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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alclofenac
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Accession:CHEBI:31183 term browser browse the term
Definition:An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
Synonyms:exact_synonym: [3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
 related_synonym: (4-Allyloxy-3-chlorphenyl)essigsaeure;   3-Chloro-4-(2-propenyloxy)benzeneacetic acid;   Formula=C11H11ClO3;   InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14);   InChIKey=ARHWPKZXBHOEEE-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccc(OCC=C)c(Cl)c1;   [4-(allyloxy)-3-chlorophenyl]acetic acid;   alclofenaco;   alclofenacum
 xref: CAS:22131-79-9;   Drug_Central:107;   KEGG:D01252
 xref_mesh: MESH:C084615
 xref: PMID:18796;   PMID:19205;   PMID:21068;   PMID:236805;   PMID:237493;   PMID:241593;   PMID:241595;   PMID:241596;   PMID:241597;   PMID:241598;   PMID:241600;   PMID:241601;   PMID:241602;   PMID:241603;   PMID:24426;   PMID:4279126;   PMID:509935;   PMID:6103793;   PMID:6106453;   PMID:6109575;   PMID:6120697;   PMID:6141199;   PMID:7853459;   PMID:7905004;   Patent:BE704368;   Reaxys:2116510;   Wikipedia:Alclofenac


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alclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO alclofenac results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Hp haptoglobin decreases expression ISO alclofenac results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          anti-inflammatory drug 13624
            non-steroidal anti-inflammatory drug 12708
              alclofenac 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          alclofenac 3
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