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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:calcium(2+)
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Accession:CHEBI:29108 term browser browse the term
Definition:A calcium cation that has formula Ca.
Synonyms:exact_synonym: calcium(2+) ion;   calcium(II) cation
 related_synonym: CALCIUM ION;   Ca(2+);   Ca2+;   Formula=Ca;   InChI=1S/Ca/q+2;   InChIKey=BHPQYMZQTOCNFJ-UHFFFAOYSA-N;   SMILES=[Ca++];   calcium, doubly charged positive ion
 alt_id: CHEBI:22988;   CHEBI:3308;   CHEBI:48760
 xref: CAS:14127-61-8;   Gmelin:6850;   KEGG:C00076;   PDBeChem:CA


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calcium carbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO Calcium Carbonate results in decreased expression of BGLAP protein CTD PMID:2027271 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Capn1 calpain 1 increases activity ISO Calcium Carbonate analog results in increased activity of CAPN1 protein CTD PMID:24412303 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Casp3 caspase 3 increases activity ISO Calcium Carbonate analog results in increased activity of CASP3 protein CTD PMID:24412303 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Calcium Carbonate analog results in increased expression of DDIT3 CTD PMID:24412303 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Pth parathyroid hormone affects expression
decreases expression
ISO Calcium Carbonate affects the expression of PTH protein
Calcium Carbonate results in decreased expression of PTH protein
CTD PMID:1752077, PMID:2027271, PMID:3826069, PMID:7891547, PMID:8481062, PMID:16006300 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Calcium Carbonate results in decreased expression of PTHLH protein CTD PMID:16006300 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Calcium Carbonate results in decreased expression of SPP1 protein CTD PMID:17977878 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
calcium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 increases expression EXP Calcium Chloride results in increased expression of ADAM10 mRNA; Calcium Chloride results in increased expression of ADAM10 protein CTD PMID:20621845 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 increases expression EXP Calcium Chloride results in increased expression of ADAM17 mRNA; Calcium Chloride results in increased expression of ADAM17 protein CTD PMID:20621845 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Calcium Chloride results in increased expression of ALPL mRNA CTD PMID:25824407 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apoc3 apolipoprotein C3 increases expression ISO Calcium Chloride results in increased expression of APOC3 protein CTD PMID:25824407 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 increases expression ISO Calcium Chloride results in increased expression of ATP5PF protein CTD PMID:25824407 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Bag4 BAG cochaperone 4 increases expression ISO Calcium Chloride results in increased expression of BAG4 protein CTD PMID:25824407 NCBI chr16:71,057,709...71,075,874
Ensembl chr16:71,058,022...71,075,320
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Calcium Chloride results in increased expression of BGLAP mRNA CTD PMID:25824407 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bicd2 BICD cargo adaptor 2 increases expression ISO Calcium Chloride results in increased expression of BICD2 protein CTD PMID:25824407 NCBI chr17:15,673,649...15,718,035
Ensembl chr17:15,673,650...15,718,035
JBrowse link
G Calm3 calmodulin 3 multiple interactions ISO Calcium Chloride inhibits the reaction [CALM3 protein binds to and results in decreased activity of UBE3B protein] CTD PMID:28003368 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Casr calcium-sensing receptor multiple interactions
increases activity
ISO Calcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein]
Calcium Chloride results in increased activity of CASR protein
CTD PMID:16316325, PMID:17376781 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases phosphorylation
increases expression
multiple interactions
ISO Calcium Chloride results in increased phosphorylation of CCL2 protein
Calcium Chloride results in increased expression of CCL2 mRNA; Calcium Chloride results in increased expression of CCL2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CCL2 protein]; Resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Calcium Chloride results in increased phosphorylation of CCL2 protein]
CTD PMID:21530968, PMID:22728078 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Calcium Chloride results in decreased expression of CCT6A protein CTD PMID:25824407 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cd68 Cd68 molecule multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CD68 mRNA] CTD PMID:21530968 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein] CTD PMID:12189186 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA]; Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A protein] CTD PMID:12189186 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases activity ISO Calcium Chloride results in increased activity of CEBPA protein CTD PMID:17214633 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Clec3b C-type lectin domain family 3, member B increases expression ISO Calcium Chloride results in increased expression of CLEC3B protein CTD PMID:25824407 NCBI chr 8:132,241,016...132,248,066
Ensembl chr 8:132,241,134...132,246,694
JBrowse link
G Clic3 chloride intracellular channel 3 decreases expression ISO Calcium Chloride results in decreased expression of CLIC3 protein CTD PMID:25824407 NCBI chr 3:2,675,732...2,678,248
Ensembl chr 3:2,676,296...2,680,565
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 increases expression ISO Calcium Chloride results in increased expression of CMTM6 protein CTD PMID:25824407 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Calcium Chloride results in increased expression of COL1A1 mRNA CTD PMID:25824407 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain increases expression ISO Calcium Chloride results in increased expression of COL8A1 protein CTD PMID:25824407 NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
JBrowse link
G Cops3 COP9 signalosome subunit 3 increases expression ISO Calcium Chloride results in increased expression of COPS3 protein CTD PMID:25824407 NCBI chr10:46,182,680...46,206,083
Ensembl chr10:46,182,687...46,206,135
JBrowse link
G Cst3 cystatin C increases expression ISO Calcium Chloride results in increased expression of CST3 protein CTD PMID:25824407 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 decreases expression ISO Calcium Chloride results in decreased expression of CTHRC1 protein CTD PMID:25824407 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Ctsb cathepsin B increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of CTSB protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CTSB protein]
CTD PMID:22728078 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsk cathepsin K increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of CTSK protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CTSK protein]
CTD PMID:22728078 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Dcn decorin decreases expression ISO Calcium Chloride results in decreased expression of DCN protein CTD PMID:25824407 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Ddx39b DExD-box helicase 39B increases expression ISO Calcium Chloride results in increased expression of DDX39B protein CTD PMID:25824407 NCBI chr20:4,806,103...4,818,600
Ensembl chr20:4,806,108...4,818,568
JBrowse link
G Ehd2 EH-domain containing 2 increases expression ISO Calcium Chloride results in increased expression of EHD2 protein CTD PMID:25824407 NCBI chr 1:77,847,599...77,865,870
Ensembl chr 1:77,847,600...77,865,870
JBrowse link
G F10 coagulation factor X multiple interactions ISO [F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F11 coagulation factor XI multiple interactions ISO [F11 protein co-treated with Calcium Chloride] results in increased activity of F9 protein CTD PMID:6604052 NCBI chr16:50,179,458...50,201,644
Ensembl chr16:50,179,458...50,201,698
JBrowse link
G F2 coagulation factor II multiple interactions ISO [F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F5 coagulation factor V multiple interactions ISO [F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G F9 coagulation factor IX multiple interactions ISO [F11 protein co-treated with Calcium Chloride] results in increased activity of F9 protein CTD PMID:6604052 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO Calcium Chloride results in increased expression of FYN protein CTD PMID:25824407 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Git1 GIT ArfGAP 1 increases expression ISO Calcium Chloride results in increased expression of GIT1 protein CTD PMID:25824407 NCBI chr10:62,656,000...62,664,467
Ensembl chr10:62,656,000...62,664,466
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP [manganese chloride co-treated with Calcium Chloride] results in increased secretion of GNRH1 protein CTD PMID:18603625 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gpr89b G protein-coupled receptor 89B increases expression ISO Calcium Chloride results in increased expression of GPR89B protein CTD PMID:25824407 NCBI chr 2:198,999,945...199,038,702
Ensembl chr 2:198,999,946...199,038,702
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA] CTD PMID:21530968, PMID:24337353 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA] CTD PMID:21530968, PMID:24337353 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA] CTD PMID:21443188 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htra1 HtrA serine peptidase 1 decreases expression ISO Calcium Chloride results in decreased expression of HTRA1 protein CTD PMID:25824407 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of ICAM1 mRNA
resveratrol inhibits the reaction [Calcium Chloride results in increased expression of ICAM1 mRNA]
CTD PMID:21530968 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ift27 intraflagellar transport 27 increases expression ISO Calcium Chloride results in increased expression of IFT27 protein CTD PMID:25824407 NCBI chr 7:119,393,384...119,409,710
Ensembl chr 7:119,393,384...119,409,710
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of IL1B protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of IL1B protein]
CTD PMID:22728078 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 multiple interactions ISO Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Klk8 kallikrein related-peptidase 8 increases activity ISO Calcium Chloride results in increased activity of KLK8 protein CTD PMID:16800733 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO Calcium Chloride results in increased expression of LASP1 protein CTD PMID:25824407 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 decreases expression ISO Calcium Chloride results in decreased expression of LRRFIP1 protein CTD PMID:25824407 NCBI chr 9:98,139,484...98,268,148
Ensembl chr 9:98,190,829...98,257,735
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Calcium Chloride results in increased phosphorylation of MAPK1 protein CTD PMID:21215118 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
increases phosphorylation
ISO
EXP
Calcium Chloride results in increased expression of MAPK3 protein
Calcium Chloride results in increased phosphorylation of MAPK3 protein
CTD PMID:21215118, PMID:25824407 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
increases activity
multiple interactions
EXP
ISO
Calcium Chloride results in increased expression of MMP2 mRNA; Calcium Chloride results in increased expression of MMP2 protein
Calcium Chloride results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]
Calcium Chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]
CTD PMID:10086886, PMID:16159824, PMID:20621845, PMID:21530968, PMID:22728078, PMID:24337353 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity
multiple interactions
EXP
ISO
Calcium Chloride results in increased expression of MMP9 mRNA; Calcium Chloride results in increased expression of MMP9 protein
Calcium Chloride results in increased activity of MMP9 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]
CTD PMID:20621845, PMID:21530968, PMID:22728078, PMID:24337353 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Calcium Chloride inhibits the reaction [Azoxymethane results in increased expression of MYC mRNA]; Calcium Chloride inhibits the reaction [Azoxymethane results in increased expression of MYC protein] CTD PMID:12189186 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of NCF1 mRNA; Calcium Chloride results in increased expression of NCF1 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NCF1 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NCF1 protein]
CTD PMID:24337353 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Calcium Chloride promotes the reaction [NOS1 protein results in increased reduction of Trinitrotoluene] CTD PMID:15223068 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of NOS2 mRNA
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NOS2 mRNA]
CTD PMID:24337353 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic increases expression ISO Calcium Chloride results in increased expression of NT5C protein CTD PMID:25824407 NCBI chr10:104,052,807...104,054,805
Ensembl chr10:104,052,831...104,054,805
JBrowse link
G Nxn nucleoredoxin increases expression ISO Calcium Chloride results in increased expression of NXN protein CTD PMID:25824407 NCBI chr10:64,411,710...64,550,147
Ensembl chr10:64,412,833...64,550,145
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:16052486 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Postn periostin decreases expression ISO Calcium Chloride results in decreased expression of POSTN protein CTD PMID:25824407 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Ppid peptidylprolyl isomerase D increases expression ISO Calcium Chloride results in increased expression of PPID mRNA; Calcium Chloride results in increased expression of PPID protein CTD PMID:18614807 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link
G Psen2 presenilin 2 increases expression ISO Calcium Chloride results in increased expression of PSEN2 protein CTD PMID:25824407 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO Calcium Chloride results in decreased expression of RAD50 protein CTD PMID:25824407 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO Calcium Chloride results in increased expression of RECK protein CTD PMID:25824407 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G S100a13 S100 calcium binding protein A13 multiple interactions ISO [Calcium Chloride co-treated with cuprous chloride] binds to and affects the folding of S100A13 protein; Calcium Chloride binds to and affects the folding of S100A13 protein CTD PMID:16766622 NCBI chr 2:189,906,022...189,912,516
Ensembl chr 2:189,906,022...189,912,516
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Calcium Chloride results in increased expression of S100A8 mRNA; Calcium Chloride results in increased expression of S100A8 protein CTD PMID:17214633 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Calcium Chloride results in increased expression of S100A9 mRNA; Calcium Chloride results in increased expression of S100A9 protein CTD PMID:17214633 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO Calcium Chloride results in increased expression of SHC1 protein CTD PMID:25824407 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions
ISO Calcium Chloride results in increased activity of SOD2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of SOD2 protein]
CTD PMID:24337353 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat6 signal transducer and activator of transcription 6 decreases expression ISO Calcium Chloride results in decreased expression of STAT6 protein CTD PMID:25824407 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Calcium Chloride results in decreased expression of TGFB1 protein CTD PMID:25824407 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions
ISO Calcium Chloride results in decreased expression of TIMP1 mRNA
Quercetin inhibits the reaction [Calcium Chloride results in decreased expression of TIMP1 mRNA]
CTD PMID:22728078 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of TNF mRNA]
Calcium Chloride results in increased expression of TNF mRNA; Calcium Chloride results in increased expression of TNF protein
CTD PMID:21530968, PMID:22728078 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity
ISO
EXP
Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]
Ionomycin inhibits the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [Calcium Chloride results in increased activity of TRPV1 protein]
CTD PMID:19553475 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ube3b ubiquitin protein ligase E3B multiple interactions ISO Calcium Chloride inhibits the reaction [CALM3 protein binds to and results in decreased activity of UBE3B protein] CTD PMID:28003368 NCBI chr12:47,946,691...47,991,973
Ensembl chr12:47,948,247...47,990,105
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases phosphorylation
multiple interactions
EXP Calcium Chloride results in decreased phosphorylation of UQCRFS1 protein
[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; [tert-Butylhydroperoxide co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]; Cyclosporine inhibits the reaction [[tert-Butylhydroperoxide co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]
CTD PMID:16023995 NCBI chr17:35,677,984...35,682,262
Ensembl chr17:35,677,984...35,682,259
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Calcium Chloride results in increased expression of VEGFA mRNA
resveratrol inhibits the reaction [Calcium Chloride results in increased expression of VEGFA mRNA]
CTD PMID:21530968 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
calcium phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO calcium phosphate results in increased expression of CXCL10 protein CTD PMID:14600836 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO calcium phosphate results in increased expression of CXCL12 protein CTD PMID:14600836 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          cofactor 15529
            calcium(2+) 88
              calcium ammonium nitrate 0
              calcium nitrate + 0
              calcium salt + 88
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        alkaline earth molecular entity 668
                          calcium molecular entity 534
                            elemental calcium 530
                              calcium ion 89
                                calcium cation 88
                                  calcium(2+) 88
                                    calcium ammonium nitrate 0
                                    calcium nitrate + 0
                                    calcium salt + 88
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.