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ONTOLOGY REPORT - ANNOTATIONS


Term:idebenone
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Accession:CHEBI:31687 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Synonyms:related_synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone;   BRN 2001459;   CV 2619;   Formula=C19H30O5;   InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3;   InChIKey=JGPMMRGNQUBGND-UHFFFAOYSA-N;   SMILES=COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O;   idebenona;   idebenonum
 xref: CAS:58186-27-9 "ChemIDplus";   Drug_Central:1416 "DrugCentral";   KEGG:D01750;   LINCS:LSM-5505
 xref_mesh: MESH:C036619
 xref: PMID:11207459 "Europe PMC";   PMID:15374364 "Europe PMC";   PMID:18045357 "Europe PMC";   PMID:18710357 "Europe PMC";   PMID:19283347 "Europe PMC";   PMID:19283350 "Europe PMC";   PMID:20955109 "Europe PMC";   PMID:22269948 "Europe PMC";   PMID:23859348 "Europe PMC";   PMID:2669658 "Europe PMC";   PMID:7981485 "Europe PMC";   PMID:7988944 "Europe PMC";   Patent:DE2519730;   Patent:US4271083;   Reaxys:2001459 "Reaxys";   Wikipedia:Idebenone


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idebenone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      chemical role 19209
        antioxidant 14108
          idebenone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      ketone 15922
                                        cyclic ketone 13359
                                          quinone 8238
                                            benzoquinones 589
                                              1,4-benzoquinones 584
                                                idebenone 4
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