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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluocinolone acetonide
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Accession:CHEBI:31623 term browser browse the term
Definition:A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.
Synonyms:exact_synonym: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
 related_synonym: 6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone 16,17-acetonide;   6alpha-fluorotriamcinolone acetonide;   Coriphate;   Cortiplastol;   Derma-Smoothe/FS;   Dermalar;   Flucinar;   Flucort;   Fluocet;   Fluonid;   Fluotrex;   Fluovitif;   Flupollon;   Fluzon;   Formula=C24H30F2O6;   Iluvien;   InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1;   InChIKey=FEBLZLNTKCEFIT-VSXGLTOVSA-N;   Jellin;   Localyn;   Omniderm;   Percutina;   Prodermin;   Radiocin;   Retisert;   SMILES=CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO;   Sinalar;   Synalar;   Synamol;   Synandone;   Synandrone;   Synemol;   Synotic;   Synsac;   Tefunote;   acetonide de fluocinolone;   acetonido de fluocinolona;   fluocinolone 16,17-acetonide;   fluocinoloni acetonidum
 xref: CAS:67-73-2;   DrugBank:DB00591;   Drug_Central:1204;   HMDB:HMDB0014729;   KEGG:D01825
 xref_mesh: MESH:D005446
 xref: PMID:21238799;   PMID:21277557;   PMID:21459216;   PMID:23321234;   PMID:23323586;   Patent:US3014938;   Patent:US3126375;   Reaxys:1358396;   Wikipedia:Fluocinolone_acetonide


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fluocinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] CTD PMID:3677084 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          anti-inflammatory drug 13624
            fluocinolone acetonide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxyketone 8635
                                          alpha-oxyketone 8635
                                            alpha-hydroxy ketone 8635
                                              primary alpha-hydroxy ketone 7520
                                                fluocinolone acetonide 2
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