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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrocortisone succinate
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Accession:CHEBI:31677 term browser browse the term
Definition:A derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).
Synonyms:related_synonym: 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(hydrogensuccinate);   11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione 21-succinate;   Cortisol succinate;   Formula=C25H34O8;   InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1;   InChIKey=VWQWXZAWFPZJDA-CGVGKPPMSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)COC(=O)CCC(O)=O
 alt_id: CHEBI:199284
 xref: Drug_Central:4456 "DrugCentral";   KEGG:C12888;   KEGG:D01442;   LINCS:LSM-5816;   LIPID_MAPS_instance:LMST02030126 "LIPID MAPS"
 xref_mesh: MESH:C007133


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hydrocortisone succinate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        anti-inflammatory agent 14947
          anti-inflammatory drug 13602
            cortisol 154
              hydrocortisone succinate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      dicarboxylic acids and O-substituted derivatives 10211
                                        dicarboxylic acid 10205
                                          alpha,omega-dicarboxylic acid 2746
                                            succinic acid 206
                                              succinate ester 96
                                                hemisuccinate 92
                                                  hydrocortisone succinate 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.