Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:3048 term browser browse the term
Definition:Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.
Synonyms:exact_synonym: (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
 related_synonym: 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane;   3alpha-(diphenylmethoxy)tropane;   3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;   3endo-benzhydryloxytropane;   Benztropine;   Formula=C21H25NO;   InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+;   InChIKey=GIJXKZJWITVLHI-PMOLBWCYSA-N;   SMILES=[H][C@]1(C[C@]2([H])CC[C@]([H])(C1)N2C)OC(c1ccccc1)c1ccccc1;   benzatropina;   benzatropinum;   benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether;   tropine benzohydryl ether
 alt_id: CHEBI:661238
 xref: Beilstein:90688 "Beilstein";   CAS:86-13-5 "ChemIDplus";   CAS:86-13-5 "KEGG COMPOUND";   CAS:86-13-5 "NIST Chemistry WebBook";   DrugBank:DB00245;   Drug_Central:333 "DrugCentral";   KEGG:C06846;   KEGG:D07511
 xref_mesh: MESH:D001590
 xref: Patent:US2595405;   Wikipedia:Benzatropine

show annotations for term's descendants       view all columns           Sort by:
benzatropine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pharmaceutical 19222
          drug 19222
            antidyskinesia agent 1133
              benzatropine 4
                benzatropine mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    main group molecular entity 19637
                      s-block molecular entity 19397
                        hydrogen molecular entity 19386
                          hydrides 18356
                            inorganic hydride 17216
                              pnictogen hydride 17180
                                nitrogen hydride 17014
                                  azane 16706
                                    ammonia 16703
                                      organic amino compound 16702
                                        tertiary amino compound 8585
                                          benzatropine 4
                                            benzatropine mesylate 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.