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ONTOLOGY REPORT - ANNOTATIONS


Term:fluorometholone
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Accession:CHEBI:31625 term browser browse the term
Definition:A member of the class of glucocorticoids that is Delta(1)-progesterone substituted at positions 11beta and 17 by hydroxy groups, at position 6alpha by a methyl group and at position 9 by a fluoro group. Used for the treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Synonyms:exact_synonym: (6alpha,11beta)-9-fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
 related_synonym: 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione;   Fluor-op;   Fluorometholon;   Formula=C22H29FO4;   InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1;   InChIKey=FAOZLTXFLGPHNG-KNAQIMQKSA-N;   NSC 33001;   Oxylone;   SMILES=C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]2(C)C=CC(=O)C=C12;   fluorometholonum;   fluorometolona
 xref: CAS:426-13-1 "ChemIDplus";   CAS:426-13-1 "KEGG DRUG";   DrugBank:DB00324;   Drug_Central:1208 "DrugCentral";   HMDB:HMDB0014469;   KEGG:D01367
 xref_mesh: MESH:D005469
 xref: PMID:22821643 "Europe PMC";   PMID:23023407 "Europe PMC";   PMID:23225837 "Europe PMC";   PMID:23429038 "Europe PMC";   PMID:23865053 "Europe PMC";   PMID:24074291 "Europe PMC";   PMID:24227962 "Europe PMC";   PMID:24493163 "Europe PMC";   Reaxys:3172388 "Reaxys";   Wikipedia:Fluorometholone


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fluorometholone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21258
    role 21241
      application 20676
        anti-inflammatory agent 15403
          anti-inflammatory drug 13984
            fluorometholone 1
              fluorometholone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21258
    subatomic particle 21254
      composite particle 21254
        hadron 21254
          baryon 21254
            nucleon 21254
              atomic nucleus 21254
                atom 21254
                  main group element atom 21120
                    p-block element atom 21120
                      carbon group element atom 20892
                        carbon atom 20783
                          organic molecular entity 20783
                            organic group 19177
                              organic divalent group 19167
                                organodiyl group 19167
                                  carbonyl group 19137
                                    carbonyl compound 19137
                                      ketone 16251
                                        oxo steroid 9455
                                          3-oxo steroid 8915
                                            3-oxo-Delta(4) steroid 8040
                                              progesterone 2782
                                                Delta(1)-progesterone 242
                                                  fluorometholone 1
                                                    fluorometholone acetate 0
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