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ONTOLOGY REPORT - ANNOTATIONS


Term:5alpha-pregnane-3,20-dione
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Accession:CHEBI:28952 term browser browse the term
Definition:A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.
Synonyms:related_synonym: 3,20-allopregnanedione;   3,20-dioxo-5alpha-pregnane;   5-alpha-dihydroprogesterone;   5alpha-dihydroprogesterone;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=XMRPGKVKISIQBV-BJMCWZGWSA-N;   SMILES=[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2
 alt_id: CHEBI:12175;   CHEBI:20657;   CHEBI:2144
 xref: CAS:566-65-4 "ChemIDplus";   CAS:566-65-4 "KEGG COMPOUND";   HMDB:HMDB0003759;   KEGG:C03681;   LIPID_MAPS_instance:LMST02030170 "LIPID MAPS"
 xref_mesh: MESH:D043582
 xref: PMID:15319353 "Europe PMC";   PMID:17683929 "Europe PMC";   PMID:19931389 "Europe PMC";   Reaxys:2058506 "Reaxys";   Wikipedia:5%CE%B1-Dihydroprogesterone


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5alpha-pregnane-3,20-dione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:6480464
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:6480464
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:6480464
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Egr2 early growth response 2 JBrowse link 20 22,452,170 22,461,018 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Sox10 SRY-box transcription factor 10 JBrowse link 7 120,393,238 120,403,523 RGD:6480464
G Srd5a1 steroid 5 alpha-reductase 1 JBrowse link 1 36,320,504 36,354,694 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    chemical entity 19747
      group 19655
        organic group 18427
          3-oxo-Delta(4)-steroid group 7935
            3-oxo-Delta(4) steroid 7935
              progesterone 2711
                5alpha-pregnane-3,20-dione 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      ketone 15922
                                        oxo steroid 9283
                                          3-oxo steroid 8807
                                            3-oxo-Delta(4) steroid 7935
                                              progesterone 2711
                                                5alpha-pregnane-3,20-dione 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.