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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron trichloride
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Accession:CHEBI:30808 term browser browse the term
Definition:An iron coordination entity that has formula Cl3Fe.
Synonyms:exact_synonym: iron(3+) chloride;   iron(III) chloride
 related_synonym: FeCl3;   Formula=Cl3Fe;   InChI=1S/3ClH.Fe/h3*1H;/q;;;+3/p-3;   InChIKey=RBTARNINKXHZNM-UHFFFAOYSA-K;   SMILES=Cl[Fe](Cl)Cl;   ferric chloride
 xref: CAS:7705-08-0;   Gmelin:1903
 xref_mesh: MESH:C024555
 xref: MolBase:1292;   Wikipedia:Iron(III)_chloride


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iron trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions EXP [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein CTD PMID:17657459 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects localization
multiple interactions
ISO ferric chloride affects the localization of APEX1 protein
[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein
CTD PMID:12023366 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO ferric chloride results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:16959548 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO [ferric chloride results in increased oxidation of 2-tert-butylhydroquinone] promotes the reaction [2-tert-butylhydroquinone analog binds to BACH1 protein]; [ferric chloride results in increased oxidation of hydroquinone] promotes the reaction [hydroquinone analog binds to BACH1 protein] CTD PMID:28645578 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein CTD PMID:19900513 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO chromous chloride inhibits the reaction [ferric chloride results in decreased activity of CAT protein]; ferric chloride inhibits the reaction [chromous chloride results in decreased activity of CAT protein] CTD PMID:30389395 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ferric chloride results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO ferric chloride results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of CXCL2] CTD PMID:21605006 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases stability
multiple interactions
ISO ferric chloride results in increased stability of CYP1A1 mRNA; ferric chloride results in increased stability of CYP1A1 protein
ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
CTD PMID:19896525 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Fech ferrochelatase increases expression
multiple interactions
ISO ferric chloride results in increased expression of FECH protein
ferric chloride inhibits the reaction [Deferoxamine results in decreased expression of FECH protein]; ferric chloride inhibits the reaction [pyridoxal isonicotinoyl hydrazone results in decreased expression of FECH protein]
CTD PMID:30517741 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO ferric chloride results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO [ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein CTD PMID:19900513 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
decreases expression
EXP ferric chloride results in decreased activity of G6PD protein
ferric chloride results in decreased expression of G6PD mRNA; ferric chloride results in decreased expression of G6PD protein
CTD PMID:24599681, PMID:30506659 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein CTD PMID:19900513 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
decreases expression
EXP ferric chloride results in increased expression of GSR protein
ferric chloride results in decreased expression of GSR mRNA
CTD PMID:30506659 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP ferric chloride results in increased expression of HAMP mRNA CTD PMID:30506659 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO ferric chloride results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO
[ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 protein
ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of HMOX1 protein]
CTD PMID:15019574, PMID:28645578 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA; ferric chloride inhibits the reaction [Deferoxamine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]
ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of IL1B mRNA]
CTD PMID:9851740, PMID:22168577, PMID:28512001 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO ferric chloride results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il6 interleukin 6 increases expression ISO ferric chloride results in increased expression of IL6 protein CTD PMID:15781289 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferric chloride results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klkb1 kallikrein B1 decreases response to substance ISO KLKB1 gene mutant form results in decreased susceptibility to ferric chloride CTD PMID:25339356 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK1 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK1 protein] CTD PMID:16728372, PMID:22168577 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [aluminum chloride co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; [Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK3 protein] CTD PMID:16728372, PMID:22168577 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO ferric chloride results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ferric chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mt1 metallothionein 1 decreases response to substance ISO MT1A protein results in decreased susceptibility to ferric chloride CTD PMID:11878821 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A decreases expression ISO ferric chloride results in decreased expression of MT2A mRNA CTD PMID:26378417 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NFE2L2 protein] CTD PMID:28645578 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [aluminum chloride co-treated with ferric chloride] results in increased expression of NOS2 protein CTD PMID:16728372 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NQO1 protein] CTD PMID:28645578 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pgd phosphogluconate dehydrogenase affects expression
decreases expression
increases expression
decreases activity
EXP ferric chloride affects the expression of PGD mRNA
ferric chloride results in decreased expression of PGD mRNA
ferric chloride results in increased expression of PGD protein
ferric chloride results in decreased activity of PGD protein
CTD PMID:24599681, PMID:30506659 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO ferric chloride results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO ferric chloride results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO ferric chloride results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO ferric chloride results in increased expression of SCARB1 protein CTD PMID:20025956 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO [Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; [Zinc Sulfate results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]; Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride] CTD PMID:20096349 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [ferric chloride co-treated with Oxyquinoline] results in decreased expression of SOD2 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 protein CTD PMID:15019574 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tf transferrin multiple interactions ISO ferric chloride promotes the reaction [TF protein results in increased uptake of Iron] CTD PMID:11335103 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO ferric chloride results in increased expression of TNF protein
[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]
[ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein; [ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein; [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein; TNF protein inhibits the reaction [ferric chloride results in increased chemical synthesis of Reactive Oxygen Species]; TNF results in decreased susceptibility to [ferric chloride co-treated with Hydrogen Peroxide]
CTD PMID:15781289, PMID:19900513, PMID:28512001 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        acid 18244
          Lewis acid 1799
            iron trichloride 43
              iron trichloride hexahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  metal atom 17260
                    transition element atom 16708
                      d-block element atom 16698
                        iron group element atom 854
                          iron atom 832
                            iron molecular entity 832
                              iron coordination entity 369
                                iron trichloride 43
                                  iron trichloride hexahydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.