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ONTOLOGY REPORT - ANNOTATIONS


Term:benazepril
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Accession:CHEBI:3011 term browser browse the term
Definition:A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Synonyms:exact_synonym: [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
 related_synonym: 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-;   Formula=C24H28N2O5;   InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1;   InChIKey=XPCFTKFZXHTYIP-PMACEKPBSA-N;   SMILES=CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O;   benazeprilum
 xref: CAS:86541-75-5 "ChemIDplus";   CAS:86541-75-5 "KEGG COMPOUND";   DrugBank:DB00542;   Drug_Central:299 "DrugCentral";   HMDB:HMDB0014682;   KEGG:C06843;   KEGG:D07499;   LINCS:LSM-5609
 xref_mesh: MESH:C044946
 xref: MetaCyc:CPD-15329;   PMID:25224804 "Europe PMC";   PMID:25738503 "Europe PMC";   PMID:25784709 "Europe PMC";   PMID:25912588 "Europe PMC";   Patent:EP72352;   Patent:US4410520;   Reaxys:4302258 "Reaxys";   Wikipedia:Benazepril
 cyclic_relationship: is_conjugate_base_of CHEBI:88201


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benazepril term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6480464
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 JBrowse link X 164,139,342 164,188,418 RGD:6480464
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Adrb2 adrenergic receptor, beta 2 JBrowse link 18 62,177,713 62,179,981 RGD:6480464
G Ager advanced glycosylation end product-specific receptor JBrowse link 17 34,597,460 34,600,937 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 13 30,336,356 30,382,867 RGD:6480464
G Ambp alpha 1 microglobulin/bikunin precursor JBrowse link 4 63,143,275 63,154,172 RGD:6480464
G Apob apolipoprotein B JBrowse link 12 7,977,629 8,016,839 RGD:6480464
G Aqp1 aquaporin 1 JBrowse link 6 55,336,299 55,348,555 RGD:6480464
G Aqp4 aquaporin 4 JBrowse link 18 15,389,394 15,410,982 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bdkrb2 bradykinin receptor, beta 2 JBrowse link 12 105,563,172 105,595,244 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 10 24,595,442 24,598,683 RGD:6480464
G Cd36 CD36 molecule JBrowse link 5 17,781,690 17,888,959 RGD:6480464
G Col4a1 collagen, type IV, alpha 1 JBrowse link 8 11,198,423 11,312,889 RGD:6480464
G Cxcl1 chemokine (C-X-C motif) ligand 1 JBrowse link 5 90,891,245 90,893,121 RGD:6480464
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 15 74,850,618 74,856,231 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 12 54,178,981 54,203,874 RGD:6480464
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:6480464
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 1 71,585,473 71,653,280 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial JBrowse link 8 95,864,133 95,888,401 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 5 16,553,495 16,619,439 RGD:6480464
G Hspe1 heat shock protein 1 (chaperonin 10) JBrowse link 1 55,088,148 55,091,317 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Kng2 kininogen 2 JBrowse link 16 22,985,852 23,029,101 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic JBrowse link 9 86,581,363 86,695,914 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 8 92,827,290 92,853,421 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Mthfr methylenetetrahydrofolate reductase JBrowse link 4 148,039,077 148,059,562 RGD:6480464
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 13 12,181,331 12,258,199 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha JBrowse link 14 54,941,921 54,968,017 RGD:6480464
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 5 134,220,053 134,229,628 RGD:6480464
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Nppb natriuretic peptide type B JBrowse link 4 147,985,786 147,987,205 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 10 89,454,234 89,533,645 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 2 132,249,286 132,253,180 RGD:6480464
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 JBrowse link 6 5,483,351 5,496,278 RGD:6480464
G Pla2g5 phospholipase A2, group V JBrowse link 4 138,799,247 138,863,562 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 14 20,836,662 20,843,388 RGD:6480464
G Plaur plasminogen activator, urokinase receptor JBrowse link 7 24,460,937 24,475,970 RGD:6480464
G Plg plasminogen JBrowse link 17 12,378,609 12,419,384 RGD:6480464
G Prcp prolylcarboxypeptidase (angiotensinase C) JBrowse link 7 92,875,253 92,934,581 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Ren1 renin 1 structural JBrowse link 1 133,350,674 133,360,320 RGD:6480464
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link 12 26,442,743 26,456,452 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 JBrowse link 7 99,345,375 99,353,239 RGD:6480464
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 JBrowse link 14 121,459,621 121,505,254 RGD:6480464
G Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 JBrowse link 16 36,750,161 36,785,158 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 76,241,090 76,311,748 RGD:6480464
G Smad3 SMAD family member 3 JBrowse link 9 63,646,766 63,757,994 RGD:6480464
G Snrpn small nuclear ribonucleoprotein N JBrowse link 7 59,982,495 60,450,177 RGD:6480464
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,762 90,226,333 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 5 104,435,111 104,441,053 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tgfbr1 transforming growth factor, beta receptor I JBrowse link 4 47,353,222 47,414,926 RGD:6480464
G Timp1 tissue inhibitor of metalloproteinase 1 JBrowse link X 20,870,166 20,874,737 RGD:6480464
G Timp2 tissue inhibitor of metalloproteinase 2 JBrowse link 11 118,301,061 118,355,411 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 3 116,110,020 116,129,688 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21258
    role 21241
      application 20676
        pro-agent 8772
          prodrug 8545
            benazepril 75
Path 2
Term Annotations click to browse term
  CHEBI ontology 21258
    subatomic particle 21254
      composite particle 21254
        hadron 21254
          baryon 21254
            nucleon 21254
              atomic nucleus 21254
                atom 21254
                  main group element atom 21120
                    p-block element atom 21120
                      carbon group element atom 20892
                        carbon atom 20783
                          organic molecular entity 20783
                            organic group 19177
                              organic divalent group 19167
                                organodiyl group 19167
                                  carbonyl group 19137
                                    carbonyl compound 19137
                                      carboxylic acid 18817
                                        carboacyl group 17466
                                          univalent carboacyl group 17466
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 7875
                                                  benazeprilat 75
                                                    benazepril 75
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.