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ONTOLOGY REPORT - ANNOTATIONS


Term:cilostazol
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Accession:CHEBI:31401 term browser browse the term
Definition:A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substiuted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Synonyms:exact_synonym: 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydroquinolin-2(1H)-one
 related_synonym: 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone;   6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril;   6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-1H-quinolin-2-one;   Formula=C20H27N5O2;   InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26);   InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N;   SMILES=O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1;   cilostazolum
 alt_id: CHEBI:150440
 xref: Beilstein:3632017 "Beilstein";   CAS:73963-72-1 "ChemIDplus";   CAS:73963-72-1 "KEGG DRUG";   DrugBank:DB01166;   Drug_Central:644 "DrugCentral";   KEGG:D01896;   LINCS:LSM-3491
 xref_mesh: MESH:C045645
 xref: PMID:17500510 "ChEMBL";   PMID:9873372 "ChEMBL";   Patent:BE878548;   Patent:US4277479;   VSDB:1939;   Wikipedia:Cilostazol


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cilostazol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIFM1 apoptosis inducing factor mitochondria associated 1 JBrowse link X 130,129,362 130,165,887 RGD:6480464
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G APP amyloid beta precursor protein JBrowse link 21 25,880,550 26,171,128 RGD:6480464
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 110,281,247 110,351,093 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G BID BH3 interacting domain death agonist JBrowse link 22 17,734,140 17,774,665 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CASP7 caspase 7 JBrowse link 10 113,679,162 113,730,909 RGD:6480464
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CCNA2 cyclin A2 JBrowse link 4 121,816,444 121,823,883 RGD:6480464
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6480464
G CFTR CF transmembrane conductance regulator JBrowse link 7 117,480,025 117,668,665 RGD:6480464
G CREB1 cAMP responsive element binding protein 1 JBrowse link 2 207,529,943 207,605,988 RGD:6480464
G CSNK2A1 casein kinase 2 alpha 1 JBrowse link 20 472,498 543,790 RGD:6480464
G E2F1 E2F transcription factor 1 JBrowse link 20 33,675,477 33,686,385 RGD:6480464
G E2F2 E2F transcription factor 2 JBrowse link 1 23,505,696 23,531,250 RGD:6480464
G EP300 E1A binding protein p300 JBrowse link 22 41,092,592 41,180,077 RGD:6480464
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:6480464
G IL5 interleukin 5 JBrowse link 5 132,539,194 132,556,864 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G MAPT microtubule associated protein tau JBrowse link 17 45,894,382 46,028,334 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6480464
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,513 35,404,749 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,017 151,014,588 RGD:6480464
G PCNA proliferating cell nuclear antigen JBrowse link 20 5,114,953 5,126,622 RGD:6480464
G PLN phospholamban JBrowse link 6 118,548,296 118,561,716 RGD:6480464
G PPARG peroxisome proliferator activated receptor gamma JBrowse link 3 12,287,485 12,434,344 RGD:6480464
G PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G SIRT1 sirtuin 1 JBrowse link 10 67,884,656 67,918,390 RGD:6480464
G SLC22A2 solute carrier family 22 member 2 JBrowse link 6 160,216,755 160,258,821 RGD:6480464
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) JBrowse link 6 44,219,587 44,234,144 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:6480464
G VCAM1 vascular cell adhesion molecule 1 JBrowse link 1 100,719,640 100,739,045 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23754
    role 23643
      application 23035
        pharmaceutical 22583
          drug 22583
            bronchodilator agent 3695
              cilostazol 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 23754
    subatomic particle 23703
      composite particle 23703
        hadron 23703
          baryon 23703
            nucleon 23703
              atomic nucleus 23703
                atom 23703
                  main group element atom 23522
                    p-block element atom 23522
                      carbon group element atom 23232
                        carbon atom 23208
                          organic molecular entity 23208
                            organic group 21894
                              organic divalent group 21866
                                organodiyl group 21866
                                  carbonyl group 21838
                                    carbonyl compound 21838
                                      carboxylic acid 20881
                                        carboacyl group 18971
                                          univalent carboacyl group 18971
                                            carbamoyl group 18357
                                              carboxamide 18357
                                                lactam 8144
                                                  cilostazol 42
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.