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ONTOLOGY REPORT - ANNOTATIONS


Term:desloratadine
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Accession:CHEBI:291342 term browser browse the term
Definition:Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
Synonyms:related_synonym: 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;   8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine;   Formula=C19H19ClN2;   InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2;   InChIKey=JAUOIFJMECXRGI-UHFFFAOYSA-N;   SMILES=Clc1ccc2c(CCc3cccnc3C2=C2CCNCC2)c1;   descarboethoxyloratadine
 xref: Beilstein:4263164 "Beilstein";   CAS:100643-71-8 "ChemIDplus";   CAS:100643-71-8 "KEGG DRUG";   DrugBank:DB00967;   Drug_Central:814 "DrugCentral";   KEGG:D03693;   LINCS:LSM-5887
 xref_mesh: MESH:C121345
 xref: PMID:11844681 "ChEMBL";   PMID:15482930 "ChEMBL";   PMID:9934454 "ChEMBL";   Patent:EP208855;   Patent:US4659716;   Wikipedia:Desloratadine


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desloratadine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      application 19350
        pharmaceutical 19224
          drug 19224
            anti-allergic agent 3788
              desloratadine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic molecule 19434
                              organic cyclic compound 19201
                                organic heterocyclic compound 18270
                                  organic heteropolycyclic compound 17577
                                    organic heterotricyclic compound 13732
                                      benzocycloheptapyridine 58
                                        desloratadine 8
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