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ONTOLOGY REPORT - ANNOTATIONS


Term:bicuculline
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Accession:CHEBI:3092 term browser browse the term
Definition:A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Synonyms:exact_synonym: (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
 related_synonym: Bicculine;   Bicucullin;   Formula=C20H17NO6;   InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1;   InChIKey=IYGYMKDQCDOMRE-ZWKOTPCHSA-N;   SMILES=[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12;   d-Bicuculline
 xref: Beilstein:98786;   CAS:485-49-4;   KEGG:C09364;   KNApSAcK:C00001820
 xref_mesh: MESH:D001640
 xref: PMID:27579770;   PMID:29137474;   PMID:29949743;   PMID:30858801;   Wikipedia:Bicuculline


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bicuculline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:6480464
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 JBrowse link 10 27,310,718 27,371,802 RGD:6480464
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 JBrowse link 14 39,662,411 39,801,082 RGD:6480464
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 10 27,847,447 27,862,896 RGD:6480464
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 14 38,631,192 39,112,598 RGD:6480464
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 JBrowse link 10 27,973,694 28,193,072 RGD:6480464
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 JBrowse link 1 113,034,251 113,265,364 RGD:6480464
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 JBrowse link 14 39,964,502 40,051,306 RGD:6480464
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 JBrowse link 10 27,090,913 27,179,786 RGD:6480464
G Gnrh1 gonadotropin releasing hormone 1 JBrowse link 15 44,441,856 44,446,064 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:6480464
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:6480464
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D JBrowse link 1 101,819,068 101,859,146 RGD:6480464
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:6480464
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:6480464
G Mpdz multiple PDZ domain crumbs cell polarity complex component JBrowse link 5 99,413,184 99,566,356 RGD:6480464
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Oxtr oxytocin receptor JBrowse link 4 144,399,326 144,417,598 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:6480464
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      application 19373
        agrochemical 14455
          bicuculline 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            heteroorganic entity 19145
                              organonitrogen compound 18254
                                alkaloid 5318
                                  isoquinoline alkaloid 1127
                                    benzylisoquinoline alkaloid 211
                                      bicuculline 31
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.