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Accession:CHEBI:3011 term browser browse the term
Definition:A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Synonyms:exact_synonym: [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
 related_synonym: 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-;   Formula=C24H28N2O5;   InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1;   InChIKey=XPCFTKFZXHTYIP-PMACEKPBSA-N;   SMILES=CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O;   benazeprilum
 xref: CAS:86541-75-5 "ChemIDplus";   CAS:86541-75-5 "KEGG COMPOUND";   DrugBank:DB00542;   Drug_Central:299 "DrugCentral";   HMDB:HMDB0014682;   KEGG:C06843;   KEGG:D07499;   LINCS:LSM-5609
 xref_mesh: MESH:C044946
 xref: MetaCyc:CPD-15329;   PMID:25224804 "Europe PMC";   PMID:25738503 "Europe PMC";   PMID:25784709 "Europe PMC";   PMID:25912588 "Europe PMC";   Patent:EP72352;   Patent:US4410520;   Reaxys:4302258 "Reaxys";   Wikipedia:Benazepril
 cyclic_relationship: is_conjugate_base_of CHEBI:88201

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benazepril term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DES desmin JBrowse link 37 25,933,525 25,939,910 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 225
    role 225
      application 191
        pro-agent 15
          prodrug 15
            benazepril 1
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Term Annotations click to browse term
  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 206
                        carbon atom 205
                          organic molecular entity 205
                            organic group 153
                              organic divalent group 152
                                organodiyl group 152
                                  carbonyl group 152
                                    carbonyl compound 152
                                      carboxylic acid 112
                                        carboacyl group 47
                                          univalent carboacyl group 47
                                            carbamoyl group 44
                                              carboxamide 44
                                                lactam 4
                                                  benazeprilat 1
                                                    benazepril 1
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