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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron(2+)
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Accession:CHEBI:29033 term browser browse the term
Definition:An iron cation that has formula Fe.
Synonyms:exact_synonym: iron(II) cation
 related_synonym: FE (II) ION;   Fe(2+);   Fe(II);   Fe2+;   Ferrous ion;   Formula=Fe;   InChI=1S/Fe/q+2;   InChIKey=CWYNVVGOOAEACU-UHFFFAOYSA-N;   SMILES=[Fe++];   iron ion(2+)
 alt_id: CHEBI:13319;   CHEBI:13321;   CHEBI:21129;   CHEBI:24876;   CHEBI:34754;   CHEBI:49599
 xref: CAS:15438-31-0;   Gmelin:6845;   KEGG:C14818;   PDBeChem:FE2


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iron(2+) sulfate (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO ferrous sulfate results in increased expression of ABCF1 mRNA CTD PMID:19428942 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Aco1 aconitase 1 multiple interactions ISO [nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein] CTD PMID:16039939 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of ACTA2 protein CTD PMID:7593635 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP ferrous sulfate results in increased expression of BAX protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein]
CTD PMID:28583816 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP ferrous sulfate results in decreased expression of BCL2 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in decreased expression of BCL2 protein]
CTD PMID:28583816 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO ferrous sulfate results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
EXP
ISO
ferrous sulfate results in increased cleavage of CASP3 protein
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased cleavage of CASP3 protein]
CTD PMID:17879260, PMID:28583816 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA] CTD PMID:17879260 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased degradation of Hyaluronic Acid]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein] CTD PMID:23692848 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 affects localization EXP ferrous sulfate affects the localization of CAV1 protein CTD PMID:17172471 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO ferrous sulfate results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO ferrous sulfate results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO ferrous sulfate results in increased expression of CCL20 mRNA CTD PMID:19428942, PMID:21540303 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO ferrous sulfate results in decreased expression of CCL21 mRNA CTD PMID:19428942 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO ferrous sulfate results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO ferrous sulfate results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO ferrous sulfate results in decreased expression of CCR7 mRNA CTD PMID:19428942 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO ferrous sulfate results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein] CTD PMID:23692848 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ferrous sulfate results in increased expression of CDKN1A mRNA CTD PMID:21540303 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO ferrous sulfate results in increased expression of CEBPB mRNA CTD PMID:19428942 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Crp C-reactive protein decreases expression ISO ferrous sulfate results in decreased expression of CRP mRNA; ferrous sulfate results in decreased expression of CRP protein CTD PMID:17119383, PMID:19428942 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO ferrous sulfate results in increased expression of CSF2 mRNA CTD PMID:21540303 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO ferrous sulfate results in increased expression of CXCL10 mRNA CTD PMID:19428942 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO ferrous sulfate results in increased expression of CXCL11 mRNA CTD PMID:19428942 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO ferrous sulfate results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO ferrous sulfate results in decreased expression of CXCL14 mRNA CTD PMID:19428942 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP ferrous sulfate results in increased expression of CXCL2 mRNA CTD PMID:11708899 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO ferrous sulfate results in decreased expression of CXCR2 mRNA CTD PMID:19428942 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; ferrous sulfate inhibits the reaction [picolinic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] CTD PMID:10799651 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 decreases response to substance ISO DNAJB1 protein results in decreased susceptibility to ferrous sulfate CTD PMID:11359866 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases activity ISO ferrous sulfate results in increased activity of EGLN1 protein CTD PMID:16649251 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egr1 early growth response 1 decreases expression ISO ferrous sulfate results in decreased expression of EGR1 mRNA CTD PMID:21540303 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] CTD PMID:17973296 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin results in decreased expression of and results in increased ubiquitination of ERBB2 protein] CTD PMID:18655187 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G F10 coagulation factor X decreases activity ISO ferrous sulfate results in decreased activity of F10 protein CTD PMID:6421970 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II decreases activity ISO ferrous sulfate results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO
EXP
[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]
ferrous sulfate results in increased expression of FTL1 protein
CTD PMID:16039939, PMID:28993186 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
ISO ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]
ferrous sulfate results in decreased expression of GCLC protein
CTD PMID:27424009 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases response to substance ISO GDNF protein results in decreased susceptibility to ferrous sulfate CTD PMID:17935603 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
EXP ferrous sulfate results in increased expression of GPX1 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein]
CTD PMID:28583816 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP ferrous sulfate results in increased phosphorylation of GSK3B protein CTD PMID:19608791 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
EXP ferrous sulfate results in increased expression of H2AX protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein]
CTD PMID:28583816 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferrous sulfate inhibits the reaction [Chromium results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Cobalt results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Nickel results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] CTD PMID:16386771, PMID:17973296 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [sulforafan results in increased expression of HMOX1 mRNA]]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of HMOX1 protein]
CTD PMID:20934533, PMID:26945724, PMID:28583816 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase affects localization
multiple interactions
EXP ferrous sulfate affects the localization of HRAS protein
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]
CTD PMID:17172471 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]] CTD PMID:18655187 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO ferrous sulfate results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of IL1B protein]
CTD PMID:23692848, PMID:28583816 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO ferrous sulfate results in increased expression of IL1RN mRNA CTD PMID:19428942 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO ferrous sulfate results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Il4 interleukin 4 increases expression ISO ferrous sulfate results in increased expression of IL4 protein CTD PMID:15963385 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression ISO ferrous sulfate results in decreased expression of IL6 protein CTD PMID:17119383 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferrous sulfate results in increased expression of JUN mRNA CTD PMID:21540303 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klk1 kallikrein 1 decreases activity ISO ferrous sulfate results in decreased activity of KLK1 protein CTD PMID:6421970 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Lep leptin increases expression ISO ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lta lymphotoxin alpha increases expression
decreases expression
ISO ferrous sulfate results in increased expression of LTA mRNA
ferrous sulfate results in decreased expression of LTA mRNA
CTD PMID:19428942, PMID:21540303 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions
increases phosphorylation
EXP ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 multiple interactions EXP MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 affects localization
increases activity
multiple interactions
EXP ferrous sulfate affects the localization of MAP3K7 protein
ferrous sulfate results in increased activity of MAP3K7 protein
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]
CTD PMID:17172471 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein] CTD PMID:17172471, PMID:19608791 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein] CTD PMID:17172471, PMID:19608791 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA; Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; Resveratrol analog inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA] CTD PMID:22099153 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression
ISO
EXP
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]
Diltiazem promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]
CTD PMID:23692848, PMID:27095094 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP ferrous sulfate results in increased expression of MT1A mRNA
[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT1A protein; ferrous sulfate results in increased expression of and affects the localization of MT1A protein
CTD PMID:17241390, PMID:19679144 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions EXP [Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT2A protein; ferrous sulfate results in increased expression of and affects the localization of MT2A protein CTD PMID:17241390 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions EXP [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MYB protein CTD PMID:7593635 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO
EXP
ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein]]
ferrous sulfate results in increased expression of NFE2L2 mRNA
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of NFE2L2 protein]; ferrous sulfate results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:26945724, PMID:28583816 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein]
CTD PMID:17879260, PMID:22099153, PMID:23692848 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein]
CTD PMID:17172471, PMID:17879260, PMID:28583816 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein] CTD PMID:23692848 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP ferrous sulfate results in increased expression of NQO1 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NQO1 protein]
CTD PMID:28583816 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 increases expression ISO ferrous sulfate results in increased expression of PMEPA1 mRNA CTD PMID:21540303 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; [Ascorbic Acid co-treated with ferrous sulfate] results in decreased activity of PON1 protein CTD PMID:12871208, PMID:15375178 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP ferrous sulfate results in increased expression of PTGS2 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of PTGS2 protein]
CTD PMID:28583816 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO
EXP
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]
ferrous sulfate affects the localization of RELA protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of RELA protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein]
CTD PMID:17879260, PMID:22099153, PMID:23692848, PMID:28583816 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Selplg selectin P ligand increases expression ISO ferrous sulfate results in increased expression of SELPLG mRNA CTD PMID:21540303 NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
JBrowse link
G Slc11a2 solute carrier family 11 member 2 decreases expression ISO ferrous sulfate results in decreased expression of SLC11A2 mRNA CTD PMID:10966897 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased abundance of Reactive Oxygen Species]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron] CTD PMID:19913091 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Snca synuclein alpha multiple interactions ISO ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]; ferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species] CTD PMID:27424009 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases activity
ISO ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]
ferrous sulfate results in decreased activity of SOD1 protein
CTD PMID:27424009 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases activity
decreases expression
ISO ferrous sulfate results in increased activity of SOD2 protein
ferrous sulfate results in decreased expression of SOD2 protein
CTD PMID:27424009 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO ferrous sulfate results in decreased expression of SPP1 mRNA CTD PMID:19428942 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases phosphorylation EXP ferrous sulfate results in increased phosphorylation of STAT1 protein CTD PMID:17607690 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [ferrous sulfate co-treated with Copper Sulfate] promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein] CTD PMID:10364193 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tas1r3 taste 1 receptor member 3 affects response to substance ISO TAS1R3 protein affects the susceptibility to ferrous sulfate CTD PMID:19244541 NCBI chr 5:173,307,325...173,312,950
Ensembl chr 5:173,308,870...173,312,023
JBrowse link
G Tf transferrin multiple interactions
increases expression
ISO
EXP
ferrous sulfate promotes the reaction [TF protein results in increased uptake of Iron]
ferrous sulfate results in increased expression of TF protein
CTD PMID:11335103, PMID:28993186 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor decreases expression ISO
EXP
ferrous sulfate results in decreased expression of TFRC mRNA
ferrous sulfate results in decreased expression of TFRC protein
CTD PMID:10966897, PMID:16039939, PMID:28993186 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
EXP Diltiazem inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] CTD PMID:27095094 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein] CTD PMID:23692848 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein] CTD PMID:23692848 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
ferrous sulfate results in increased expression of TNF mRNA; ferrous sulfate results in increased expression of TNF protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; tetramethylthiourea inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; U 0126 inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]
ferrous sulfate inhibits the reaction [Deferoxamine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
CTD PMID:7539275, PMID:15550384, PMID:15963385, PMID:17172471, PMID:19428942, PMID:21540303, PMID:23692848, PMID:28583816 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 affects response to substance ISO TRPM5 protein affects the susceptibility to ferrous sulfate CTD PMID:19244541 NCBI chr 1:216,256,653...216,281,504
Ensembl chr 1:216,257,820...216,274,930
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO ferrous sulfate results in increased activity of TRPV1 protein CTD PMID:17567713 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO ferrous sulfate results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:132,911,474...132,919,110
Ensembl chr 8:132,911,486...132,919,110
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          cofactor 15531
            iron(2+) 100
              ferrous ammonium sulfate (anhydrous) + 0
              iron(2+) sulfate (anhydrous) + 100
              iron(2+) sulfides + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  metal atom 17263
                    transition element atom 16711
                      d-block element atom 16701
                        iron group element atom 854
                          iron atom 832
                            iron molecular entity 832
                              elemental iron 487
                                iron cation 204
                                  iron(2+) 100
                                    ferrous ammonium sulfate (anhydrous) + 0
                                    iron(2+) sulfate (anhydrous) + 100
                                    iron(2+) sulfides + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.