoacid 10987
                                    sulfonic acid 7240
                                      sulfo group 5627
                                        organosulfonic acid 5627
                                          alkanesulfonic acid 3976
                                            methanesulfonic acid 3965
                                              methanesulfonates 3962
                                                methanesulfonate ester 3962
                                                  busulfan 57
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.