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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrocortisone succinate
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Accession:CHEBI:31677 term browser browse the term
Definition:A derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).
Synonyms:related_synonym: 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(hydrogensuccinate);   11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione 21-succinate;   Cortisol succinate;   Formula=C25H34O8;   InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1;   InChIKey=VWQWXZAWFPZJDA-CGVGKPPMSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)COC(=O)CCC(O)=O
 alt_id: CHEBI:199284
 xref: Drug_Central:4456 "DrugCentral";   KEGG:C12888;   KEGG:D01442;   LINCS:LSM-5816;   LIPID_MAPS_instance:LMST02030126 "LIPID MAPS"
 xref_mesh: MESH:C007133


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hydrocortisone succinate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      application 19246
        anti-inflammatory agent 14919
          anti-inflammatory drug 13601
            cortisol 154
              hydrocortisone succinate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      dicarboxylic acids and O-substituted derivatives 10168
                                        dicarboxylic acid 10161
                                          alpha,omega-dicarboxylic acid 2742
                                            succinic acid 202
                                              succinate ester 96
                                                hemisuccinate 92
                                                  hydrocortisone succinate 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.