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ONTOLOGY REPORT - ANNOTATIONS


Term:nicorandil
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Accession:CHEBI:31905 term browser browse the term
Definition:A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.
Synonyms:exact_synonym: 2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate
 related_synonym: 2-nicotinamidoethyl nitrate;   Adancor;   Formula=C8H9N3O4;   Ikorel;   InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12);   InChIKey=LBHIOVVIQHSOQN-UHFFFAOYSA-N;   N-(2-hydroxyethyl)nicotinamide nitrate;   Perisalol;   SG 75;   SMILES=[O-][N+](=O)OCCNC(=O)c1cccnc1;   Sigmart;   nicorandilum
 xref: CAS:65141-46-0 "ChemIDplus";   CAS:65141-46-0 "KEGG COMPOUND";   Drug_Central:1919 "DrugCentral";   KEGG:C13280;   KEGG:D01810;   LINCS:LSM-6009
 xref_mesh: MESH:D020108
 xref: PMID:23841868 "Europe PMC";   PMID:23845070 "Europe PMC";   PMID:24685703 "Europe PMC";   PMID:24837014 "Europe PMC";   PMID:24952900 "Europe PMC";   PMID:25319832 "Europe PMC";   Patent:DE2714713;   Patent:US4200640;   Wikipedia:Nicorandil


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nicorandil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link 4 176,806,098 176,928,540 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Gal galanin and GMAP prepropeptide JBrowse link 1 218,653,059 218,657,922 RGD:6480464
G Gusb glucuronidase, beta JBrowse link 12 30,202,066 30,215,583 RGD:6480464
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      chemical role 19218
        antioxidant 14147
          nicotinamide 131
            nicorandil 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      carboxylic acid 17971
                                        carboacyl group 17091
                                          univalent carboacyl group 17091
                                            carbamoyl group 16813
                                              carboxamide 16813
                                                pyridinecarboxamide 267
                                                  nicotinamide 131
                                                    nicorandil 18
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.